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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 3.04
Motif logo
Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SIX5
|
ENSG00000177045.10 | SIX homeobox 5 |
|
SMARCC2
|
ENSG00000139613.12 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 |
|
HCFC1
|
ENSG00000172534.14 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg38_v1_chr12_-_56189548_56189609 | 0.66 | 7.5e-02 | Click! |
| HCFC1 | hg38_v1_chrX_-_153971810_153971844, hg38_v1_chrX_-_153971169_153971233 | -0.61 | 1.1e-01 | Click! |
| SIX5 | hg38_v1_chr19_-_45768627_45768745 | 0.58 | 1.3e-01 | Click! |
Activity profile of SIX5_SMARCC2_HCFC1 motif
Sorted Z-values of SIX5_SMARCC2_HCFC1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.5 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 1.1 | 3.3 | GO:1903465 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.9 | 2.6 | GO:2000777 | positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.5 | 1.6 | GO:0042357 | thiamine diphosphate metabolic process(GO:0042357) |
| 0.5 | 1.4 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.5 | 4.1 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
| 0.5 | 4.1 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.4 | 1.9 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 0.4 | 1.8 | GO:0019075 | virus maturation(GO:0019075) |
| 0.3 | 1.7 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.3 | 1.6 | GO:0090611 | ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
| 0.3 | 1.6 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.3 | 1.0 | GO:0036111 | very long-chain fatty-acyl-CoA metabolic process(GO:0036111) |
| 0.3 | 0.9 | GO:2001153 | regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153) |
| 0.3 | 5.1 | GO:1905097 | regulation of guanyl-nucleotide exchange factor activity(GO:1905097) |
| 0.3 | 1.8 | GO:0035624 | receptor transactivation(GO:0035624) |
| 0.3 | 1.2 | GO:0090156 | cellular sphingolipid homeostasis(GO:0090156) |
| 0.3 | 5.3 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.3 | 1.0 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
| 0.3 | 1.0 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.2 | 1.4 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.2 | 0.7 | GO:1902824 | positive regulation of late endosome to lysosome transport(GO:1902824) |
| 0.2 | 0.7 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.2 | 0.7 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.2 | 0.6 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 0.2 | 0.6 | GO:0035552 | oxidative single-stranded DNA demethylation(GO:0035552) |
| 0.2 | 1.2 | GO:0006574 | valine catabolic process(GO:0006574) |
| 0.2 | 2.0 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.2 | 2.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.2 | 0.8 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.2 | 1.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.2 | 1.6 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.2 | 1.1 | GO:0051461 | positive regulation of corticotropin secretion(GO:0051461) |
| 0.2 | 0.7 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.2 | 2.4 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 0.7 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.1 | 3.7 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.1 | 0.4 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.1 | 1.1 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.1 | 1.1 | GO:0044211 | CTP salvage(GO:0044211) |
| 0.1 | 9.9 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.1 | 1.7 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.1 | 1.3 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.1 | 2.5 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 0.4 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.1 | 1.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 0.5 | GO:0006172 | ADP biosynthetic process(GO:0006172) purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) |
| 0.1 | 0.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 0.1 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
| 0.1 | 0.8 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.1 | 0.6 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.1 | 0.2 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.1 | 0.3 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.1 | 0.5 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.1 | 1.3 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 0.1 | 0.4 | GO:1990166 | protein localization to site of double-strand break(GO:1990166) |
| 0.1 | 1.0 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.1 | 0.3 | GO:0015847 | putrescine transport(GO:0015847) |
| 0.1 | 1.8 | GO:0000052 | citrulline metabolic process(GO:0000052) |
| 0.1 | 1.3 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.1 | 0.3 | GO:0070676 | intralumenal vesicle formation(GO:0070676) negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 0.3 | GO:1903939 | negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939) |
| 0.1 | 1.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 0.4 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 0.3 | GO:1903217 | regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217) |
| 0.1 | 0.3 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
| 0.1 | 0.2 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.1 | 2.9 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 0.1 | 1.5 | GO:0070314 | G1 to G0 transition(GO:0070314) |
| 0.1 | 0.4 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 0.3 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 0.1 | 0.8 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.1 | 0.4 | GO:0000454 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) |
| 0.1 | 0.8 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 2.4 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.1 | 0.8 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 2.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 1.1 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.1 | 0.8 | GO:0043951 | negative regulation of cAMP-mediated signaling(GO:0043951) |
| 0.1 | 0.6 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.1 | 0.7 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 1.1 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.1 | 0.2 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 3.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 0.2 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 3.0 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.1 | 0.5 | GO:2000784 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.1 | 1.4 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.1 | 0.4 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.1 | 6.4 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.1 | 0.3 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 0.1 | 0.6 | GO:2000582 | regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.1 | 0.4 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 0.1 | 0.6 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 0.1 | 0.5 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.1 | 0.1 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.1 | 0.2 | GO:0060661 | submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.1 | 0.5 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.1 | 0.2 | GO:0048104 | establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105) |
| 0.1 | 0.9 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.1 | 0.7 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.1 | 4.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.6 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.1 | 1.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 1.5 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.1 | 0.2 | GO:0070844 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.1 | 1.3 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 0.9 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.1 | 0.7 | GO:0097688 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.1 | 1.1 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 0.8 | GO:1901661 | quinone metabolic process(GO:1901661) |
| 0.1 | 0.2 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.1 | 0.3 | GO:0042853 | L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853) |
| 0.1 | 0.3 | GO:0018197 | peptidyl-aspartic acid modification(GO:0018197) |
| 0.1 | 0.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 0.6 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 5.8 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.0 | 0.1 | GO:0006258 | UDP-glucose catabolic process(GO:0006258) |
| 0.0 | 0.4 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.0 | 0.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 0.2 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 0.0 | 0.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.0 | 0.1 | GO:0002876 | positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876) |
| 0.0 | 1.0 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 3.0 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 0.1 | GO:0021997 | neural plate axis specification(GO:0021997) |
| 0.0 | 0.2 | GO:0097056 | selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056) |
| 0.0 | 0.6 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.0 | 5.3 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 0.3 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 0.4 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.0 | 1.3 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.0 | 0.1 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.0 | 0.3 | GO:0018317 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.2 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.3 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.4 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
| 0.0 | 0.3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.0 | 0.5 | GO:0001767 | establishment of lymphocyte polarity(GO:0001767) |
| 0.0 | 0.5 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 0.5 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.0 | 0.9 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.0 | 1.0 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
| 0.0 | 0.6 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.6 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.9 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.3 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.0 | 0.2 | GO:0018343 | protein farnesylation(GO:0018343) |
| 0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 0.0 | 0.2 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.0 | 0.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.9 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.1 | GO:0021592 | fourth ventricle development(GO:0021592) |
| 0.0 | 0.2 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.0 | 1.6 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.3 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.0 | 0.2 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.0 | 0.1 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 2.3 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.8 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.0 | 0.2 | GO:0044375 | peroxisome membrane biogenesis(GO:0016557) regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.1 | GO:0030070 | insulin processing(GO:0030070) |
| 0.0 | 0.5 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.0 | 0.4 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.0 | 1.3 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) |
| 0.0 | 0.4 | GO:0098792 | xenophagy(GO:0098792) |
| 0.0 | 0.1 | GO:0035645 | enteric smooth muscle cell differentiation(GO:0035645) |
| 0.0 | 0.1 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.0 | 0.0 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.0 | 0.2 | GO:0036093 | male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093) |
| 0.0 | 0.8 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 2.2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 0.1 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.0 | 0.1 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.0 | 0.5 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.2 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.0 | 1.7 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 0.8 | GO:0032401 | establishment of melanosome localization(GO:0032401) melanosome transport(GO:0032402) |
| 0.0 | 0.4 | GO:1903671 | negative regulation of sprouting angiogenesis(GO:1903671) |
| 0.0 | 0.1 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.0 | 1.8 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.4 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.2 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 0.0 | 0.4 | GO:0044036 | cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554) |
| 0.0 | 0.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 0.3 | GO:0048820 | hair follicle maturation(GO:0048820) |
| 0.0 | 0.1 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 0.4 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.0 | 0.1 | GO:0090230 | regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234) |
| 0.0 | 1.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.0 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 0.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.0 | 0.1 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.0 | 0.1 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.0 | 0.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.0 | 3.3 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.0 | 1.5 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 1.7 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.0 | GO:0021555 | midbrain-hindbrain boundary morphogenesis(GO:0021555) |
| 0.0 | 0.1 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.0 | 0.1 | GO:0010902 | positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902) |
| 0.0 | 0.1 | GO:2000676 | positive regulation of type B pancreatic cell apoptotic process(GO:2000676) |
| 0.0 | 0.1 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
| 0.0 | 1.9 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.0 | 0.4 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 5.0 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.0 | 0.0 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.0 | 0.1 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.0 | 0.2 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.0 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
| 0.0 | 0.4 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.4 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.2 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.0 | 0.2 | GO:0033622 | integrin activation(GO:0033622) |
| 0.0 | 0.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.5 | GO:0035306 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.0 | 0.1 | GO:0034628 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 0.0 | 0.1 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.0 | 0.1 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.0 | 0.1 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 0.0 | 0.1 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 0.0 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.0 | 0.5 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.0 | 0.6 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 0.2 | GO:0070071 | proton-transporting two-sector ATPase complex assembly(GO:0070071) |
| 0.0 | 0.2 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.2 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.0 | 1.0 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.0 | 0.6 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 0.6 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.0 | 0.9 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.0 | 0.1 | GO:0055059 | asymmetric neuroblast division(GO:0055059) |
| 0.0 | 0.4 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.1 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.7 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.8 | 4.1 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.6 | 2.9 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.6 | 1.7 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 0.5 | 4.2 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.5 | 1.4 | GO:1902636 | kinociliary basal body(GO:1902636) |
| 0.3 | 2.6 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.2 | 1.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.2 | 0.6 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.2 | 1.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.2 | 1.2 | GO:0031417 | NatC complex(GO:0031417) |
| 0.2 | 0.4 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.2 | 0.7 | GO:0035517 | PR-DUB complex(GO:0035517) |
| 0.2 | 3.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.2 | 0.5 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 0.3 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 7.3 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 1.1 | GO:0002177 | manchette(GO:0002177) |
| 0.2 | 1.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 1.2 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 2.0 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 2.2 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 2.0 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.1 | 1.5 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 1.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 0.5 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.1 | 1.8 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 0.8 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 1.7 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 8.7 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.3 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 2.2 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.3 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 0.1 | 0.3 | GO:1905103 | integral component of lysosomal membrane(GO:1905103) |
| 0.1 | 0.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 2.3 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 1.1 | GO:0051286 | cell tip(GO:0051286) |
| 0.1 | 0.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 2.8 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.8 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 2.3 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.1 | 0.7 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 5.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 1.1 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 1.4 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 0.2 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 1.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 1.1 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.1 | 0.3 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.1 | 0.8 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.1 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
| 0.1 | 0.6 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 0.4 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 4.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.3 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 0.4 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 0.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.1 | 1.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 0.3 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.1 | 0.6 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.3 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.1 | 0.4 | GO:0072589 | box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 0.0 | 0.4 | GO:0001939 | female pronucleus(GO:0001939) male pronucleus(GO:0001940) |
| 0.0 | 0.2 | GO:0005965 | protein farnesyltransferase complex(GO:0005965) |
| 0.0 | 0.4 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.1 | GO:0001534 | radial spoke(GO:0001534) |
| 0.0 | 0.8 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.4 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 2.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.8 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.1 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 0.7 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.0 | 0.1 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.0 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.7 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 2.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.3 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 1.0 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.3 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.3 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 0.2 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.0 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 2.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.7 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.1 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.0 | 0.9 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 1.1 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 1.0 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.6 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 0.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0071014 | post-mRNA release spliceosomal complex(GO:0071014) |
| 0.0 | 0.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.1 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.1 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.2 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.5 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 1.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.2 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.2 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.1 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.6 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 2.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.3 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 0.4 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.1 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.2 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.1 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.9 | 2.6 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.8 | 4.1 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.7 | 2.0 | GO:0016649 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 0.6 | 1.7 | GO:0000994 | RNA polymerase III core binding(GO:0000994) |
| 0.6 | 5.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.6 | 2.9 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.4 | 2.4 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.4 | 1.9 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.4 | 1.4 | GO:0002046 | opsin binding(GO:0002046) |
| 0.3 | 1.6 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.3 | 1.0 | GO:0033989 | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity(GO:0033989) 17-beta-hydroxysteroid dehydrogenase (NAD+) activity(GO:0044594) |
| 0.3 | 2.1 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.2 | 1.7 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.2 | 0.7 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.2 | 1.8 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.2 | 3.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.2 | 0.8 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.2 | 0.6 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 0.2 | 1.2 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.2 | 0.9 | GO:0050254 | rhodopsin kinase activity(GO:0050254) |
| 0.2 | 0.5 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.2 | 5.9 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 0.8 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.2 | 3.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 0.5 | GO:0047025 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 9.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 3.0 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 1.0 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 0.4 | GO:0071209 | U7 snRNA binding(GO:0071209) |
| 0.1 | 0.5 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 0.1 | 1.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 0.9 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.1 | 0.8 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.1 | 2.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 3.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.6 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.1 | 1.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.5 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.2 | GO:0004660 | protein farnesyltransferase activity(GO:0004660) |
| 0.1 | 0.3 | GO:0015489 | polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489) |
| 0.1 | 0.6 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.1 | 0.3 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.1 | 1.1 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 1.2 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 0.8 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 0.7 | GO:0031812 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 0.3 | GO:0004021 | L-alanine:2-oxoglutarate aminotransferase activity(GO:0004021) alanine-oxo-acid transaminase activity(GO:0047635) |
| 0.1 | 1.6 | GO:0016892 | endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892) |
| 0.1 | 1.2 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 0.3 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 0.1 | 0.4 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.1 | 4.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.3 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.1 | 1.7 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.6 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 0.4 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.1 | 0.7 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.1 | 0.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 0.5 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.3 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.1 | 0.4 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.1 | 0.2 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.1 | 0.8 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 2.7 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.3 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 1.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 0.2 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 1.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.1 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651) |
| 0.0 | 0.8 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 1.0 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.0 | 0.4 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 1.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.6 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 0.3 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.3 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.0 | 0.1 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.0 | 1.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 4.1 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.2 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 0.0 | 0.5 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.0 | 1.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.3 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.0 | 1.5 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.4 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.0 | 0.1 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.0 | 0.1 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.0 | 0.3 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.1 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.0 | 0.5 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.0 | 0.2 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.2 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 6.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.8 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.2 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.2 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 0.1 | GO:0030272 | 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272) |
| 0.0 | 0.3 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.2 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.0 | 0.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.5 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.3 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.0 | 1.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.2 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 2.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.2 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.0 | 0.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.1 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 0.4 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.1 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.0 | 6.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 2.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.2 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.0 | 2.5 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.4 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 0.1 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 0.0 | 30.8 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.1 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.0 | 0.2 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.0 | 0.6 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.5 | GO:0019783 | ubiquitin-like protein-specific protease activity(GO:0019783) |
| 0.0 | 0.1 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515) |
| 0.0 | 0.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 21.6 | GO:0003677 | DNA binding(GO:0003677) |
| 0.0 | 0.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.3 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 0.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 2.1 | GO:0019902 | phosphatase binding(GO:0019902) |
| 0.0 | 0.9 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.0 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.0 | 0.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.1 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 0.0 | 0.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.8 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.0 | 0.1 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.1 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 0.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 0.1 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 7.2 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 3.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 2.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 3.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 3.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 0.6 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.8 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 1.2 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.9 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.2 | 1.3 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.1 | 4.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 2.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 3.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.8 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 1.1 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 1.7 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 7.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 42.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 8.2 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 2.4 | REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK |
| 0.1 | 1.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 1.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 1.6 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 2.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.0 | 1.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.5 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 1.1 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.6 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.4 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 3.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.0 | 0.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.5 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 0.2 | REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA | Genes involved in Processing of Capped Intronless Pre-mRNA |
| 0.0 | 0.3 | REACTOME SIGNALING BY WNT | Genes involved in Signaling by Wnt |
| 0.0 | 0.2 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.2 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |