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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TCF7L2

Z-value: 0.84

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.17 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg38_v1_chr10_+_112950240_112950272-0.571.4e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_23570370 1.31 ENST00000403372.6
ENST00000248484.9
TNFRSF19
TNF receptor superfamily member 19
chr13_+_101489940 1.16 ENST00000376162.7
ITGBL1
integrin subunit beta like 1
chr13_+_75760362 0.93 ENST00000534657.5
LMO7
LIM domain 7
chrX_+_153494970 0.92 ENST00000331595.9
ENST00000431891.1
BGN
biglycan
chr10_+_69088096 0.84 ENST00000242465.4
SRGN
serglycin
chr7_+_94394886 0.65 ENST00000297268.11
ENST00000620463.1
COL1A2
collagen type I alpha 2 chain
chr13_+_75760659 0.63 ENST00000526202.5
ENST00000465261.6
LMO7
LIM domain 7
chr7_+_120988683 0.55 ENST00000340646.9
ENST00000310396.10
CPED1
cadherin like and PC-esterase domain containing 1
chr13_+_75760431 0.55 ENST00000321797.12
LMO7
LIM domain 7
chr12_+_1629197 0.55 ENST00000397196.7
WNT5B
Wnt family member 5B
chr17_-_69141878 0.43 ENST00000590645.1
ENST00000284425.7
ABCA6
ATP binding cassette subfamily A member 6
chr1_+_222928415 0.43 ENST00000284476.7
DISP1
dispatched RND transporter family member 1
chr3_-_15797930 0.42 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr16_-_73048104 0.36 ENST00000268489.10
ZFHX3
zinc finger homeobox 3
chr4_-_156970903 0.35 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr6_-_34248989 0.33 ENST00000481533.5
ENST00000468145.1
ENST00000476320.6
ENST00000394990.8
SMIM29
small integral membrane protein 29
chr1_+_60865259 0.33 ENST00000371191.5
NFIA
nuclear factor I A
chr4_-_165279679 0.32 ENST00000505354.2
GK3P
glycerol kinase 3 pseudogene
chr11_-_70717994 0.31 ENST00000659264.1
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr2_+_200440649 0.29 ENST00000366118.2
SPATS2L
spermatogenesis associated serine rich 2 like
chr3_+_29281552 0.28 ENST00000452462.5
ENST00000456853.1
RBMS3
RNA binding motif single stranded interacting protein 3
chr5_-_16742221 0.28 ENST00000505695.5
MYO10
myosin X
chr8_+_38787218 0.28 ENST00000317827.9
ENST00000276520.12
TACC1
transforming acidic coiled-coil containing protein 1
chr13_+_31945826 0.27 ENST00000647500.1
FRY
FRY microtubule binding protein
chr3_+_141368497 0.27 ENST00000321464.7
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_153550083 0.26 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chrX_+_54809060 0.26 ENST00000396224.1
MAGED2
MAGE family member D2
chr11_+_69641146 0.26 ENST00000227507.3
ENST00000536559.1
CCND1
cyclin D1
chr4_+_112860912 0.25 ENST00000671951.1
ANK2
ankyrin 2
chr4_+_112861053 0.25 ENST00000672221.1
ANK2
ankyrin 2
chr4_+_112860981 0.25 ENST00000671704.1
ANK2
ankyrin 2
chr19_+_1266653 0.24 ENST00000586472.5
ENST00000589266.5
CIRBP
cold inducible RNA binding protein
chrX_-_63785510 0.24 ENST00000437457.6
ENST00000374878.5
ENST00000623517.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr17_+_77451244 0.24 ENST00000591088.5
SEPTIN9
septin 9
chr16_+_53208438 0.24 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr2_-_55419821 0.24 ENST00000644630.1
ENST00000471947.2
ENST00000436346.7
ENST00000642200.1
ENST00000413716.7
ENST00000263630.13
ENST00000645072.1
CCDC88A
coiled-coil domain containing 88A
chr2_-_55419565 0.23 ENST00000647341.1
ENST00000647401.1
ENST00000336838.10
ENST00000621814.4
ENST00000644033.1
ENST00000645477.1
ENST00000647517.1
CCDC88A
coiled-coil domain containing 88A
chr7_-_139777986 0.23 ENST00000406875.8
HIPK2
homeodomain interacting protein kinase 2
chr15_+_92904447 0.22 ENST00000626782.2
CHD2
chromodomain helicase DNA binding protein 2
chr5_+_61332236 0.22 ENST00000252744.6
ZSWIM6
zinc finger SWIM-type containing 6
chr1_+_77918128 0.22 ENST00000342754.5
NEXN
nexilin F-actin binding protein
chrX_-_100928903 0.22 ENST00000372956.3
XKRX
XK related X-linked
chr14_-_52791597 0.21 ENST00000216410.8
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr6_-_34249102 0.20 ENST00000636500.1
SMIM29
small integral membrane protein 29
chr5_-_59039454 0.20 ENST00000358923.10
PDE4D
phosphodiesterase 4D
chr6_+_155216637 0.20 ENST00000275246.11
TIAM2
TIAM Rac1 associated GEF 2
chr11_-_111879154 0.20 ENST00000260257.9
FDXACB1
ferredoxin-fold anticodon binding domain containing 1
chrX_-_40097403 0.19 ENST00000397354.7
BCOR
BCL6 corepressor
chr15_-_89751292 0.19 ENST00000300057.4
MESP1
mesoderm posterior bHLH transcription factor 1
chr1_+_206865620 0.18 ENST00000367098.6
IL20
interleukin 20
chr19_-_43504711 0.18 ENST00000601646.1
PHLDB3
pleckstrin homology like domain family B member 3
chr17_-_65561640 0.17 ENST00000618960.4
ENST00000307078.10
AXIN2
axin 2
chr18_+_6729698 0.17 ENST00000383472.9
ARHGAP28
Rho GTPase activating protein 28
chr5_+_102865805 0.16 ENST00000346918.7
PAM
peptidylglycine alpha-amidating monooxygenase
chr11_-_62707413 0.16 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr10_+_52314272 0.16 ENST00000373970.4
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr2_+_69013379 0.16 ENST00000409349.7
ANTXR1
ANTXR cell adhesion molecule 1
chr5_+_112738331 0.16 ENST00000512211.6
APC
APC regulator of WNT signaling pathway
chr3_+_141387801 0.16 ENST00000514251.5
ZBTB38
zinc finger and BTB domain containing 38
chr11_-_62707581 0.15 ENST00000684475.1
ENST00000683296.1
ENST00000684067.1
ENST00000682223.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr20_-_675793 0.15 ENST00000488788.2
ENST00000246104.7
ENSG00000270299.1
SCRT2
novel protein
scratch family transcriptional repressor 2
chr12_-_49189053 0.14 ENST00000550767.6
ENST00000546918.1
ENST00000679733.1
ENST00000552924.2
ENST00000301071.12
TUBA1A
tubulin alpha 1a
chr5_-_135954962 0.14 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr5_-_157575767 0.14 ENST00000257527.9
ADAM19
ADAM metallopeptidase domain 19
chr17_+_1771688 0.14 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chr9_-_15510289 0.13 ENST00000397519.6
PSIP1
PC4 and SFRS1 interacting protein 1
chr7_-_80512041 0.13 ENST00000398291.4
GNAT3
G protein subunit alpha transducin 3
chr17_+_44846318 0.13 ENST00000591513.5
HIGD1B
HIG1 hypoxia inducible domain family member 1B
chr17_-_39864304 0.12 ENST00000346872.8
IKZF3
IKAROS family zinc finger 3
chr2_+_203936755 0.12 ENST00000316386.11
ENST00000435193.1
ICOS
inducible T cell costimulator
chr2_+_69013170 0.12 ENST00000303714.9
ANTXR1
ANTXR cell adhesion molecule 1
chr2_-_157628852 0.12 ENST00000243349.13
ACVR1C
activin A receptor type 1C
chr11_+_114257800 0.12 ENST00000535401.5
NNMT
nicotinamide N-methyltransferase
chr7_-_151814636 0.12 ENST00000652047.1
ENST00000650858.1
PRKAG2
protein kinase AMP-activated non-catalytic subunit gamma 2
chr4_-_68349981 0.12 ENST00000510746.1
ENST00000355665.7
ENST00000344157.9
YTHDC1
YTH domain containing 1
chr15_-_89221558 0.12 ENST00000268125.10
RLBP1
retinaldehyde binding protein 1
chr19_-_51082883 0.12 ENST00000650543.2
KLK14
kallikrein related peptidase 14
chr16_+_29808051 0.11 ENST00000568544.5
ENST00000569978.1
MAZ
MYC associated zinc finger protein
chr7_-_151814668 0.11 ENST00000651764.1
PRKAG2
protein kinase AMP-activated non-catalytic subunit gamma 2
chr4_+_2818155 0.11 ENST00000511747.6
SH3BP2
SH3 domain binding protein 2
chr5_+_141417659 0.11 ENST00000398594.4
PCDHGB7
protocadherin gamma subfamily B, 7
chr5_+_140107777 0.11 ENST00000505703.2
ENST00000651386.1
PURA
purine rich element binding protein A
chr11_-_6006946 0.10 ENST00000641156.1
ENST00000641835.1
OR56A4
olfactory receptor family 56 subfamily A member 4
chr2_+_203867943 0.10 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4
chrX_-_43973382 0.10 ENST00000642620.1
ENST00000647044.1
NDP
norrin cystine knot growth factor NDP
chr14_+_74348440 0.10 ENST00000256362.5
VRTN
vertebrae development associated
chr2_-_71130214 0.10 ENST00000494660.6
ENST00000244217.6
ENST00000486135.1
MCEE
methylmalonyl-CoA epimerase
chr6_-_166167832 0.10 ENST00000366876.7
TBXT
T-box transcription factor T
chr12_+_121888751 0.09 ENST00000261817.6
ENST00000538613.5
ENST00000542602.1
ENST00000541212.6
PSMD9
proteasome 26S subunit, non-ATPase 9
chr17_+_44004604 0.09 ENST00000293404.8
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr7_-_148884266 0.09 ENST00000483967.5
ENST00000320356.7
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr7_+_27242796 0.09 ENST00000496902.7
EVX1
even-skipped homeobox 1
chr12_-_12338674 0.09 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr2_+_69013282 0.09 ENST00000409829.7
ANTXR1
ANTXR cell adhesion molecule 1
chr1_-_19923617 0.09 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr10_+_99782628 0.09 ENST00000648689.1
ENST00000647814.1
ABCC2
ATP binding cassette subfamily C member 2
chr16_+_29808125 0.09 ENST00000568282.1
MAZ
MYC associated zinc finger protein
chr19_-_58519554 0.09 ENST00000354590.7
ENST00000596739.1
ZBTB45
zinc finger and BTB domain containing 45
chr12_-_49188811 0.09 ENST00000295766.9
TUBA1A
tubulin alpha 1a
chr17_-_39864140 0.09 ENST00000623724.3
ENST00000439167.6
ENST00000377945.7
ENST00000394189.6
ENST00000377944.7
ENST00000377958.6
ENST00000535189.5
ENST00000377952.6
IKZF3
IKAROS family zinc finger 3
chr19_-_18606779 0.09 ENST00000684169.1
ENST00000392386.8
CRLF1
cytokine receptor like factor 1
chr2_+_69013414 0.09 ENST00000681816.1
ENST00000482235.2
ANTXR1
ANTXR cell adhesion molecule 1
chr14_-_80959484 0.09 ENST00000555529.5
ENST00000556042.5
ENST00000556981.5
CEP128
centrosomal protein 128
chr15_-_55588337 0.09 ENST00000563719.4
PYGO1
pygopus family PHD finger 1
chr7_+_27242700 0.09 ENST00000222761.7
EVX1
even-skipped homeobox 1
chr19_-_58519751 0.09 ENST00000600990.1
ENST00000594051.6
ZBTB45
zinc finger and BTB domain containing 45
chr6_+_63571702 0.09 ENST00000672924.1
PTP4A1
protein tyrosine phosphatase 4A1
chr10_+_113553039 0.09 ENST00000351270.4
HABP2
hyaluronan binding protein 2
chrX_+_47078380 0.09 ENST00000352078.8
RGN
regucalcin
chr6_-_89217339 0.09 ENST00000454853.7
GABRR1
gamma-aminobutyric acid type A receptor subunit rho1
chr10_-_73591330 0.08 ENST00000451492.5
ENST00000681793.1
ENST00000680396.1
ENST00000413442.5
USP54
ubiquitin specific peptidase 54
chr7_-_148884159 0.08 ENST00000478654.5
ENST00000460911.5
ENST00000350995.6
EZH2
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr10_-_102432565 0.08 ENST00000369937.5
CUEDC2
CUE domain containing 2
chr5_+_55160161 0.08 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
GPX8
glutathione peroxidase 8 (putative)
chr8_-_143973520 0.08 ENST00000356346.7
PLEC
plectin
chr1_+_147541491 0.07 ENST00000683836.1
ENST00000234739.8
BCL9
BCL9 transcription coactivator
chr14_+_32329256 0.07 ENST00000280979.9
AKAP6
A-kinase anchoring protein 6
chrX_+_47078330 0.07 ENST00000457380.5
RGN
regucalcin
chrX_+_47078434 0.07 ENST00000397180.6
RGN
regucalcin
chr12_+_8914525 0.07 ENST00000543824.5
PHC1
polyhomeotic homolog 1
chr17_+_81712236 0.07 ENST00000545862.5
ENST00000350690.10
ENST00000331531.9
SLC25A10
solute carrier family 25 member 10
chr14_+_74763308 0.06 ENST00000325680.12
ENST00000552421.5
YLPM1
YLP motif containing 1
chr17_-_42018488 0.06 ENST00000589773.5
ENST00000674214.1
DNAJC7
DnaJ heat shock protein family (Hsp40) member C7
chr4_+_169660062 0.06 ENST00000507875.5
ENST00000613795.4
CLCN3
chloride voltage-gated channel 3
chr1_-_201127184 0.06 ENST00000449188.3
ASCL5
achaete-scute family bHLH transcription factor 5
chr17_-_49230728 0.06 ENST00000503902.1
ENST00000512250.1
ENST00000413580.5
ENST00000511066.5
PHOSPHO1
phosphoethanolamine/phosphocholine phosphatase 1
chr17_-_75393741 0.06 ENST00000578961.5
ENST00000392564.5
GRB2
growth factor receptor bound protein 2
chr17_-_49230770 0.06 ENST00000310544.9
PHOSPHO1
phosphoethanolamine/phosphocholine phosphatase 1
chr2_-_88128049 0.06 ENST00000393750.3
ENST00000295834.8
FABP1
fatty acid binding protein 1
chr2_+_227813834 0.06 ENST00000358813.5
ENST00000409189.7
CCL20
C-C motif chemokine ligand 20
chr3_-_177196451 0.06 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr17_-_75393656 0.05 ENST00000392563.5
GRB2
growth factor receptor bound protein 2
chr14_+_21797272 0.05 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr3_+_137764296 0.05 ENST00000306087.3
SOX14
SRY-box transcription factor 14
chr19_-_40285277 0.05 ENST00000579047.5
ENST00000392038.7
AKT2
AKT serine/threonine kinase 2
chr4_+_85604146 0.05 ENST00000512201.5
ARHGAP24
Rho GTPase activating protein 24
chr3_-_134374439 0.05 ENST00000513145.1
ENST00000249883.10
ENST00000422605.6
AMOTL2
angiomotin like 2
chr6_+_151809105 0.05 ENST00000427531.6
ESR1
estrogen receptor 1
chr5_+_161850597 0.05 ENST00000634335.1
ENST00000635880.1
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr3_-_42410558 0.05 ENST00000441172.1
ENST00000287748.8
LYZL4
lysozyme like 4
chr9_-_97944832 0.05 ENST00000259456.7
HEMGN
hemogen
chr2_-_9630491 0.04 ENST00000381844.8
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
chr8_-_142879820 0.04 ENST00000377675.3
ENST00000517471.5
ENST00000292427.10
CYP11B1
cytochrome P450 family 11 subfamily B member 1
chr20_-_57265738 0.04 ENST00000433911.1
BMP7
bone morphogenetic protein 7
chr10_+_103245887 0.04 ENST00000441178.2
RPEL1
ribulose-5-phosphate-3-epimerase like 1
chr1_+_154272589 0.04 ENST00000457918.6
ENST00000483970.6
ENST00000328703.12
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr17_-_41065879 0.04 ENST00000394015.3
KRTAP2-4
keratin associated protein 2-4
chr15_-_93089192 0.04 ENST00000329082.11
RGMA
repulsive guidance molecule BMP co-receptor a
chr1_-_162023826 0.04 ENST00000294794.8
OLFML2B
olfactomedin like 2B
chr1_-_44141631 0.04 ENST00000634670.1
KLF18
Kruppel like factor 18
chr16_+_72054477 0.04 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
HP
haptoglobin
chr11_-_40294089 0.04 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr4_-_138242325 0.04 ENST00000280612.9
SLC7A11
solute carrier family 7 member 11
chr22_+_40951364 0.03 ENST00000216225.9
RBX1
ring-box 1
chr7_+_80646305 0.03 ENST00000426978.5
ENST00000432207.5
CD36
CD36 molecule
chrX_+_2752024 0.03 ENST00000644266.2
ENST00000419513.7
ENST00000509484.3
ENST00000381174.10
XG
Xg glycoprotein (Xg blood group)
chr3_-_45915698 0.03 ENST00000539217.5
LZTFL1
leucine zipper transcription factor like 1
chr16_+_72063226 0.03 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
HPR
haptoglobin-related protein
chr13_-_71867192 0.03 ENST00000611519.4
ENST00000620444.4
ENST00000613252.5
DACH1
dachshund family transcription factor 1
chr11_-_62805429 0.03 ENST00000294172.7
ENST00000531131.1
ENST00000530875.5
ENST00000531709.6
NXF1
nuclear RNA export factor 1
chr14_-_63318933 0.03 ENST00000621500.2
GPHB5
glycoprotein hormone subunit beta 5
chr11_+_111878926 0.03 ENST00000528125.5
C11orf1
chromosome 11 open reading frame 1
chr2_-_9630946 0.03 ENST00000446619.1
ENST00000238081.8
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
chr14_-_93976550 0.03 ENST00000555019.6
ASB2
ankyrin repeat and SOCS box containing 2
chr6_-_25930678 0.03 ENST00000377850.8
SLC17A2
solute carrier family 17 member 2
chr6_-_28252246 0.03 ENST00000377294.3
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr19_-_39433703 0.02 ENST00000602153.5
RPS16
ribosomal protein S16
chr2_+_233712905 0.02 ENST00000373414.4
UGT1A5
UDP glucuronosyltransferase family 1 member A5
chr17_-_47957824 0.02 ENST00000300557.3
PRR15L
proline rich 15 like
chr3_+_174859315 0.02 ENST00000454872.6
NAALADL2
N-acetylated alpha-linked acidic dipeptidase like 2
chr6_-_25930611 0.02 ENST00000360488.7
SLC17A2
solute carrier family 17 member 2
chrX_-_123733023 0.02 ENST00000245838.13
ENST00000355725.8
THOC2
THO complex 2
chr3_-_179974254 0.02 ENST00000468741.5
PEX5L
peroxisomal biogenesis factor 5 like
chr2_+_71130586 0.02 ENST00000498451.2
ENST00000244230.7
MPHOSPH10
M-phase phosphoprotein 10
chr11_+_112074287 0.02 ENST00000532163.5
ENST00000280352.13
ENST00000393047.8
ENST00000526879.5
ENST00000525785.5
NKAPD1
NKAP domain containing 1
chr8_-_132111159 0.02 ENST00000673615.1
ENST00000434736.6
HHLA1
HERV-H LTR-associating 1
chr19_-_40285395 0.02 ENST00000424901.5
ENST00000578123.5
AKT2
AKT serine/threonine kinase 2
chr7_+_100015572 0.02 ENST00000535170.5
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr1_+_109548567 0.02 ENST00000369851.7
GNAI3
G protein subunit alpha i3
chr15_+_57219411 0.02 ENST00000543579.5
ENST00000537840.5
ENST00000343827.7
TCF12
transcription factor 12
chr2_+_112911159 0.02 ENST00000263326.8
IL37
interleukin 37
chr9_-_74887720 0.02 ENST00000449912.6
TRPM6
transient receptor potential cation channel subfamily M member 6
chr22_+_19962537 0.02 ENST00000449653.5
COMT
catechol-O-methyltransferase
chr15_+_64460728 0.01 ENST00000416172.1
ZNF609
zinc finger protein 609
chrX_+_106920393 0.01 ENST00000336803.2
CLDN2
claudin 2
chr5_-_24644968 0.01 ENST00000264463.8
CDH10
cadherin 10
chr9_-_74887914 0.01 ENST00000360774.6
TRPM6
transient receptor potential cation channel subfamily M member 6
chrX_+_123860262 0.01 ENST00000355640.3
XIAP
X-linked inhibitor of apoptosis
chr16_+_50548387 0.01 ENST00000268459.6
NKD1
NKD inhibitor of WNT signaling pathway 1
chr2_-_232776555 0.01 ENST00000438786.1
ENST00000233826.4
ENST00000409779.1
KCNJ13
potassium inwardly rectifying channel subfamily J member 13
chr7_+_100015588 0.01 ENST00000324306.11
ENST00000426572.5
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr12_+_8914464 0.01 ENST00000544916.6
PHC1
polyhomeotic homolog 1
chr3_+_156120572 0.01 ENST00000389636.9
ENST00000490337.6
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr18_+_32190015 0.01 ENST00000581447.1
MEP1B
meprin A subunit beta
chr3_-_33645433 0.01 ENST00000635664.1
ENST00000485378.6
ENST00000313350.10
ENST00000487200.5
CLASP2
cytoplasmic linker associated protein 2
chr7_-_27180230 0.01 ENST00000396344.4
HOXA10
homeobox A10
chr4_-_68349750 0.01 ENST00000579690.5
YTHDC1
YTH domain containing 1
chr7_+_80646436 0.01 ENST00000419819.2
CD36
CD36 molecule
chr5_+_171419635 0.01 ENST00000274625.6
FGF18
fibroblast growth factor 18
chr2_+_203867764 0.01 ENST00000648405.2
CTLA4
cytotoxic T-lymphocyte associated protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:0007225 patched ligand maturation(GO:0007225) signal maturation(GO:0035638)
0.1 0.4 GO:0042662 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of mesodermal cell fate specification(GO:0042662)
0.1 0.4 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 0.8 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 0.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.3 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.1 0.3 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.1 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.2 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.2 GO:1903627 regulation of calcium-dependent ATPase activity(GO:1903610) negative regulation of calcium-dependent ATPase activity(GO:1903611) regulation of dUTP diphosphatase activity(GO:1903627) positive regulation of dUTP diphosphatase activity(GO:1903629) negative regulation of aminoacyl-tRNA ligase activity(GO:1903631) regulation of leucine-tRNA ligase activity(GO:1903633) negative regulation of leucine-tRNA ligase activity(GO:1903634)
0.0 0.2 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.7 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0018032 protein amidation(GO:0018032)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0016999 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.0 0.1 GO:0097360 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.5 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.3 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.1 GO:0071486 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009)
0.0 0.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.1 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882) lens induction in camera-type eye(GO:0060235)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.1 GO:0071279 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.3 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.2 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:0070221 succinate transport(GO:0015744) sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) succinate transmembrane transport(GO:0071422)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.0 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.0 GO:1903564 regulation of protein localization to cilium(GO:1903564)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134) allantois development(GO:1905069)
0.0 0.2 GO:0006853 carnitine shuttle(GO:0006853)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.9 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.3 GO:0005883 neurofilament(GO:0005883)
0.0 0.1 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0043203 axon hillock(GO:0043203)
0.0 0.8 GO:0031430 M band(GO:0031430)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004370 glycerol kinase activity(GO:0004370)
0.1 0.2 GO:0004341 gluconolactonase activity(GO:0004341)
0.0 0.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 1.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0015140 malate transmembrane transporter activity(GO:0015140)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.5 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.0 GO:0004507 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0004750 ribulose-phosphate 3-epimerase activity(GO:0004750)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK