Project

Epithelial-Mesenchymal Transition, human (Scheel, 2011)

Navigation
Downloads

Results for SMAD2

Z-value: 0.80

Motif logo

logo of

Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.16 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg38_v1_chr18_-_47930630_479306810.472.5e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_159171607 1.49 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr12_+_53050179 1.46 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
TNS2
tensin 2
chrX_+_153494970 1.44 ENST00000331595.9
ENST00000431891.1
BGN
biglycan
chrX_-_107775740 1.29 ENST00000372383.9
TSC22D3
TSC22 domain family member 3
chrX_-_107775951 1.07 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chr22_-_24245059 0.98 ENST00000398292.3
ENST00000263112.11
ENST00000327365.10
ENST00000424217.1
GGT5
gamma-glutamyltransferase 5
chr5_-_151141631 0.87 ENST00000523714.5
ENST00000521749.5
ANXA6
annexin A6
chr12_-_55712402 0.85 ENST00000452168.6
ITGA7
integrin subunit alpha 7
chr16_+_55479188 0.83 ENST00000219070.9
MMP2
matrix metallopeptidase 2
chr12_+_53050014 0.73 ENST00000314250.11
TNS2
tensin 2
chr6_-_152168291 0.68 ENST00000354674.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr6_-_152168349 0.67 ENST00000539504.5
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr19_+_49513154 0.61 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr17_-_78925376 0.57 ENST00000262768.11
TIMP2
TIMP metallopeptidase inhibitor 2
chr4_-_39638893 0.57 ENST00000511809.5
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr4_-_39638846 0.50 ENST00000295958.10
SMIM14
small integral membrane protein 14
chr10_+_71212524 0.43 ENST00000335350.10
UNC5B
unc-5 netrin receptor B
chr8_-_94895195 0.42 ENST00000308108.9
ENST00000396133.7
CCNE2
cyclin E2
chr5_+_321695 0.42 ENST00000684583.1
ENST00000514523.1
AHRR
aryl-hydrocarbon receptor repressor
chr5_-_151686908 0.40 ENST00000231061.9
SPARC
secreted protein acidic and cysteine rich
chr6_+_56955097 0.38 ENST00000370746.8
ENST00000370748.7
BEND6
BEN domain containing 6
chr6_+_101393699 0.36 ENST00000369134.9
ENST00000684068.1
ENST00000683903.1
ENST00000681975.1
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr18_-_3013114 0.34 ENST00000677752.1
LPIN2
lipin 2
chr4_+_673518 0.30 ENST00000506838.5
MYL5
myosin light chain 5
chr6_-_56954747 0.30 ENST00000680361.1
DST
dystonin
chr3_+_194685874 0.30 ENST00000329759.6
FAM43A
family with sequence similarity 43 member A
chr12_-_95996302 0.30 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
HAL
histidine ammonia-lyase
chr7_+_66629023 0.29 ENST00000639879.1
ENST00000640851.1
KCTD7
potassium channel tetramerization domain containing 7
chr10_-_14330879 0.29 ENST00000357447.7
FRMD4A
FERM domain containing 4A
chr6_+_41042557 0.27 ENST00000373158.6
ENST00000470917.1
TSPO2
translocator protein 2
chrX_-_63754664 0.27 ENST00000677315.1
ENST00000636392.1
ENST00000637040.1
ENST00000637178.1
ENST00000637557.1
ENST00000636048.1
ENST00000638021.1
ENST00000672513.1
ENSG00000288661.1
ARHGEF9
novel protein
Cdc42 guanine nucleotide exchange factor 9
chr5_-_88731827 0.27 ENST00000627170.2
MEF2C
myocyte enhancer factor 2C
chr5_+_141382702 0.26 ENST00000617050.1
ENST00000518325.2
PCDHGA7
protocadherin gamma subfamily A, 7
chr7_-_100896123 0.25 ENST00000428317.7
ACHE
acetylcholinesterase (Cartwright blood group)
chr5_+_134526176 0.25 ENST00000681820.1
ENST00000512386.6
ENST00000612830.2
JADE2
jade family PHD finger 2
chrX_-_151974668 0.25 ENST00000370328.4
GABRE
gamma-aminobutyric acid type A receptor subunit epsilon
chr7_-_105876575 0.24 ENST00000318724.8
ENST00000419735.8
ATXN7L1
ataxin 7 like 1
chr16_+_2148603 0.24 ENST00000210187.11
RAB26
RAB26, member RAS oncogene family
chr7_+_66629078 0.24 ENST00000449064.6
ENST00000638540.1
ENST00000640234.1
KCTD7
potassium channel tetramerization domain containing 7
chr9_+_122510802 0.23 ENST00000335302.5
OR1J2
olfactory receptor family 1 subfamily J member 2
chr3_+_111674654 0.23 ENST00000636933.1
ENST00000393934.7
ENST00000477665.2
PLCXD2
phosphatidylinositol specific phospholipase C X domain containing 2
chr4_-_113761068 0.23 ENST00000342666.9
ENST00000514328.5
ENST00000515496.5
ENST00000508738.5
ENST00000379773.6
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr4_+_37244735 0.22 ENST00000309447.6
NWD2
NACHT and WD repeat domain containing 2
chr1_+_185734362 0.22 ENST00000271588.9
HMCN1
hemicentin 1
chr19_+_35775530 0.22 ENST00000314737.9
ENST00000007510.8
ARHGAP33
Rho GTPase activating protein 33
chr19_+_35775515 0.21 ENST00000378944.9
ARHGAP33
Rho GTPase activating protein 33
chr6_+_39792298 0.21 ENST00000633794.1
ENST00000274867.9
DAAM2
dishevelled associated activator of morphogenesis 2
chr4_-_113761441 0.21 ENST00000394524.7
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr11_-_117295485 0.21 ENST00000680971.1
BACE1
beta-secretase 1
chr5_+_134526100 0.20 ENST00000395003.5
JADE2
jade family PHD finger 2
chr6_+_39792993 0.20 ENST00000538976.5
DAAM2
dishevelled associated activator of morphogenesis 2
chr6_+_39793008 0.20 ENST00000398904.6
DAAM2
dishevelled associated activator of morphogenesis 2
chr11_-_75669028 0.20 ENST00000304771.8
MAP6
microtubule associated protein 6
chr1_-_1307861 0.19 ENST00000354700.10
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr7_-_100895878 0.19 ENST00000419336.6
ENST00000241069.11
ENST00000411582.4
ENST00000302913.8
ACHE
acetylcholinesterase (Cartwright blood group)
chr16_+_28878382 0.19 ENST00000357084.7
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr17_-_15262537 0.19 ENST00000395936.7
ENST00000675819.1
ENST00000674707.1
ENST00000675854.1
ENST00000426385.4
ENST00000395938.7
ENST00000612492.5
ENST00000675808.1
PMP22
peripheral myelin protein 22
chr4_-_113761724 0.19 ENST00000511664.6
CAMK2D
calcium/calmodulin dependent protein kinase II delta
chr4_-_5888400 0.19 ENST00000397890.6
CRMP1
collapsin response mediator protein 1
chr14_-_104978360 0.18 ENST00000333244.6
AHNAK2
AHNAK nucleoprotein 2
chr5_+_43603163 0.18 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
NNT
nicotinamide nucleotide transhydrogenase
chr1_-_153985366 0.18 ENST00000614713.4
RAB13
RAB13, member RAS oncogene family
chr16_+_28878480 0.18 ENST00000395503.9
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr19_+_36140059 0.18 ENST00000246533.8
ENST00000587718.5
ENST00000592483.5
ENST00000590874.5
ENST00000588815.5
CAPNS1
calpain small subunit 1
chr17_+_4950147 0.18 ENST00000522301.5
ENO3
enolase 3
chr16_+_3305472 0.17 ENST00000574298.6
ENST00000669516.2
ZNF75A
zinc finger protein 75a
chr22_-_31489528 0.17 ENST00000397525.5
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr18_+_3448456 0.16 ENST00000549780.5
TGIF1
TGFB induced factor homeobox 1
chr21_-_37267511 0.16 ENST00000398998.1
VPS26C
VPS26 endosomal protein sorting factor C
chr16_+_2033264 0.16 ENST00000565855.5
ENST00000566198.1
SLC9A3R2
SLC9A3 regulator 2
chr3_-_165196369 0.16 ENST00000475390.2
SLITRK3
SLIT and NTRK like family member 3
chr8_+_94895763 0.15 ENST00000523378.5
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr12_+_49961864 0.15 ENST00000293599.7
AQP5
aquaporin 5
chr19_+_38390055 0.15 ENST00000587947.5
ENST00000338502.8
SPRED3
sprouty related EVH1 domain containing 3
chr9_+_34990250 0.15 ENST00000454002.6
ENST00000545841.5
DNAJB5
DnaJ heat shock protein family (Hsp40) member B5
chr7_-_105876477 0.15 ENST00000478915.1
ATXN7L1
ataxin 7 like 1
chr11_-_33892010 0.15 ENST00000257818.3
LMO2
LIM domain only 2
chr4_-_102828022 0.15 ENST00000502690.5
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr22_+_22734577 0.15 ENST00000390310.3
IGLV2-18
immunoglobulin lambda variable 2-18
chr19_-_45785659 0.14 ENST00000537879.1
ENST00000596586.5
ENST00000595946.1
DMWD
ENSG00000268434.5
DM1 locus, WD repeat containing
novel protein
chr1_+_36306359 0.14 ENST00000453908.8
SH3D21
SH3 domain containing 21
chr17_+_68205453 0.14 ENST00000674770.2
AMZ2
archaelysin family metallopeptidase 2
chr1_-_149936816 0.14 ENST00000439741.4
MTMR11
myotubularin related protein 11
chr9_-_128067310 0.14 ENST00000373078.5
NAIF1
nuclear apoptosis inducing factor 1
chr19_+_735026 0.14 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr11_-_65382632 0.14 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
SLC25A45
solute carrier family 25 member 45
chr22_-_38455199 0.13 ENST00000303592.3
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
chrX_+_153764178 0.13 ENST00000538966.5
PLXNB3
plexin B3
chr4_-_102827723 0.13 ENST00000349311.12
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr1_-_149936324 0.13 ENST00000369140.7
MTMR11
myotubularin related protein 11
chr2_-_240682879 0.13 ENST00000407834.4
ENST00000621682.4
AQP12B
aquaporin 12B
chr9_+_5890872 0.13 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
MLANA
melan-A
chr1_-_201946469 0.13 ENST00000367288.5
LMOD1
leiomodin 1
chr1_-_201946571 0.13 ENST00000616739.1
LMOD1
leiomodin 1
chr11_-_75668566 0.13 ENST00000526740.3
MAP6
microtubule associated protein 6
chr17_-_3668557 0.12 ENST00000225525.4
TAX1BP3
Tax1 binding protein 3
chr19_+_11355386 0.12 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
PLPPR2
phospholipid phosphatase related 2
chr4_-_102827948 0.12 ENST00000394804.6
ENST00000394801.8
UBE2D3
ubiquitin conjugating enzyme E2 D3
chrX_+_48801949 0.12 ENST00000376610.6
ENST00000462730.5
ENST00000376619.6
ENST00000465269.5
ENST00000334136.11
ENST00000476625.5
ENST00000646703.1
HDAC6
histone deacetylase 6
chr9_+_79573162 0.12 ENST00000425506.5
TLE4
TLE family member 4, transcriptional corepressor
chr7_-_14841267 0.12 ENST00000406247.7
ENST00000399322.7
DGKB
diacylglycerol kinase beta
chrX_+_48802156 0.12 ENST00000643374.1
ENST00000644068.1
ENST00000441703.6
ENST00000643934.1
ENST00000489352.5
HDAC6
histone deacetylase 6
chr3_-_88058928 0.12 ENST00000482016.6
CGGBP1
CGG triplet repeat binding protein 1
chr1_+_36307090 0.12 ENST00000505871.7
SH3D21
SH3 domain containing 21
chrX_+_101488044 0.12 ENST00000423738.4
ARMCX4
armadillo repeat containing X-linked 4
chr5_+_134525649 0.11 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
JADE2
jade family PHD finger 2
chr15_+_96332432 0.11 ENST00000559679.1
ENST00000394171.6
NR2F2
nuclear receptor subfamily 2 group F member 2
chr22_+_22822658 0.11 ENST00000620395.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr9_+_79572715 0.11 ENST00000265284.10
TLE4
TLE family member 4, transcriptional corepressor
chr12_-_119804298 0.11 ENST00000678652.1
ENST00000678494.1
CIT
citron rho-interacting serine/threonine kinase
chr16_+_57668299 0.11 ENST00000333493.9
ENST00000450388.7
ADGRG3
adhesion G protein-coupled receptor G3
chr1_-_206946448 0.11 ENST00000356495.5
PIGR
polymeric immunoglobulin receptor
chr3_-_88059042 0.11 ENST00000309534.10
CGGBP1
CGG triplet repeat binding protein 1
chrX_+_153764233 0.10 ENST00000361971.10
PLXNB3
plexin B3
chr22_-_36028773 0.10 ENST00000438146.7
RBFOX2
RNA binding fox-1 homolog 2
chr4_-_102828048 0.10 ENST00000508249.1
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr6_-_159045010 0.10 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr16_+_53130921 0.10 ENST00000564845.5
CHD9
chromodomain helicase DNA binding protein 9
chr17_-_3668640 0.10 ENST00000611779.4
TAX1BP3
Tax1 binding protein 3
chr15_+_45587366 0.10 ENST00000220531.9
BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
chr4_-_102828159 0.10 ENST00000394803.9
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr3_+_40505992 0.10 ENST00000420891.5
ENST00000314529.10
ENST00000418905.1
ZNF620
zinc finger protein 620
chr19_+_11355491 0.10 ENST00000591608.1
PLPPR2
phospholipid phosphatase related 2
chr9_+_137251261 0.10 ENST00000620243.4
ENST00000388931.7
ENST00000412566.5
ENST00000611378.4
STPG3
sperm-tail PG-rich repeat containing 3
chr15_+_45587580 0.09 ENST00000566801.5
ENST00000565323.6
ENST00000568816.5
BLOC1S6
biogenesis of lysosomal organelles complex 1 subunit 6
chr11_-_65381951 0.09 ENST00000526432.5
ENST00000527174.5
SLC25A45
solute carrier family 25 member 45
chr3_-_71130892 0.09 ENST00000491238.7
ENST00000674446.1
FOXP1
forkhead box P1
chr2_-_219308963 0.09 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
PTPRN
protein tyrosine phosphatase receptor type N
chr3_+_50279080 0.09 ENST00000316436.4
LSMEM2
leucine rich single-pass membrane protein 2
chr12_+_110468803 0.08 ENST00000377673.10
FAM216A
family with sequence similarity 216 member A
chr7_-_10940123 0.08 ENST00000339600.6
NDUFA4
NDUFA4 mitochondrial complex associated
chr3_-_71130963 0.08 ENST00000649695.2
FOXP1
forkhead box P1
chr3_-_71130557 0.08 ENST00000497355.7
FOXP1
forkhead box P1
chr3_-_9792404 0.08 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr4_-_112516176 0.08 ENST00000313341.4
NEUROG2
neurogenin 2
chr5_+_64768921 0.08 ENST00000381070.8
ENST00000508024.1
CWC27
CWC27 spliceosome associated cyclophilin
chr7_+_129126518 0.07 ENST00000467614.2
ENSG00000230626.4
novel protein similar to mitogen-activated protein kinase kinase 2 MAP2K2
chrX_-_48470243 0.07 ENST00000429543.2
ENST00000620913.5
SLC38A5
solute carrier family 38 member 5
chr18_+_13218195 0.07 ENST00000679167.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr19_+_48469354 0.07 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr1_-_58784035 0.07 ENST00000371222.4
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
chr7_-_75994574 0.07 ENST00000439537.5
ENST00000493111.7
ENST00000417509.5
ENST00000485200.1
TMEM120A
transmembrane protein 120A
chr13_-_26760741 0.07 ENST00000405846.5
GPR12
G protein-coupled receptor 12
chr17_-_42185452 0.07 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chrX_-_48470163 0.07 ENST00000595796.5
SLC38A5
solute carrier family 38 member 5
chr16_-_375205 0.07 ENST00000448854.1
PGAP6
post-glycosylphosphatidylinositol attachment to proteins 6
chr17_+_7407838 0.07 ENST00000302926.7
NLGN2
neuroligin 2
chr19_-_35135011 0.07 ENST00000310123.8
LGI4
leucine rich repeat LGI family member 4
chr5_-_43412323 0.07 ENST00000361115.4
CCL28
C-C motif chemokine ligand 28
chr2_-_219243577 0.06 ENST00000409640.5
GLB1L
galactosidase beta 1 like
chr15_+_75206398 0.06 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr5_-_74640575 0.06 ENST00000651128.1
ENC1
ectodermal-neural cortex 1
chr22_+_50089879 0.06 ENST00000545383.5
ENST00000262794.10
MOV10L1
Mov10 like RISC complex RNA helicase 1
chr7_+_99408609 0.06 ENST00000403633.6
BUD31
BUD31 homolog
chr22_+_22327298 0.06 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr3_-_51903341 0.06 ENST00000310914.10
IQCF1
IQ motif containing F1
chr1_+_160115715 0.06 ENST00000361216.8
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr9_+_130835246 0.06 ENST00000318560.6
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
chr14_-_106038355 0.06 ENST00000390597.3
IGHV2-5
immunoglobulin heavy variable 2-5
chrX_+_102651366 0.05 ENST00000415986.5
ENST00000444152.5
ENST00000361600.9
GPRASP1
G protein-coupled receptor associated sorting protein 1
chr20_-_17682234 0.05 ENST00000377813.6
ENST00000377807.6
ENST00000360807.8
ENST00000398782.2
RRBP1
ribosome binding protein 1
chr1_-_154961720 0.05 ENST00000368457.3
PYGO2
pygopus family PHD finger 2
chr3_+_9792495 0.05 ENST00000498623.6
ARPC4
actin related protein 2/3 complex subunit 4
chr12_-_10098940 0.05 ENST00000420265.2
CLEC1A
C-type lectin domain family 1 member A
chr19_+_47130782 0.05 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SAE1
SUMO1 activating enzyme subunit 1
chr3_-_168095885 0.05 ENST00000470487.6
GOLIM4
golgi integral membrane protein 4
chr5_+_71455636 0.05 ENST00000358731.9
ENST00000380675.3
BDP1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr12_-_8612850 0.05 ENST00000229335.11
ENST00000537228.5
AICDA
activation induced cytidine deaminase
chr17_-_7207245 0.05 ENST00000649971.1
DLG4
discs large MAGUK scaffold protein 4
chr5_+_180494344 0.05 ENST00000261951.9
CNOT6
CCR4-NOT transcription complex subunit 6
chr12_+_109900518 0.04 ENST00000312777.9
ENST00000536408.2
TCHP
trichoplein keratin filament binding
chr14_+_35826298 0.04 ENST00000216807.12
BRMS1L
BRMS1 like transcriptional repressor
chr1_+_160127672 0.04 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr19_-_51458448 0.04 ENST00000430817.5
ENST00000321424.7
ENST00000340550.5
SIGLEC8
sialic acid binding Ig like lectin 8
chr7_-_102517755 0.04 ENST00000306682.6
ENST00000465829.6
ENST00000541662.5
RASA4B
RAS p21 protein activator 4B
chr21_+_44600597 0.04 ENST00000609664.2
KRTAP10-7
keratin associated protein 10-7
chr3_-_62373538 0.04 ENST00000283268.8
FEZF2
FEZ family zinc finger 2
chr21_-_33479914 0.04 ENST00000542230.7
TMEM50B
transmembrane protein 50B
chr17_-_10114546 0.04 ENST00000323816.8
GAS7
growth arrest specific 7
chr11_-_66317037 0.04 ENST00000311330.4
CD248
CD248 molecule
chr2_-_219309350 0.04 ENST00000295718.7
PTPRN
protein tyrosine phosphatase receptor type N
chr9_-_28670285 0.04 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
LINGO2
leucine rich repeat and Ig domain containing 2
chr9_-_133356448 0.04 ENST00000615505.4
ENST00000371974.8
SURF1
SURF1 cytochrome c oxidase assembly factor
chr4_-_102827494 0.04 ENST00000453744.7
ENST00000321805.11
UBE2D3
ubiquitin conjugating enzyme E2 D3
chr10_+_101061973 0.03 ENST00000370200.6
KAZALD1
Kazal type serine peptidase inhibitor domain 1
chr12_+_67648737 0.03 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr19_-_42132391 0.03 ENST00000528894.8
ENST00000560804.6
ENST00000560558.5
ENST00000560398.5
ENST00000526816.6
ENST00000625670.2
POU2F2
POU class 2 homeobox 2
chr9_+_101028721 0.03 ENST00000374874.8
PLPPR1
phospholipid phosphatase related 1
chr22_+_41560973 0.03 ENST00000306149.12
CSDC2
cold shock domain containing C2
chrX_-_135098695 0.03 ENST00000433425.4
SMIM10L2B
small integral membrane protein 10 like 2B
chrX_+_21940693 0.03 ENST00000404933.7
ENST00000379404.5
SMS
spermine synthase
chr1_+_15456727 0.03 ENST00000359621.5
CELA2A
chymotrypsin like elastase 2A
chr19_+_48624952 0.03 ENST00000599748.5
ENST00000599029.2
SPHK2
sphingosine kinase 2
chr1_+_27725945 0.03 ENST00000373954.11
ENST00000419687.6
FAM76A
family with sequence similarity 76 member A
chr7_-_150955796 0.03 ENST00000330883.9
KCNH2
potassium voltage-gated channel subfamily H member 2
chr3_+_52495330 0.03 ENST00000321725.10
STAB1
stabilin 1
chr20_+_58651785 0.03 ENST00000358029.8
STX16
syntaxin 16
chr7_-_99408548 0.03 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr4_-_54064586 0.03 ENST00000263921.8
CHIC2
cysteine rich hydrophobic domain 2
chr6_+_34514853 0.03 ENST00000538621.2
PACSIN1
protein kinase C and casein kinase substrate in neurons 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.4 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 1.3 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.4 GO:0031443 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.1 0.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.6 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.2 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.2 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 2.2 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.3 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 1.0 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.2 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.0 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.0 0.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.6 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0 0.9 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.1 GO:0051365 leading edge cell differentiation(GO:0035026) cellular response to potassium ion starvation(GO:0051365)
0.0 0.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.0 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.9 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.4 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 1.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.2 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 1.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0001156 TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.1 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins