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Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for ZNF691

Z-value: 0.54

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Transcription factors associated with ZNF691

Gene Symbol Gene ID Gene Info
ZNF691
ENSG00000164011.18 zinc finger protein 691

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF691hg38_v1_chr1_+_42846573_42846640-0.265.3e-01Click!

Activity profile of ZNF691 motif

Sorted Z-values of ZNF691 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_147760592 1.12 ENST00000579774.3
GJA5
gap junction protein alpha 5
chr3_-_172523460 0.56 ENST00000420541.6
TNFSF10
TNF superfamily member 10
chr3_-_172523423 0.55 ENST00000241261.7
TNFSF10
TNF superfamily member 10
chr16_+_57628507 0.54 ENST00000456916.5
ENST00000567154.5
ENST00000388813.9
ENST00000562558.6
ENST00000566271.6
ENST00000563374.5
ENST00000673126.2
ENST00000562631.7
ENST00000568234.5
ENST00000565770.5
ENST00000566164.5
ADGRG1
adhesion G protein-coupled receptor G1
chr2_+_68734773 0.48 ENST00000409202.8
ARHGAP25
Rho GTPase activating protein 25
chr19_+_49581304 0.44 ENST00000246794.10
PRRG2
proline rich and Gla domain 2
chr18_+_11751494 0.44 ENST00000269162.9
GNAL
G protein subunit alpha L
chr19_-_50968966 0.43 ENST00000376851.7
KLK6
kallikrein related peptidase 6
chr19_-_50968775 0.40 ENST00000391808.5
KLK6
kallikrein related peptidase 6
chr2_+_105851748 0.37 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr11_-_5301946 0.36 ENST00000380224.2
OR51B4
olfactory receptor family 51 subfamily B member 4
chr2_-_74441882 0.32 ENST00000272430.10
RTKN
rhotekin
chr8_+_32721823 0.30 ENST00000539990.3
ENST00000519240.5
NRG1
neuregulin 1
chr14_-_91867529 0.28 ENST00000435962.7
TC2N
tandem C2 domains, nuclear
chr11_+_121590388 0.27 ENST00000527934.1
SORL1
sortilin related receptor 1
chr17_-_82840010 0.26 ENST00000269394.4
ENST00000572562.1
ZNF750
zinc finger protein 750
chr2_+_68734861 0.25 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chr15_-_74433942 0.24 ENST00000543145.6
ENST00000261918.9
SEMA7A
semaphorin 7A (John Milton Hagen blood group)
chr2_+_96760857 0.22 ENST00000377075.3
CNNM4
cyclin and CBS domain divalent metal cation transport mediator 4
chrX_-_104013708 0.21 ENST00000217926.7
H2BW1
H2B.W histone 1
chr10_+_127907036 0.20 ENST00000254667.8
ENST00000442830.5
PTPRE
protein tyrosine phosphatase receptor type E
chr16_+_84294853 0.18 ENST00000219454.10
WFDC1
WAP four-disulfide core domain 1
chr11_+_44726811 0.17 ENST00000533202.5
ENST00000520358.7
ENST00000533080.5
ENST00000520999.6
TSPAN18
tetraspanin 18
chr16_+_84294823 0.17 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr9_+_136952256 0.17 ENST00000371633.8
LCN12
lipocalin 12
chr21_-_46155567 0.16 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
FTCD
formimidoyltransferase cyclodeaminase
chrX_+_103710907 0.16 ENST00000319560.7
TMEM31
transmembrane protein 31
chr3_+_46370854 0.16 ENST00000292303.4
CCR5
C-C motif chemokine receptor 5
chr11_-_36598221 0.13 ENST00000311485.8
ENST00000527033.5
ENST00000532616.1
ENST00000618712.4
RAG2
recombination activating 2
chr9_+_136952896 0.13 ENST00000371632.7
LCN12
lipocalin 12
chr17_+_32444379 0.13 ENST00000578213.5
ENST00000649012.1
ENST00000457654.6
ENST00000579451.1
ENST00000261712.8
PSMD11
proteasome 26S subunit, non-ATPase 11
chr17_-_75844334 0.12 ENST00000592386.5
ENST00000412096.6
ENST00000586147.1
ENST00000207549.9
UNC13D
unc-13 homolog D
chr1_-_203086001 0.11 ENST00000241651.5
MYOG
myogenin
chr11_+_102317542 0.11 ENST00000532808.5
BIRC3
baculoviral IAP repeat containing 3
chr1_+_226870561 0.11 ENST00000678320.1
ENST00000676945.1
ENST00000677599.1
ENST00000677414.1
ENST00000679088.1
ENST00000495488.5
ENST00000677880.1
ENST00000366783.8
ENST00000422240.6
PSEN2
presenilin 2
chr9_+_136658854 0.11 ENST00000371699.5
EGFL7
EGF like domain multiple 7
chr11_-_57381146 0.11 ENST00000287143.2
PRG3
proteoglycan 3, pro eosinophil major basic protein 2
chr14_-_20802402 0.10 ENST00000412779.2
RNASE1
ribonuclease A family member 1, pancreatic
chr14_-_20802836 0.10 ENST00000397967.5
ENST00000555698.5
ENST00000397970.4
ENST00000340900.3
RNASE1
ribonuclease A family member 1, pancreatic
chr12_-_51324652 0.10 ENST00000544402.5
BIN2
bridging integrator 2
chr12_-_108827384 0.10 ENST00000326470.9
SSH1
slingshot protein phosphatase 1
chr19_-_45973863 0.10 ENST00000263257.6
NOVA2
NOVA alternative splicing regulator 2
chr6_+_28525986 0.10 ENST00000469384.1
GPX5
glutathione peroxidase 5
chr16_+_78099400 0.09 ENST00000627394.3
WWOX
WW domain containing oxidoreductase
chrX_+_103215072 0.09 ENST00000372695.6
ENST00000372691.3
BEX4
brain expressed X-linked 4
chr10_+_102918276 0.09 ENST00000369878.9
ENST00000369875.3
CNNM2
cyclin and CBS domain divalent metal cation transport mediator 2
chr15_-_25863304 0.09 ENST00000555815.6
ENST00000673716.1
ATP10A
ATPase phospholipid transporting 10A (putative)
chr3_-_45995807 0.08 ENST00000535325.5
ENST00000296137.7
FYCO1
FYVE and coiled-coil domain autophagy adaptor 1
chr11_+_5389377 0.08 ENST00000328611.5
OR51M1
olfactory receptor family 51 subfamily M member 1
chr12_-_23584600 0.08 ENST00000396007.6
SOX5
SRY-box transcription factor 5
chr9_+_81988772 0.08 ENST00000344803.3
SPATA31D1
SPATA31 subfamily D member 1
chr15_-_58279245 0.08 ENST00000558231.5
ALDH1A2
aldehyde dehydrogenase 1 family member A2
chr11_+_66257265 0.08 ENST00000531240.5
ENST00000417856.5
KLC2
kinesin light chain 2
chr12_-_51324138 0.07 ENST00000452142.7
BIN2
bridging integrator 2
chr12_-_51324164 0.07 ENST00000615107.6
BIN2
bridging integrator 2
chr12_-_10909562 0.07 ENST00000390677.2
TAS2R13
taste 2 receptor member 13
chr17_+_82458174 0.07 ENST00000579198.5
ENST00000390006.8
ENST00000580296.5
NARF
nuclear prelamin A recognition factor
chr9_+_135561749 0.07 ENST00000479141.6
ENST00000611414.4
ENST00000371766.6
ENST00000277508.9
ENST00000433563.5
PAEP
progestagen associated endometrial protein
chr17_+_82458649 0.07 ENST00000345415.11
ENST00000412079.6
ENST00000457415.7
ENST00000584411.5
ENST00000577432.5
NARF
nuclear prelamin A recognition factor
chr10_+_102918344 0.07 ENST00000433628.2
CNNM2
cyclin and CBS domain divalent metal cation transport mediator 2
chr8_+_141416078 0.07 ENST00000349124.3
PTP4A3
protein tyrosine phosphatase 4A3
chr3_-_167734465 0.07 ENST00000487947.6
PDCD10
programmed cell death 10
chr12_-_51324091 0.07 ENST00000604560.6
BIN2
bridging integrator 2
chr17_-_40665121 0.07 ENST00000394052.5
KRT222
keratin 222
chr3_-_167734510 0.07 ENST00000475915.6
ENST00000462725.6
ENST00000461494.5
PDCD10
programmed cell death 10
chr1_+_33472622 0.06 ENST00000361328.7
ENST00000684572.1
ENST00000373413.2
ZSCAN20
zinc finger and SCAN domain containing 20
chr1_-_233295712 0.06 ENST00000258229.14
PCNX2
pecanex 2
chr4_-_82798735 0.06 ENST00000273908.4
ENST00000319540.9
SCD5
stearoyl-CoA desaturase 5
chr1_+_248038172 0.06 ENST00000366479.4
OR2L2
olfactory receptor family 2 subfamily L member 2
chr17_-_3513768 0.06 ENST00000570318.1
ENST00000541913.5
SPATA22
spermatogenesis associated 22
chr9_+_113505256 0.06 ENST00000374136.5
RGS3
regulator of G protein signaling 3
chr15_-_49620747 0.06 ENST00000559905.5
ENST00000560246.1
ENST00000299338.11
ENST00000558594.5
FAM227B
family with sequence similarity 227 member B
chr19_-_45973986 0.06 ENST00000676183.1
NOVA2
NOVA alternative splicing regulator 2
chr19_+_58544447 0.05 ENST00000594806.5
ENST00000341753.10
TRIM28
tripartite motif containing 28
chr8_+_141416141 0.05 ENST00000680615.1
PTP4A3
protein tyrosine phosphatase 4A3
chrX_+_78104229 0.05 ENST00000373316.5
PGK1
phosphoglycerate kinase 1
chr5_-_39074377 0.05 ENST00000514735.1
ENST00000357387.8
ENST00000296782.9
RICTOR
RPTOR independent companion of MTOR complex 2
chr20_-_23688951 0.05 ENST00000217423.4
CST4
cystatin S
chr6_-_27312258 0.05 ENST00000444565.2
POM121L2
POM121 transmembrane nucleoporin like 2
chr11_+_67586104 0.05 ENST00000495996.1
GSTP1
glutathione S-transferase pi 1
chr5_-_132011811 0.05 ENST00000379255.5
ENST00000430403.5
ENST00000357096.5
ACSL6
acyl-CoA synthetase long chain family member 6
chr6_+_31586124 0.05 ENST00000418507.6
ENST00000376096.5
ENST00000376099.5
ENST00000376110.7
LST1
leukocyte specific transcript 1
chr9_+_37485938 0.05 ENST00000377798.9
POLR1E
RNA polymerase I subunit E
chrX_-_152769677 0.04 ENST00000457643.1
ENST00000616035.4
ENST00000412733.1
ENST00000329342.9
MAGEA6
MAGE family member A6
chr9_+_37486006 0.04 ENST00000377792.3
POLR1E
RNA polymerase I subunit E
chr22_-_43143339 0.04 ENST00000327555.5
ENST00000290429.11
MCAT
malonyl-CoA-acyl carrier protein transacylase
chr10_-_59362584 0.04 ENST00000618427.4
ENST00000611933.4
FAM13C
family with sequence similarity 13 member C
chr8_-_144103678 0.04 ENST00000398712.7
SHARPIN
SHANK associated RH domain interactor
chr6_-_89819699 0.04 ENST00000439638.1
ENST00000629399.2
ENST00000369393.8
MDN1
midasin AAA ATPase 1
chr10_-_97498378 0.04 ENST00000327238.14
ENST00000437002.5
ENST00000438925.7
ENST00000422685.5
MMS19
MMS19 homolog, cytosolic iron-sulfur assembly component
chr1_+_26317950 0.03 ENST00000374213.3
CD52
CD52 molecule
chr6_-_144008396 0.03 ENST00000354765.6
ENST00000416623.5
ENST00000649211.1
PLAGL1
PLAG1 like zinc finger 1
chr8_-_28490220 0.03 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
FBXO16
F-box protein 16
chr5_-_179617581 0.03 ENST00000523449.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr3_-_167734832 0.03 ENST00000464360.5
ENST00000492139.5
ENST00000471885.5
ENST00000392750.7
ENST00000470131.5
PDCD10
programmed cell death 10
chr6_+_31586269 0.03 ENST00000438075.7
LST1
leukocyte specific transcript 1
chr6_+_28525877 0.03 ENST00000412168.7
GPX5
glutathione peroxidase 5
chr6_-_119149124 0.03 ENST00000368475.8
FAM184A
family with sequence similarity 184 member A
chr9_+_132978687 0.03 ENST00000372122.4
ENST00000372123.5
GFI1B
growth factor independent 1B transcriptional repressor
chr11_-_3671367 0.03 ENST00000534359.1
ENST00000250699.2
CHRNA10
cholinergic receptor nicotinic alpha 10 subunit
chr12_-_132687307 0.02 ENST00000535270.5
ENST00000320574.10
POLE
DNA polymerase epsilon, catalytic subunit
chr15_-_82349437 0.02 ENST00000621197.4
ENST00000610657.2
ENST00000619556.4
GOLGA6L10
golgin A6 family like 10
chr9_-_120929160 0.02 ENST00000540010.1
TRAF1
TNF receptor associated factor 1
chr1_+_15659869 0.02 ENST00000345034.1
RSC1A1
regulator of solute carriers 1
chr9_-_132878262 0.02 ENST00000298545.4
AK8
adenylate kinase 8
chr10_-_49970203 0.02 ENST00000402038.7
PARG
poly(ADP-ribose) glycohydrolase
chr5_-_175968280 0.02 ENST00000513482.1
ENST00000265097.9
ENST00000628318.2
THOC3
THO complex 3
chr6_-_144008364 0.02 ENST00000625622.2
PLAGL1
PLAG1 like zinc finger 1
chr20_-_63572455 0.02 ENST00000467148.1
HELZ2
helicase with zinc finger 2
chr10_-_59362460 0.01 ENST00000422313.6
ENST00000435852.6
ENST00000614220.4
ENST00000618804.5
ENST00000621119.4
FAM13C
family with sequence similarity 13 member C
chr5_+_135834641 0.01 ENST00000425402.5
ENST00000681962.1
ENST00000650267.1
ENST00000510147.2
ENST00000274513.9
ENST00000433282.6
ENST00000412661.3
SLC25A48
solute carrier family 25 member 48
chr17_+_45844875 0.01 ENST00000329196.7
SPPL2C
signal peptide peptidase like 2C
chr1_+_178513103 0.01 ENST00000319416.7
ENST00000367643.7
ENST00000367642.3
ENST00000367641.7
ENST00000367639.1
TEX35
testis expressed 35
chr20_+_3046008 0.01 ENST00000380325.4
MRPS26
mitochondrial ribosomal protein S26
chr1_-_16437416 0.01 ENST00000375577.5
ENST00000335496.5
SPATA21
spermatogenesis associated 21
chr10_-_89251768 0.01 ENST00000336233.10
LIPA
lipase A, lysosomal acid type
chr5_+_3595820 0.00 ENST00000302006.4
IRX1
iroquois homeobox 1
chr8_-_120445140 0.00 ENST00000306185.8
MRPL13
mitochondrial ribosomal protein L13
chr1_-_146344790 0.00 ENST00000584068.3
PPIAL4H
peptidylprolyl isomerase A like 4H
chr9_+_132978651 0.00 ENST00000636137.1
GFI1B
growth factor independent 1B transcriptional repressor
chr1_+_203765168 0.00 ENST00000367217.5
ENST00000442561.7
LAX1
lymphocyte transmembrane adaptor 1
chr19_-_15449920 0.00 ENST00000263381.12
ENST00000643092.1
ENST00000673675.1
WIZ
WIZ zinc finger
chr16_-_53703810 0.00 ENST00000569716.1
ENST00000562588.5
ENST00000621565.5
ENST00000562230.5
ENST00000563746.5
ENST00000568653.7
ENST00000647211.2
RPGRIP1L
RPGRIP1 like

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF691

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0098905 pulmonary valve formation(GO:0003193) foramen ovale closure(GO:0035922) regulation of bundle of His cell action potential(GO:0098905)
0.1 0.3 GO:1902948 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.3 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.1 0.4 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0 0.8 GO:0016540 protein autoprocessing(GO:0016540)
0.0 1.0 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:0014873 response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0 0.5 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.2 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.1 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.0 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.3 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:1902490 regulation of sperm capacitation(GO:1902490)
0.0 0.4 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.0 GO:0035732 nitric oxide storage(GO:0035732)
0.0 0.2 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.0 0.2 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:1901536 positive regulation of methylation-dependent chromatin silencing(GO:0090309) regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536) regulation of genetic imprinting(GO:2000653)
0.0 0.1 GO:0045416 positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 1.1 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.0 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.0 0.0 GO:0016420 [acyl-carrier-protein] S-malonyltransferase activity(GO:0004314) S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.8 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac