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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for AHR_ARNT2
Z-value: 1.21
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Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AHR | hg38_v1_chr7_+_17298642_17298658 | -0.54 | 1.6e-01 | Click! |
| ARNT2 | hg38_v1_chr15_+_80404320_80404414, hg38_v1_chr15_+_80441229_80441313 | 0.34 | 4.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.5 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.2 | 3.0 | GO:0070445 | oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445) |
| 0.1 | 2.9 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
| 0.1 | 2.9 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 2.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 2.5 | GO:0038129 | ERBB3 signaling pathway(GO:0038129) |
| 0.2 | 2.1 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 1.8 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.6 | 1.7 | GO:0042668 | auditory receptor cell fate determination(GO:0042668) |
| 0.1 | 1.7 | GO:0018095 | protein polyglutamylation(GO:0018095) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.6 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.1 | 3.1 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 3.1 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 3.0 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 2.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 2.5 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 1.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.8 | GO:0005916 | fascia adherens(GO:0005916) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.2 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 3.6 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 3.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 2.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.3 | 2.3 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 2.3 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 2.3 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 2.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 2.1 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 1.9 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 3.8 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 1.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 3.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 3.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 2.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 2.5 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 2.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.8 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |