Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for DUXA
Z-value: 1.69
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Transcription factors associated with DUXA
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91153149 Show fit | 4.39 |
ENST00000550758.1
|
decorin |
|
| chr9_-_92424427 Show fit | 1.70 |
ENST00000375550.5
|
osteomodulin |
|
| chr5_-_111976925 Show fit | 1.48 |
ENST00000395634.7
|
neuronal regeneration related protein |
|
| chr13_+_101489940 Show fit | 1.39 |
ENST00000376162.7
|
integrin subunit beta like 1 |
|
| chr10_+_68106109 Show fit | 1.23 |
ENST00000540630.5
ENST00000354393.6 |
myopalladin |
|
| chr5_-_151157722 Show fit | 1.19 |
ENST00000517486.5
ENST00000377751.9 ENST00000521512.5 ENST00000517757.5 ENST00000354546.10 |
annexin A6 |
|
| chr1_+_78490966 Show fit | 1.17 |
ENST00000370757.8
ENST00000370756.3 |
prostaglandin F receptor |
|
| chr1_+_78303865 Show fit | 0.93 |
ENST00000370758.5
|
prostaglandin F receptor |
|
| chr1_+_12857086 Show fit | 0.92 |
ENST00000240189.2
|
PRAME family member 2 |
|
| chr2_-_224947030 Show fit | 0.90 |
ENST00000409592.7
|
dedicator of cytokinesis 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.3 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 2.1 | GO:0071798 | response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799) |
| 0.1 | 1.9 | GO:0051560 | mitochondrial calcium ion homeostasis(GO:0051560) |
| 0.1 | 1.8 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.1 | 1.7 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.4 | 1.5 | GO:0034699 | transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699) |
| 0.1 | 0.9 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.1 | 0.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 0.9 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.2 | 0.7 | GO:0002305 | gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 2.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.3 | 1.5 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.1 | 0.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 0.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.4 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.3 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 2.1 | GO:0004958 | prostaglandin F receptor activity(GO:0004958) |
| 0.0 | 1.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 1.5 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 1.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.9 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.7 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.0 | 0.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.6 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.6 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.5 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 2.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 1.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.5 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.4 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.4 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |