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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for DBX2_HLX

Z-value: 1.32

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Transcription factors associated with DBX2_HLX

Gene Symbol Gene ID Gene Info
DBX2
ENSG00000185610.6 developing brain homeobox 2
HLX
ENSG00000136630.13 H2.0 like homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HLXhg38_v1_chr1_+_220879434_2208794570.866.1e-03Click!

Activity profile of DBX2_HLX motif

Sorted Z-values of DBX2_HLX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_91179355 2.53 ENST00000550563.5
ENST00000546370.5
DCN
decorin
chr10_+_68106109 1.49 ENST00000540630.5
ENST00000354393.6
MYPN
myopalladin
chr5_-_20575850 1.19 ENST00000507958.5
CDH18
cadherin 18
chr11_-_63608542 1.17 ENST00000540943.1
PLAAT3
phospholipase A and acyltransferase 3
chr9_-_92482350 1.14 ENST00000375543.2
ASPN
asporin
chr19_+_49513353 0.89 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr5_-_147401591 0.88 ENST00000520473.1
DPYSL3
dihydropyrimidinase like 3
chr2_-_178478499 0.84 ENST00000434643.6
FKBP7
FKBP prolyl isomerase 7
chr8_-_13276491 0.79 ENST00000512044.6
DLC1
DLC1 Rho GTPase activating protein
chr17_+_1771688 0.79 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin family F member 1
chr9_+_96928310 0.76 ENST00000354649.7
NUTM2G
NUT family member 2G
chr2_-_224947030 0.75 ENST00000409592.7
DOCK10
dedicator of cytokinesis 10
chr5_+_95731300 0.75 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chr4_+_70050431 0.73 ENST00000511674.5
ENST00000246896.8
HTN1
histatin 1
chr13_+_101489940 0.70 ENST00000376162.7
ITGBL1
integrin subunit beta like 1
chr10_+_69088096 0.63 ENST00000242465.4
SRGN
serglycin
chr11_-_124800630 0.56 ENST00000239614.8
ENST00000674284.1
MSANTD2
Myb/SANT DNA binding domain containing 2
chr4_-_137532452 0.53 ENST00000412923.6
ENST00000511115.5
ENST00000344876.9
ENST00000507846.5
ENST00000510305.5
ENST00000611581.1
PCDH18
protocadherin 18
chr2_-_189179754 0.50 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr1_-_91906280 0.49 ENST00000370399.6
TGFBR3
transforming growth factor beta receptor 3
chr5_+_157269317 0.49 ENST00000618329.4
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_-_92404559 0.46 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr7_+_142111739 0.46 ENST00000550469.6
ENST00000477922.3
MGAM2
maltase-glucoamylase 2 (putative)
chr17_-_445939 0.44 ENST00000329099.4
RFLNB
refilin B
chr3_+_138621225 0.43 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr19_+_926001 0.42 ENST00000263620.8
ARID3A
AT-rich interaction domain 3A
chr19_+_49513154 0.42 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
FCGRT
Fc fragment of IgG receptor and transporter
chr1_-_48472166 0.40 ENST00000371847.8
ENST00000396199.7
SPATA6
spermatogenesis associated 6
chr9_-_21482313 0.40 ENST00000448696.4
IFNE
interferon epsilon
chr4_+_70242583 0.40 ENST00000304954.3
CSN3
casein kappa
chr19_-_58353482 0.39 ENST00000263100.8
A1BG
alpha-1-B glycoprotein
chr12_-_91111460 0.39 ENST00000266718.5
LUM
lumican
chrX_+_10158448 0.37 ENST00000380829.5
ENST00000421085.7
ENST00000674669.1
ENST00000454850.1
CLCN4
chloride voltage-gated channel 4
chr10_-_27240505 0.36 ENST00000375888.5
ENST00000676732.1
ACBD5
acyl-CoA binding domain containing 5
chr20_-_35147285 0.36 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr3_-_115071333 0.35 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_10420550 0.35 ENST00000381903.2
ENST00000396439.7
KLRC3
killer cell lectin like receptor C3
chr6_-_87095059 0.35 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr8_-_115492221 0.34 ENST00000518018.1
TRPS1
transcriptional repressor GATA binding 1
chr10_-_77638369 0.34 ENST00000372443.6
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr2_-_157444044 0.33 ENST00000264192.8
CYTIP
cytohesin 1 interacting protein
chrX_-_77634229 0.33 ENST00000675732.1
ATRX
ATRX chromatin remodeler
chr15_-_19988117 0.32 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr16_+_14708944 0.32 ENST00000526520.5
ENST00000531598.6
NPIPA3
nuclear pore complex interacting protein family member A3
chr5_+_68292562 0.31 ENST00000523872.1
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chrX_-_15314543 0.31 ENST00000344384.8
ASB11
ankyrin repeat and SOCS box containing 11
chr10_-_28282086 0.31 ENST00000375719.7
ENST00000375732.5
MPP7
membrane palmitoylated protein 7
chr3_-_132684685 0.31 ENST00000512094.5
ENST00000632629.1
NPHP3
NPHP3-ACAD11
nephrocystin 3
NPHP3-ACAD11 readthrough (NMD candidate)
chr8_-_92103217 0.31 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr10_+_62374361 0.30 ENST00000395254.8
ZNF365
zinc finger protein 365
chr2_+_161136901 0.30 ENST00000259075.6
ENST00000432002.5
TANK
TRAF family member associated NFKB activator
chr3_+_138621207 0.29 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr4_-_117085541 0.29 ENST00000310754.5
TRAM1L1
translocation associated membrane protein 1 like 1
chr18_+_6834473 0.29 ENST00000581099.5
ENST00000419673.6
ENST00000531294.5
ARHGAP28
Rho GTPase activating protein 28
chr12_+_59664677 0.29 ENST00000548610.5
SLC16A7
solute carrier family 16 member 7
chr6_-_52994248 0.29 ENST00000457564.1
ENST00000370960.5
GSTA4
glutathione S-transferase alpha 4
chr4_+_112647059 0.28 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr10_-_77637902 0.28 ENST00000286627.10
ENST00000639486.1
ENST00000640523.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr12_+_8157034 0.28 ENST00000396570.7
ZNF705A
zinc finger protein 705A
chr10_-_13972355 0.27 ENST00000264546.10
FRMD4A
FERM domain containing 4A
chr21_-_30480364 0.27 ENST00000390689.3
KRTAP19-1
keratin associated protein 19-1
chr11_-_26572130 0.27 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr10_-_77637721 0.26 ENST00000638848.1
ENST00000639406.1
ENST00000618048.2
ENST00000639120.1
ENST00000640834.1
ENST00000639601.1
ENST00000638514.1
ENST00000457953.6
ENST00000639090.1
ENST00000639489.1
ENST00000372440.6
ENST00000404771.8
ENST00000638203.1
ENST00000638306.1
ENST00000638351.1
ENST00000638606.1
ENST00000639591.1
ENST00000640182.1
ENST00000640605.1
ENST00000640141.1
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr11_-_117316230 0.26 ENST00000313005.11
ENST00000528053.5
BACE1
beta-secretase 1
chr7_+_130293134 0.26 ENST00000445470.6
ENST00000492072.5
ENST00000222482.10
ENST00000473956.5
ENST00000493259.5
ENST00000486598.1
CPA4
carboxypeptidase A4
chr10_-_77637789 0.26 ENST00000481070.1
ENST00000640969.1
ENST00000286628.14
ENST00000638991.1
ENST00000639913.1
ENST00000480683.2
KCNMA1
potassium calcium-activated channel subfamily M alpha 1
chr5_+_55160161 0.25 ENST00000296734.6
ENST00000515370.1
ENST00000503787.6
GPX8
glutathione peroxidase 8 (putative)
chr5_+_173918186 0.25 ENST00000657000.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr11_+_5689780 0.23 ENST00000379965.8
ENST00000454828.5
TRIM22
tripartite motif containing 22
chr14_+_34993240 0.23 ENST00000677647.1
SRP54
signal recognition particle 54
chrX_+_55717733 0.23 ENST00000414239.5
ENST00000374941.9
RRAGB
Ras related GTP binding B
chr11_+_92969651 0.23 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr2_+_108588286 0.23 ENST00000332345.10
LIMS1
LIM zinc finger domain containing 1
chr10_+_122560639 0.23 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
DMBT1
deleted in malignant brain tumors 1
chr7_-_93148345 0.23 ENST00000437805.5
ENST00000446959.5
ENST00000439952.5
ENST00000414791.5
ENST00000446033.1
ENST00000411955.5
ENST00000318238.9
SAMD9L
sterile alpha motif domain containing 9 like
chr15_+_67125707 0.23 ENST00000540846.6
SMAD3
SMAD family member 3
chr12_+_18242955 0.22 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr8_-_30812867 0.22 ENST00000518243.5
PPP2CB
protein phosphatase 2 catalytic subunit beta
chr9_+_18474206 0.22 ENST00000276935.6
ADAMTSL1
ADAMTS like 1
chrX_+_55717796 0.21 ENST00000262850.7
RRAGB
Ras related GTP binding B
chr5_+_141382702 0.21 ENST00000617050.1
ENST00000518325.2
PCDHGA7
protocadherin gamma subfamily A, 7
chr10_+_122560679 0.21 ENST00000657942.1
DMBT1
deleted in malignant brain tumors 1
chr5_+_173918216 0.21 ENST00000519467.1
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr1_-_53945584 0.21 ENST00000371377.3
HSPB11
heat shock protein family B (small) member 11
chr5_-_126595237 0.21 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr1_-_53945567 0.21 ENST00000371378.6
HSPB11
heat shock protein family B (small) member 11
chr14_-_89619118 0.21 ENST00000345097.8
ENST00000555855.5
ENST00000555353.5
FOXN3
forkhead box N3
chr8_+_12104389 0.21 ENST00000400085.7
ZNF705D
zinc finger protein 705D
chr10_+_122560751 0.21 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
DMBT1
deleted in malignant brain tumors 1
chr12_+_18262730 0.21 ENST00000675017.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr20_+_45416551 0.21 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr19_-_51417791 0.20 ENST00000353836.9
SIGLEC10
sialic acid binding Ig like lectin 10
chr7_+_100119607 0.19 ENST00000262932.5
CNPY4
canopy FGF signaling regulator 4
chr12_-_10435940 0.19 ENST00000381901.5
ENST00000381902.7
ENST00000539033.1
KLRC2
ENSG00000255641.1
killer cell lectin like receptor C2
novel protein
chr3_-_58627567 0.19 ENST00000649301.1
FAM107A
family with sequence similarity 107 member A
chr7_-_13986439 0.19 ENST00000443608.5
ENST00000438956.5
ETV1
ETS variant transcription factor 1
chr21_+_32298849 0.19 ENST00000303645.10
MRAP
melanocortin 2 receptor accessory protein
chr13_+_23570370 0.19 ENST00000403372.6
ENST00000248484.9
TNFRSF19
TNF receptor superfamily member 19
chr5_+_141392616 0.18 ENST00000398604.3
PCDHGA8
protocadherin gamma subfamily A, 8
chr9_+_122371014 0.18 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr6_-_52995170 0.18 ENST00000370959.1
ENST00000370963.9
GSTA4
glutathione S-transferase alpha 4
chr16_-_66549839 0.18 ENST00000527800.6
ENST00000677555.1
ENST00000563369.6
TK2
thymidine kinase 2
chr2_-_165203870 0.18 ENST00000639244.1
ENST00000409101.7
ENST00000668657.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr4_-_158159657 0.18 ENST00000590648.5
GASK1B
golgi associated kinase 1B
chr7_+_142800957 0.18 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr1_+_103617427 0.17 ENST00000423678.2
ENST00000414303.7
AMY2A
amylase alpha 2A
chr4_-_139280179 0.17 ENST00000398955.2
MGARP
mitochondria localized glutamic acid rich protein
chr1_+_84164962 0.17 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr9_-_96778053 0.17 ENST00000375231.5
ENST00000223428.9
ZNF510
zinc finger protein 510
chr6_+_113857333 0.17 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr12_+_26195313 0.17 ENST00000422622.3
SSPN
sarcospan
chr19_+_14583076 0.17 ENST00000547437.5
ENST00000417570.6
CLEC17A
C-type lectin domain containing 17A
chr16_-_66550091 0.17 ENST00000564917.5
ENST00000677420.1
TK2
thymidine kinase 2
chr21_-_30497160 0.17 ENST00000334058.3
KRTAP19-4
keratin associated protein 19-4
chr4_-_169612571 0.17 ENST00000507142.6
ENST00000510533.5
ENST00000439128.6
ENST00000511633.5
ENST00000512193.5
NEK1
NIMA related kinase 1
chr15_-_55365231 0.17 ENST00000568543.1
CCPG1
cell cycle progression 1
chr3_-_18438767 0.16 ENST00000454909.6
SATB1
SATB homeobox 1
chr5_-_88823763 0.16 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
MEF2C
myocyte enhancer factor 2C
chr4_+_70028452 0.16 ENST00000530128.5
ENST00000381057.3
ENST00000673563.1
HTN3
histatin 3
chr19_-_53254841 0.16 ENST00000601828.5
ENST00000599012.5
ENST00000598513.6
ENST00000598806.5
ZNF677
zinc finger protein 677
chr7_+_138460238 0.16 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr2_+_108621260 0.16 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chr1_-_1390943 0.16 ENST00000408952.8
CCNL2
cyclin L2
chr19_-_51417700 0.16 ENST00000529627.1
ENST00000439889.6
SIGLEC10
sialic acid binding Ig like lectin 10
chr2_+_54558348 0.16 ENST00000333896.5
SPTBN1
spectrin beta, non-erythrocytic 1
chr16_-_66550005 0.16 ENST00000527284.6
TK2
thymidine kinase 2
chr15_+_76336755 0.15 ENST00000290759.9
ISL2
ISL LIM homeobox 2
chr2_+_108607140 0.15 ENST00000410093.5
LIMS1
LIM zinc finger domain containing 1
chr5_+_141364153 0.15 ENST00000518069.2
PCDHGA5
protocadherin gamma subfamily A, 5
chr7_-_14903319 0.15 ENST00000403951.6
DGKB
diacylglycerol kinase beta
chr3_-_142000353 0.15 ENST00000499676.5
TFDP2
transcription factor Dp-2
chr10_+_87357720 0.14 ENST00000412718.3
ENST00000381697.7
NUTM2D
NUT family member 2D
chrX_+_77910656 0.14 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATP7A
PGK1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr2_+_26401909 0.14 ENST00000288710.7
DRC1
dynein regulatory complex subunit 1
chr5_+_141412979 0.14 ENST00000612503.1
ENST00000398610.3
PCDHGA10
protocadherin gamma subfamily A, 10
chr19_-_43883964 0.14 ENST00000587539.2
ZNF404
zinc finger protein 404
chr9_+_128787331 0.14 ENST00000223865.8
TBC1D13
TBC1 domain family member 13
chr2_+_209653171 0.14 ENST00000447185.5
MAP2
microtubule associated protein 2
chr3_+_38496467 0.14 ENST00000453767.1
EXOG
exo/endonuclease G
chr7_+_134891566 0.14 ENST00000424922.5
ENST00000495522.1
CALD1
caldesmon 1
chr1_-_204213943 0.14 ENST00000308302.4
GOLT1A
golgi transport 1A
chr15_+_94355956 0.14 ENST00000557742.1
MCTP2
multiple C2 and transmembrane domain containing 2
chr1_+_59310071 0.14 ENST00000371212.5
FGGY
FGGY carbohydrate kinase domain containing
chr11_+_121102666 0.14 ENST00000264037.2
TECTA
tectorin alpha
chr9_+_128787243 0.14 ENST00000372648.10
TBC1D13
TBC1 domain family member 13
chr4_+_186069144 0.13 ENST00000513189.1
ENST00000296795.8
TLR3
toll like receptor 3
chr21_+_37420299 0.13 ENST00000455097.6
ENST00000643854.1
ENST00000645424.1
ENST00000642309.1
ENST00000645774.1
ENST00000398956.2
DYRK1A
dual specificity tyrosine phosphorylation regulated kinase 1A
chr2_+_169584332 0.13 ENST00000414307.6
ENST00000433207.6
ENST00000678088.1
ENST00000676508.1
ENST00000260970.8
ENST00000409714.7
PPIG
peptidylprolyl isomerase G
chr12_+_57782742 0.13 ENST00000540550.6
ENST00000323833.12
ENST00000652027.2
ENST00000550559.5
ENST00000548851.5
ENST00000543727.5
ENST00000434359.5
ENST00000457189.1
TSFM
Ts translation elongation factor, mitochondrial
chr2_+_87748087 0.13 ENST00000359481.9
PLGLB2
plasminogen like B2
chr12_-_76423256 0.13 ENST00000546946.5
OSBPL8
oxysterol binding protein like 8
chr17_-_41467386 0.13 ENST00000225899.4
KRT32
keratin 32
chr14_-_106117159 0.13 ENST00000390601.3
IGHV3-11
immunoglobulin heavy variable 3-11
chrX_+_56729231 0.13 ENST00000637096.1
ENST00000374922.9
ENST00000423617.2
NBDY
negative regulator of P-body association
chr16_-_66550142 0.13 ENST00000417693.8
ENST00000299697.12
ENST00000451102.7
TK2
thymidine kinase 2
chr1_-_113871665 0.13 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr8_+_61287950 0.13 ENST00000519846.5
ENST00000325897.5
ENST00000523868.2
ENST00000518592.5
CLVS1
clavesin 1
chr10_+_89392546 0.13 ENST00000546318.2
ENST00000371804.4
IFIT1
interferon induced protein with tetratricopeptide repeats 1
chr9_+_34652167 0.13 ENST00000441545.7
ENST00000553620.5
IL11RA
interleukin 11 receptor subunit alpha
chr1_+_196819731 0.12 ENST00000320493.10
ENST00000367424.4
CFHR1
complement factor H related 1
chr14_+_61697622 0.12 ENST00000539097.2
HIF1A
hypoxia inducible factor 1 subunit alpha
chr11_-_122116215 0.12 ENST00000560104.2
BLID
BH3-like motif containing, cell death inducer
chr15_+_21651844 0.12 ENST00000623441.1
OR4N4C
olfactory receptor family 4 subfamily N member 4C
chr9_+_2015186 0.12 ENST00000357248.8
ENST00000450198.6
ENST00000634287.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_-_75455767 0.12 ENST00000360439.8
SIN3A
SIN3 transcription regulator family member A
chr4_-_151227881 0.12 ENST00000652233.1
ENST00000514152.5
SH3D19
SH3 domain containing 19
chr2_+_108588453 0.12 ENST00000393310.5
LIMS1
LIM zinc finger domain containing 1
chr9_-_21305313 0.12 ENST00000610521.2
IFNA5
interferon alpha 5
chr15_+_22094522 0.12 ENST00000328795.5
OR4N4
olfactory receptor family 4 subfamily N member 4
chr1_+_103749898 0.12 ENST00000622339.5
AMY1C
amylase alpha 1C
chr15_-_56465130 0.11 ENST00000260453.4
MNS1
meiosis specific nuclear structural 1
chr8_+_12108172 0.11 ENST00000400078.3
ZNF705D
zinc finger protein 705D
chr5_+_42548043 0.11 ENST00000618088.4
ENST00000612382.4
GHR
growth hormone receptor
chr5_+_58491427 0.11 ENST00000396776.6
ENST00000502276.6
ENST00000511930.2
GAPT
GRB2 binding adaptor protein, transmembrane
chr12_+_75480745 0.11 ENST00000266659.8
GLIPR1
GLI pathogenesis related 1
chr10_-_88851809 0.11 ENST00000371930.5
ANKRD22
ankyrin repeat domain 22
chr5_+_58491451 0.11 ENST00000513924.2
ENST00000515443.2
GAPT
GRB2 binding adaptor protein, transmembrane
chr11_-_2141238 0.11 ENST00000434045.6
IGF2
insulin like growth factor 2
chr9_+_2015335 0.11 ENST00000636559.1
ENST00000349721.8
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr15_+_64387828 0.11 ENST00000261884.8
TRIP4
thyroid hormone receptor interactor 4
chr6_+_10521337 0.11 ENST00000495262.7
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr4_-_162163955 0.11 ENST00000379164.8
FSTL5
follistatin like 5
chr5_+_43602648 0.11 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
NNT
nicotinamide nucleotide transhydrogenase
chr17_-_82037677 0.11 ENST00000581584.5
ENST00000577712.5
ENST00000582900.5
ENST00000579155.1
ENST00000306869.7
DCXR
dicarbonyl and L-xylulose reductase
chr5_+_141150012 0.11 ENST00000231136.4
ENST00000622991.1
PCDHB6
protocadherin beta 6
chr6_+_28124596 0.11 ENST00000340487.5
ZSCAN16
zinc finger and SCAN domain containing 16
chr5_+_102808057 0.10 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr12_+_26011713 0.10 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr11_-_26572254 0.10 ENST00000529533.6
MUC15
mucin 15, cell surface associated
chrX_+_43656289 0.10 ENST00000338702.4
MAOA
monoamine oxidase A
chr21_+_14216145 0.10 ENST00000400577.4
RBM11
RNA binding motif protein 11
chr13_-_109786567 0.10 ENST00000375856.5
IRS2
insulin receptor substrate 2
chr9_+_72577369 0.10 ENST00000651183.1
TMC1
transmembrane channel like 1
chr10_-_24706622 0.10 ENST00000680286.1
ARHGAP21
Rho GTPase activating protein 21
chr20_+_1118590 0.10 ENST00000246015.8
ENST00000335877.11
PSMF1
proteasome inhibitor subunit 1
chr18_-_712618 0.10 ENST00000647584.2
ENST00000583771.1
ENST00000383578.7
ENOSF1
enolase superfamily member 1
chr12_-_7444139 0.10 ENST00000416109.2
ENST00000313599.8
CD163L1
CD163 molecule like 1
chr6_+_52423680 0.10 ENST00000538167.2
EFHC1
EF-hand domain containing 1
chr16_-_66550112 0.10 ENST00000544898.6
ENST00000620035.5
ENST00000545043.6
TK2
thymidine kinase 2
chr6_-_145735964 0.10 ENST00000640980.1
ENST00000639423.1
ENST00000611340.5
EPM2A
EPM2A glucan phosphatase, laforin

Network of associatons between targets according to the STRING database.

First level regulatory network of DBX2_HLX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 1.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.2 0.5 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 2.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.4 GO:0061182 negative regulation of chondrocyte development(GO:0061182)
0.1 0.9 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.5 GO:0034699 transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699)
0.1 0.7 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.1 0.4 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.1 0.3 GO:0034092 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.1 1.1 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 1.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.1 0.2 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.1 0.2 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.1 0.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.4 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.8 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly(GO:0010607)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.2 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.3 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.7 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0070409 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.3 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0034343 microglial cell activation involved in immune response(GO:0002282) regulation of dendritic cell cytokine production(GO:0002730) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.0 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.0 GO:0072573 tolerance induction to lipopolysaccharide(GO:0072573)
0.0 0.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:1904424 regulation of GTP binding(GO:1904424)
0.0 0.1 GO:0070101 B-1 B cell homeostasis(GO:0001922) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) negative regulation of thymocyte apoptotic process(GO:0070244)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.1 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.1 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.2 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.7 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.5 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 0.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.0 0.4 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.3 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 0.2 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.4 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.8 GO:0043203 axon hillock(GO:0043203)
0.0 1.2 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 0.9 GO:0031941 filamentous actin(GO:0031941)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0019770 IgG receptor activity(GO:0019770)
0.2 0.6 GO:0035375 zymogen binding(GO:0035375)
0.2 0.5 GO:0004339 glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.1 1.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 0.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.2 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.1 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 1.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.2 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.4 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 4.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.0 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.0 GO:0033265 choline binding(GO:0033265)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine