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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for BRCA1

Z-value: 0.72

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.23 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg38_v1_chr17_-_43125450_43125493-0.383.5e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_159171607 1.12 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr14_-_59630806 0.53 ENST00000342503.8
RTN1
reticulon 1
chr14_-_59630582 0.52 ENST00000395090.5
RTN1
reticulon 1
chr9_-_92424427 0.45 ENST00000375550.5
OMD
osteomodulin
chr20_-_35438218 0.43 ENST00000374369.8
GDF5
growth differentiation factor 5
chr11_-_27700472 0.32 ENST00000418212.5
ENST00000533246.5
BDNF
brain derived neurotrophic factor
chr11_-_27700447 0.32 ENST00000356660.9
BDNF
brain derived neurotrophic factor
chr5_-_124746630 0.28 ENST00000513986.2
ZNF608
zinc finger protein 608
chr7_-_23470469 0.24 ENST00000258729.8
IGF2BP3
insulin like growth factor 2 mRNA binding protein 3
chrX_-_143635081 0.20 ENST00000338017.8
SLITRK4
SLIT and NTRK like family member 4
chrX_+_10156960 0.19 ENST00000380833.9
CLCN4
chloride voltage-gated channel 4
chr3_-_127736329 0.18 ENST00000398101.7
MGLL
monoglyceride lipase
chr7_+_100119607 0.16 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr2_-_144517663 0.16 ENST00000427902.5
ENST00000462355.2
ENST00000470879.5
ENST00000409487.7
ENST00000435831.5
ENST00000630572.2
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_151261839 0.15 ENST00000331426.6
RBM43
RNA binding motif protein 43
chr21_+_44646414 0.15 ENST00000334670.9
KRTAP10-11
keratin associated protein 10-11
chr14_+_88385643 0.14 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chr14_+_88385714 0.13 ENST00000045347.11
SPATA7
spermatogenesis associated 7
chrX_-_71068384 0.13 ENST00000276105.3
ENST00000622259.4
SNX12
sorting nexin 12
chr19_-_12801787 0.12 ENST00000334482.9
ENST00000301522.3
PRDX2
peroxiredoxin 2
chr11_+_101914997 0.11 ENST00000263468.13
CEP126
centrosomal protein 126
chr20_+_58907981 0.10 ENST00000656419.1
GNAS
GNAS complex locus
chr5_+_154941063 0.10 ENST00000523037.6
ENST00000265229.12
ENST00000439747.7
ENST00000522038.5
MRPL22
mitochondrial ribosomal protein L22
chr12_-_80937918 0.10 ENST00000552864.6
LIN7A
lin-7 homolog A, crumbs cell polarity complex component
chr1_-_160262522 0.09 ENST00000440682.5
DCAF8
DDB1 and CUL4 associated factor 8
chr1_-_160262501 0.09 ENST00000447377.5
DCAF8
DDB1 and CUL4 associated factor 8
chrX_-_71068311 0.09 ENST00000374274.8
SNX12
sorting nexin 12
chr6_+_16129077 0.08 ENST00000356840.8
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr2_+_108378176 0.07 ENST00000409309.3
SULT1C4
sulfotransferase family 1C member 4
chr10_+_100535927 0.07 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr5_+_140700437 0.07 ENST00000274712.8
ZMAT2
zinc finger matrin-type 2
chr19_-_37172432 0.07 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr11_+_73308237 0.07 ENST00000263674.4
ARHGEF17
Rho guanine nucleotide exchange factor 17
chr12_-_122395422 0.07 ENST00000540304.6
CLIP1
CAP-Gly domain containing linker protein 1
chr19_-_37172670 0.06 ENST00000588354.1
ENST00000292841.10
ENST00000356958.8
ZNF585A
zinc finger protein 585A
chr1_+_84181630 0.06 ENST00000610457.1
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr3_-_177196451 0.06 ENST00000430069.5
ENST00000630796.2
ENST00000428970.5
TBL1XR1
TBL1X receptor 1
chr13_+_29428709 0.06 ENST00000542829.1
MTUS2
microtubule associated scaffold protein 2
chr2_+_108377947 0.06 ENST00000272452.7
SULT1C4
sulfotransferase family 1C member 4
chr19_-_55580829 0.05 ENST00000592239.1
ENST00000325421.7
ZNF579
zinc finger protein 579
chr6_-_43014254 0.05 ENST00000642748.1
MEA1
male-enhanced antigen 1
chr11_+_33258304 0.05 ENST00000531504.5
ENST00000456517.2
HIPK3
homeodomain interacting protein kinase 3
chr19_-_47555856 0.05 ENST00000391901.7
ENST00000314121.8
ZNF541
zinc finger protein 541
chr19_+_46347063 0.05 ENST00000012443.9
ENST00000391919.1
PPP5C
protein phosphatase 5 catalytic subunit
chr19_+_47130782 0.05 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SAE1
SUMO1 activating enzyme subunit 1
chr1_-_160262407 0.05 ENST00000419626.1
ENST00000610139.5
ENST00000475733.5
ENST00000407642.6
ENST00000368073.7
ENST00000326837.6
DCAF8
DDB1 and CUL4 associated factor 8
chr13_-_30464234 0.05 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr19_-_39834127 0.04 ENST00000601972.1
ENST00000430012.6
ENST00000323039.10
ENST00000348817.7
DYRK1B
dual specificity tyrosine phosphorylation regulated kinase 1B
chr17_+_38752731 0.04 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr18_-_26091175 0.04 ENST00000579061.5
ENST00000542420.6
SS18
SS18 subunit of BAF chromatin remodeling complex
chr14_+_22040576 0.04 ENST00000390448.3
TRAV20
T cell receptor alpha variable 20
chr20_-_49913693 0.04 ENST00000422556.1
SPATA2
spermatogenesis associated 2
chr7_-_100119323 0.04 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr13_-_49444004 0.04 ENST00000410043.5
ENST00000409308.6
CAB39L
calcium binding protein 39 like
chr2_+_135741814 0.04 ENST00000272638.14
UBXN4
UBX domain protein 4
chr4_-_184649436 0.04 ENST00000308394.9
ENST00000517513.5
ENST00000447121.2
ENST00000393588.8
ENST00000523916.5
CASP3
caspase 3
chr2_-_24972032 0.03 ENST00000534855.5
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr3_-_142448028 0.03 ENST00000392981.7
XRN1
5'-3' exoribonuclease 1
chr6_+_96563117 0.03 ENST00000450218.6
FHL5
four and a half LIM domains 5
chr2_-_49974083 0.03 ENST00000636345.1
NRXN1
neurexin 1
chr3_-_142448060 0.03 ENST00000264951.8
XRN1
5'-3' exoribonuclease 1
chr5_+_146203544 0.03 ENST00000506502.2
ENSG00000275740.1
novel readthrough transcript
chr11_-_72112750 0.03 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr1_-_160262540 0.02 ENST00000368074.6
DCAF8
DDB1 and CUL4 associated factor 8
chr10_-_24706622 0.02 ENST00000680286.1
ARHGAP21
Rho GTPase activating protein 21
chr4_+_109827963 0.02 ENST00000317735.7
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr16_-_740934 0.02 ENST00000540986.5
CIAO3
cytosolic iron-sulfur assembly component 3
chr16_-_740980 0.02 ENST00000251588.7
CIAO3
cytosolic iron-sulfur assembly component 3
chr10_+_120851341 0.02 ENST00000263461.11
WDR11
WD repeat domain 11
chr2_-_24971900 0.02 ENST00000264711.7
DNAJC27
DnaJ heat shock protein family (Hsp40) member C27
chr6_-_158999748 0.02 ENST00000449822.5
RSPH3
radial spoke head 3
chr10_+_90871946 0.01 ENST00000413330.5
ENST00000371703.8
ENST00000277882.7
RPP30
ribonuclease P/MRP subunit p30
chr2_+_203014721 0.01 ENST00000683091.1
NBEAL1
neurobeachin like 1
chr1_-_17045219 0.01 ENST00000491274.5
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr10_+_47322450 0.01 ENST00000581492.3
GDF2
growth differentiation factor 2
chr5_+_146203593 0.01 ENST00000265271.7
RBM27
RNA binding motif protein 27
chr1_-_41242106 0.01 ENST00000337495.9
ENST00000372597.5
ENST00000372596.5
SCMH1
Scm polycomb group protein homolog 1
chr1_+_171557845 0.01 ENST00000644916.1
PRRC2C
proline rich coiled-coil 2C
chr19_+_48469354 0.01 ENST00000452733.7
ENST00000641098.1
CYTH2
cytohesin 2
chr9_-_83978429 0.01 ENST00000351839.7
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr2_+_203014842 0.00 ENST00000683969.1
ENST00000449802.5
NBEAL1
neurobeachin like 1
chr14_+_20190896 0.00 ENST00000641879.2
ENST00000641682.1
OR11G2
olfactory receptor family 11 subfamily G member 2
chr11_-_61430008 0.00 ENST00000394888.8
CPSF7
cleavage and polyadenylation specific factor 7
chr10_-_100529854 0.00 ENST00000370320.4
ENST00000299166.9
ENST00000370322.5
NDUFB8
NADH:ubiquinone oxidoreductase subunit B8

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550)
0.1 0.2 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.4 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.0 0.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.3 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 1.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.0 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.4 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation