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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ZKSCAN3

Z-value: 0.39

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.14 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg38_v1_chr6_+_28349907_28349983-0.137.5e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39296399 0.72 ENST00000333625.3
IFNL1
interferon lambda 1
chr21_+_46001300 0.47 ENST00000612273.2
ENST00000682634.1
COL6A1
collagen type VI alpha 1 chain
chr5_+_176810498 0.40 ENST00000509580.2
UNC5A
unc-5 netrin receptor A
chr5_+_176810552 0.37 ENST00000329542.9
UNC5A
unc-5 netrin receptor A
chr2_-_166375969 0.30 ENST00000454569.6
ENST00000409672.5
SCN9A
sodium voltage-gated channel alpha subunit 9
chr2_-_166375901 0.29 ENST00000303354.11
ENST00000645907.1
ENST00000642356.2
ENST00000452182.2
SCN9A
sodium voltage-gated channel alpha subunit 9
chr2_+_190880809 0.24 ENST00000320717.8
GLS
glutaminase
chrX_+_86148441 0.19 ENST00000373125.9
ENST00000373131.5
DACH2
dachshund family transcription factor 2
chr19_-_39245006 0.16 ENST00000413851.3
ENST00000613087.4
IFNL3
interferon lambda 3
chr1_-_19484635 0.14 ENST00000433834.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr22_-_49918404 0.12 ENST00000330817.11
ALG12
ALG12 alpha-1,6-mannosyltransferase
chr14_-_106130061 0.11 ENST00000390602.3
IGHV3-13
immunoglobulin heavy variable 3-13
chr5_-_65722094 0.11 ENST00000381007.9
SGTB
small glutamine rich tetratricopeptide repeat containing beta
chrX_+_151694967 0.10 ENST00000448726.5
ENST00000538575.5
PRRG3
proline rich and Gla domain 3
chrX_+_154547606 0.09 ENST00000594239.6
ENST00000615874.4
ENST00000619941.4
ENST00000617207.4
ENST00000611176.4
IKBKG
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
chr14_-_80231052 0.08 ENST00000557010.5
DIO2
iodothyronine deiodinase 2
chr1_-_19485502 0.08 ENST00000264203.7
ENST00000375144.6
ENST00000674432.1
ENST00000264202.8
CAPZB
capping actin protein of muscle Z-line subunit beta
chr1_-_19485468 0.07 ENST00000375142.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr16_-_695946 0.07 ENST00000562563.1
FBXL16
F-box and leucine rich repeat protein 16
chr17_-_18644418 0.07 ENST00000575220.5
ENST00000405044.6
ENST00000573652.1
TBC1D28
TBC1 domain family member 28
chr14_-_106675544 0.06 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr19_+_52369911 0.06 ENST00000424032.6
ENST00000422689.3
ENST00000600321.5
ENST00000344085.9
ENST00000597976.5
ZNF880
zinc finger protein 880
chr3_+_50279080 0.05 ENST00000316436.4
LSMEM2
leucine rich single-pass membrane protein 2
chr17_+_38752731 0.05 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr5_+_140700437 0.05 ENST00000274712.8
ZMAT2
zinc finger matrin-type 2
chr14_-_106593319 0.04 ENST00000390627.3
IGHV3-53
immunoglobulin heavy variable 3-53
chr15_+_74318553 0.04 ENST00000558821.5
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr1_+_93448108 0.04 ENST00000271234.13
ENST00000260506.12
FNBP1L
formin binding protein 1 like
chr16_-_28495519 0.04 ENST00000569430.7
CLN3
CLN3 lysosomal/endosomal transmembrane protein, battenin
chr5_-_115262851 0.04 ENST00000379615.3
ENST00000419445.6
PGGT1B
protein geranylgeranyltransferase type I subunit beta
chr12_+_71754834 0.04 ENST00000261263.5
RAB21
RAB21, member RAS oncogene family
chr1_+_93448155 0.03 ENST00000370253.6
FNBP1L
formin binding protein 1 like
chr1_+_226062704 0.03 ENST00000366814.3
ENST00000366815.10
ENST00000655399.1
ENST00000667897.1
H3-3A
H3.3 histone A
chr11_-_64246190 0.02 ENST00000392210.6
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
chr14_+_64113084 0.02 ENST00000673797.1
SYNE2
spectrin repeat containing nuclear envelope protein 2
chr7_+_1044542 0.02 ENST00000444847.2
GPR146
G protein-coupled receptor 146
chr22_+_49918626 0.02 ENST00000328268.9
ENST00000404488.7
CRELD2
cysteine rich with EGF like domains 2
chr11_-_119346695 0.02 ENST00000619721.6
MFRP
membrane frizzled-related protein
chr5_+_65722190 0.01 ENST00000380985.10
ENST00000502464.5
NLN
neurolysin
chr11_-_61295289 0.01 ENST00000335613.10
VWCE
von Willebrand factor C and EGF domains
chr6_-_31540536 0.01 ENST00000376177.6
DDX39B
DExD-box helicase 39B
chr7_+_155298561 0.01 ENST00000476756.1
INSIG1
insulin induced gene 1
chr14_+_64113054 0.01 ENST00000673869.1
SYNE2
spectrin repeat containing nuclear envelope protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 0.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.6 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.0 GO:0035752 lysosomal lumen pH elevation(GO:0035752)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.0 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.0 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis