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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ZIC3_ZIC4

Z-value: 0.84

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ENSG00000156925.12 Zic family member 3
ENSG00000174963.18 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC4hg38_v1_chr3_-_147406520_1474065490.186.8e-01Click!
ZIC3hg38_v1_chrX_+_137566119_1375661670.137.6e-01Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_76403266 1.60 ENST00000274364.11
IQ motif containing GTPase activating protein 2
chr8_+_1763766 1.00 ENST00000635751.1
ENST00000331222.6
ENST00000637156.1
ENST00000636934.1
ENST00000637083.1
CLN8 transmembrane ER and ERGIC protein
chr2_-_98936155 0.98 ENST00000428096.5
ENST00000397899.7
ENST00000420294.1
CRACD like
chr12_+_55681711 0.83 ENST00000394252.4
methyltransferase like 7B
chr12_+_55681647 0.83 ENST00000614691.1
methyltransferase like 7B
chr1_+_201648136 0.75 ENST00000367296.8
neuron navigator 1
chr10_-_13099652 0.73 ENST00000378839.1
coiled-coil domain containing 3
chr17_-_44968263 0.72 ENST00000253407.4
complement C1q like 1
chr17_-_5500997 0.67 ENST00000568641.2
novel protein
chr5_+_127290785 0.62 ENST00000503335.7
multiple EGF like domains 10
chr7_+_149873956 0.60 ENST00000425642.3
ENST00000479613.5
ENST00000606024.5
ENST00000464662.5
ATPase H+ transporting V0 subunit e2
chr4_+_55346349 0.58 ENST00000505210.1
steroid 5 alpha-reductase 3
chr2_+_109129199 0.53 ENST00000309415.8
SH3 domain containing ring finger 3
chr8_+_1763752 0.53 ENST00000519254.2
CLN8 transmembrane ER and ERGIC protein
chr16_+_30985181 0.52 ENST00000262520.10
ENST00000297679.10
ENST00000562932.5
ENST00000574447.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr8_+_1763832 0.51 ENST00000520991.3
CLN8 transmembrane ER and ERGIC protein
chr17_+_80220406 0.51 ENST00000573809.5
ENST00000361193.8
ENST00000574967.5
ENST00000576126.5
ENST00000411502.7
ENST00000546047.6
ENST00000572725.5
solute carrier family 26 member 11
chr4_+_15002443 0.49 ENST00000538197.7
cytoplasmic polyadenylation element binding protein 2
chr4_+_15002541 0.48 ENST00000507071.6
ENST00000345451.8
ENST00000382395.8
ENST00000382401.8
ENST00000442003.6
cytoplasmic polyadenylation element binding protein 2
chr2_+_23385170 0.48 ENST00000486442.6
kelch like family member 29
chr3_-_112638097 0.47 ENST00000461431.1
coiled-coil domain containing 80
chr5_+_127290806 0.47 ENST00000508365.5
ENST00000418761.6
ENST00000274473.6
multiple EGF like domains 10
chr21_+_36135071 0.47 ENST00000290354.6
carbonyl reductase 3
chr10_+_13100075 0.45 ENST00000378747.8
ENST00000378757.6
ENST00000378752.7
ENST00000378748.7
optineurin
chr1_+_89524871 0.44 ENST00000639264.1
leucine rich repeat containing 8 VRAC subunit B
chr1_+_89524819 0.44 ENST00000439853.6
ENST00000330947.7
ENST00000449440.5
ENST00000640258.1
leucine rich repeat containing 8 VRAC subunit B
chr17_-_80220325 0.44 ENST00000326317.11
ENST00000570427.1
ENST00000570923.1
N-sulfoglucosamine sulfohydrolase
chr18_-_28177934 0.44 ENST00000676445.1
cadherin 2
chr10_-_77637558 0.42 ENST00000372421.10
ENST00000639370.1
ENST00000640773.1
ENST00000638895.1
potassium calcium-activated channel subfamily M alpha 1
chr3_+_12289061 0.42 ENST00000652522.1
ENST00000652431.1
ENST00000652098.1
ENST00000651735.1
ENST00000397026.7
peroxisome proliferator activated receptor gamma
chr1_+_215082731 0.41 ENST00000444842.7
potassium two pore domain channel subfamily K member 2
chr3_+_12288838 0.41 ENST00000455517.6
ENST00000681982.1
peroxisome proliferator activated receptor gamma
chr19_-_31349408 0.41 ENST00000240587.5
teashirt zinc finger homeobox 3
chr5_-_9546066 0.40 ENST00000382496.10
ENST00000652226.1
semaphorin 5A
chr10_-_77638369 0.39 ENST00000372443.6
potassium calcium-activated channel subfamily M alpha 1
chr12_+_49961864 0.37 ENST00000293599.7
aquaporin 5
chr10_-_77637902 0.37 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
potassium calcium-activated channel subfamily M alpha 1
chr19_-_58098203 0.37 ENST00000600845.1
ENST00000240727.10
ENST00000600897.5
ENST00000421612.6
ENST00000601063.1
ENST00000601144.6
zinc finger and SCAN domain containing 18
chr2_-_45009401 0.35 ENST00000303077.7
SIX homeobox 2
chr10_-_77637444 0.35 ENST00000639205.1
ENST00000639498.1
ENST00000372408.7
ENST00000372403.9
ENST00000640626.1
ENST00000404857.6
ENST00000638252.1
ENST00000640029.1
ENST00000640934.1
ENST00000639823.1
ENST00000372437.6
ENST00000639344.1
potassium calcium-activated channel subfamily M alpha 1
chr13_+_34942263 0.34 ENST00000379939.7
ENST00000400445.7
neurobeachin
chr1_-_212699817 0.34 ENST00000243440.2
basic leucine zipper ATF-like transcription factor 3
chr2_+_127423265 0.34 ENST00000402125.2
protein C, inactivator of coagulation factors Va and VIIIa
chr6_-_88166339 0.33 ENST00000369501.3
ENST00000551417.2
cannabinoid receptor 1
chr6_+_33200860 0.31 ENST00000374677.8
solute carrier family 39 member 7
chr10_-_77637789 0.31 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
potassium calcium-activated channel subfamily M alpha 1
chr20_+_3888915 0.31 ENST00000316562.9
ENST00000495692.5
pantothenate kinase 2
chr6_+_33200820 0.31 ENST00000374675.7
solute carrier family 39 member 7
chr10_-_77637721 0.30 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
potassium calcium-activated channel subfamily M alpha 1
chr10_+_13099585 0.30 ENST00000378764.6
optineurin
chr14_+_100381974 0.30 ENST00000542471.2
WD repeat domain 25
chr17_+_40443441 0.29 ENST00000269593.5
insulin like growth factor binding protein 4
chr20_-_57711536 0.28 ENST00000265626.8
prostate transmembrane protein, androgen induced 1
chr19_+_36605292 0.27 ENST00000460670.5
ENST00000292928.7
ENST00000439428.5
zinc finger protein 382
chr5_-_111756245 0.27 ENST00000447165.6
neuronal regeneration related protein
chr2_+_20447065 0.27 ENST00000272233.6
ras homolog family member B
chr5_-_14871757 0.25 ENST00000284268.8
ANKH inorganic pyrophosphate transport regulator
chrX_+_153517672 0.25 ENST00000349466.6
ENST00000370186.5
ENST00000359149.8
ATPase plasma membrane Ca2+ transporting 3
chr12_+_51391273 0.25 ENST00000535225.6
ENST00000358657.7
solute carrier family 4 member 8
chr10_+_84194621 0.25 ENST00000332904.7
cadherin related family member 1
chr10_+_13099440 0.25 ENST00000263036.9
optineurin
chr20_-_41366805 0.24 ENST00000332312.4
elastin microfibril interfacer 3
chrX_+_154458274 0.24 ENST00000369682.4
plexin A3
chr11_-_27700447 0.24 ENST00000356660.9
brain derived neurotrophic factor
chr5_+_141373878 0.24 ENST00000517434.3
ENST00000610583.1
protocadherin gamma subfamily A, 6
chr19_+_49114324 0.23 ENST00000391864.7
lin-7 homolog B, crumbs cell polarity complex component
chr11_-_74398378 0.23 ENST00000298198.5
phosphoglucomutase 2 like 1
chr1_-_42766978 0.23 ENST00000372526.2
ENST00000236040.8
ENST00000296388.10
ENST00000397054.7
prolyl 3-hydroxylase 1
chr16_-_49856105 0.23 ENST00000563137.7
zinc finger protein 423
chr17_+_76737387 0.23 ENST00000590393.1
ENST00000355954.7
ENST00000586689.5
ENST00000587661.5
ENST00000593181.5
ENST00000336509.8
major facilitator superfamily domain containing 11
chr6_-_38639898 0.22 ENST00000481247.6
BTB domain containing 9
chr17_-_41034871 0.22 ENST00000344363.7
keratin associated protein 1-3
chr12_-_48004496 0.22 ENST00000337299.7
collagen type II alpha 1 chain
chr7_-_50782853 0.22 ENST00000401949.6
growth factor receptor bound protein 10
chr5_+_176810498 0.22 ENST00000509580.2
unc-5 netrin receptor A
chr19_+_36604817 0.22 ENST00000423582.5
zinc finger protein 382
chr11_-_67505323 0.22 ENST00000356404.8
ENST00000436757.6
phosphatidylinositol transfer protein membrane associated 1
chrX_-_34657274 0.21 ENST00000275954.4
transmembrane protein 47
chr6_-_84763437 0.21 ENST00000606784.5
ENST00000606325.5
T-box transcription factor 18
chr7_-_117873420 0.21 ENST00000160373.8
cortactin binding protein 2
chr5_+_176810552 0.21 ENST00000329542.9
unc-5 netrin receptor A
chr1_-_30908681 0.20 ENST00000339394.7
syndecan 3
chr17_+_40062810 0.20 ENST00000584985.5
ENST00000264637.8
thyroid hormone receptor alpha
chr8_-_27605271 0.19 ENST00000522098.1
clusterin
chr11_-_2161158 0.19 ENST00000421783.1
ENST00000397262.5
ENST00000381330.5
ENST00000250971.7
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr3_-_46882106 0.19 ENST00000662933.1
myosin light chain 3
chr2_+_108534353 0.19 ENST00000544547.5
LIM zinc finger domain containing 1
chr4_+_55346213 0.19 ENST00000679836.1
ENST00000264228.9
ENST00000679707.1
steroid 5 alpha-reductase 3
novel protein, SRD5A3-RP11-177J6.1 readthrough
chr7_-_23347704 0.19 ENST00000619562.4
insulin like growth factor 2 mRNA binding protein 3
chr8_+_22165140 0.19 ENST00000397814.7
ENST00000354870.5
bone morphogenetic protein 1
chr20_+_43514426 0.19 ENST00000422861.3
L3MBTL histone methyl-lysine binding protein 1
chr16_-_18376839 0.18 ENST00000427999.6
nuclear pore complex interacting protein family, member A9
chr6_-_41705813 0.18 ENST00000419574.6
ENST00000445214.2
transcription factor EB
chr5_-_38556625 0.18 ENST00000506990.5
ENST00000453190.7
LIF receptor subunit alpha
chr12_-_58920465 0.18 ENST00000320743.8
leucine rich repeats and immunoglobulin like domains 3
chr17_-_41027198 0.18 ENST00000361883.6
keratin associated protein 1-5
chr9_+_128420812 0.18 ENST00000372838.9
cerebral endothelial cell adhesion molecule
chr13_-_98752619 0.17 ENST00000376503.10
solute carrier family 15 member 1
chr11_-_6320494 0.17 ENST00000303927.4
ENST00000530979.1
caveolae associated protein 3
chr19_+_49114352 0.17 ENST00000221459.7
ENST00000486217.2
lin-7 homolog B, crumbs cell polarity complex component
chr2_+_64989343 0.17 ENST00000234256.4
solute carrier family 1 member 4
chr11_-_12008584 0.17 ENST00000534511.5
ENST00000683431.1
dickkopf WNT signaling pathway inhibitor 3
chr5_-_157575767 0.16 ENST00000257527.9
ADAM metallopeptidase domain 19
chr14_+_105314711 0.16 ENST00000447393.6
ENST00000547217.5
phosphofurin acidic cluster sorting protein 2
chr14_+_24161257 0.16 ENST00000396864.8
ENST00000557894.5
ENST00000559284.5
ENST00000560275.5
interferon regulatory factor 9
chr11_-_65382632 0.16 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
solute carrier family 25 member 45
chr20_+_35615812 0.16 ENST00000679710.1
ENST00000374273.8
sperm associated antigen 4
chr7_-_50450324 0.16 ENST00000356889.8
ENST00000420829.5
ENST00000448788.1
ENST00000395556.6
ENST00000433017.6
ENST00000422854.5
ENST00000435566.5
ENST00000617389.4
ENST00000611938.4
ENST00000615084.4
fidgetin like 1
chr19_+_1266653 0.16 ENST00000586472.5
ENST00000589266.5
cold inducible RNA binding protein
chr5_+_141338753 0.16 ENST00000528330.2
ENST00000394576.3
protocadherin gamma subfamily A, 2
chr2_+_24491239 0.16 ENST00000348332.8
nuclear receptor coactivator 1
chr12_-_98644733 0.16 ENST00000299157.5
ENST00000393042.3
IKBKB interacting protein
chr13_-_23433676 0.16 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
sacsin molecular chaperone
chr17_+_20009320 0.15 ENST00000679049.1
ENST00000472876.5
ENST00000583528.6
ENST00000680019.1
ENST00000681593.1
ENST00000395527.8
ENST00000583482.7
ENST00000679255.1
ENST00000681202.1
ENST00000677914.1
sperm antigen with calponin homology and coiled-coil domains 1
chr20_-_49278034 0.15 ENST00000371744.5
ENST00000396105.6
ENST00000371752.5
zinc finger NFX1-type containing 1
chr7_-_134316912 0.15 ENST00000378509.9
solute carrier family 35 member B4
chr1_+_218346235 0.15 ENST00000366929.4
transforming growth factor beta 2
chr10_-_87094761 0.15 ENST00000684338.1
ENST00000684201.1
ENST00000277865.5
glutamate dehydrogenase 1
chr11_-_67373584 0.15 ENST00000543494.1
ENST00000312438.8
novel protein
cardiotrophin like cytokine factor 1
chr18_+_50560070 0.15 ENST00000400384.7
ENST00000540640.3
ENST00000592595.5
mitogen-activated protein kinase 4
chr4_+_73853290 0.15 ENST00000226524.4
platelet factor 4 variant 1
chr1_+_52056284 0.15 ENST00000313334.13
ENST00000472944.6
ENST00000484036.1
basic transcription factor 3 like 4
chr4_+_38867789 0.15 ENST00000358869.5
family with sequence similarity 114 member A1
chr4_-_128288791 0.15 ENST00000613358.4
ENST00000520121.6
progesterone receptor membrane component 2
chr1_-_37034492 0.15 ENST00000373091.8
glutamate ionotropic receptor kainate type subunit 3
chr6_-_38639852 0.14 ENST00000498633.1
ENST00000649492.1
BTB domain containing 9
chr22_-_41446777 0.14 ENST00000434408.1
ENST00000327492.4
transducer of ERBB2, 2
chr4_+_38867677 0.14 ENST00000510213.5
ENST00000515037.5
family with sequence similarity 114 member A1
chr19_-_9913819 0.14 ENST00000593091.2
olfactomedin 2
chr9_-_111484353 0.14 ENST00000338205.9
ENST00000684092.1
Ecm29 proteasome adaptor and scaffold
chr4_-_128287785 0.14 ENST00000296425.10
progesterone receptor membrane component 2
chr19_+_1908258 0.14 ENST00000411971.5
ENST00000588907.2
secretory carrier membrane protein 4
chr16_-_800705 0.14 ENST00000248150.5
G protein subunit gamma 13
chr17_+_79034185 0.14 ENST00000581774.5
C1q and TNF related 1
chr20_+_3888772 0.14 ENST00000497424.5
pantothenate kinase 2
chr8_+_43140405 0.14 ENST00000379644.9
heparan-alpha-glucosaminide N-acetyltransferase
chr19_+_17967072 0.14 ENST00000684775.1
ENST00000615435.2
ENST00000683588.1
ENST00000684725.1
ENST00000682421.1
potassium calcium-activated channel subfamily N member 1
chr2_+_37344594 0.14 ENST00000404976.5
ENST00000338415.8
glutaminyl-peptide cyclotransferase
chr11_+_65014103 0.14 ENST00000246747.9
ENST00000529384.5
ENST00000533729.1
ADP ribosylation factor like GTPase 2
chr16_+_28985043 0.13 ENST00000395456.7
ENST00000564277.5
ENST00000630764.2
ENST00000354453.7
linker for activation of T cells
chr21_+_44697172 0.13 ENST00000400365.3
keratin associated protein 10-12
chr4_+_2963580 0.13 ENST00000398051.8
ENST00000503518.2
G protein-coupled receptor kinase 4
chr10_+_28677487 0.13 ENST00000375533.6
BMP and activin membrane bound inhibitor
chrX_+_24693879 0.13 ENST00000379068.8
ENST00000677890.1
ENST00000379059.7
DNA polymerase alpha 1, catalytic subunit
chr9_+_136980211 0.13 ENST00000444903.2
prostaglandin D2 synthase
chr14_-_23352741 0.13 ENST00000354772.9
solute carrier family 22 member 17
chr8_+_17156463 0.13 ENST00000262096.13
zinc finger DHHC-type palmitoyltransferase 2
chr9_-_83063159 0.13 ENST00000340717.4
RAS and EF-hand domain containing
chr2_-_97995916 0.13 ENST00000186436.10
transmembrane protein 131
chr22_-_41240925 0.13 ENST00000216241.14
chondroadherin like
chr3_-_64268161 0.13 ENST00000564377.6
prickle planar cell polarity protein 2
chr19_-_2151525 0.13 ENST00000345016.9
ENST00000643116.3
adaptor related protein complex 3 subunit delta 1
chr19_+_33194308 0.13 ENST00000253193.9
LDL receptor related protein 3
chr5_+_134371561 0.13 ENST00000265339.7
ENST00000506787.5
ENST00000507277.1
ubiquitin conjugating enzyme E2 B
chr20_+_58840692 0.13 ENST00000306090.12
GNAS complex locus
chr9_+_19230435 0.13 ENST00000602925.5
DENN domain containing 4C
chr19_-_48249841 0.13 ENST00000447740.6
caspase recruitment domain family member 8
chr4_+_52051285 0.12 ENST00000295213.9
ENST00000419395.6
spermatogenesis associated 18
chr3_-_9769910 0.12 ENST00000256460.8
calcium/calmodulin dependent protein kinase I
chr2_-_200510044 0.12 ENST00000359878.8
ENST00000409157.5
potassium channel tetramerization domain containing 18
chr4_-_21948733 0.12 ENST00000447367.6
ENST00000382152.7
potassium voltage-gated channel interacting protein 4
chr16_+_28985251 0.12 ENST00000360872.9
ENST00000566177.5
linker for activation of T cells
chrX_+_153517626 0.12 ENST00000263519.5
ATPase plasma membrane Ca2+ transporting 3
chr10_-_98268186 0.12 ENST00000260702.4
lysyl oxidase like 4
chr9_+_137077467 0.12 ENST00000409858.8
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
chr17_-_39688016 0.12 ENST00000579146.5
ENST00000300658.9
ENST00000378011.8
ENST00000429199.6
post-GPI attachment to proteins phospholipase 3
chr20_-_33686371 0.12 ENST00000343380.6
E2F transcription factor 1
chr11_-_3165264 0.12 ENST00000389989.7
ENST00000263650.12
oxysterol binding protein like 5
chr3_-_177197429 0.11 ENST00000457928.7
TBL1X receptor 1
chr2_+_100820102 0.11 ENST00000335681.10
neuronal PAS domain protein 2
chr1_-_182672232 0.11 ENST00000508450.5
regulator of G protein signaling 8
chr5_-_157575741 0.11 ENST00000517905.1
ADAM metallopeptidase domain 19
chr17_+_28728781 0.11 ENST00000268766.11
NIMA related kinase 8
chr14_-_23352872 0.11 ENST00000397267.5
solute carrier family 22 member 17
chr4_+_114598738 0.11 ENST00000507710.1
ENST00000310836.11
UDP glycosyltransferase 8
chr7_-_150323489 0.11 ENST00000683684.1
ENST00000478393.5
actin related protein 3C
chrX_-_129843388 0.11 ENST00000371064.7
zinc finger DHHC-type palmitoyltransferase 9
chr17_-_10729973 0.11 ENST00000578345.1
ENST00000341871.8
ENST00000455996.6
transmembrane protein 220
chr9_+_97412062 0.11 ENST00000355295.5
tudor domain containing 7
chr7_+_37848953 0.11 ENST00000444718.5
ENST00000440017.5
NME/NM23 family member 8
chr4_-_170089930 0.11 ENST00000337664.9
aminoadipate aminotransferase
chr21_-_43776238 0.10 ENST00000639959.1
ENST00000291568.7
ENST00000640406.1
cystatin B
chr3_-_149086488 0.10 ENST00000392912.6
ENST00000465259.5
ENST00000310053.10
ENST00000494055.5
helicase like transcription factor
chr22_-_46738205 0.10 ENST00000216264.13
ceramide kinase
chr1_-_223845894 0.10 ENST00000391878.6
ENST00000343537.12
tumor protein p53 binding protein 2
chr20_-_63627049 0.10 ENST00000370077.2
glucocorticoid modulatory element binding protein 2
chr8_-_27992624 0.10 ENST00000524352.5
scavenger receptor class A member 5
chr1_+_32886456 0.10 ENST00000373467.4
hippocalcin
chr11_+_1223053 0.10 ENST00000529681.5
mucin 5B, oligomeric mucus/gel-forming
chr6_+_144583198 0.10 ENST00000367526.8
utrophin
chr17_-_19716604 0.10 ENST00000325411.9
ENST00000350657.9
solute carrier family 47 member 2
chr5_-_177497561 0.10 ENST00000359895.6
ENST00000355572.6
ENST00000393551.5
ENST00000505074.5
ENST00000393546.8
ENST00000355841.7
PDZ and LIM domain 7
chr17_-_51120855 0.10 ENST00000618113.4
ENST00000357122.8
ENST00000262013.12
sperm associated antigen 9
chr8_-_140457719 0.10 ENST00000438773.4
trafficking protein particle complex 9
chr17_-_76141240 0.10 ENST00000322957.7
forkhead box J1
chr7_+_37848597 0.10 ENST00000199447.9
ENST00000455500.5
NME/NM23 family member 8
chr14_-_102509798 0.10 ENST00000560748.5
ankyrin repeat domain 9
chr11_+_73308237 0.10 ENST00000263674.4
Rho guanine nucleotide exchange factor 17
chr3_-_86991135 0.09 ENST00000398399.7
vestigial like family member 3
chr8_+_67064316 0.09 ENST00000675306.2
ENST00000678017.1
ENST00000262210.11
ENST00000675869.1
ENST00000677009.1
ENST00000676847.1
ENST00000676471.1
ENST00000678542.1
ENST00000677619.1
ENST00000676605.1
ENST00000678553.1
ENST00000674993.1
ENST00000678318.1
ENST00000676573.1
ENST00000676317.1
ENST00000677592.1
ENST00000679226.1
ENST00000675955.1
ENST00000676882.1
ENST00000678616.1
ENST00000678645.1
ENST00000678747.1
centrosome and spindle pole associated protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1900247 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 0.7 GO:0099558 maintenance of synapse structure(GO:0099558)
0.2 2.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 0.8 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 1.0 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 1.1 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.1 0.8 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.3 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 0.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.3 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 0.5 GO:1901662 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1 0.4 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.4 GO:1902732 mesenchymal stem cell proliferation(GO:0097168) positive regulation of chondrocyte proliferation(GO:1902732)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.2 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.1 0.1 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.1 0.2 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.1 1.6 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.3 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.1 0.5 GO:0035754 B cell chemotaxis(GO:0035754)
0.1 0.2 GO:0006113 fermentation(GO:0006113) regulation of fermentation(GO:0043465)
0.1 0.4 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:1990569 UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569)
0.0 0.1 GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905006)
0.0 0.2 GO:0042450 arginine biosynthetic process via ornithine(GO:0042450)
0.0 0.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.0 0.4 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of meiosis I(GO:0060903)
0.0 0.4 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.2 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.0 0.2 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:1990086 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930) lens fiber cell apoptotic process(GO:1990086)
0.0 0.4 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.1 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.2 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0009631 cold acclimation(GO:0009631)
0.0 0.8 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.4 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 0.2 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0060913 cardiac cell fate determination(GO:0060913) negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0040030 regulation of molecular function, epigenetic(GO:0040030)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 2.1 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.1 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.1 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.1 GO:2000410 regulation of thymocyte migration(GO:2000410)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 0.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:0035674 tricarboxylic acid transmembrane transport(GO:0035674)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.4 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.0 0.1 GO:1903998 regulation of eating behavior(GO:1903998)
0.0 0.1 GO:0072553 terminal button organization(GO:0072553)
0.0 0.2 GO:2000399 negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0 0.1 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.2 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.1 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.1 GO:0007468 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.0 GO:0070105 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.2 GO:0002031 G-protein coupled receptor internalization(GO:0002031)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0044301 climbing fiber(GO:0044301)
0.1 0.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.4 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0070701 mucus layer(GO:0070701)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.8 GO:0031941 filamentous actin(GO:0031941)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.2 GO:0033503 HULC complex(GO:0033503)
0.0 1.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0097229 sperm end piece(GO:0097229)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) chromaffin granule(GO:0042583)
0.0 0.0 GO:0034515 proteasome storage granule(GO:0034515)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 0.8 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.2 0.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 1.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.1 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.3 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.2 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.8 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 0.2 GO:0004056 argininosuccinate lyase activity(GO:0004056)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.2 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1 0.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.2 GO:0033142 progesterone receptor binding(GO:0033142)
0.1 0.2 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.1 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.0 0.1 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 1.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.2 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.2 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0015250 water channel activity(GO:0015250)
0.0 0.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.6 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.1 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.5 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA