Project

avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

Navigation
Downloads

Results for DDIT3

Z-value: 0.39

Motif logo

logo of

Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.13 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg38_v1_chr12_-_57520480_575205210.137.6e-01Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_157436842 0.33 ENST00000295927.4
PTX3
pentraxin 3
chr7_-_56034133 0.24 ENST00000421626.5
PSPH
phosphoserine phosphatase
chr3_+_12351493 0.21 ENST00000683699.1
PPARG
peroxisome proliferator activated receptor gamma
chr3_+_12351470 0.20 ENST00000287820.10
PPARG
peroxisome proliferator activated receptor gamma
chr9_+_78297143 0.20 ENST00000347159.6
PSAT1
phosphoserine aminotransferase 1
chr9_+_78297117 0.16 ENST00000376588.4
PSAT1
phosphoserine aminotransferase 1
chr8_-_92017292 0.15 ENST00000521553.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr20_+_56412249 0.15 ENST00000679887.1
ENST00000434344.2
CASS4
Cas scaffold protein family member 4
chr20_+_56412112 0.13 ENST00000360314.7
CASS4
Cas scaffold protein family member 4
chr8_-_92017637 0.13 ENST00000422361.6
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr20_+_56412393 0.13 ENST00000679529.1
CASS4
Cas scaffold protein family member 4
chr11_+_20022550 0.12 ENST00000533917.5
NAV2
neuron navigator 2
chr15_+_40953463 0.11 ENST00000617768.5
CHAC1
ChaC glutathione specific gamma-glutamylcyclotransferase 1
chr19_-_6604083 0.11 ENST00000597430.2
CD70
CD70 molecule
chr8_+_27771942 0.10 ENST00000523566.5
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr1_+_113905156 0.10 ENST00000650596.1
DCLRE1B
DNA cross-link repair 1B
chr17_-_37542361 0.08 ENST00000614196.1
SYNRG
synergin gamma
chr11_+_62728069 0.08 ENST00000530625.5
TTC9C
tetratricopeptide repeat domain 9C
chr12_-_24949026 0.08 ENST00000539780.5
ENST00000546285.1
ENST00000342945.9
ENST00000261192.12
BCAT1
branched chain amino acid transaminase 1
chr4_-_98657635 0.08 ENST00000515287.5
ENST00000511651.5
ENST00000505184.5
TSPAN5
tetraspanin 5
chr19_+_12806550 0.08 ENST00000221486.6
RNASEH2A
ribonuclease H2 subunit A
chr1_-_19923617 0.08 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr6_+_31927486 0.07 ENST00000442278.6
C2
complement C2
chrX_-_52517213 0.07 ENST00000375616.5
XAGE1B
X antigen family member 1B
chrX_+_9463272 0.07 ENST00000407597.7
ENST00000380961.5
ENST00000424279.6
TBL1X
transducin beta like 1 X-linked
chr2_-_43226594 0.07 ENST00000282388.4
ZFP36L2
ZFP36 ring finger protein like 2
chr3_+_44799187 0.07 ENST00000425755.5
KIF15
kinesin family member 15
chr6_+_31897775 0.07 ENST00000469372.5
ENST00000497706.5
C2
complement C2
chr8_-_18887018 0.06 ENST00000523619.5
PSD3
pleckstrin and Sec7 domain containing 3
chr17_-_81937221 0.06 ENST00000402252.6
ENST00000583564.5
ENST00000585244.1
ENST00000337943.9
ENST00000579698.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr12_-_12338674 0.06 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr17_-_79839387 0.06 ENST00000448310.1
ENST00000269397.9
CBX4
chromobox 4
chr17_-_81937277 0.06 ENST00000405481.8
ENST00000329875.13
ENST00000585215.5
PYCR1
pyrroline-5-carboxylate reductase 1
chr17_-_81937320 0.06 ENST00000577624.5
ENST00000403172.8
ENST00000619204.4
ENST00000629768.2
PYCR1
pyrroline-5-carboxylate reductase 1
chr18_-_63158208 0.06 ENST00000678301.1
BCL2
BCL2 apoptosis regulator
chr2_-_40453438 0.06 ENST00000455476.5
SLC8A1
solute carrier family 8 member A1
chr4_+_157076119 0.06 ENST00000541722.5
ENST00000264428.9
ENST00000512619.5
GLRB
glycine receptor beta
chr2_+_226835936 0.05 ENST00000341329.7
ENST00000437454.5
ENST00000443477.5
ENST00000423616.1
ENST00000392062.7
ENST00000448992.5
RHBDD1
rhomboid domain containing 1
chr20_-_33004307 0.05 ENST00000420875.5
ENST00000375519.2
ENST00000375523.7
ENST00000356173.8
SUN5
Sad1 and UNC84 domain containing 5
chr5_-_178590367 0.05 ENST00000390654.8
COL23A1
collagen type XXIII alpha 1 chain
chr2_+_168901290 0.05 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr11_+_47257953 0.05 ENST00000437276.1
ENST00000436029.5
ENST00000467728.5
ENST00000441012.7
ENST00000405853.7
NR1H3
nuclear receptor subfamily 1 group H member 3
chr5_+_72848161 0.05 ENST00000506351.6
TNPO1
transportin 1
chr9_+_109780292 0.05 ENST00000374530.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr8_+_24294107 0.05 ENST00000437154.6
ADAM28
ADAM metallopeptidase domain 28
chr1_+_154257071 0.05 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2 like
chr3_-_56468346 0.05 ENST00000288221.11
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr11_-_33892010 0.05 ENST00000257818.3
LMO2
LIM domain only 2
chr1_+_33081145 0.05 ENST00000294517.11
ENST00000373443.7
AZIN2
antizyme inhibitor 2
chr2_+_113067970 0.05 ENST00000341010.6
IL1F10
interleukin 1 family member 10
chrX_+_52495791 0.05 ENST00000375602.2
ENST00000375600.5
XAGE1A
X antigen family member 1A
chr11_-_10294194 0.04 ENST00000676387.1
ENST00000256190.13
ENST00000675281.1
SBF2
SET binding factor 2
chr14_+_32329256 0.04 ENST00000280979.9
AKAP6
A-kinase anchoring protein 6
chr12_-_62935117 0.04 ENST00000228705.7
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent 1H
chr14_-_55191534 0.04 ENST00000395425.6
ENST00000247191.7
DLGAP5
DLG associated protein 5
chr10_-_90921079 0.04 ENST00000371697.4
ANKRD1
ankyrin repeat domain 1
chr1_+_61203496 0.04 ENST00000663597.1
NFIA
nuclear factor I A
chr8_+_117134989 0.04 ENST00000456015.7
SLC30A8
solute carrier family 30 member 8
chr1_-_113905020 0.04 ENST00000432415.5
ENST00000369571.2
ENST00000256658.8
ENST00000369564.5
AP4B1
adaptor related protein complex 4 subunit beta 1
chr1_+_174875505 0.04 ENST00000486220.5
RABGAP1L
RAB GTPase activating protein 1 like
chr1_-_113904789 0.04 ENST00000369569.6
ENST00000369567.5
AP4B1
adaptor related protein complex 4 subunit beta 1
chr11_+_114296347 0.04 ENST00000299964.4
NNMT
nicotinamide N-methyltransferase
chr17_-_35930767 0.04 ENST00000619262.4
ENST00000620284.5
RDM1
RAD52 motif containing 1
chr2_-_63588390 0.03 ENST00000272321.12
ENST00000409562.7
WDPCP
WD repeat containing planar cell polarity effector
chr8_+_117135259 0.03 ENST00000519688.5
SLC30A8
solute carrier family 30 member 8
chr15_+_85380625 0.03 ENST00000560302.5
AKAP13
A-kinase anchoring protein 13
chr9_+_107283256 0.03 ENST00000358015.8
RAD23B
RAD23 homolog B, nucleotide excision repair protein
chr17_-_35930727 0.03 ENST00000616596.4
ENST00000612980.4
ENST00000613308.4
ENST00000619876.4
RDM1
RAD52 motif containing 1
chr13_+_32031706 0.03 ENST00000542859.6
FRY
FRY microtubule binding protein
chr5_+_154755272 0.03 ENST00000518297.6
LARP1
La ribonucleoprotein 1, translational regulator
chr5_+_119476530 0.03 ENST00000645099.1
ENST00000513628.5
HSD17B4
hydroxysteroid 17-beta dehydrogenase 4
chr15_-_63833911 0.03 ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
ENST00000443617.7
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr7_+_99408609 0.03 ENST00000403633.6
BUD31
BUD31 homolog
chr5_+_141364153 0.02 ENST00000518069.2
PCDHGA5
protocadherin gamma subfamily A, 5
chr8_+_26577843 0.02 ENST00000311151.9
DPYSL2
dihydropyrimidinase like 2
chr15_+_85380565 0.02 ENST00000559362.5
ENST00000394518.7
AKAP13
A-kinase anchoring protein 13
chr19_+_48755512 0.02 ENST00000593756.6
FGF21
fibroblast growth factor 21
chr14_+_21797272 0.02 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr8_+_24294044 0.02 ENST00000265769.9
ADAM28
ADAM metallopeptidase domain 28
chr16_-_70289480 0.02 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr7_+_90469634 0.02 ENST00000509356.2
PTTG1IP2
PTTG1IP family member 2
chr9_+_109780312 0.02 ENST00000483909.5
ENST00000413420.5
ENST00000302798.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr5_+_112738331 0.02 ENST00000512211.6
APC
APC regulator of WNT signaling pathway
chr11_+_62728465 0.02 ENST00000316461.9
TTC9C
tetratricopeptide repeat domain 9C
chr15_+_85380672 0.02 ENST00000361243.6
ENST00000560256.1
AKAP13
A-kinase anchoring protein 13
chrX_-_139642835 0.02 ENST00000536274.5
MCF2
MCF.2 cell line derived transforming sequence
chr7_+_99408958 0.02 ENST00000222969.10
BUD31
BUD31 homolog
chr14_+_32329341 0.02 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
AKAP6
A-kinase anchoring protein 6
chr3_+_190388120 0.02 ENST00000456423.2
ENST00000264734.3
CLDN16
claudin 16
chr10_-_17617235 0.02 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr7_-_99408548 0.02 ENST00000626285.1
ENST00000350498.8
PDAP1
PDGFA associated protein 1
chr11_+_34051722 0.01 ENST00000341394.9
ENST00000389645.7
CAPRIN1
cell cycle associated protein 1
chr10_+_100997040 0.01 ENST00000370223.7
LZTS2
leucine zipper tumor suppressor 2
chr4_+_183659267 0.01 ENST00000357207.8
ENST00000334690.11
TRAPPC11
trafficking protein particle complex 11
chrX_-_100874209 0.01 ENST00000372964.5
ENST00000217885.5
NOX1
NADPH oxidase 1
chr3_-_149221811 0.01 ENST00000455472.3
ENST00000264613.11
CP
ceruloplasmin
chr19_+_10625507 0.01 ENST00000590857.5
ENST00000588688.5
ENST00000586078.5
ENST00000335757.10
SLC44A2
solute carrier family 44 member 2
chrX_-_40647509 0.01 ENST00000378421.1
ENST00000378426.5
ENST00000327877.10
CXorf38
chromosome X open reading frame 38
chr2_-_160493799 0.01 ENST00000348849.8
RBMS1
RNA binding motif single stranded interacting protein 1
chr22_-_30505650 0.01 ENST00000381982.3
ENST00000255858.12
SEC14L4
SEC14 like lipid binding 4
chr9_-_74887914 0.01 ENST00000360774.6
TRPM6
transient receptor potential cation channel subfamily M member 6
chr20_+_24949256 0.01 ENST00000480798.2
CST7
cystatin F
chr9_-_74887720 0.01 ENST00000449912.6
TRPM6
transient receptor potential cation channel subfamily M member 6
chr1_-_161307420 0.01 ENST00000491222.5
ENST00000672287.2
MPZ
myelin protein zero
chr10_-_24706622 0.01 ENST00000680286.1
ARHGAP21
Rho GTPase activating protein 21
chr19_+_40991274 0.01 ENST00000324071.10
CYP2B6
cytochrome P450 family 2 subfamily B member 6
chr2_-_215436061 0.01 ENST00000421182.5
ENST00000432072.6
ENST00000323926.10
ENST00000336916.8
ENST00000357867.8
ENST00000359671.5
ENST00000446046.5
ENST00000354785.11
ENST00000356005.8
ENST00000443816.5
ENST00000426059.1
FN1
fibronectin 1
chrX_-_139642889 0.01 ENST00000370576.9
MCF2
MCF.2 cell line derived transforming sequence
chr7_+_44000889 0.01 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr14_+_101809855 0.01 ENST00000557714.1
ENST00000445439.7
ENST00000334743.9
ENST00000557095.5
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr1_-_44355061 0.01 ENST00000649995.1
ENST00000457571.1
ENST00000372257.7
ENST00000452396.5
ERI3
ERI1 exoribonuclease family member 3
chr21_-_30492008 0.00 ENST00000334063.6
KRTAP19-3
keratin associated protein 19-3
chr6_-_157323498 0.00 ENST00000400788.9
ENST00000367144.4
TMEM242
transmembrane protein 242
chr20_+_6007245 0.00 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr6_+_150865815 0.00 ENST00000367308.8
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr2_-_178807415 0.00 ENST00000342992.10
ENST00000460472.6
ENST00000589042.5
ENST00000591111.5
ENST00000360870.10
TTN
titin
chr6_-_31897200 0.00 ENST00000395728.7
ENST00000375528.8
EHMT2
euchromatic histone lysine methyltransferase 2
chr5_+_146203544 0.00 ENST00000506502.2
ENSG00000275740.1
novel readthrough transcript
chr3_+_1093002 0.00 ENST00000446702.7
CNTN6
contactin 6
chr14_+_101809795 0.00 ENST00000350249.7
ENST00000557621.5
ENST00000556946.1
PPP2R5C
protein phosphatase 2 regulatory subunit B'gamma
chr1_-_36482904 0.00 ENST00000373106.6
CSF3R
colony stimulating factor 3 receptor
chr5_+_146203593 0.00 ENST00000265271.7
RBM27
RNA binding motif protein 27

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.3 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.1 0.4 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.1 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.1 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0031627 telomeric loop formation(GO:0031627)
0.0 0.0 GO:1902269 putrescine transport(GO:0015847) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.1 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.1 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.0 GO:0016476 regulation of embryonic cell shape(GO:0016476)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.2 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.0 GO:0015203 polyamine transmembrane transporter activity(GO:0015203) putrescine transmembrane transporter activity(GO:0015489)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)