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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SOX21

Z-value: 0.38

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.6 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg38_v1_chr13_-_94712505_94712553-0.039.4e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_35180342 0.38 ENST00000639002.1
CD44
CD44 molecule (Indian blood group)
chr3_+_58008350 0.29 ENST00000490882.5
ENST00000358537.7
ENST00000429972.6
ENST00000682871.1
ENST00000295956.9
FLNB
filamin B
chr1_+_152908538 0.27 ENST00000368764.4
IVL
involucrin
chr8_+_100158576 0.27 ENST00000388798.7
SPAG1
sperm associated antigen 1
chr11_+_118077009 0.24 ENST00000616579.4
ENST00000534111.5
TMPRSS4
transmembrane serine protease 4
chr11_+_118077067 0.23 ENST00000522307.5
ENST00000523251.5
ENST00000437212.8
ENST00000522824.5
ENST00000522151.5
TMPRSS4
transmembrane serine protease 4
chr8_-_86069662 0.23 ENST00000276616.3
PSKH2
protein serine kinase H2
chr11_+_35180279 0.21 ENST00000531873.5
CD44
CD44 molecule (Indian blood group)
chr9_-_101487120 0.20 ENST00000374848.8
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chr12_+_34022462 0.20 ENST00000538927.1
ENST00000266483.7
ALG10
ALG10 alpha-1,2-glucosyltransferase
chr4_+_68447453 0.18 ENST00000305363.9
TMPRSS11E
transmembrane serine protease 11E
chr6_+_116399395 0.18 ENST00000644499.1
ENSG00000285446.1
novel protein
chr6_+_31403553 0.17 ENST00000449934.7
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chrX_+_3066833 0.17 ENST00000359361.2
ARSF
arylsulfatase F
chr9_-_101487091 0.16 ENST00000374847.5
PGAP4
post-GPI attachment to proteins GalNAc transferase 4
chrX_-_153944621 0.15 ENST00000393700.8
RENBP
renin binding protein
chr1_-_169485931 0.14 ENST00000367804.4
ENST00000646596.1
ENST00000236137.10
SLC19A2
solute carrier family 19 member 2
chr11_+_89924064 0.13 ENST00000623787.3
TRIM49D2
tripartite motif containing 49D2
chr12_+_122527229 0.13 ENST00000450485.6
ENST00000333479.12
KNTC1
kinetochore associated 1
chr3_+_186570663 0.12 ENST00000265028.8
DNAJB11
DnaJ heat shock protein family (Hsp40) member B11
chr4_+_74308463 0.12 ENST00000413830.6
EPGN
epithelial mitogen
chr14_+_21030201 0.11 ENST00000321760.11
ENST00000460647.6
ENST00000530140.6
ENST00000472458.5
TPPP2
tubulin polymerization promoting protein family member 2
chrX_-_153944655 0.11 ENST00000369997.7
RENBP
renin binding protein
chr12_-_10998304 0.10 ENST00000538986.2
TAS2R20
taste 2 receptor member 20
chr3_-_155854375 0.10 ENST00000643144.2
ENST00000359479.7
ENST00000646424.1
SLC33A1
solute carrier family 33 member 1
chrX_+_66164210 0.10 ENST00000343002.7
ENST00000336279.9
HEPH
hephaestin
chr12_-_89352487 0.10 ENST00000548755.1
ENST00000279488.8
DUSP6
dual specificity phosphatase 6
chr12_+_57591158 0.09 ENST00000422156.7
ENST00000354947.10
ENST00000540759.6
ENST00000551772.5
ENST00000550465.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
chr12_+_101280093 0.09 ENST00000261637.5
UTP20
UTP20 small subunit processome component
chr1_-_26067622 0.09 ENST00000374272.4
TRIM63
tripartite motif containing 63
chr1_-_217076889 0.09 ENST00000493748.5
ENST00000463665.5
ESRRG
estrogen related receptor gamma
chr4_-_176269213 0.09 ENST00000296525.7
ASB5
ankyrin repeat and SOCS box containing 5
chr14_+_22226711 0.09 ENST00000390463.3
TRAV36DV7
T cell receptor alpha variable 36/delta variable 7
chr12_-_89352395 0.08 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr6_+_151494007 0.08 ENST00000239374.8
CCDC170
coiled-coil domain containing 170
chr20_+_44715360 0.08 ENST00000190983.5
CCN5
cellular communication network factor 5
chr8_-_141367276 0.08 ENST00000377741.4
GPR20
G protein-coupled receptor 20
chr1_+_207325629 0.08 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr11_+_5389377 0.08 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr7_-_16421524 0.08 ENST00000407010.7
CRPPA
CDP-L-ribitol pyrophosphorylase A
chr7_+_2354810 0.07 ENST00000360876.9
ENST00000413917.5
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3 subunit B
chr15_-_79971164 0.07 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2A1
BCL2 related protein A1
chr10_-_12042771 0.07 ENST00000357604.10
UPF2
UPF2 regulator of nonsense mediated mRNA decay
chr5_+_176448363 0.07 ENST00000261942.7
FAF2
Fas associated factor family member 2
chr16_-_18433412 0.07 ENST00000620440.4
NOMO2
NODAL modulator 2
chr1_+_67166448 0.06 ENST00000347310.10
IL23R
interleukin 23 receptor
chr3_-_155806260 0.05 ENST00000534941.2
ENST00000340171.7
C3orf33
chromosome 3 open reading frame 33
chr18_+_32190033 0.05 ENST00000269202.11
MEP1B
meprin A subunit beta
chr6_+_42563981 0.05 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chrX_-_101291325 0.05 ENST00000356784.2
TAF7L
TATA-box binding protein associated factor 7 like
chr18_+_32190015 0.05 ENST00000581447.1
MEP1B
meprin A subunit beta
chr1_+_200027605 0.05 ENST00000236914.7
NR5A2
nuclear receptor subfamily 5 group A member 2
chr7_+_138076453 0.05 ENST00000242375.8
ENST00000411726.6
AKR1D1
aldo-keto reductase family 1 member D1
chr14_+_103529163 0.04 ENST00000389749.9
TRMT61A
tRNA methyltransferase 61A
chr1_+_158931539 0.04 ENST00000368140.6
ENST00000368138.7
ENST00000392254.6
ENST00000392252.7
ENST00000368135.4
PYHIN1
pyrin and HIN domain family member 1
chr14_-_106470788 0.03 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr8_+_127409026 0.03 ENST00000465342.4
POU5F1B
POU class 5 homeobox 1B
chr11_-_8263858 0.03 ENST00000534484.1
ENST00000335790.8
LMO1
LIM domain only 1
chrX_+_131083706 0.03 ENST00000370921.1
ARHGAP36
Rho GTPase activating protein 36
chr15_+_58410543 0.02 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr1_+_200027702 0.02 ENST00000367362.8
NR5A2
nuclear receptor subfamily 5 group A member 2
chr10_-_13234329 0.02 ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr3_+_36993350 0.02 ENST00000536378.5
ENST00000673899.1
ENST00000231790.8
ENST00000673715.1
ENST00000456676.6
ENST00000673673.1
MLH1
mutL homolog 1
chr3_-_36993103 0.02 ENST00000322716.8
EPM2AIP1
EPM2A interacting protein 1
chr10_-_13234368 0.02 ENST00000378681.8
UCMA
upper zone of growth plate and cartilage matrix associated
chr6_+_131637296 0.01 ENST00000358229.6
ENST00000357639.8
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chrX_-_51682831 0.01 ENST00000634648.1
CENPVL2
centromere protein V like 2
chr19_-_2783241 0.01 ENST00000676943.1
ENST00000589251.5
ENST00000221566.7
ENST00000676984.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr6_+_29396555 0.01 ENST00000623183.1
OR12D2
olfactory receptor family 12 subfamily D member 2
chr19_-_7040179 0.01 ENST00000381394.9
MBD3L4
methyl-CpG binding domain protein 3 like 4
chr3_+_36993764 0.01 ENST00000674019.1
ENST00000458205.6
MLH1
mutL homolog 1
chr14_+_92121953 0.00 ENST00000298875.9
ENST00000553427.5
CPSF2
cleavage and polyadenylation specific factor 2
chr7_-_73719629 0.00 ENST00000395155.3
ENST00000395154.7
ENST00000395156.7
ENST00000222812.8
STX1A
syntaxin 1A
chr1_+_203795614 0.00 ENST00000367210.3
ENST00000432282.5
ENST00000453771.5
ENST00000367214.5
ENST00000639812.1
ENST00000367212.7
ENST00000332127.8
ENST00000550078.2
ZC3H11A
ZBED6
zinc finger CCCH-type containing 11A
zinc finger BED-type containing 6
chr4_-_103719980 0.00 ENST00000304883.3
TACR3
tachykinin receptor 3
chrX_-_139642518 0.00 ENST00000370573.8
ENST00000338585.6
MCF2
MCF.2 cell line derived transforming sequence
chrX_+_11760035 0.00 ENST00000482871.6
ENST00000648013.1
MSL3
MSL complex subunit 3
chr19_-_2783308 0.00 ENST00000677562.1
ENST00000677754.1
SGTA
small glutamine rich tetratricopeptide repeat containing alpha
chr22_+_22720615 0.00 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.3 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.3 GO:0007016 keratinocyte development(GO:0003334) cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:1990423 RZZ complex(GO:1990423)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.0 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation