Project
Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for SP3
Z-value: 0.79
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg38_v1_chr2_-_173965356_173965380 | -0.27 | 5.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_29927596 Show fit | 2.08 |
ENST00000415220.6
|
protein kinase D1 |
|
| chr21_+_46098102 Show fit | 1.93 |
ENST00000300527.9
ENST00000310645.9 |
collagen type VI alpha 2 chain |
|
| chr14_-_29927801 Show fit | 1.90 |
ENST00000331968.11
|
protein kinase D1 |
|
| chr14_-_29927473 Show fit | 1.82 |
ENST00000616995.4
|
protein kinase D1 |
|
| chr2_+_11155498 Show fit | 1.66 |
ENST00000402361.5
ENST00000428481.1 |
solute carrier family 66 member 3 |
|
| chr5_-_9546066 Show fit | 1.22 |
ENST00000382496.10
ENST00000652226.1 |
semaphorin 5A |
|
| chr14_-_91947654 Show fit | 1.10 |
ENST00000342058.9
|
fibulin 5 |
|
| chr1_-_3611470 Show fit | 1.06 |
ENST00000356575.9
|
multiple EGF like domains 6 |
|
| chr21_+_46001300 Show fit | 0.99 |
ENST00000612273.2
ENST00000682634.1 |
collagen type VI alpha 1 chain |
|
| chrX_+_153494970 Show fit | 0.94 |
ENST00000331595.9
ENST00000431891.1 |
biglycan |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.2 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.2 | 4.0 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.4 | 2.5 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.2 | 2.5 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.0 | 2.5 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 2.4 | GO:0036109 | alpha-linolenic acid metabolic process(GO:0036109) |
| 0.2 | 2.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 2.3 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) |
| 0.0 | 2.0 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.6 | 1.8 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 7.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 4.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.3 | 2.6 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 2.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 2.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 2.2 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 2.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 1.8 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.7 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.3 | 2.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.2 | 2.5 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 2.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 2.2 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.2 | 2.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 2.0 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.4 | 1.8 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 1.8 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 1.6 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.2 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.6 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.8 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 1.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 6.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 3.2 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 2.1 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 2.0 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.0 | 2.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.7 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |