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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for FIGLA

Z-value: 1.91

Motif logo

Transcription factors associated with FIGLA

Gene Symbol Gene ID Gene Info
ENSG00000183733.6 folliculogenesis specific bHLH transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FIGLAhg38_v1_chr2_-_70790643_70790643-0.373.6e-01Click!

Activity profile of FIGLA motif

Sorted Z-values of FIGLA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_136550407 1.93 ENST00000354570.8
microtubule associated protein 7
chr17_+_9645502 1.50 ENST00000285199.12
ubiquitin specific peptidase 43
chr1_+_183186238 1.42 ENST00000493293.5
ENST00000264144.5
laminin subunit gamma 2
chr17_-_41118369 1.39 ENST00000391413.4
keratin associated protein 4-11
chr8_+_32548303 1.24 ENST00000650967.1
neuregulin 1
chr13_-_20192928 1.24 ENST00000382848.5
gap junction protein beta 2
chr19_+_35248375 1.18 ENST00000602122.5
lipolysis stimulated lipoprotein receptor
chr8_-_126557691 1.16 ENST00000652209.1
LRAT domain containing 2
chr19_+_35248656 1.14 ENST00000621372.4
lipolysis stimulated lipoprotein receptor
chr19_+_35248694 1.13 ENST00000361790.7
lipolysis stimulated lipoprotein receptor
chr19_+_35248879 1.13 ENST00000347609.8
lipolysis stimulated lipoprotein receptor
chr19_+_35248728 1.12 ENST00000602003.1
ENST00000360798.7
ENST00000354900.7
lipolysis stimulated lipoprotein receptor
chr19_-_50952942 1.12 ENST00000594846.1
ENST00000336334.8
kallikrein related peptidase 5
chr11_-_120120880 1.09 ENST00000526881.1
tripartite motif containing 29
chr7_+_148339452 1.09 ENST00000463592.3
contactin associated protein 2
chr8_+_32548210 1.08 ENST00000523079.5
ENST00000650919.1
neuregulin 1
chr11_-_118252279 1.00 ENST00000525386.5
ENST00000527472.1
ENST00000278949.9
myelin protein zero like 3
chr17_+_41226648 0.91 ENST00000377721.3
keratin associated protein 9-2
chr3_-_69386079 0.89 ENST00000398540.8
FERM domain containing 4B
chr17_-_41124178 0.89 ENST00000394014.2
keratin associated protein 4-12
chr1_-_161021096 0.88 ENST00000537746.1
ENST00000368026.11
F11 receptor
chr17_+_75525682 0.85 ENST00000392550.8
ENST00000167462.9
ENST00000375227.8
ENST00000578363.5
ENST00000579392.5
LLGL scribble cell polarity complex component 2
chr5_+_69492767 0.83 ENST00000681041.1
ENST00000680098.1
ENST00000680784.1
ENST00000396442.7
ENST00000681895.1
occludin
chr11_-_88337722 0.81 ENST00000677976.1
ENST00000528020.2
ENST00000393301.5
ENST00000529974.2
ENST00000227266.10
ENST00000678464.1
ENST00000679199.1
ENST00000527018.6
ENST00000679224.1
ENST00000678506.1
ENST00000678915.1
ENST00000524463.6
cathepsin C
chr14_+_75279637 0.81 ENST00000555686.1
ENST00000555672.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr17_-_7262343 0.75 ENST00000571881.2
ENST00000360325.11
claudin 7
chr17_+_41237998 0.72 ENST00000254072.7
keratin associated protein 9-8
chr5_-_1886938 0.72 ENST00000613726.4
iroquois homeobox 4
chr14_+_75280078 0.72 ENST00000555347.1
Fos proto-oncogene, AP-1 transcription factor subunit
chr16_+_67199509 0.71 ENST00000477898.5
engulfment and cell motility 3
chr1_-_12616762 0.69 ENST00000464917.5
dehydrogenase/reductase 3
chr8_-_80080816 0.68 ENST00000520527.5
ENST00000517427.5
ENST00000379097.7
ENST00000448733.3
tumor protein D52
chr1_-_54801290 0.67 ENST00000371276.9
tetratricopeptide repeat domain 22
chr7_+_18496162 0.67 ENST00000406072.5
histone deacetylase 9
chr6_+_18387326 0.66 ENST00000259939.4
ring finger protein 144B
chr4_+_105895458 0.66 ENST00000379987.7
nephronectin
chr6_-_39229465 0.64 ENST00000359534.4
potassium two pore domain channel subfamily K member 5
chr2_+_46297397 0.64 ENST00000263734.5
endothelial PAS domain protein 1
chr16_+_4795378 0.62 ENST00000588606.5
small integral membrane protein 22
chrX_-_33128360 0.61 ENST00000378677.6
dystrophin
chr5_-_141878396 0.61 ENST00000503492.5
ENST00000287008.8
ENST00000394536.4
protocadherin 1
chr16_+_4795357 0.60 ENST00000586005.6
small integral membrane protein 22
chr1_-_156705742 0.58 ENST00000368221.1
cellular retinoic acid binding protein 2
chr10_+_23694707 0.58 ENST00000376462.5
KIAA1217
chr15_+_90184912 0.58 ENST00000561085.1
ENST00000332496.10
semaphorin 4B
chr1_-_156705764 0.57 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr17_-_41140487 0.56 ENST00000345847.4
keratin associated protein 4-6
chr4_+_105895435 0.56 ENST00000453617.6
ENST00000427316.6
ENST00000514622.5
ENST00000305572.12
nephronectin
chr7_+_129144691 0.53 ENST00000486685.3
tetraspanin 33
chr20_-_22585451 0.50 ENST00000377115.4
forkhead box A2
chr2_-_75560893 0.49 ENST00000410113.5
ENST00000393913.8
eva-1 homolog A, regulator of programmed cell death
chr15_+_88638947 0.49 ENST00000559876.2
interferon stimulated exonuclease gene 20
chr1_+_155078829 0.48 ENST00000368408.4
ephrin A3
chr4_-_89836213 0.48 ENST00000618500.4
ENST00000508895.5
synuclein alpha
chr8_+_32548267 0.48 ENST00000356819.7
neuregulin 1
chr10_+_24466487 0.48 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr1_-_156705575 0.47 ENST00000368222.8
cellular retinoic acid binding protein 2
chr15_+_88639009 0.46 ENST00000306072.10
interferon stimulated exonuclease gene 20
chr14_-_81436447 0.45 ENST00000649389.1
ENST00000557055.5
stonin 2
chr17_-_41168219 0.45 ENST00000391356.4
keratin associated protein 4-3
chr22_-_37486357 0.44 ENST00000356998.8
ENST00000416983.7
ENST00000424765.2
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr11_-_123654581 0.44 ENST00000392770.6
ENST00000530277.5
ENST00000299333.8
sodium voltage-gated channel beta subunit 3
chr8_-_90082871 0.44 ENST00000265431.7
calbindin 1
chr10_+_24208774 0.44 ENST00000376456.8
ENST00000458595.5
ENST00000376452.7
ENST00000430453.6
KIAA1217
chr6_-_42142604 0.42 ENST00000356542.5
ENST00000341865.9
chromosome 6 open reading frame 132
chr3_+_50155024 0.41 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
semaphorin 3F
chr1_+_24319342 0.41 ENST00000361548.9
grainyhead like transcription factor 3
chr1_-_39901996 0.41 ENST00000397332.2
MYCL proto-oncogene, bHLH transcription factor
chr6_-_31582415 0.40 ENST00000429299.3
ENST00000446745.2
lymphotoxin beta
chr19_+_6464229 0.40 ENST00000600229.6
ENST00000356762.7
crumbs cell polarity complex component 3
chr1_+_24319511 0.40 ENST00000356046.6
grainyhead like transcription factor 3
chr11_+_44726811 0.40 ENST00000533202.5
ENST00000520358.7
ENST00000533080.5
ENST00000520999.6
tetraspanin 18
chr11_-_123654939 0.39 ENST00000657191.1
sodium voltage-gated channel beta subunit 3
chr16_-_84239750 0.39 ENST00000568181.1
potassium voltage-gated channel modifier subfamily G member 4
chr7_+_20330893 0.39 ENST00000222573.5
integrin subunit beta 8
chr19_+_6464491 0.39 ENST00000308243.7
crumbs cell polarity complex component 3
chr2_-_164841812 0.38 ENST00000652658.2
ENST00000444537.5
ENST00000414843.5
cordon-bleu WH2 repeat protein like 1
chr10_+_24209129 0.36 ENST00000376454.8
ENST00000635504.1
KIAA1217
chr2_-_162152404 0.36 ENST00000375497.3
glucagon
chr18_+_58045683 0.36 ENST00000592846.5
ENST00000675801.1
NEDD4 like E3 ubiquitin protein ligase
chr6_+_17281341 0.35 ENST00000379052.10
RNA binding motif protein 24
chr2_+_64454145 0.35 ENST00000238875.10
galectin like
chr18_+_31498168 0.35 ENST00000261590.13
ENST00000585206.1
ENST00000683654.1
desmoglein 2
chr5_+_142771119 0.34 ENST00000642734.1
Rho GTPase activating protein 26
chr7_+_18496269 0.34 ENST00000432645.6
histone deacetylase 9
chr18_+_50879056 0.34 ENST00000321341.11
ENST00000638937.1
ENST00000382927.3
ENST00000639850.1
ENST00000638410.1
ENST00000639255.1
ENST00000640965.1
malic enzyme 2
chr18_+_58045642 0.33 ENST00000676223.1
ENST00000675147.1
NEDD4 like E3 ubiquitin protein ligase
chr17_+_41249687 0.32 ENST00000334109.3
keratin associated protein 9-4
chr15_+_59438149 0.32 ENST00000288228.10
ENST00000559628.5
ENST00000557914.5
ENST00000560474.5
family with sequence similarity 81 member A
chr11_+_68312542 0.32 ENST00000294304.12
LDL receptor related protein 5
chr3_+_184249621 0.32 ENST00000324557.9
ENST00000402825.7
EEF1A lysine methyltransferase 4
EEF1AKMT4-ECE2 readthrough
chr5_-_16936231 0.32 ENST00000507288.1
ENST00000274203.13
ENST00000513610.6
myosin X
chr14_-_54902807 0.32 ENST00000543643.6
ENST00000536224.2
ENST00000395514.5
ENST00000491895.7
GTP cyclohydrolase 1
chr8_-_144358458 0.32 ENST00000331890.6
ENST00000455319.6
F-box and leucine rich repeat protein 6
chr8_-_98825628 0.31 ENST00000617590.1
ENST00000518165.5
ENST00000419617.7
serine/threonine kinase 3
chr1_+_101238090 0.31 ENST00000475289.2
sphingosine-1-phosphate receptor 1
chr17_-_4555371 0.31 ENST00000254718.9
ENST00000381556.6
MYB binding protein 1a
chr12_+_6200327 0.30 ENST00000610354.5
CD9 molecule
chr12_+_6200759 0.29 ENST00000645565.1
ENST00000382515.7
CD9 molecule
chr19_-_45768843 0.28 ENST00000560168.1
SIX homeobox 5
chr2_+_64453969 0.28 ENST00000464281.5
galectin like
chr11_-_44950151 0.28 ENST00000533940.5
ENST00000533937.1
tumor protein p53 inducible protein 11
chr19_-_15479469 0.28 ENST00000292609.8
ENST00000340880.5
peptidoglycan recognition protein 2
chr6_-_39322688 0.27 ENST00000437525.3
potassium two pore domain channel subfamily K member 16
chr7_-_157010615 0.27 ENST00000252971.11
motor neuron and pancreas homeobox 1
chr4_-_109729956 0.27 ENST00000502283.1
phospholipase A2 group XIIA
chr6_+_41921491 0.26 ENST00000230340.9
bystin like
chr17_-_41178219 0.25 ENST00000377726.3
keratin associated protein 4-2
chr2_-_164841410 0.25 ENST00000342193.8
ENST00000375458.6
cordon-bleu WH2 repeat protein like 1
chr17_-_31297231 0.24 ENST00000247271.5
oligodendrocyte myelin glycoprotein
chr12_+_6200351 0.24 ENST00000679331.1
ENST00000382519.9
ENST00000009180.10
ENST00000536586.7
CD9 molecule
chr3_+_124584625 0.24 ENST00000291478.9
ENST00000682363.1
ENST00000454902.1
kalirin RhoGEF kinase
chr6_+_150683593 0.24 ENST00000644968.1
pleckstrin homology and RhoGEF domain containing G1
chr1_+_99850348 0.24 ENST00000361915.8
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr7_+_130380339 0.24 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
carboxypeptidase A1
chr17_-_41098084 0.24 ENST00000318329.6
ENST00000333822.5
keratin associated protein 4-8
chr17_+_7558774 0.24 ENST00000396545.4
TNF superfamily member 13
chr2_+_219442023 0.23 ENST00000431523.5
ENST00000396698.5
striated muscle enriched protein kinase
chr8_-_129939872 0.22 ENST00000519540.5
CYFIP related Rac1 interactor B
chr17_+_41105332 0.22 ENST00000391415.1
ENST00000617453.1
keratin associated protein 4-9
chr6_+_135181361 0.22 ENST00000527615.5
ENST00000420123.6
ENST00000525369.5
ENST00000528774.5
ENST00000533624.5
ENST00000534044.5
ENST00000534121.5
MYB proto-oncogene, transcription factor
chr8_-_28490220 0.22 ENST00000517673.5
ENST00000380254.7
ENST00000518734.5
ENST00000346498.6
F-box protein 16
chr18_-_55587335 0.22 ENST00000638154.3
transcription factor 4
chr6_+_135181323 0.22 ENST00000367814.8
MYB proto-oncogene, transcription factor
chrX_+_16786421 0.22 ENST00000398155.4
ENST00000380122.10
taxilin gamma
chr6_+_135181268 0.22 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr4_-_138242325 0.22 ENST00000280612.9
solute carrier family 7 member 11
chr19_-_53267723 0.22 ENST00000311170.5
vomeronasal 1 receptor 4
chr14_-_106324743 0.22 ENST00000390612.3
immunoglobulin heavy variable 4-28
chr1_+_99850485 0.22 ENST00000370165.7
ENST00000370163.7
ENST00000294724.8
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr11_+_118304721 0.21 ENST00000361763.9
CD3e molecule
chr11_-_62984690 0.21 ENST00000421062.2
ENST00000458333.6
solute carrier family 22 member 6
chr17_+_7558712 0.21 ENST00000338784.9
ENST00000625791.2
TNF superfamily member 13
chr2_-_219571529 0.21 ENST00000404537.6
obscurin like cytoskeletal adaptor 1
chr12_+_55931148 0.21 ENST00000549629.5
ENST00000555218.5
ENST00000331886.10
diacylglycerol kinase alpha
chr16_-_11915991 0.20 ENST00000420576.6
G1 to S phase transition 1
chr11_+_118304881 0.20 ENST00000528600.1
CD3e molecule
chr6_+_31827730 0.20 ENST00000375650.5
heat shock protein family A (Hsp70) member 1B
chr1_-_24415035 0.20 ENST00000374409.5
sperm tail PG-rich repeat containing 1
chr12_+_55932028 0.20 ENST00000394147.5
ENST00000551156.5
ENST00000553783.5
ENST00000557080.5
ENST00000432422.7
ENST00000556001.5
diacylglycerol kinase alpha
chr15_-_45378519 0.19 ENST00000558163.1
ENST00000396659.8
ENST00000675323.1
ENST00000558336.5
glycine amidinotransferase
chr6_-_39322540 0.19 ENST00000425054.6
ENST00000373227.8
ENST00000373229.9
potassium two pore domain channel subfamily K member 16
chr18_+_57352541 0.19 ENST00000324000.4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr5_+_76819022 0.19 ENST00000296677.5
F2R like trypsin receptor 1
chr15_+_45430579 0.19 ENST00000558435.5
ENST00000344300.3
ENST00000396650.7
chromosome 15 open reading frame 48
chr3_+_127915469 0.18 ENST00000407609.7
kelch repeat and BTB domain containing 12
chr8_-_129939694 0.18 ENST00000522250.5
ENST00000522941.5
ENST00000522746.5
ENST00000520204.5
ENST00000519070.5
ENST00000520254.5
ENST00000519824.6
CYFIP related Rac1 interactor B
chr19_+_42269219 0.18 ENST00000681038.1
capicua transcriptional repressor
chr17_-_41149823 0.17 ENST00000343246.6
keratin associated protein 4-5
chr11_-_35419213 0.17 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
solute carrier family 1 member 2
chr6_+_33204645 0.17 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr3_+_127915226 0.17 ENST00000405109.5
kelch repeat and BTB domain containing 12
chrX_+_71095838 0.17 ENST00000374259.8
forkhead box O4
chr16_-_53572 0.17 ENST00000293860.6
RNA polymerase III subunit K
chr12_+_121712740 0.16 ENST00000449592.7
transmembrane protein 120B
chr5_-_62403506 0.16 ENST00000680062.1
DIMT1 rRNA methyltransferase and ribosome maturation factor
chr7_-_11832190 0.16 ENST00000423059.9
ENST00000617773.1
thrombospondin type 1 domain containing 7A
chr8_-_101204697 0.16 ENST00000517844.5
zinc finger protein 706
chr16_+_83899079 0.16 ENST00000262430.6
malonyl-CoA decarboxylase
chr7_+_120273129 0.16 ENST00000331113.9
potassium voltage-gated channel subfamily D member 2
chr1_-_11060000 0.16 ENST00000376957.7
spermidine synthase
chr14_+_22226711 0.16 ENST00000390463.3
T cell receptor alpha variable 36/delta variable 7
chr9_+_133534697 0.15 ENST00000651351.2
ADAMTS like 2
chr6_+_31815532 0.15 ENST00000375651.7
ENST00000608703.1
heat shock protein family A (Hsp70) member 1A
chr7_-_149028651 0.15 ENST00000286091.9
protein disulfide isomerase family A member 4
chr17_-_47957824 0.15 ENST00000300557.3
proline rich 15 like
chr5_-_160312524 0.15 ENST00000520748.1
ENST00000257536.13
ENST00000393977.7
cyclin J like
chr13_+_27620945 0.15 ENST00000621089.2
RNA polymerase I and III subunit D
chr1_-_54801161 0.15 ENST00000371274.8
tetratricopeptide repeat domain 22
chr10_-_123008784 0.14 ENST00000368886.10
IKAROS family zinc finger 5
chr11_+_57753243 0.14 ENST00000524630.5
ENST00000529919.5
ENST00000533189.1
catenin delta 1
chr11_-_22625804 0.14 ENST00000327470.6
FA complementation group F
chr8_+_144358557 0.14 ENST00000530047.5
ENST00000527078.6
ENST00000674870.1
ENST00000526338.7
ENST00000402965.5
ENST00000329994.7
ENST00000526752.3
ENST00000533662.2
ENST00000534725.6
ENST00000674929.1
ENST00000675597.1
ENST00000643944.2
ENST00000675121.1
solute carrier family 52 member 2
chr7_-_149028452 0.14 ENST00000413966.1
ENST00000652332.1
protein disulfide isomerase family A member 4
chr8_-_48921419 0.14 ENST00000020945.4
snail family transcriptional repressor 2
chr11_-_35419462 0.14 ENST00000643522.1
solute carrier family 1 member 2
chr22_-_42720861 0.14 ENST00000642412.2
alpha 1,4-galactosyltransferase (P blood group)
chr15_+_90868580 0.14 ENST00000268171.8
furin, paired basic amino acid cleaving enzyme
chr16_-_11281322 0.14 ENST00000312511.4
protamine 1
chrX_-_154014246 0.14 ENST00000444254.1
interleukin 1 receptor associated kinase 1
chr1_-_171652675 0.13 ENST00000037502.11
myocilin
chr16_-_74774812 0.13 ENST00000219368.8
fatty acid 2-hydroxylase
chr18_-_48137295 0.13 ENST00000535628.6
zinc finger and BTB domain containing 7C
chr11_-_35419098 0.13 ENST00000606205.6
ENST00000645303.1
solute carrier family 1 member 2
chr22_-_42720813 0.13 ENST00000381278.4
alpha 1,4-galactosyltransferase (P blood group)
chr1_+_54806063 0.13 ENST00000358193.7
ENST00000371273.4
lymphocyte expansion molecule
chr11_+_67586104 0.13 ENST00000495996.1
glutathione S-transferase pi 1
chr15_+_45402324 0.13 ENST00000305560.11
spermatogenesis associated 5 like 1
chr13_+_26254098 0.13 ENST00000381527.8
cyclin dependent kinase 8
chr8_+_144358633 0.13 ENST00000675280.1
solute carrier family 52 member 2
chr5_-_137736066 0.13 ENST00000309755.9
kelch like family member 3
chr9_+_133534807 0.13 ENST00000393060.1
ADAMTS like 2
chr5_-_160312756 0.13 ENST00000644313.1
cyclin J like
chr13_-_27620520 0.13 ENST00000316334.5
ligand of numb-protein X 2
chr10_-_123008687 0.13 ENST00000617859.4
IKAROS family zinc finger 5
chr19_+_11547840 0.13 ENST00000588935.1
calponin 1
chr11_-_35418966 0.12 ENST00000531628.2
solute carrier family 1 member 2
chr1_-_154870264 0.12 ENST00000618040.4
ENST00000271915.9
potassium calcium-activated channel subfamily N member 3
chr1_+_65792889 0.12 ENST00000341517.9
phosphodiesterase 4B
chr16_+_48244331 0.12 ENST00000535754.5
lon peptidase 2, peroxisomal

Network of associatons between targets according to the STRING database.

First level regulatory network of FIGLA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 1.2 GO:0044752 response to human chorionic gonadotropin(GO:0044752)
0.2 0.7 GO:0048560 establishment of anatomical structure orientation(GO:0048560)
0.2 1.2 GO:0097195 pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.2 1.0 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 2.9 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 0.7 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 1.1 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 1.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803)
0.2 1.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.5 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 1.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.8 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.1 0.4 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1 0.3 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.3 GO:0032826 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.1 0.4 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.1 0.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.5 GO:0051622 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 0.8 GO:0070673 response to interleukin-18(GO:0070673)
0.1 0.4 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.1 0.3 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.3 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.1 0.6 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 0.7 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.5 GO:1905247 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 0.8 GO:0009414 response to water deprivation(GO:0009414)
0.1 0.4 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 0.3 GO:0003164 His-Purkinje system development(GO:0003164)
0.1 0.4 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 0.3 GO:0001575 globoside metabolic process(GO:0001575)
0.1 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 1.4 GO:0070831 basement membrane assembly(GO:0070831)
0.1 0.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 0.4 GO:2000980 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:1902568 positive regulation of glomerular filtration(GO:0003104) positive regulation of eosinophil degranulation(GO:0043311) regulation of renin secretion into blood stream(GO:1900133) positive regulation of eosinophil activation(GO:1902568)
0.0 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0035732 nitric oxide storage(GO:0035732)
0.0 0.7 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.8 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.3 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.0 0.3 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.3 GO:0014916 tetrahydrobiopterin biosynthetic process(GO:0006729) regulation of lung blood pressure(GO:0014916) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.2 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.2 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 0.6 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.3 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.3 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.0 0.1 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.0 0.4 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.2 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0046959 habituation(GO:0046959)
0.0 0.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.7 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 4.2 GO:0031424 keratinization(GO:0031424)
0.0 0.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.6 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.0 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.8 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.0 1.0 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 1.8 GO:0006970 response to osmotic stress(GO:0006970)
0.0 0.1 GO:0032425 positive regulation of mismatch repair(GO:0032425)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.6 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.0 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.7 GO:0061689 tricellular tight junction(GO:0061689)
0.2 1.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 1.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 1.1 GO:0035976 AP1 complex(GO:0035976)
0.1 0.4 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 1.4 GO:0043256 laminin complex(GO:0043256)
0.1 0.3 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1 4.1 GO:0030673 axolemma(GO:0030673)
0.1 1.2 GO:0097449 astrocyte projection(GO:0097449)
0.1 5.4 GO:0045095 keratin filament(GO:0045095)
0.1 0.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.1 0.8 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.9 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 2.8 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.3 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.5 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.6 GO:0019841 retinol binding(GO:0019841)
0.1 0.2 GO:0016503 pheromone receptor activity(GO:0016503)
0.1 0.3 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.1 0.3 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 1.2 GO:0031404 chloride ion binding(GO:0031404)
0.1 0.4 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.2 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.1 0.5 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.1 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.1 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.2 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
0.1 0.2 GO:0004766 spermidine synthase activity(GO:0004766)
0.0 0.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.4 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.0 0.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.3 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 1.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.3 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.4 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0046625 sphingolipid binding(GO:0046625)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.0 GO:0005178 integrin binding(GO:0005178)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 1.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.5 REACTOME AMYLOIDS Genes involved in Amyloids