ISMARA results: TAL1

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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TAL1

Z-value: 0.95

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Transcription factors associated with TAL1

Gene Symbol	Gene ID	Gene Info
TAL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000162367.11	TAL bHLH transcription factor 1, erythroid differentiation factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TAL1	hg38_v1_chr1_-_47231715_47231786	0.63	9.4e-02	Click!

Activity profile of TAL1 motif

Sorted Z-values of TAL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_52452139 Show fit	1.71	ENST00000252252.4	KRT6B Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 6B
chr18_-_49849827 Show fit	1.64	ENST00000592688.1	MYO5B Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin VB
chr12_-_52473798 Show fit	1.50	ENST00000252250.7	KRT6C Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 6C
chr8_-_56320098 Show fit	1.43	ENST00000303749.8 ENST00000396721.6	SDR16C5 Ensembl NCBI GeneCards UniProt NextProt Show fit	short chain dehydrogenase/reductase family 16C member 5
chr4_+_48016764 Show fit	1.37	ENST00000295461.10	NIPAL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NIPA like domain containing 1
chr19_+_35116262 Show fit	1.19	ENST00000604255.5 ENST00000344013.10 ENST00000346446.9 ENST00000603449.5 ENST00000605550.5 ENST00000604804.5 ENST00000605552.5	FXYD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 3
chr2_-_31138429 Show fit	1.11	ENST00000349752.10	GALNT14 Ensembl NCBI GeneCards UniProt NextProt Show fit	polypeptide N-acetylgalactosaminyltransferase 14
chr20_+_63696643 Show fit	1.11	ENST00000369996.3	TNFRSF6B Ensembl NCBI GeneCards UniProt NextProt Show fit	TNF receptor superfamily member 6b
chr10_+_80413817 Show fit	1.10	ENST00000372187.9	PRXL2A Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxiredoxin like 2A
chr4_-_80073057 Show fit	1.05	ENST00000681710.1	ANTXR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ANTXR cell adhesion molecule 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TAL1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	10.3	GO:0070268	cornification(GO:0070268)
0.2	5.6	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	5.3	GO:1901998	toxin transport(GO:1901998)
0.0	5.2	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	2.8	GO:0006953	acute-phase response(GO:0006953)
0.2	2.6	GO:0015820	leucine transport(GO:0015820)
0.2	2.5	GO:0031642	negative regulation of myelination(GO:0031642)
0.5	2.4	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.1	2.4	GO:0016540	protein autoprocessing(GO:0016540)
0.1	2.0	GO:0070445	oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)

Showing 1 to 10 of 628 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	5.1	GO:0034707	chloride channel complex(GO:0034707)
0.0	5.0	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1	4.8	GO:0045095	keratin filament(GO:0045095)
0.0	4.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	3.6	GO:0030056	hemidesmosome(GO:0030056)
0.0	3.2	GO:0070821	tertiary granule membrane(GO:0070821)
0.2	3.0	GO:0045179	apical cortex(GO:0045179)
0.1	3.0	GO:0030057	desmosome(GO:0030057)
0.0	2.9	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Showing 1 to 10 of 188 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	6.0	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	3.5	GO:0017080	sodium channel regulator activity(GO:0017080)
0.1	2.9	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	2.8	GO:0000146	microfilament motor activity(GO:0000146)
0.1	2.4	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.2	2.2	GO:0031014	troponin T binding(GO:0031014)
0.1	2.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	2.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	1.9	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)

Showing 1 to 10 of 411 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	3.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	2.7	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	2.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	2.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.5	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	2.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.5	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	1.2	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 53 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	3.7	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	3.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.5	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	2.2	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	1.9	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	1.8	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	1.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	1.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	1.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation

Showing 1 to 10 of 91 entries

Results for TAL1

Z-value: 0.95

Motif logo

Transcription factors associated with TAL1

Activity-expression correlation:

Activity profile of TAL1 motif

Sorted Z-values of TAL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TAL1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: