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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for AR_NR3C2

Z-value: 0.40

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
ENSG00000169083.18 androgen receptor
ENSG00000151623.15 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_19386785 1.21 ENST00000497081.6
microfibril associated protein 4
chr17_-_19387170 1.16 ENST00000395592.6
ENST00000299610.5
microfibril associated protein 4
chr12_+_53050179 0.66 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
tensin 2
chr12_+_53050014 0.66 ENST00000314250.11
tensin 2
chr16_+_56632651 0.56 ENST00000379818.4
ENST00000570233.1
metallothionein 1M
chr3_-_58577367 0.54 ENST00000464064.5
ENST00000360997.7
family with sequence similarity 107 member A
chr3_-_58577648 0.49 ENST00000394481.5
family with sequence similarity 107 member A
chr1_+_22653189 0.46 ENST00000432749.6
complement C1q B chain
chr8_+_90001448 0.39 ENST00000519410.5
ENST00000522161.5
ENST00000220764.7
ENST00000517761.5
ENST00000520227.1
2,4-dienoyl-CoA reductase 1
chr19_+_35140022 0.30 ENST00000588081.5
ENST00000589121.1
FXYD domain containing ion transport regulator 1
chr19_+_35139724 0.29 ENST00000588715.5
ENST00000588607.5
FXYD domain containing ion transport regulator 1
chr15_+_31366138 0.28 ENST00000558844.1
Kruppel like factor 13
chr7_+_94656325 0.28 ENST00000482108.1
ENST00000488574.5
ENST00000612748.1
ENST00000613043.1
paternally expressed 10
chr16_+_67173935 0.26 ENST00000566871.5
nucleolar protein 3
chr16_+_56682461 0.26 ENST00000562939.1
ENST00000394485.5
ENST00000567563.1
metallothionein 1X
novel transcript
chr1_+_22653228 0.25 ENST00000509305.6
complement C1q B chain
chr19_+_35139440 0.24 ENST00000455515.6
FXYD domain containing ion transport regulator 1
chr5_-_142012973 0.24 ENST00000503794.5
ENST00000510194.5
ENST00000504424.1
ENST00000513454.5
ENST00000311337.11
ENST00000503229.5
ENST00000500692.6
ENST00000504139.5
ENST00000505689.5
glucosamine-6-phosphate deaminase 1
chr1_-_1214146 0.21 ENST00000379236.4
TNF receptor superfamily member 4
chr22_+_22704265 0.21 ENST00000390307.2
immunoglobulin lambda variable 3-22
chr16_+_67173971 0.20 ENST00000563258.1
ENST00000568146.1
nucleolar protein 3
chr16_+_56625775 0.19 ENST00000330439.7
ENST00000568293.1
metallothionein 1E
chr2_+_237487239 0.19 ENST00000338530.8
ENST00000264605.8
ENST00000409373.5
melanophilin
chr9_+_128920966 0.17 ENST00000428610.5
ENST00000372592.8
phytanoyl-CoA dioxygenase domain containing 1
chr3_+_52245721 0.17 ENST00000323588.9
protein phosphatase, Mg2+/Mn2+ dependent 1M
chr8_-_71844402 0.15 ENST00000325509.5
musculin
chr20_+_15196834 0.15 ENST00000402914.5
mono-ADP ribosylhydrolase 2
chr11_-_236326 0.14 ENST00000525237.1
ENST00000382743.9
ENST00000532956.5
ENST00000525319.5
ENST00000524564.5
sirtuin 3
chr13_+_113759219 0.14 ENST00000375353.5
ENST00000488362.5
transmembrane protein 255B
chr7_+_20615653 0.13 ENST00000404938.7
ATP binding cassette subfamily B member 5
chr1_+_111619751 0.13 ENST00000433097.5
ENST00000369709.3
RAP1A, member of RAS oncogene family
chr12_+_66189178 0.13 ENST00000545837.1
interleukin 1 receptor associated kinase 3
chr12_-_56221701 0.12 ENST00000615206.4
ENST00000549038.5
ENST00000552244.5
ring finger protein 41
chr8_+_61287950 0.12 ENST00000519846.5
ENST00000325897.5
ENST00000523868.2
ENST00000518592.5
clavesin 1
chr4_-_68951763 0.12 ENST00000251566.9
UDP glucuronosyltransferase family 2 member A3
chr16_-_66550142 0.12 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
thymidine kinase 2
chr18_-_50819982 0.12 ENST00000398439.8
ENST00000431965.6
ENST00000436348.6
maestro
chr3_-_15341368 0.11 ENST00000408919.7
SH3 domain binding protein 5
chr17_-_8152380 0.11 ENST00000317276.9
period circadian regulator 1
chr14_-_106675544 0.11 ENST00000390632.2
immunoglobulin heavy variable 3-66
chr17_+_39667964 0.11 ENST00000394246.1
phenylethanolamine N-methyltransferase
chrY_-_13986473 0.11 ENST00000250825.5
variable charge Y-linked
chr12_+_50925007 0.11 ENST00000332160.5
methyltransferase like 7A
chrY_+_14056226 0.10 ENST00000250823.5
variable charge Y-linked 1B
chr12_-_56221909 0.10 ENST00000394013.6
ENST00000345093.9
ENST00000551711.5
ENST00000552656.5
ring finger protein 41
chr11_-_114400417 0.10 ENST00000325636.8
ENST00000623205.2
chromosome 11 open reading frame 71
chr11_+_8911154 0.10 ENST00000309357.8
ENST00000529876.5
ENST00000309377.9
ENST00000525005.5
ENST00000524577.5
ENST00000534506.5
A-kinase interacting protein 1
chr4_-_8440712 0.09 ENST00000356406.10
ENST00000413009.6
acyl-CoA oxidase 3, pristanoyl
chr11_+_8911106 0.09 ENST00000299576.9
A-kinase interacting protein 1
chr19_-_42412347 0.09 ENST00000601189.1
ENST00000599211.1
lipase E, hormone sensitive type
chr11_+_8911280 0.09 ENST00000530281.5
ENST00000396648.6
ENST00000534147.5
ENST00000529942.1
A-kinase interacting protein 1
chr6_-_26234978 0.08 ENST00000244534.7
H1.3 linker histone, cluster member
chr22_+_21567705 0.08 ENST00000342192.9
ubiquitin conjugating enzyme E2 L3
chr19_+_55676621 0.08 ENST00000411543.6
epsin 1
chr19_-_14835162 0.08 ENST00000322301.5
olfactory receptor family 7 subfamily A member 5
chrX_-_8171267 0.08 ENST00000317103.5
variable charge X-linked 2
chr3_-_119677346 0.07 ENST00000484810.5
ENST00000497116.1
ENST00000261070.7
cytochrome c oxidase copper chaperone COX17
chr20_-_37158904 0.07 ENST00000417458.5
maestro heat like repeat family member 8
chrX_-_18220878 0.07 ENST00000380033.9
BEN domain containing 2
chr17_-_16569169 0.07 ENST00000395824.5
zinc finger protein 287
chr14_-_106411021 0.07 ENST00000390618.2
immunoglobulin heavy variable 3-38 (non-functional)
chr18_-_50819764 0.06 ENST00000592966.5
maestro
chr5_-_173616588 0.06 ENST00000285908.5
ENST00000311086.9
ENST00000480951.1
biorientation of chromosomes in cell division 1
chr4_-_75672868 0.06 ENST00000678123.1
ENST00000678578.1
ENST00000677876.1
ENST00000676839.1
ENST00000678265.1
G3BP stress granule assembly factor 2
chr17_-_16569184 0.06 ENST00000448349.2
ENST00000395825.4
zinc finger protein 287
chr4_+_37891060 0.06 ENST00000261439.9
ENST00000508802.5
ENST00000402522.1
TBC1 domain family member 1
chr10_-_27983103 0.06 ENST00000672841.1
outer dynein arm docking complex subunit 2
chr11_-_75669028 0.06 ENST00000304771.8
microtubule associated protein 6
chr14_-_106538331 0.06 ENST00000390624.3
immunoglobulin heavy variable 3-48
chr6_+_18387326 0.05 ENST00000259939.4
ring finger protein 144B
chr17_-_63918817 0.05 ENST00000458650.6
ENST00000351388.8
ENST00000342364.8
ENST00000617086.1
ENST00000323322.10
ENST00000392824.8
growth hormone 1
chorionic somatomammotropin hormone like 1
chr18_+_58862904 0.05 ENST00000591083.5
zinc finger protein 532
chr4_-_185425941 0.05 ENST00000264689.11
ENST00000505357.1
UFM1 specific peptidase 2
chr16_-_4802615 0.05 ENST00000591392.5
ENST00000587711.5
ENST00000322048.12
rogdi atypical leucine zipper
chr17_+_43171187 0.05 ENST00000542611.5
ENST00000590996.6
ENST00000589872.1
NBR1 autophagy cargo receptor
chr1_+_145719483 0.05 ENST00000369288.7
CD160 molecule
chr9_-_35563867 0.05 ENST00000399742.7
ENST00000619051.4
family with sequence similarity 166 member B
chr2_-_37324826 0.05 ENST00000234179.8
protein kinase D3
chr18_+_7754959 0.04 ENST00000400053.8
protein tyrosine phosphatase receptor type M
chr16_+_8642375 0.04 ENST00000562973.1
methyltransferase like 22
chr11_-_506739 0.04 ENST00000529306.5
ENST00000438658.6
ENST00000527485.5
ENST00000397615.6
ENST00000397614.5
ribonuclease/angiogenin inhibitor 1
chr2_+_241637682 0.04 ENST00000419606.5
ENST00000404914.8
ENST00000400771.7
autophagy related 4B cysteine peptidase
chr1_+_1915080 0.04 ENST00000378604.3
calmodulin like 6
chr1_+_75796867 0.04 ENST00000263187.4
mutS homolog 4
chr8_+_24440930 0.04 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM metallopeptidase domain 7
chr15_-_19988117 0.03 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr19_+_58059236 0.03 ENST00000359978.10
ENST00000401053.8
ENST00000511556.5
ENST00000506786.1
ENST00000313434.10
zinc finger protein 135
chr1_+_93345893 0.03 ENST00000370272.9
ENST00000370267.1
down-regulator of transcription 1
chr17_+_20579724 0.03 ENST00000661883.1
ENST00000399044.1
CMT1A duplicated region transcript 15 like 2
chr11_+_114400592 0.03 ENST00000541475.5
RNA binding motif protein 7
chr2_-_230960954 0.03 ENST00000392039.2
G protein-coupled receptor 55
chr11_+_114400646 0.02 ENST00000375490.10
ENST00000544582.1
ENST00000545678.1
RNA binding motif protein 7
chr16_+_56638659 0.02 ENST00000290705.12
metallothionein 1A
chrX_+_8465426 0.02 ENST00000381029.4
variable charge X-linked 3B
chr12_-_10098977 0.02 ENST00000315330.8
ENST00000457018.6
C-type lectin domain family 1 member A
chr14_-_45253402 0.02 ENST00000627697.1
MIS18 binding protein 1
chr14_+_73886617 0.02 ENST00000540593.5
ENST00000555730.6
zinc finger protein 410
chr2_-_108989206 0.02 ENST00000258443.7
ENST00000409271.5
ENST00000376651.1
ectodysplasin A receptor
chr16_+_56608577 0.02 ENST00000245185.6
ENST00000561491.1
metallothionein 2A
chr14_-_106658251 0.02 ENST00000454421.2
immunoglobulin heavy variable 3-64
chr19_+_8052752 0.01 ENST00000315626.6
ENST00000253451.9
C-C motif chemokine ligand 25
chr6_+_127577168 0.01 ENST00000329722.8
chromosome 6 open reading frame 58
chr11_+_114400030 0.01 ENST00000540163.5
RNA binding motif protein 7
chr17_-_63873676 0.01 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
chorionic somatomammotropin hormone 2
chr1_-_48776811 0.01 ENST00000371833.4
BEN domain containing 5
chrX_+_2691270 0.01 ENST00000381187.8
ENST00000381184.6
CD99 molecule (Xg blood group)
chr19_+_8053000 0.01 ENST00000390669.7
C-C motif chemokine ligand 25
chr3_+_13480215 0.01 ENST00000446613.6
ENST00000402259.5
ENST00000402271.5
ENST00000295757.8
ENST00000404548.5
ENST00000404040.5
histone deacetylase 11
chr16_-_67944113 0.01 ENST00000264005.10
lecithin-cholesterol acyltransferase
chr2_+_190180930 0.01 ENST00000443551.2
chromosome 2 open reading frame 88
chrX_-_24027186 0.01 ENST00000328046.8
kelch like family member 15
chr22_+_23688133 0.01 ENST00000401461.5
ral guanine nucleotide dissociation stimulator like 4
chr8_-_48921419 0.01 ENST00000020945.4
snail family transcriptional repressor 2
chrX_+_2691310 0.01 ENST00000482405.7
ENST00000624481.4
ENST00000381180.9
CD99 molecule (Xg blood group)
chr16_+_32066065 0.01 ENST00000354689.6
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr17_-_63896621 0.00 ENST00000453363.7
chorionic somatomammotropin hormone 1
chrX_+_2691164 0.00 ENST00000611428.5
CD99 molecule (Xg blood group)
chr4_+_87006988 0.00 ENST00000307808.10
AF4/FMR2 family member 1
chr8_-_22156789 0.00 ENST00000306317.7
leucine rich repeat LGI family member 3
chrX_+_2691284 0.00 ENST00000381192.10
CD99 molecule (Xg blood group)
chr2_-_74648307 0.00 ENST00000421985.2
ENST00000536235.5
meiosis 1 associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.2 0.5 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.1 0.8 GO:0010731 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.2 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.1 GO:0048058 compound eye corneal lens development(GO:0048058)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 1.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0042414 epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418)
0.0 1.3 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.1 GO:1904732 regulation of electron carrier activity(GO:1904732)
0.0 0.1 GO:0010932 macrophage tolerance induction(GO:0010931) regulation of macrophage tolerance induction(GO:0010932) positive regulation of macrophage tolerance induction(GO:0010933)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.2 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.1 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.2 GO:0051024 positive regulation of immunoglobulin secretion(GO:0051024)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0071953 elastic fiber(GO:0071953)
0.2 0.7 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.5 GO:0089720 death effector domain binding(GO:0035877) caspase binding(GO:0089720)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0004797 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation