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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for GATA6

Z-value: 0.50

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.11 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg38_v1_chr18_+_22169580_221695960.686.4e-02Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_127892930 0.67 ENST00000368671.4
CLRN3
clarin 3
chr18_+_22169580 0.59 ENST00000269216.10
GATA6
GATA binding protein 6
chr8_+_123182635 0.50 ENST00000276699.10
ENST00000522648.5
FAM83A
family with sequence similarity 83 member A
chr19_-_51019699 0.43 ENST00000358789.8
KLK10
kallikrein related peptidase 10
chr17_-_49764123 0.40 ENST00000240364.7
ENST00000506156.1
FAM117A
family with sequence similarity 117 member A
chr2_+_102311502 0.37 ENST00000404917.6
ENST00000410040.5
IL1RL1
IL18R1
interleukin 1 receptor like 1
interleukin 18 receptor 1
chr6_+_12290353 0.36 ENST00000379375.6
EDN1
endothelin 1
chr1_-_24143112 0.29 ENST00000270800.2
IL22RA1
interleukin 22 receptor subunit alpha 1
chr1_-_225999312 0.29 ENST00000272091.8
SDE2
SDE2 telomere maintenance homolog
chr3_+_148865288 0.27 ENST00000296046.4
CPA3
carboxypeptidase A3
chr17_+_76385256 0.26 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr11_-_116837586 0.25 ENST00000375320.5
ENST00000359492.6
ENST00000375329.6
ENST00000375323.5
ENST00000236850.5
APOA1
apolipoprotein A1
chr1_-_93585071 0.25 ENST00000539242.5
BCAR3
BCAR3 adaptor protein, NSP family member
chr5_+_132073782 0.23 ENST00000296871.4
CSF2
colony stimulating factor 2
chr8_-_20183090 0.21 ENST00000265808.11
ENST00000522513.5
SLC18A1
solute carrier family 18 member A1
chr7_-_142962206 0.21 ENST00000460479.2
ENST00000476829.5
ENST00000355265.7
KEL
Kell metallo-endopeptidase (Kell blood group)
chr4_-_102345196 0.19 ENST00000683412.1
ENST00000682227.1
SLC39A8
solute carrier family 39 member 8
chr18_-_31162849 0.19 ENST00000257197.7
ENST00000257198.6
DSC1
desmocollin 1
chr6_+_31706866 0.18 ENST00000375832.5
ENST00000503322.1
LY6G6F
LY6G6F-LY6G6D
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr1_+_154321107 0.17 ENST00000484864.1
AQP10
aquaporin 10
chr1_+_154321076 0.17 ENST00000324978.8
AQP10
aquaporin 10
chr8_-_20183127 0.17 ENST00000276373.10
ENST00000519026.5
ENST00000440926.3
ENST00000437980.3
SLC18A1
solute carrier family 18 member A1
chr13_-_46142834 0.16 ENST00000674665.1
LCP1
lymphocyte cytosolic protein 1
chr10_+_24466487 0.16 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
KIAA1217
chr20_+_45306834 0.16 ENST00000343694.8
ENST00000372741.7
ENST00000372743.5
RBPJL
recombination signal binding protein for immunoglobulin kappa J region like
chr2_-_68871382 0.16 ENST00000295379.2
BMP10
bone morphogenetic protein 10
chr8_-_38150943 0.15 ENST00000276449.9
STAR
steroidogenic acute regulatory protein
chr6_+_130018565 0.15 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr10_-_97771954 0.14 ENST00000266066.4
SFRP5
secreted frizzled related protein 5
chr3_-_119660580 0.12 ENST00000493094.6
ENST00000264231.7
ENST00000468801.1
POPDC2
popeye domain containing 2
chr4_+_15374541 0.12 ENST00000382383.7
ENST00000429690.5
C1QTNF7
C1q and TNF related 7
chr14_+_22497657 0.11 ENST00000390496.1
TRAJ41
T cell receptor alpha joining 41
chrX_+_108045050 0.11 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chrX_+_108044967 0.11 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr17_-_40782544 0.11 ENST00000301656.4
KRT27
keratin 27
chr20_-_56392131 0.10 ENST00000422322.5
ENST00000371356.6
ENST00000451915.1
ENST00000347343.6
ENST00000395911.5
ENST00000395915.8
ENST00000395907.5
ENST00000441357.5
ENST00000456249.5
ENST00000420474.5
ENST00000395914.5
ENST00000312783.10
ENST00000395913.7
AURKA
aurora kinase A
chr19_+_10286971 0.10 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10286944 0.10 ENST00000380770.5
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr22_-_29388530 0.10 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
AP1B1
adaptor related protein complex 1 subunit beta 1
chr4_-_102345061 0.10 ENST00000394833.6
SLC39A8
solute carrier family 39 member 8
chr12_-_21775581 0.10 ENST00000537950.1
ENST00000665145.1
KCNJ8
potassium inwardly rectifying channel subfamily J member 8
chr11_-_1036706 0.09 ENST00000421673.7
MUC6
mucin 6, oligomeric mucus/gel-forming
chr7_+_155298561 0.09 ENST00000476756.1
INSIG1
insulin induced gene 1
chr14_-_22815421 0.09 ENST00000674313.1
ENST00000555959.1
SLC7A7
solute carrier family 7 member 7
chr5_-_33984681 0.09 ENST00000296589.9
SLC45A2
solute carrier family 45 member 2
chr14_-_22815801 0.09 ENST00000397532.9
SLC7A7
solute carrier family 7 member 7
chr7_+_130380339 0.08 ENST00000481342.5
ENST00000604896.5
ENST00000011292.8
CPA1
carboxypeptidase A1
chr1_+_174877430 0.08 ENST00000392064.6
RABGAP1L
RAB GTPase activating protein 1 like
chr14_-_22815856 0.08 ENST00000554758.1
ENST00000397528.8
SLC7A7
solute carrier family 7 member 7
chr15_-_43220989 0.08 ENST00000540029.5
ENST00000441366.7
ENST00000648595.1
EPB42
erythrocyte membrane protein band 4.2
chr11_-_59845496 0.08 ENST00000257248.3
CBLIF
cobalamin binding intrinsic factor
chr2_+_86441341 0.08 ENST00000312912.10
ENST00000409064.5
KDM3A
lysine demethylase 3A
chr2_+_168901290 0.08 ENST00000429379.2
ENST00000375363.8
ENST00000421979.1
G6PC2
glucose-6-phosphatase catalytic subunit 2
chr19_-_13102848 0.08 ENST00000264824.5
LYL1
LYL1 basic helix-loop-helix family member
chr1_+_25272492 0.08 ENST00000454452.6
RHD
Rh blood group D antigen
chr8_-_94436926 0.07 ENST00000481490.3
FSBP
fibrinogen silencer binding protein
chr4_+_165873231 0.07 ENST00000061240.7
TLL1
tolloid like 1
chr6_+_117675448 0.07 ENST00000368494.4
NUS1
NUS1 dehydrodolichyl diphosphate synthase subunit
chr2_+_102311546 0.06 ENST00000233954.6
ENST00000447231.5
IL1RL1
interleukin 1 receptor like 1
chr17_+_4932285 0.05 ENST00000611961.1
GP1BA
glycoprotein Ib platelet subunit alpha
chr1_+_12464912 0.05 ENST00000543766.2
VPS13D
vacuolar protein sorting 13 homolog D
chr17_+_4932248 0.05 ENST00000329125.6
GP1BA
glycoprotein Ib platelet subunit alpha
chr17_-_35560812 0.05 ENST00000674182.1
SLFN14
schlafen family member 14
chr9_-_114930508 0.05 ENST00000223795.3
ENST00000618336.4
TNFSF8
TNF superfamily member 8
chr2_+_172928165 0.05 ENST00000535187.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr15_+_49423233 0.05 ENST00000560270.1
ENST00000267843.9
ENST00000560979.1
FGF7
fibroblast growth factor 7
chr2_-_40512423 0.04 ENST00000402441.5
ENST00000448531.1
SLC8A1
solute carrier family 8 member A1
chr5_-_33984636 0.04 ENST00000382102.7
ENST00000509381.1
SLC45A2
solute carrier family 45 member 2
chr20_+_56392607 0.04 ENST00000217109.9
ENST00000452950.1
CSTF1
cleavage stimulation factor subunit 1
chr16_+_31527876 0.04 ENST00000302312.9
ENST00000564707.1
AHSP
alpha hemoglobin stabilizing protein
chr5_-_135954962 0.04 ENST00000522943.5
ENST00000514447.2
ENST00000274507.6
LECT2
leukocyte cell derived chemotaxin 2
chr12_+_69825221 0.04 ENST00000552032.7
MYRFL
myelin regulatory factor like
chrX_-_10833643 0.04 ENST00000380785.5
ENST00000380787.5
MID1
midline 1
chr22_+_35066136 0.03 ENST00000308700.6
ENST00000404699.7
ISX
intestine specific homeobox
chr20_-_32207708 0.03 ENST00000246229.5
PLAGL2
PLAG1 like zinc finger 2
chr15_+_58987652 0.03 ENST00000348370.9
ENST00000559160.1
RNF111
ring finger protein 111
chr2_+_3595049 0.03 ENST00000236693.11
ENST00000349077.9
COLEC11
collectin subfamily member 11
chr15_-_63833911 0.03 ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
ENST00000443617.7
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr12_-_6124662 0.03 ENST00000261405.10
VWF
von Willebrand factor
chr18_-_48137295 0.03 ENST00000535628.6
ZBTB7C
zinc finger and BTB domain containing 7C
chr2_-_40512361 0.03 ENST00000403092.5
SLC8A1
solute carrier family 8 member A1
chr2_-_213150236 0.03 ENST00000442445.1
ENST00000342002.6
IKZF2
IKAROS family zinc finger 2
chr12_-_9999176 0.03 ENST00000298527.10
ENST00000348658.4
CLEC1B
C-type lectin domain family 1 member B
chr12_+_69825273 0.03 ENST00000547771.6
MYRFL
myelin regulatory factor like
chr19_-_38812936 0.03 ENST00000307751.9
ENST00000594209.1
LGALS4
galectin 4
chr11_+_119087979 0.03 ENST00000535253.5
ENST00000392841.1
ENST00000648374.1
HMBS
hydroxymethylbilane synthase
chr8_+_21966215 0.02 ENST00000433566.8
XPO7
exportin 7
chr6_-_30161200 0.02 ENST00000449742.7
TRIM10
tripartite motif containing 10
chr21_-_38498415 0.02 ENST00000398905.5
ENST00000398907.5
ENST00000453032.6
ENST00000288319.12
ERG
ETS transcription factor ERG
chr1_+_25272502 0.02 ENST00000328664.9
RHD
Rh blood group D antigen
chr17_+_19411220 0.02 ENST00000461366.2
RNF112
ring finger protein 112
chr7_+_128739292 0.02 ENST00000535011.6
ENST00000542996.6
ENST00000249364.9
ENST00000449187.6
CALU
calumenin
chr1_-_205943449 0.02 ENST00000367135.8
ENST00000367134.2
SLC26A9
solute carrier family 26 member 9
chr19_-_55038256 0.02 ENST00000417454.5
ENST00000310373.7
ENST00000333884.2
GP6
glycoprotein VI platelet
chr1_+_50108856 0.02 ENST00000650764.1
ENST00000494555.2
ENST00000371824.7
ENST00000371823.8
ENST00000652693.1
ELAVL4
ELAV like RNA binding protein 4
chr6_-_46080332 0.02 ENST00000185206.12
CLIC5
chloride intracellular channel 5
chr9_-_112175185 0.02 ENST00000355396.7
SUSD1
sushi domain containing 1
chr1_-_26913964 0.02 ENST00000254227.4
NR0B2
nuclear receptor subfamily 0 group B member 2
chr14_+_52707192 0.02 ENST00000445930.7
ENST00000555339.5
ENST00000556813.1
PSMC6
proteasome 26S subunit, ATPase 6
chr14_+_52707178 0.01 ENST00000612399.4
PSMC6
proteasome 26S subunit, ATPase 6
chr1_+_25272439 0.01 ENST00000648012.1
RHD
Rh blood group D antigen
chr5_+_132556911 0.01 ENST00000651541.1
ENST00000378823.8
ENST00000652485.1
RAD50
RAD50 double strand break repair protein
chr10_+_69315760 0.01 ENST00000298649.8
HK1
hexokinase 1
chr1_-_167518521 0.01 ENST00000362089.10
CD247
CD247 molecule
chr1_-_167518583 0.01 ENST00000392122.3
CD247
CD247 molecule
chr14_+_75522531 0.01 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr2_+_137964446 0.01 ENST00000280096.5
ENST00000280097.5
HNMT
histamine N-methyltransferase
chr1_+_25272479 0.01 ENST00000622561.4
RHD
Rh blood group D antigen
chr5_+_1201588 0.01 ENST00000304460.11
SLC6A19
solute carrier family 6 member 19
chr2_-_151973991 0.01 ENST00000534999.6
ENST00000637217.1
ENST00000360283.11
CACNB4
calcium voltage-gated channel auxiliary subunit beta 4
chr10_+_116591010 0.00 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr9_-_97938157 0.00 ENST00000616898.2
HEMGN
hemogen

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0032912 negative regulation of transforming growth factor beta2 production(GO:0032912)
0.1 0.4 GO:0030185 nitric oxide transport(GO:0030185)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.2 GO:0018963 phthalate metabolic process(GO:0018963)
0.1 0.4 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1 0.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.3 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.3 GO:0015793 glycerol transport(GO:0015793)
0.0 0.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.1 GO:0015766 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.2 GO:0031133 regulation of axon diameter(GO:0031133)
0.0 0.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0046292 formaldehyde metabolic process(GO:0046292)
0.0 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0002003 angiotensin maturation(GO:0002003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.4 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.4 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.1 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport