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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for E4F1

Z-value: 1.11

Motif logo

Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
ENSG00000167967.16 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg38_v1_chr16_+_2223555_22236360.334.3e-01Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_59604527 1.14 ENST00000371015.6
phosphatase and actin regulator 3
chr1_+_2073462 0.93 ENST00000400921.6
protein kinase C zeta
chr1_+_2073986 0.90 ENST00000461106.6
protein kinase C zeta
chr11_+_111540659 0.43 ENST00000375615.7
ENST00000525126.5
ENST00000375614.7
ENST00000533265.5
layilin
chr19_+_33796268 0.41 ENST00000587559.5
ENST00000588637.5
potassium channel tetramerization domain containing 15
chr17_-_4739866 0.38 ENST00000574412.6
ENST00000293778.12
C-X-C motif chemokine ligand 16
chr18_+_26226417 0.37 ENST00000269142.10
TATA-box binding protein associated factor 4b
chr2_-_60553558 0.36 ENST00000642439.1
ENST00000356842.9
BAF chromatin remodeling complex subunit BCL11A
chr7_+_30134956 0.36 ENST00000324453.13
ENST00000409688.1
maturin, neural progenitor differentiation regulator homolog
chr19_+_45001430 0.36 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB proto-oncogene, NF-kB subunit
chr8_-_94262308 0.35 ENST00000297596.3
ENST00000396194.6
GTP binding protein overexpressed in skeletal muscle
chr4_+_74445126 0.34 ENST00000395748.8
amphiregulin
chr8_-_65842051 0.33 ENST00000401827.8
phosphodiesterase 7A
chr6_+_139135063 0.31 ENST00000367658.3
hdc homolog, cell cycle regulator
chr7_-_36367141 0.31 ENST00000453212.5
ENST00000415803.2
ENST00000431396.1
ENST00000440378.6
ENST00000317020.10
ENST00000436884.5
KIAA0895
chr2_-_60553618 0.29 ENST00000643716.1
ENST00000359629.10
ENST00000642384.2
ENST00000335712.11
BAF chromatin remodeling complex subunit BCL11A
chr18_+_26226472 0.28 ENST00000578121.5
TATA-box binding protein associated factor 4b
chr4_+_74445302 0.28 ENST00000502307.1
amphiregulin
chr2_-_60553409 0.27 ENST00000358510.6
ENST00000643004.1
BAF chromatin remodeling complex subunit BCL11A
chr12_-_84911178 0.26 ENST00000681688.1
solute carrier family 6 member 15
chr2_-_219543793 0.26 ENST00000243776.11
chondroitin polymerizing factor
chr6_-_34696839 0.25 ENST00000374026.7
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr6_-_34696733 0.24 ENST00000374023.8
inflammation and lipid regulator with UBA-like and NBR1-like domains
chr1_+_26169891 0.23 ENST00000374266.7
ENST00000270812.6
zinc finger protein 593
chr16_+_81444799 0.23 ENST00000537098.8
c-Maf inducing protein
chr14_+_58637934 0.22 ENST00000395153.8
dishevelled binding antagonist of beta catenin 1
chr17_+_43398984 0.20 ENST00000320033.5
ADP ribosylation factor like GTPase 4D
chr10_-_49762276 0.20 ENST00000374103.9
oxoglutarate dehydrogenase L
chr14_-_22919124 0.19 ENST00000555209.5
ENST00000554256.5
ENST00000557403.5
ENST00000359890.8
ENST00000557549.5
ENST00000555676.5
ENST00000557571.5
ENST00000557464.5
ENST00000554618.5
ENST00000556862.5
ENST00000555722.5
ENST00000346528.9
ENST00000542016.6
ENST00000399922.6
ENST00000557227.5
RNA binding motif protein 23
chr7_-_129952631 0.18 ENST00000473814.6
ENST00000490974.1
ubiquitin conjugating enzyme E2 H
chr10_-_49762335 0.18 ENST00000419399.4
ENST00000432695.2
oxoglutarate dehydrogenase L
chr6_+_30061231 0.17 ENST00000376782.6
ENST00000359374.8
ENST00000376785.2
ENST00000332435.10
RNA polymerase I subunit H
chr17_+_28744034 0.16 ENST00000444415.7
ENST00000262396.10
TNF receptor associated factor 4
chr3_+_184335906 0.15 ENST00000450976.5
ENST00000418281.5
ENST00000340957.9
ENST00000433578.5
family with sequence similarity 131 member A
chr17_+_18183803 0.15 ENST00000399138.5
alkB homolog 5, RNA demethylase
chr17_+_4739791 0.14 ENST00000433935.6
zinc finger MYND-type containing 15
chr5_-_95961830 0.14 ENST00000513343.1
ENST00000237853.9
elongation factor for RNA polymerase II 2
chr7_-_129952901 0.14 ENST00000472396.5
ENST00000355621.8
ubiquitin conjugating enzyme E2 H
chr6_-_32844643 0.14 ENST00000374881.3
proteasome 20S subunit beta 8
chr19_-_42255119 0.13 ENST00000222329.9
ENST00000594664.1
ETS2 repressor factor
novel protein
chr17_-_38674940 0.13 ENST00000621654.2
elongin BC and polycomb repressive complex 2 associated protein
chr22_+_38705922 0.13 ENST00000216044.10
GTP binding protein 1
chr4_+_47485268 0.12 ENST00000273859.8
ENST00000504445.1
ATPase phospholipid transporting 10D (putative)
chr17_+_4740042 0.12 ENST00000592813.5
zinc finger MYND-type containing 15
chr17_+_4740005 0.12 ENST00000269289.10
zinc finger MYND-type containing 15
chr22_+_17638584 0.11 ENST00000337612.9
ENST00000418951.6
ENST00000538149.5
ENST00000543133.5
ENST00000611738.4
ENST00000616863.4
ENST00000618481.4
ENST00000317582.10
ENST00000493680.5
BCL2 like 13
chr1_-_8026283 0.11 ENST00000474874.5
ENST00000469499.5
ENST00000377482.10
ERBB receptor feedback inhibitor 1
chr22_+_17638796 0.11 ENST00000355028.4
BCL2 like 13
chr9_+_128882119 0.11 ENST00000372600.9
ENST00000372599.7
leucine rich repeat containing 8 VRAC subunit A
chr2_-_75199511 0.11 ENST00000305249.10
tachykinin receptor 1
chr14_+_100239121 0.11 ENST00000262238.10
YY1 transcription factor
chr3_+_150408314 0.11 ENST00000361875.7
TSC22 domain family member 2
chr9_+_128882502 0.10 ENST00000259324.5
leucine rich repeat containing 8 VRAC subunit A
chr11_-_77474087 0.09 ENST00000356341.8
p21 (RAC1) activated kinase 1
chr10_+_133308874 0.09 ENST00000361518.10
ENST00000359035.4
zinc finger protein 511
chr19_+_52190006 0.09 ENST00000454220.6
ENST00000322088.11
ENST00000477989.1
ENST00000628959.1
protein phosphatase 2 scaffold subunit Aalpha
chr3_-_108222362 0.09 ENST00000492106.1
intraflagellar transport 57
chr12_+_121712740 0.09 ENST00000449592.7
transmembrane protein 120B
chr6_-_31806937 0.09 ENST00000375661.6
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr16_+_29900474 0.09 ENST00000308748.10
aspartate beta-hydroxylase domain containing 1
chr2_+_74958635 0.09 ENST00000483063.2
DNA polymerase epsilon 4, accessory subunit
chr6_+_32844789 0.09 ENST00000414474.5
proteasome 20S subunit beta 9
chr6_+_15248855 0.08 ENST00000397311.4
jumonji and AT-rich interaction domain containing 2
chr16_+_68023276 0.08 ENST00000567100.5
ENST00000565263.6
ENST00000432752.5
ENST00000569289.5
ENST00000564781.1
dihydrouridine synthase 2
chr16_+_68023249 0.08 ENST00000358896.10
ENST00000568099.6
dihydrouridine synthase 2
chr11_-_77474041 0.08 ENST00000278568.8
p21 (RAC1) activated kinase 1
chr19_-_29213110 0.08 ENST00000304863.6
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr17_+_57256727 0.08 ENST00000675656.1
musashi RNA binding protein 2
chr16_-_3717505 0.08 ENST00000538171.5
ENST00000246957.10
TNF receptor associated protein 1
chr17_-_15999634 0.08 ENST00000472495.5
zinc finger SWIM-type containing 7
chr22_-_40856565 0.08 ENST00000620312.4
ENST00000216218.8
ST13 Hsp70 interacting protein
chr2_+_218880844 0.07 ENST00000258411.8
Wnt family member 10A
chr1_-_31644866 0.07 ENST00000373703.5
penta-EF-hand domain containing 1
chr20_-_45791865 0.07 ENST00000243938.9
WAP four-disulfide core domain 3
chr11_+_66421004 0.07 ENST00000639555.1
ENST00000311034.7
neuronal PAS domain protein 4
chr7_-_100428657 0.07 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
zinc finger CW-type and PWWP domain containing 1
chr10_+_63133279 0.07 ENST00000277746.11
nuclear receptor binding factor 2
chr14_+_60249191 0.07 ENST00000395076.9
protein phosphatase, Mg2+/Mn2+ dependent 1A
chr12_-_93441886 0.07 ENST00000552442.1
ENST00000550657.1
ENST00000318066.7
ubiquitin conjugating enzyme E2 N
chr7_-_140924900 0.07 ENST00000646891.1
ENST00000644969.2
B-Raf proto-oncogene, serine/threonine kinase
chr1_+_180230257 0.06 ENST00000263726.4
LIM homeobox 4
chr1_+_109984756 0.06 ENST00000393614.8
ENST00000369799.10
adenosylhomocysteinase like 1
chr6_+_47477731 0.06 ENST00000359314.5
CD2 associated protein
chr14_+_94026314 0.06 ENST00000203664.10
ENST00000553723.1
OTU deubiquitinase, ubiquitin aldehyde binding 2
chr9_-_96619783 0.06 ENST00000375241.6
cell division cycle 14B
chr18_+_22933321 0.06 ENST00000327155.10
RB binding protein 8, endonuclease
chr9_-_128881922 0.06 ENST00000320665.10
ENST00000436267.7
ENST00000302586.8
ENST00000651925.1
kynurenine aminotransferase 1
kynurenine aminotransferase 1
chr10_+_132537814 0.05 ENST00000368593.7
inositol polyphosphate-5-phosphatase A
chr5_-_134371004 0.05 ENST00000521755.1
ENST00000523054.5
ENST00000518409.1
cyclin dependent kinase like 3
novel transcript
chr12_+_53985138 0.05 ENST00000303460.5
homeobox C10
chrX_-_153971810 0.05 ENST00000310441.12
host cell factor C1
chr3_+_101574157 0.05 ENST00000265260.8
ENST00000469941.5
ENST00000627393.1
PEST proteolytic signal containing nuclear protein
chr6_-_144095556 0.05 ENST00000367569.4
splicing factor 3b subunit 5
chr14_-_49586325 0.05 ENST00000557519.1
ENST00000396020.7
ENST00000554075.2
ENST00000245458.11
ribosomal protein S29
chr10_+_132537778 0.05 ENST00000368594.8
inositol polyphosphate-5-phosphatase A
chr18_+_48539112 0.05 ENST00000382998.8
cap binding complex dependent translation initiation factor
chr1_+_85062304 0.04 ENST00000326813.12
ENST00000528899.5
ENST00000294664.11
dynein axonemal intermediate chain 3
chr14_-_39432414 0.04 ENST00000554932.1
ENST00000298097.7
F-box protein 33
chr6_-_162727748 0.04 ENST00000366892.5
ENST00000366898.6
ENST00000366897.5
ENST00000366896.5
ENST00000674250.1
parkin RBR E3 ubiquitin protein ligase
chr10_+_117241107 0.04 ENST00000644641.2
solute carrier family 18 member A2
chr18_+_48539017 0.04 ENST00000256413.8
cap binding complex dependent translation initiation factor
chr9_-_122264798 0.03 ENST00000417201.4
RNA binding motif protein 18
chr11_+_3797819 0.03 ENST00000396986.6
ENST00000300730.10
ENST00000396993.8
ENST00000532523.5
ENST00000459679.5
ENST00000464229.5
ENST00000464261.5
ENST00000490830.5
ENST00000464906.6
ENST00000464441.5
post-GPI attachment to proteins 2
chr4_-_110636963 0.03 ENST00000394595.8
paired like homeodomain 2
chr11_+_809961 0.03 ENST00000321153.9
ENST00000530797.5
ribosomal protein lateral stalk subunit P2
chr9_-_96619378 0.03 ENST00000375240.7
ENST00000463569.5
cell division cycle 14B
chr2_-_61888570 0.03 ENST00000394440.8
ENST00000544079.2
chaperonin containing TCP1 subunit 4
chr6_-_7389709 0.03 ENST00000296742.11
ENST00000502583.6
cancer antigen 1
chr7_-_87220567 0.03 ENST00000433078.5
transmembrane protein 243
chr19_+_42076129 0.03 ENST00000359044.5
zinc finger protein 574
chr10_+_63133247 0.03 ENST00000435510.6
nuclear receptor binding factor 2
chr11_+_810227 0.03 ENST00000530398.1
ribosomal protein lateral stalk subunit P2
chr3_+_185586270 0.03 ENST00000296257.10
SUMO specific peptidase 2
chr16_-_46973634 0.03 ENST00000317089.10
DnaJ heat shock protein family (Hsp40) member A2
chr19_+_54200849 0.02 ENST00000626547.2
ENST00000302907.9
ENST00000391752.5
ENST00000402367.5
ENST00000391751.7
ribosomal protein S9
chr17_+_28744002 0.02 ENST00000618771.1
ENST00000262395.10
ENST00000422344.5
TNF receptor associated factor 4
chr17_+_7572818 0.02 ENST00000293831.13
ENST00000582169.5
ENST00000578754.5
ENST00000578495.5
ENST00000585024.5
ENST00000583802.5
ENST00000577269.5
ENST00000584784.5
ENST00000582746.5
ENST00000581621.1
eukaryotic translation initiation factor 4A1
novel transcript
chr1_+_63322558 0.02 ENST00000371116.4
forkhead box D3
chr1_-_228103235 0.02 ENST00000272139.5
chromosome 1 open reading frame 35
chr3_-_108222383 0.02 ENST00000264538.4
intraflagellar transport 57
chr19_+_3506355 0.02 ENST00000652521.1
fizzy and cell division cycle 20 related 1
chr3_+_38165484 0.02 ENST00000446845.5
ENST00000311806.8
oxidative stress responsive kinase 1
chr9_+_122264857 0.02 ENST00000344641.8
ENST00000441707.5
ENST00000373723.9
ENST00000373729.5
mitochondrial ribosome recycling factor
chr2_-_240025299 0.02 ENST00000404554.5
ENST00000407129.3
ENST00000307300.8
ENST00000678455.1
ENST00000444548.6
ENST00000252711.7
ENST00000620965.5
ENST00000443626.5
NADH:ubiquinone oxidoreductase subunit A10
chr9_+_122264603 0.02 ENST00000297908.7
mitochondrial ribosome recycling factor
chr11_+_67606894 0.01 ENST00000532303.5
ENST00000532244.5
ENST00000528328.1
ENST00000322776.11
ENST00000529927.5
ENST00000532343.5
ENST00000415352.6
ENST00000533075.5
ENST00000529867.5
ENST00000530638.1
NADH:ubiquinone oxidoreductase core subunit V1
chr22_+_40857076 0.01 ENST00000614001.1
ENST00000357137.9
X-prolyl aminopeptidase 3
chr11_-_6612141 0.01 ENST00000527248.2
ENST00000299424.9
TATA-box binding protein associated factor 10
chr5_-_133612524 0.01 ENST00000265342.12
follistatin like 4
chr6_+_63572472 0.01 ENST00000370651.7
ENST00000626021.3
novel protein
protein tyrosine phosphatase 4A1
chr16_-_68023201 0.01 ENST00000332395.7
DEAD-box helicase 28
chr19_+_1941118 0.01 ENST00000255641.13
casein kinase 1 gamma 2
chr6_+_26204552 0.01 ENST00000615164.2
H4 clustered histone 5
chr21_-_39349048 0.01 ENST00000380748.5
ENST00000380749.10
high mobility group nucleosome binding domain 1
chr6_+_7389774 0.01 ENST00000379834.7
RIO kinase 1
chr1_-_16156059 0.01 ENST00000358432.8
EPH receptor A2
chr17_+_41688879 0.00 ENST00000469257.2
ENST00000591776.5
eukaryotic translation initiation factor 1
chr12_+_122078740 0.00 ENST00000319080.12
MLX interacting protein
chr20_-_45972171 0.00 ENST00000322927.3
zinc finger protein 335

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 0.9 GO:1904799 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 0.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.6 GO:0060750 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.2 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:1903537 meiotic spindle elongation(GO:0051232) meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.0 0.2 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.2 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.5 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.3 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.2 GO:0061052 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.0 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.0 0.7 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.0 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.0 GO:0060578 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0043203 axon hillock(GO:0043203)
0.0 0.4 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.0 GO:0097196 Shu complex(GO:0097196)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.1 GO:0070449 elongin complex(GO:0070449)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.1 0.2 GO:0000035 acyl binding(GO:0000035)
0.1 0.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1 0.4 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0005298 proline:sodium symporter activity(GO:0005298)
0.0 0.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.1 GO:0047804 cysteine-S-conjugate beta-lyase activity(GO:0047804) L-phenylalanine aminotransferase activity(GO:0070546)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening