Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for EOMES
Z-value: 1.27
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Transcription factors associated with EOMES
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EOMES | hg38_v1_chr3_-_27722699_27722717 | 0.71 | 4.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_20192928 Show fit | 0.95 |
ENST00000382848.5
|
gap junction protein beta 2 |
|
| chr20_-_18057841 Show fit | 0.78 |
ENST00000278780.7
|
ovo like zinc finger 2 |
|
| chr15_-_83284645 Show fit | 0.74 |
ENST00000345382.7
|
basonuclin 1 |
|
| chr10_+_93893931 Show fit | 0.71 |
ENST00000371408.7
ENST00000427197.2 |
solute carrier family 35 member G1 |
|
| chr5_+_66828762 Show fit | 0.71 |
ENST00000490016.6
ENST00000403666.5 ENST00000450827.5 |
microtubule associated serine/threonine kinase family member 4 |
|
| chr1_+_14929734 Show fit | 0.70 |
ENST00000376028.8
ENST00000400798.6 |
kazrin, periplakin interacting protein |
|
| chr22_-_37188281 Show fit | 0.69 |
ENST00000397110.6
|
C1q and TNF related 6 |
|
| chr1_-_12616762 Show fit | 0.62 |
ENST00000464917.5
|
dehydrogenase/reductase 3 |
|
| chr2_+_17541157 Show fit | 0.60 |
ENST00000406397.1
|
visinin like 1 |
|
| chr1_-_206921867 Show fit | 0.60 |
ENST00000628511.2
ENST00000367091.8 |
Fc fragment of IgM receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of EOMES
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 1.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 1.2 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 1.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 1.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.2 | 0.9 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) |
| 0.1 | 0.9 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.2 | 0.8 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.2 | 0.8 | GO:0098904 | regulation of AV node cell action potential(GO:0098904) |
| 0.1 | 0.8 | GO:0060214 | endocardium formation(GO:0060214) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.9 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.0 | 0.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.1 | 0.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 0.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.5 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.4 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.4 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 1.0 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.9 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.9 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.7 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
| 0.1 | 0.7 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.2 | 0.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 0.6 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 0.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 0.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.5 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.4 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |