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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TP63
Z-value: 1.25
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Transcription factors associated with TP63
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP63 | hg38_v1_chr3_+_189789643_189789670 | 0.92 | 1.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51001138 Show fit | 2.83 |
ENST00000593490.1
|
kallikrein related peptidase 8 |
|
| chr1_-_153615858 Show fit | 2.66 |
ENST00000476873.5
|
S100 calcium binding protein A14 |
|
| chr12_-_52493250 Show fit | 2.45 |
ENST00000330722.7
|
keratin 6A |
|
| chr12_-_52452139 Show fit | 2.38 |
ENST00000252252.4
|
keratin 6B |
|
| chr1_+_86424154 Show fit | 2.25 |
ENST00000370565.5
|
chloride channel accessory 2 |
|
| chr11_+_18266254 Show fit | 1.77 |
ENST00000532858.5
ENST00000649195.1 ENST00000356524.9 ENST00000405158.2 |
serum amyloid A1 |
|
| chr4_-_10021490 Show fit | 1.73 |
ENST00000264784.8
|
solute carrier family 2 member 9 |
|
| chr16_+_57620077 Show fit | 1.72 |
ENST00000567835.5
ENST00000569372.5 ENST00000563548.5 ENST00000562003.5 |
adhesion G protein-coupled receptor G1 |
|
| chr16_+_57619942 Show fit | 1.60 |
ENST00000568908.5
ENST00000568909.5 ENST00000566778.5 ENST00000561988.5 |
adhesion G protein-coupled receptor G1 |
|
| chr3_-_57079287 Show fit | 1.50 |
ENST00000338458.8
ENST00000468727.5 |
Rho guanine nucleotide exchange factor 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP63
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.2 | 3.3 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.2 | 2.7 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.1 | 2.7 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.6 | 2.5 | GO:0051710 | cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710) |
| 0.0 | 2.1 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.1 | 2.0 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 1.8 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.1 | 1.7 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 1.7 | GO:0046415 | urate metabolic process(GO:0046415) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.4 | 3.3 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.0 | 2.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 2.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 1.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 1.7 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 1.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 1.2 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.0 | 0.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.9 | GO:0031941 | filamentous actin(GO:0031941) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.7 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.0 | 2.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 2.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 2.0 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 1.7 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.0 | 1.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.9 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.8 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.8 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.4 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |