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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SHOX2_HOXC5

Z-value: 0.71

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Transcription factors associated with SHOX2_HOXC5

Gene Symbol Gene ID Gene Info
ENSG00000168779.20 short stature homeobox 2
ENSG00000172789.4 homeobox C5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SHOX2hg38_v1_chr3_-_158106050_1581062910.791.9e-02Click!
HOXC5hg38_v1_chr12_+_54033026_54033069-0.265.3e-01Click!

Activity profile of SHOX2_HOXC5 motif

Sorted Z-values of SHOX2_HOXC5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_20575850 0.66 ENST00000507958.5
cadherin 18
chr12_-_91153149 0.59 ENST00000550758.1
decorin
chr12_+_26195313 0.53 ENST00000422622.3
sarcospan
chr5_+_172641241 0.51 ENST00000369800.6
ENST00000520919.5
ENST00000522853.5
neuralized E3 ubiquitin protein ligase 1B
chr4_+_70050431 0.50 ENST00000511674.5
ENST00000246896.8
histatin 1
chr12_-_91179472 0.50 ENST00000550099.5
ENST00000546391.5
decorin
chr11_-_63608542 0.50 ENST00000540943.1
phospholipase A and acyltransferase 3
chr17_+_1771688 0.48 ENST00000572048.1
ENST00000573763.1
serpin family F member 1
chr1_-_72100930 0.48 ENST00000306821.3
neuronal growth regulator 1
chr17_+_69502397 0.47 ENST00000613873.4
ENST00000589647.5
mitogen-activated protein kinase kinase 6
chr13_+_101489940 0.45 ENST00000376162.7
integrin subunit beta like 1
chr9_-_92482350 0.44 ENST00000375543.2
asporin
chrX_+_136205982 0.44 ENST00000628568.1
four and a half LIM domains 1
chr9_+_96928310 0.44 ENST00000354649.7
NUT family member 2G
chr12_-_91179355 0.43 ENST00000550563.5
ENST00000546370.5
decorin
chr4_-_137532452 0.43 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
protocadherin 18
chr3_-_165837412 0.41 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
butyrylcholinesterase
chr11_-_101129706 0.39 ENST00000534013.5
progesterone receptor
chr17_-_55722857 0.39 ENST00000424486.3
transmembrane protein 100
chr17_+_68515399 0.37 ENST00000588188.6
protein kinase cAMP-dependent type I regulatory subunit alpha
chr20_+_142573 0.34 ENST00000382398.4
defensin beta 126
chr10_-_28282086 0.34 ENST00000375719.7
ENST00000375732.5
membrane palmitoylated protein 7
chr19_-_58353482 0.33 ENST00000263100.8
alpha-1-B glycoprotein
chr13_+_93226787 0.33 ENST00000377047.9
glypican 6
chr17_+_41237998 0.32 ENST00000254072.7
keratin associated protein 9-8
chr21_-_30480364 0.32 ENST00000390689.3
keratin associated protein 19-1
chr19_+_49513353 0.32 ENST00000596975.5
Fc fragment of IgG receptor and transporter
chrX_-_15314543 0.31 ENST00000344384.8
ankyrin repeat and SOCS box containing 11
chr2_+_188974364 0.31 ENST00000304636.9
ENST00000317840.9
collagen type III alpha 1 chain
chr15_+_94355956 0.30 ENST00000557742.1
multiple C2 and transmembrane domain containing 2
chr12_+_8157034 0.30 ENST00000396570.7
zinc finger protein 705A
chr1_+_70411241 0.29 ENST00000370938.8
ENST00000346806.2
cystathionine gamma-lyase
chr9_+_87497222 0.28 ENST00000358077.9
death associated protein kinase 1
chr16_-_66550091 0.28 ENST00000564917.5
ENST00000677420.1
thymidine kinase 2
chr16_+_77722502 0.27 ENST00000564085.5
ENST00000268533.9
ENST00000568787.5
ENST00000437314.3
ENST00000563839.1
nudix hydrolase 7
chr16_-_66549839 0.26 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
thymidine kinase 2
chr8_-_115492221 0.25 ENST00000518018.1
transcriptional repressor GATA binding 1
chr11_-_58844695 0.25 ENST00000287275.6
glycine-N-acyltransferase like 2
chr7_+_120988683 0.23 ENST00000340646.9
ENST00000310396.10
cadherin like and PC-esterase domain containing 1
chr16_-_66550005 0.23 ENST00000527284.6
thymidine kinase 2
chr2_+_219279330 0.23 ENST00000425450.5
ENST00000392086.8
ENST00000421532.5
ENST00000336576.10
DnaJ heat shock protein family (Hsp40) member B2
chr22_-_38794111 0.23 ENST00000406622.5
ENST00000216068.9
ENST00000406199.3
Sad1 and UNC84 domain containing 2
dynein axonemal light chain 4
chr4_+_118888918 0.23 ENST00000434046.6
synaptopodin 2
chr16_+_11965193 0.22 ENST00000053243.6
ENST00000396495.3
TNF receptor superfamily member 17
chr6_+_135851681 0.21 ENST00000308191.11
phosphodiesterase 7B
chr11_+_55811367 0.21 ENST00000625203.2
olfactory receptor family 5 subfamily L member 1
chr11_-_13496018 0.21 ENST00000529816.1
parathyroid hormone
chr6_-_87095059 0.20 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
glycoprotein hormones, alpha polypeptide
chr9_+_87497852 0.20 ENST00000408954.8
death associated protein kinase 1
chr12_+_26195543 0.20 ENST00000242729.7
sarcospan
chr5_+_120531464 0.20 ENST00000505123.5
proline rich 16
chr2_-_187554351 0.20 ENST00000437725.5
ENST00000409676.5
ENST00000233156.9
ENST00000339091.8
ENST00000420747.1
tissue factor pathway inhibitor
chr17_-_445939 0.20 ENST00000329099.4
refilin B
chr1_+_159302321 0.19 ENST00000368114.1
Fc fragment of IgE receptor Ia
chr1_-_230869564 0.19 ENST00000470540.5
chromosome 1 open reading frame 198
chr2_+_151357583 0.19 ENST00000243347.5
TNF alpha induced protein 6
chr15_+_24823625 0.19 ENST00000400100.5
ENST00000645002.1
ENST00000642807.1
small nuclear ribonucleoprotein polypeptide N
chr7_+_134843884 0.19 ENST00000445569.6
caldesmon 1
chr12_-_10453330 0.19 ENST00000347831.9
ENST00000359151.8
killer cell lectin like receptor C1
chr19_+_49513154 0.19 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
Fc fragment of IgG receptor and transporter
chr9_-_96778053 0.19 ENST00000375231.5
ENST00000223428.9
zinc finger protein 510
chrX_+_22032301 0.19 ENST00000379374.5
phosphate regulating endopeptidase homolog X-linked
chr9_-_92404559 0.19 ENST00000262551.8
ENST00000375561.10
osteoglycin
chr19_-_43883964 0.18 ENST00000587539.2
zinc finger protein 404
chr4_-_69860138 0.18 ENST00000226444.4
sulfotransferase family 1E member 1
chr3_+_155083889 0.18 ENST00000680282.1
membrane metalloendopeptidase
chr11_-_58844484 0.18 ENST00000532258.1
glycine-N-acyltransferase like 2
chr11_-_7941708 0.18 ENST00000642047.1
olfactory receptor family 10 subfamily A member 3
chr19_-_58440129 0.18 ENST00000254166.4
zinc finger protein 132
chr3_+_138621225 0.17 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr6_-_46491956 0.17 ENST00000306764.11
regulator of calcineurin 2
chr1_-_246193727 0.17 ENST00000391836.3
SET and MYND domain containing 3
chr11_-_105035113 0.17 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr16_-_3024230 0.17 ENST00000572355.5
ENST00000574980.5
ENST00000354679.3
ENST00000573842.1
host cell factor C1 regulator 1
chr4_+_112860981 0.17 ENST00000671704.1
ankyrin 2
chr2_-_189179754 0.17 ENST00000374866.9
ENST00000618828.1
collagen type V alpha 2 chain
chr1_+_217631337 0.17 ENST00000366933.5
spermatogenesis associated 17
chr2_-_227379297 0.17 ENST00000304568.4
transmembrane 4 L six family member 20
chr3_-_142029108 0.17 ENST00000497579.5
transcription factor Dp-2
chr2_-_224947030 0.17 ENST00000409592.7
dedicator of cytokinesis 10
chr12_+_64404338 0.16 ENST00000332707.10
exportin for tRNA
chr16_-_66550142 0.16 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
thymidine kinase 2
chr7_+_150405146 0.16 ENST00000498682.3
ENST00000641717.1
novel zinc finger protein
chr10_+_80131660 0.16 ENST00000372270.6
placenta associated 9
chr6_-_46491431 0.16 ENST00000371374.6
regulator of calcineurin 2
chr2_-_206765274 0.16 ENST00000454776.6
ENST00000449792.5
ENST00000374412.8
malate dehydrogenase 1B
chr13_-_75537805 0.16 ENST00000626103.1
ENST00000682242.1
ENST00000355801.4
COMM domain containing 6
chr12_+_119668109 0.16 ENST00000229328.10
ENST00000630317.1
protein kinase AMP-activated non-catalytic subunit beta 1
chr12_+_6904733 0.16 ENST00000007969.12
ENST00000622489.4
ENST00000443597.7
ENST00000323702.9
leucine rich repeat containing 23
chrX_-_103255117 0.16 ENST00000372685.8
ENST00000360000.8
ENST00000451678.1
transcription elongation factor A like 8
chrX_+_43656289 0.16 ENST00000338702.4
monoamine oxidase A
chr2_-_159798234 0.15 ENST00000429078.6
ENST00000553424.5
CD302 molecule
chr12_-_47771029 0.15 ENST00000549151.5
ENST00000548919.5
Rap guanine nucleotide exchange factor 3
chr11_-_13495984 0.15 ENST00000282091.6
parathyroid hormone
chr8_+_12108172 0.15 ENST00000400078.3
zinc finger protein 705D
chr1_+_196819731 0.15 ENST00000320493.10
ENST00000367424.4
complement factor H related 1
chr15_-_45201094 0.15 ENST00000561278.1
ENST00000290894.12
Src homology 2 domain containing F
chr14_-_50561119 0.15 ENST00000555216.5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_+_188292814 0.15 ENST00000409580.5
ENST00000409637.7
GULP PTB domain containing engulfment adaptor 1
chr7_+_48171451 0.15 ENST00000435803.6
ATP binding cassette subfamily A member 13
chr2_-_159798043 0.15 ENST00000664982.1
ENST00000259053.6
novel transcript, sense intronic to CD302and LY75-CD302
CD302 molecule
chr1_+_70411180 0.15 ENST00000411986.6
cystathionine gamma-lyase
chr3_+_138621207 0.15 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr7_-_22822829 0.14 ENST00000358435.9
ENST00000621567.1
translocase of outer mitochondrial membrane 7
chr11_+_57597563 0.14 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
serpin family G member 1
chr1_+_248445512 0.14 ENST00000642130.1
ENST00000641925.2
olfactory receptor family 2 subfamily T member 2
chrX_+_109535775 0.14 ENST00000218004.5
nuclear transport factor 2 like export factor 2
chr15_-_64989435 0.14 ENST00000433215.6
ENST00000558415.5
ENST00000557795.5
SPG21 abhydrolase domain containing, maspardin
chr18_-_36798482 0.14 ENST00000590258.2
tubulin polyglutamylase complex subunit 2
chr3_-_185821092 0.14 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr6_-_57221402 0.14 ENST00000317483.4
RAB23, member RAS oncogene family
chr5_-_82278341 0.14 ENST00000510210.5
ENST00000512493.5
ENST00000296674.13
ENST00000507980.1
ENST00000511844.1
ENST00000651545.1
ribosomal protein S23
chr11_-_124315099 0.14 ENST00000641897.1
olfactory receptor family 8 subfamily D member 1
chr8_+_109086585 0.14 ENST00000518632.2
thyrotropin releasing hormone receptor
chr4_-_121765104 0.14 ENST00000643802.2
ENST00000643663.2
small integral membrane protein 43
chr21_-_43075831 0.14 ENST00000398158.5
ENST00000398165.8
cystathionine beta-synthase
chr6_+_80106623 0.14 ENST00000369760.8
ENST00000356489.9
branched chain keto acid dehydrogenase E1 subunit beta
chr1_+_171090892 0.13 ENST00000367755.9
ENST00000479749.1
flavin containing dimethylaniline monoxygenase 3
chr8_-_92103217 0.13 ENST00000615601.4
ENST00000523629.5
RUNX1 partner transcriptional co-repressor 1
chr11_-_101129806 0.13 ENST00000325455.10
ENST00000617858.4
ENST00000619228.2
progesterone receptor
chr1_+_192809031 0.13 ENST00000235382.7
regulator of G protein signaling 2
chr4_-_139280179 0.13 ENST00000398955.2
mitochondria localized glutamic acid rich protein
chr12_+_51907478 0.13 ENST00000388922.9
activin A receptor like type 1
chr2_-_174847765 0.13 ENST00000443238.6
chimerin 1
chr2_+_87748087 0.13 ENST00000359481.9
plasminogen like B2
chrX_-_93673558 0.13 ENST00000475430.2
ENST00000373079.4
nucleosome assembly protein 1 like 3
chr11_+_15114912 0.13 ENST00000379556.8
INSC spindle orientation adaptor protein
chrX_+_136148440 0.13 ENST00000627383.2
ENST00000630084.2
four and a half LIM domains 1
chr16_-_66550112 0.13 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
thymidine kinase 2
chr7_-_102642791 0.13 ENST00000340457.8
uroplakin 3B like 1
chr2_+_216659600 0.13 ENST00000456764.1
insulin like growth factor binding protein 2
chr8_-_92966129 0.13 ENST00000522925.5
ENST00000522903.5
ENST00000537541.1
ENST00000521988.6
ENST00000518748.5
ENST00000519069.5
triple QxxK/R motif containing
chr6_+_168017873 0.13 ENST00000351261.4
ENST00000354419.6
kinesin family member 25
chr15_+_73926443 0.13 ENST00000261921.8
lysyl oxidase like 1
chr9_-_28670285 0.12 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2
chr3_-_142000353 0.12 ENST00000499676.5
transcription factor Dp-2
chr1_+_225825346 0.12 ENST00000366837.5
epoxide hydrolase 1
chr5_-_151141631 0.12 ENST00000523714.5
ENST00000521749.5
annexin A6
chr4_-_7871986 0.12 ENST00000360265.9
actin filament associated protein 1
chr17_+_7015035 0.12 ENST00000552775.1
chromosome 17 open reading frame 49
chrX_-_21758097 0.12 ENST00000379494.4
small muscle protein X-linked
chr11_+_5351508 0.12 ENST00000380219.1
olfactory receptor family 51 subfamily B member 6
chr1_+_212791828 0.12 ENST00000532324.5
ENST00000530441.5
ENST00000526641.5
ENST00000531963.5
ENST00000366973.8
ENST00000366974.9
ENST00000526997.5
ENST00000488246.6
TatD DNase domain containing 3
chr5_+_55851378 0.12 ENST00000396836.6
ENST00000359040.10
interleukin 31 receptor A
chr2_-_174847525 0.12 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
chimerin 1
chr2_-_210315160 0.12 ENST00000352451.4
myosin light chain 1
chr5_-_56116946 0.12 ENST00000434982.2
ankyrin repeat domain 55
chr20_-_31390483 0.12 ENST00000376315.2
defensin beta 119
chr13_+_45702411 0.12 ENST00000610924.1
chibby family member 2
chr17_-_44968263 0.12 ENST00000253407.4
complement C1q like 1
chr1_-_79006773 0.12 ENST00000671209.1
adhesion G protein-coupled receptor L4
chr10_-_48652493 0.12 ENST00000435790.6
Rho GTPase activating protein 22
chr6_+_148342759 0.12 ENST00000367467.8
SAM and SH3 domain containing 1
chr6_+_26199509 0.12 ENST00000356530.5
H2B clustered histone 7
chr2_+_165294031 0.12 ENST00000283256.10
sodium voltage-gated channel alpha subunit 2
chr21_+_30396030 0.12 ENST00000355459.4
keratin associated protein 13-1
chr17_-_42185452 0.12 ENST00000293330.1
hypocretin neuropeptide precursor
chr8_+_12104389 0.12 ENST00000400085.7
zinc finger protein 705D
chr11_-_111923722 0.12 ENST00000527950.5
crystallin alpha B
chr1_-_198540674 0.11 ENST00000489986.1
ENST00000367382.6
ATPase H+ transporting V1 subunit G3
chr1_-_175023408 0.11 ENST00000476371.1
mitochondrial ribosomal protein S14
chr1_+_151762899 0.11 ENST00000635322.1
ENST00000321531.10
ornithine decarboxylase antizyme 3
chr11_+_77821125 0.11 ENST00000526415.5
ENST00000393427.6
ENST00000527134.5
ENST00000304716.12
ENST00000630098.2
adipogenesis associated Mth938 domain containing
chr2_+_161136901 0.11 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chrX_-_101617921 0.11 ENST00000361910.9
ENST00000538627.5
ENST00000539247.5
armadillo repeat containing X-linked 6
chr8_-_7475082 0.11 ENST00000316169.2
defensin beta 104B
chr6_+_160702238 0.11 ENST00000366924.6
ENST00000308192.14
ENST00000418964.1
plasminogen
chr3_+_12287899 0.11 ENST00000643888.2
peroxisome proliferator activated receptor gamma
chr7_-_22822779 0.11 ENST00000372879.8
translocase of outer mitochondrial membrane 7
chr10_+_94762673 0.11 ENST00000480405.2
ENST00000371321.9
cytochrome P450 family 2 subfamily C member 19
chr3_-_146528750 0.11 ENST00000483300.5
phospholipid scramblase 1
chr4_+_85778681 0.11 ENST00000395183.6
Rho GTPase activating protein 24
chr12_+_12357418 0.11 ENST00000298571.6
BLOC-1 related complex subunit 5
chr5_-_134174765 0.11 ENST00000520417.1
S-phase kinase associated protein 1
chr17_+_18183052 0.11 ENST00000541285.1
alkB homolog 5, RNA demethylase
chr21_-_43076362 0.11 ENST00000359624.7
ENST00000352178.9
cystathionine beta-synthase
chr1_+_12857086 0.11 ENST00000240189.2
PRAME family member 2
chr6_-_154430495 0.11 ENST00000424998.3
CNKSR family member 3
chr1_-_1778790 0.11 ENST00000341991.7
NAD kinase
chr12_+_26011713 0.11 ENST00000542004.5
Ras association domain family member 8
chr2_-_87021844 0.11 ENST00000355705.4
ENST00000409310.6
plasminogen like B1
chr6_-_129710145 0.11 ENST00000368149.3
Rho GTPase activating protein 18
chr10_+_52128343 0.11 ENST00000672084.1
protein kinase cGMP-dependent 1
chr7_+_142111739 0.10 ENST00000550469.6
ENST00000477922.3
maltase-glucoamylase 2 (putative)
chr17_+_7252502 0.10 ENST00000570322.5
ENST00000576496.5
ENST00000574841.2
elongator acetyltransferase complex subunit 5
chr9_+_72577939 0.10 ENST00000645773.1
transmembrane channel like 1
chr10_+_87357720 0.10 ENST00000412718.3
ENST00000381697.7
NUT family member 2D
chr15_+_58138368 0.10 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr8_-_7385558 0.10 ENST00000400156.4
zinc finger protein 705G
chr3_-_115071333 0.10 ENST00000462705.5
zinc finger and BTB domain containing 20
chr11_+_114296347 0.10 ENST00000299964.4
nicotinamide N-methyltransferase
chr5_-_147906530 0.10 ENST00000318315.5
ENST00000515291.1
chromosome 5 open reading frame 46
chr1_-_205121964 0.10 ENST00000264515.11
RB binding protein 5, histone lysine methyltransferase complex subunit
chr4_+_168497066 0.10 ENST00000261509.10
palladin, cytoskeletal associated protein
chr3_+_12287859 0.10 ENST00000309576.11
ENST00000397015.7
peroxisome proliferator activated receptor gamma
chr3_+_42979281 0.10 ENST00000488863.5
ENST00000430121.3
golgi associated kinase 1A
chr3_+_179604785 0.10 ENST00000611971.4
ENST00000493866.5
ENST00000259037.8
ENST00000472629.5
ENST00000482604.5
NADH:ubiquinone oxidoreductase subunit B5
chr7_+_124476371 0.10 ENST00000473520.1
SSU72 pseudogene 8
chr3_+_15601720 0.10 ENST00000673620.1
biotinidase
chr8_-_7430348 0.10 ENST00000318124.3
defensin beta 103B

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX2_HOXC5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.2 0.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 0.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.1 0.4 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.5 GO:0060748 tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.1 0.6 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.3 GO:0006711 estrogen catabolic process(GO:0006711)
0.1 0.7 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343)
0.1 0.3 GO:0034031 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 0.4 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 1.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.2 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.5 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.3 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 0.2 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.2 GO:0001812 positive regulation of type I hypersensitivity(GO:0001812)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.0 0.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0015847 putrescine transport(GO:0015847)
0.0 0.1 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.0 0.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.1 GO:1903259 exon-exon junction complex disassembly(GO:1903259)
0.0 0.1 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.1 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.0 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.1 GO:0036146 cellular response to mycotoxin(GO:0036146)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.0 GO:0072573 tolerance induction to lipopolysaccharide(GO:0072573)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.1 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.0 0.1 GO:0035907 dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0 0.1 GO:0045643 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.0 0.1 GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433)
0.0 0.1 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.0 0.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174) telomeric 3' overhang formation(GO:0031860)
0.0 0.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.0 GO:0035645 enteric smooth muscle cell differentiation(GO:0035645)
0.0 0.1 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.0 GO:0003363 lamellipodium assembly involved in ameboidal cell migration(GO:0003363)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.1 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.0 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:0030807 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.2 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.0 0.1 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.0 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.2 GO:0042340 keratan sulfate catabolic process(GO:0042340)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.2 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.5 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.7 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.3 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.0 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.0 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.1 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0033265 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.1 0.2 GO:0098809 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.1 0.4 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.1 0.2 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.1 0.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.2 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.3 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0015203 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:1990405 protein antigen binding(GO:1990405)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0004773 steryl-sulfatase activity(GO:0004773)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0045550 geranylgeranyl reductase activity(GO:0045550)
0.0 0.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0004979 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.0 0.1 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.3 GO:0015266 protein channel activity(GO:0015266)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.0 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.0 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.0 GO:0035375 zymogen binding(GO:0035375)
0.0 0.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.5 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.4 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.0 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.9 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB