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Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TWIST1_SNAI1
Z-value: 2.48
Motif logo
Transcription factors associated with TWIST1_SNAI1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
TWIST1
|
ENSG00000122691.13 | twist family bHLH transcription factor 1 |
|
SNAI1
|
ENSG00000124216.4 | snail family transcriptional repressor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TWIST1 | hg38_v1_chr7_-_19117625_19117645 | -0.96 | 1.4e-04 | Click! |
| SNAI1 | hg38_v1_chr20_+_49982969_49982989 | 0.47 | 2.4e-01 | Click! |
Activity profile of TWIST1_SNAI1 motif
Sorted Z-values of TWIST1_SNAI1 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.1 | GO:0043000 | Golgi to plasma membrane CFTR protein transport(GO:0043000) |
| 1.9 | 5.8 | GO:0032912 | negative regulation of transforming growth factor beta2 production(GO:0032912) negative regulation of hair follicle maturation(GO:0048817) regulation of melanosome transport(GO:1902908) |
| 1.4 | 8.6 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 1.2 | 7.2 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 0.8 | 2.4 | GO:0061573 | endoplasmic reticulum polarization(GO:0061163) actin filament bundle retrograde transport(GO:0061573) actin filament bundle distribution(GO:0070650) |
| 0.8 | 4.7 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.8 | 2.3 | GO:0009720 | detection of hormone stimulus(GO:0009720) |
| 0.8 | 3.0 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.7 | 2.0 | GO:2000412 | positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309) positive regulation of thymocyte migration(GO:2000412) |
| 0.6 | 8.1 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.6 | 2.4 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.6 | 2.3 | GO:0033606 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.6 | 2.8 | GO:0032185 | septin cytoskeleton organization(GO:0032185) |
| 0.5 | 2.2 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.5 | 2.1 | GO:0042361 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.5 | 0.9 | GO:1900220 | semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220) |
| 0.5 | 5.6 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.5 | 1.4 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.4 | 3.6 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) |
| 0.4 | 1.7 | GO:0010979 | regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) |
| 0.4 | 1.3 | GO:0009386 | translational attenuation(GO:0009386) |
| 0.4 | 2.0 | GO:2000721 | positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721) |
| 0.4 | 1.2 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.4 | 2.7 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.4 | 5.0 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.4 | 1.4 | GO:0048627 | myoblast development(GO:0048627) |
| 0.3 | 5.9 | GO:0015871 | choline transport(GO:0015871) |
| 0.3 | 1.4 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.3 | 1.3 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.3 | 2.4 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.3 | 1.2 | GO:0002913 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
| 0.3 | 3.3 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.3 | 1.7 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.3 | 2.0 | GO:0032439 | endosome localization(GO:0032439) |
| 0.3 | 0.8 | GO:1903570 | regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572) |
| 0.3 | 0.8 | GO:0060003 | copper ion export(GO:0060003) |
| 0.3 | 1.5 | GO:0019060 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.3 | 1.3 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.2 | 0.2 | GO:0051695 | actin filament uncapping(GO:0051695) |
| 0.2 | 2.6 | GO:0071680 | response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681) |
| 0.2 | 0.9 | GO:0042223 | response to molecule of fungal origin(GO:0002238) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226) |
| 0.2 | 1.1 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) |
| 0.2 | 5.8 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.2 | 1.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.2 | 1.0 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 0.2 | 0.8 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.2 | 0.8 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.2 | 0.6 | GO:0046271 | phenylpropanoid catabolic process(GO:0046271) |
| 0.2 | 0.6 | GO:1904845 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.2 | 1.5 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.2 | 0.9 | GO:1904219 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.2 | 1.6 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.2 | 1.8 | GO:0009950 | dorsal/ventral axis specification(GO:0009950) |
| 0.2 | 0.5 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.2 | 1.4 | GO:0015705 | iodide transport(GO:0015705) |
| 0.2 | 0.9 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.2 | 0.7 | GO:0016256 | N-glycan processing to lysosome(GO:0016256) |
| 0.2 | 3.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.2 | 1.0 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.2 | 0.8 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.2 | 0.7 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 0.5 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.1 | 0.4 | GO:0060775 | mediolateral intercalation(GO:0060031) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) |
| 0.1 | 2.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 1.5 | GO:0060897 | neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897) |
| 0.1 | 0.7 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.1 | 0.8 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.1 | 2.3 | GO:0035269 | protein O-linked mannosylation(GO:0035269) |
| 0.1 | 0.8 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.1 | 0.5 | GO:0006175 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) |
| 0.1 | 0.8 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 0.4 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582) |
| 0.1 | 1.1 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.1 | 1.5 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 0.1 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
| 0.1 | 0.6 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.1 | 0.5 | GO:1902961 | regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.1 | 1.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 0.3 | GO:0070256 | germinal center B cell differentiation(GO:0002314) positive regulation of germinal center formation(GO:0002636) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) xanthine metabolic process(GO:0046110) negative regulation of mucus secretion(GO:0070256) |
| 0.1 | 0.6 | GO:0048669 | collateral sprouting in absence of injury(GO:0048669) |
| 0.1 | 2.8 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 1.7 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 1.1 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.1 | 0.3 | GO:0016321 | female meiosis chromosome segregation(GO:0016321) |
| 0.1 | 6.8 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.1 | 1.5 | GO:0042355 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.1 | 6.0 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.1 | 1.6 | GO:0042635 | positive regulation of hair cycle(GO:0042635) |
| 0.1 | 1.4 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 5.0 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 0.9 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.1 | 0.3 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.1 | 0.3 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.3 | GO:0071393 | cellular response to progesterone stimulus(GO:0071393) |
| 0.1 | 0.5 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.1 | 1.7 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
| 0.1 | 0.3 | GO:1903719 | regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721) |
| 0.1 | 1.0 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.9 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.1 | 0.6 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.1 | 0.4 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) |
| 0.1 | 3.2 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.1 | 0.3 | GO:0019082 | viral protein processing(GO:0019082) negative regulation of neurotrophin production(GO:0032900) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472) |
| 0.1 | 1.0 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 1.7 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.1 | 2.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 2.0 | GO:0045056 | transcytosis(GO:0045056) |
| 0.1 | 1.8 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.1 | 0.6 | GO:0015860 | purine nucleoside transmembrane transport(GO:0015860) |
| 0.1 | 2.4 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.1 | 0.5 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.1 | 0.2 | GO:0002086 | diaphragm contraction(GO:0002086) |
| 0.1 | 0.1 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 0.1 | 0.3 | GO:1903371 | regulation of endoplasmic reticulum tubular network organization(GO:1903371) |
| 0.1 | 0.2 | GO:0071469 | sensory perception of touch(GO:0050975) detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469) |
| 0.1 | 1.2 | GO:0006670 | sphingosine metabolic process(GO:0006670) |
| 0.1 | 0.3 | GO:0036483 | neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382) |
| 0.1 | 0.2 | GO:0099538 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
| 0.1 | 0.6 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.1 | 0.5 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.1 | 1.3 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.1 | 0.5 | GO:1903862 | positive regulation of oxidative phosphorylation(GO:1903862) |
| 0.1 | 0.6 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.5 | GO:0016139 | glycoside catabolic process(GO:0016139) |
| 0.1 | 0.2 | GO:2000752 | glucosylceramide catabolic process(GO:0006680) regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
| 0.1 | 0.2 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.1 | 0.3 | GO:1902499 | positive regulation of protein autoubiquitination(GO:1902499) |
| 0.1 | 0.3 | GO:1990918 | meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.1 | 1.2 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 0.1 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
| 0.1 | 0.3 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 0.2 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.1 | 0.2 | GO:0010193 | response to ozone(GO:0010193) |
| 0.1 | 0.2 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.1 | 0.5 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
| 0.1 | 1.0 | GO:1904776 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 3.7 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 3.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 0.1 | GO:2000077 | negative regulation of type B pancreatic cell development(GO:2000077) |
| 0.1 | 0.5 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.2 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.1 | 0.2 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.1 | 2.0 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 0.3 | GO:2000587 | regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.1 | 9.4 | GO:0031424 | keratinization(GO:0031424) |
| 0.1 | 4.9 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.1 | 2.9 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.1 | 0.9 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.1 | 0.2 | GO:0017198 | N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920) |
| 0.1 | 0.6 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.1 | 4.6 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.1 | 0.2 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 0.1 | 0.3 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 0.3 | GO:0021633 | optic nerve structural organization(GO:0021633) |
| 0.1 | 1.3 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 0.3 | GO:0071802 | negative regulation of podosome assembly(GO:0071802) |
| 0.1 | 0.2 | GO:1904862 | inhibitory synapse assembly(GO:1904862) |
| 0.0 | 0.4 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 0.0 | 1.0 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 0.0 | 0.4 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.1 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.0 | 1.9 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 1.8 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
| 0.0 | 0.1 | GO:0048162 | preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162) |
| 0.0 | 3.0 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 0.4 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.0 | 0.4 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 1.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.6 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.2 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.0 | 0.4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.0 | 0.2 | GO:0007571 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.0 | 0.9 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.0 | 0.2 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.0 | 0.1 | GO:1902490 | regulation of sperm capacitation(GO:1902490) |
| 0.0 | 0.0 | GO:0097477 | lateral motor column neuron migration(GO:0097477) |
| 0.0 | 0.2 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.0 | 0.2 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.0 | 0.1 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.0 | 0.2 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.0 | 1.8 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
| 0.0 | 0.0 | GO:0032425 | positive regulation of mismatch repair(GO:0032425) |
| 0.0 | 0.9 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.0 | 0.2 | GO:0032485 | Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485) |
| 0.0 | 0.1 | GO:0001189 | RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189) |
| 0.0 | 0.5 | GO:0015732 | prostaglandin transport(GO:0015732) |
| 0.0 | 0.7 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.0 | 3.1 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.3 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 0.0 | 0.2 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.0 | 2.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.1 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.0 | 0.1 | GO:0034031 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) |
| 0.0 | 0.1 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 0.6 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 0.3 | GO:0061370 | testosterone biosynthetic process(GO:0061370) |
| 0.0 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.0 | 0.4 | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.0 | 0.2 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.0 | 2.1 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.0 | 0.4 | GO:0044821 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 0.7 | GO:0051255 | spindle midzone assembly(GO:0051255) |
| 0.0 | 0.2 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
| 0.0 | 0.3 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.0 | 0.9 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 0.1 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.0 | 0.4 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 0.1 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.0 | 0.4 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
| 0.0 | 0.1 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 0.3 | GO:1902572 | negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572) |
| 0.0 | 1.8 | GO:0008088 | axo-dendritic transport(GO:0008088) |
| 0.0 | 0.3 | GO:0070970 | interleukin-2 secretion(GO:0070970) |
| 0.0 | 0.2 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.0 | 0.5 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.5 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.0 | 0.3 | GO:0002024 | diet induced thermogenesis(GO:0002024) |
| 0.0 | 0.2 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.0 | 1.9 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.0 | 0.3 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.1 | GO:0019364 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.0 | 0.5 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 0.1 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.0 | 0.7 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.0 | 0.0 | GO:2000664 | positive regulation of interleukin-5 secretion(GO:2000664) |
| 0.0 | 0.3 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) |
| 0.0 | 0.2 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.0 | 0.3 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.0 | 0.8 | GO:0001913 | T cell mediated cytotoxicity(GO:0001913) |
| 0.0 | 0.1 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.3 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.0 | 0.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.1 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.0 | 0.1 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.4 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.0 | 0.4 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.0 | 0.8 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
| 0.0 | 0.3 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.3 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.0 | 0.2 | GO:0061051 | positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051) |
| 0.0 | 0.6 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.2 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 0.1 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.0 | 0.3 | GO:0030046 | parallel actin filament bundle assembly(GO:0030046) |
| 0.0 | 0.1 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.0 | 0.2 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.0 | 0.0 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.0 | 0.4 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.0 | 0.1 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.0 | 1.1 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.6 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.0 | 0.2 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 1.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.1 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
| 0.0 | 0.5 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.0 | 0.4 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.1 | GO:0035871 | protein K11-linked deubiquitination(GO:0035871) |
| 0.0 | 0.2 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.0 | 0.1 | GO:1904970 | brush border assembly(GO:1904970) |
| 0.0 | 0.1 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.1 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.1 | GO:0060296 | regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 0.0 | 0.2 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.1 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.0 | 1.5 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 0.0 | GO:0045645 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.0 | 0.2 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 0.2 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 0.2 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
| 0.0 | 0.1 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.0 | 0.1 | GO:0072656 | maintenance of protein location in mitochondrion(GO:0072656) |
| 0.0 | 0.0 | GO:0003199 | endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) |
| 0.0 | 0.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 0.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.0 | GO:0021502 | neural fold elevation formation(GO:0021502) allantois development(GO:1905069) |
| 0.0 | 0.2 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.3 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 8.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.9 | 9.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.7 | 2.0 | GO:0032127 | dense core granule membrane(GO:0032127) alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.6 | 2.4 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.5 | 6.7 | GO:0045179 | apical cortex(GO:0045179) |
| 0.5 | 2.8 | GO:0070695 | FHF complex(GO:0070695) |
| 0.4 | 5.7 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.4 | 10.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 2.0 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.3 | 1.5 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.3 | 0.9 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.2 | 0.7 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.2 | 0.7 | GO:0005600 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.2 | 7.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.2 | 1.7 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 0.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.2 | 0.9 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.2 | 2.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 1.0 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.2 | 2.8 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.2 | 8.5 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 2.9 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 2.4 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 10.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 3.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 3.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.6 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.1 | 1.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 3.0 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 2.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.3 | GO:0030849 | autosome(GO:0030849) |
| 0.1 | 2.2 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.3 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.3 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.7 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.1 | 2.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.1 | GO:0061673 | mitotic spindle astral microtubule(GO:0061673) |
| 0.1 | 1.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 0.3 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.1 | 0.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 1.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.1 | 9.1 | GO:0070160 | occluding junction(GO:0070160) |
| 0.1 | 0.5 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 1.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 3.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 6.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 0.2 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.0 | 0.1 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 0.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.2 | GO:0000126 | transcription factor TFIIIB complex(GO:0000126) |
| 0.0 | 0.5 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 1.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.1 | GO:1990742 | microvesicle(GO:1990742) |
| 0.0 | 0.6 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 1.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.2 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 1.3 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 2.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 0.3 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.0 | 2.9 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.2 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 2.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.1 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 3.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.0 | 0.3 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 1.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 0.1 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 0.2 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 2.3 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 1.7 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.3 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.1 | GO:0043541 | UDP-N-acetylglucosamine transferase complex(GO:0043541) |
| 0.0 | 0.1 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 0.3 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 1.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.6 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 2.0 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 1.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.1 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 2.4 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 0.2 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.0 | 3.2 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.1 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.0 | 0.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 1.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.6 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 0.1 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.0 | 0.5 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.4 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 0.7 | 2.1 | GO:0030305 | heparanase activity(GO:0030305) |
| 0.7 | 6.1 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.6 | 2.3 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 0.6 | 1.7 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.5 | 8.1 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.4 | 3.6 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.4 | 13.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.4 | 1.5 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.4 | 1.1 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 0.4 | 2.9 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.3 | 1.4 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.3 | 4.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.3 | 0.9 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.3 | 6.3 | GO:0019841 | retinol binding(GO:0019841) |
| 0.3 | 0.8 | GO:0004008 | copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682) |
| 0.3 | 1.3 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.2 | 1.5 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.2 | 5.9 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.2 | 3.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 0.7 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.2 | 6.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 5.0 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.2 | 1.2 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.2 | 1.0 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
| 0.2 | 1.2 | GO:0050294 | steroid sulfotransferase activity(GO:0050294) |
| 0.2 | 1.2 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.2 | 0.8 | GO:0015154 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.2 | 0.9 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.2 | 3.9 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 3.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.2 | 1.9 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.2 | 0.8 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.2 | 1.8 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 2.3 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.2 | 1.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 1.7 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.2 | 0.6 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.2 | 0.6 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.1 | 1.5 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.1 | 0.7 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.1 | 0.5 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.1 | 1.4 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 0.4 | GO:0031862 | prostanoid receptor binding(GO:0031862) |
| 0.1 | 0.5 | GO:0004052 | arachidonate 12-lipoxygenase activity(GO:0004052) |
| 0.1 | 0.5 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
| 0.1 | 0.9 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 0.6 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.1 | 0.5 | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity(GO:0004419) |
| 0.1 | 1.2 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 3.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.3 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.1 | 0.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 0.3 | GO:0015389 | pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389) |
| 0.1 | 0.4 | GO:0097677 | STAT family protein binding(GO:0097677) |
| 0.1 | 0.6 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.1 | 0.8 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.1 | 5.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 0.3 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.1 | 0.5 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 0.3 | GO:0097363 | protein O-GlcNAc transferase activity(GO:0097363) |
| 0.1 | 0.3 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.1 | 1.3 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 1.8 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 1.5 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.1 | 0.3 | GO:0004040 | amidase activity(GO:0004040) |
| 0.1 | 1.5 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 0.6 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.1 | 0.4 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.1 | 0.2 | GO:0008988 | rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) |
| 0.1 | 1.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 0.5 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 3.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.4 | GO:0015315 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 0.2 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
| 0.1 | 0.2 | GO:0000994 | RNA polymerase III core binding(GO:0000994) |
| 0.1 | 2.6 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 0.3 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.1 | 1.0 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 2.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 1.0 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.3 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 0.9 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.1 | 1.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.2 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 1.1 | GO:0031404 | chloride ion binding(GO:0031404) |
| 0.1 | 1.5 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.1 | 1.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.9 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 4.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 0.6 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 0.9 | GO:0050544 | icosatetraenoic acid binding(GO:0050543) arachidonic acid binding(GO:0050544) |
| 0.1 | 0.2 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.1 | 0.2 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.1 | 0.2 | GO:1990190 | peptide-glutamate-N-acetyltransferase activity(GO:1990190) |
| 0.1 | 1.2 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 0.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 1.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 0.2 | GO:0003839 | gamma-glutamylcyclotransferase activity(GO:0003839) |
| 0.1 | 0.2 | GO:0052857 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.0 | 3.9 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 1.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.2 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 2.2 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.2 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 0.3 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.0 | 1.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.4 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.0 | 0.2 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 0.5 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.5 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 1.5 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.2 | GO:0001026 | TFIIIB-type transcription factor activity(GO:0001026) |
| 0.0 | 0.1 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.0 | 1.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.3 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.4 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.0 | 0.5 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 4.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 2.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 1.1 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.1 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.0 | 0.6 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 7.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.3 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 1.4 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.1 | GO:0001855 | complement component C4b binding(GO:0001855) |
| 0.0 | 0.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 1.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.1 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.0 | 3.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.0 | 3.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.4 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.2 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.0 | 0.3 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.6 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.8 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.1 | GO:0031687 | A2A adenosine receptor binding(GO:0031687) |
| 0.0 | 0.2 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 1.4 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.1 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.0 | 0.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 0.1 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.0 | 0.4 | GO:0016595 | glutamate binding(GO:0016595) |
| 0.0 | 0.2 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 0.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.1 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.0 | 6.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.0 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.0 | 0.3 | GO:0008061 | chitin binding(GO:0008061) |
| 0.0 | 0.5 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.1 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.0 | 0.1 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.0 | 0.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.1 | GO:0030882 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.0 | 0.1 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.1 | GO:0005497 | androgen binding(GO:0005497) |
| 0.0 | 0.2 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.0 | 0.1 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.2 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.0 | 0.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.2 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.2 | GO:0043008 | U4 snRNA binding(GO:0030621) ATP-dependent protein binding(GO:0043008) |
| 0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.1 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.0 | 0.2 | GO:0005283 | sodium:amino acid symporter activity(GO:0005283) |
| 0.0 | 0.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.2 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 0.2 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 0.1 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.1 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.0 | 0.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.1 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 0.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.2 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.1 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.0 | 0.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.0 | 0.1 | GO:0004983 | neuropeptide Y receptor activity(GO:0004983) |
| 0.0 | 0.2 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.0 | 0.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.3 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 0.0 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 0.2 | GO:0043142 | single-stranded DNA-dependent ATPase activity(GO:0043142) |
| 0.0 | 0.1 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.0 | 0.6 | GO:0051219 | phosphoprotein binding(GO:0051219) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 8.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 6.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 7.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.8 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 0.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.7 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 7.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.5 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 2.0 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 2.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 1.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 3.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 1.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.5 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.8 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 3.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.0 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.1 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 1.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 2.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.6 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.4 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.1 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.9 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 11.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 10.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 7.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 8.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 8.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 5.6 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 2.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 4.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 3.6 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 4.5 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.1 | 1.0 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 2.3 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.1 | 1.7 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 2.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 1.8 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 2.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.3 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 2.0 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 0.9 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 2.1 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.8 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 1.5 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.1 | 0.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 0.7 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 3.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.0 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.8 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.2 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 2.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 2.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.7 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 2.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 8.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.9 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.9 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.7 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.0 | 3.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.6 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.1 | REACTOME SIGNALING BY ERBB2 | Genes involved in Signaling by ERBB2 |
| 0.0 | 0.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.3 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 1.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.0 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.7 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 2.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.3 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.2 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 1.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.4 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |