Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for GLI3
Z-value: 2.35
Motif logo
Transcription factors associated with GLI3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GLI3
|
ENSG00000106571.15 | GLI family zinc finger 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLI3 | hg38_v1_chr7_-_42152396_42152440, hg38_v1_chr7_-_42237187_42237216 | -0.49 | 2.1e-01 | Click! |
Activity profile of GLI3 motif
Sorted Z-values of GLI3 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of GLI3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.3 | GO:0032600 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 1.1 | 6.3 | GO:0002225 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antibacterial peptide production(GO:0002803) |
| 0.6 | 2.3 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.5 | 2.1 | GO:0001897 | cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710) |
| 0.4 | 1.7 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.3 | 1.0 | GO:0060279 | positive regulation of ovulation(GO:0060279) |
| 0.3 | 1.2 | GO:1902162 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.3 | 0.9 | GO:0060086 | circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 0.3 | 1.5 | GO:0097021 | lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.3 | 1.7 | GO:1903282 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 0.8 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) |
| 0.3 | 1.8 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.2 | 0.7 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
| 0.2 | 1.4 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
| 0.2 | 6.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 1.0 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) |
| 0.2 | 0.8 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.2 | 0.9 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.2 | 1.0 | GO:0061502 | early endosome to recycling endosome transport(GO:0061502) |
| 0.2 | 0.9 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.2 | 0.7 | GO:0042335 | cuticle development(GO:0042335) |
| 0.2 | 0.8 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.2 | 1.2 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
| 0.1 | 0.9 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.1 | 1.2 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 0.4 | GO:0070429 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
| 0.1 | 1.0 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 0.8 | GO:2000491 | positive regulation of hepatic stellate cell activation(GO:2000491) |
| 0.1 | 0.6 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.1 | 1.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.3 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.1 | 1.7 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
| 0.1 | 1.0 | GO:0019344 | cysteine biosynthetic process(GO:0019344) |
| 0.1 | 0.6 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 0.1 | 0.6 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.1 | 0.8 | GO:0098582 | innate vocalization behavior(GO:0098582) positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.1 | 0.4 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.1 | 0.4 | GO:0010157 | response to chlorate(GO:0010157) |
| 0.1 | 0.9 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.1 | 0.3 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 0.2 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.1 | 0.5 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.1 | 0.5 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) |
| 0.1 | 0.2 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
| 0.1 | 0.2 | GO:0014813 | skeletal muscle satellite cell commitment(GO:0014813) |
| 0.1 | 2.0 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.2 | GO:0071469 | detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469) |
| 0.1 | 0.2 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 0.1 | 0.2 | GO:0018057 | peptidyl-lysine oxidation(GO:0018057) |
| 0.1 | 0.2 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 0.1 | GO:0002625 | regulation of T cell antigen processing and presentation(GO:0002625) |
| 0.1 | 0.3 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.1 | 0.2 | GO:0000432 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.1 | 0.2 | GO:0002339 | B cell selection(GO:0002339) |
| 0.1 | 0.9 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.1 | 0.2 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.1 | 0.6 | GO:0097647 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 0.1 | 0.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.1 | 0.6 | GO:0070673 | response to interleukin-18(GO:0070673) |
| 0.1 | 0.8 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) |
| 0.1 | 1.1 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 0.3 | GO:0070383 | DNA cytosine deamination(GO:0070383) |
| 0.1 | 0.2 | GO:0003095 | pressure natriuresis(GO:0003095) |
| 0.1 | 0.2 | GO:2000724 | mineralocorticoid receptor signaling pathway(GO:0031959) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724) |
| 0.0 | 0.2 | GO:0032499 | detection of peptidoglycan(GO:0032499) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.0 | 0.3 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.0 | 0.9 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.0 | 0.2 | GO:0000711 | meiotic DNA repair synthesis(GO:0000711) |
| 0.0 | 0.5 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.0 | 0.1 | GO:1903973 | negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) |
| 0.0 | 0.1 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.0 | 0.0 | GO:0072054 | renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) |
| 0.0 | 0.3 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.2 | GO:0006169 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) |
| 0.0 | 0.1 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.0 | 0.1 | GO:1902303 | negative regulation of potassium ion export(GO:1902303) |
| 0.0 | 1.5 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.8 | GO:0002138 | retinoic acid biosynthetic process(GO:0002138) |
| 0.0 | 0.6 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.0 | 0.2 | GO:0048669 | somite specification(GO:0001757) collateral sprouting in absence of injury(GO:0048669) |
| 0.0 | 0.1 | GO:0098736 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
| 0.0 | 0.5 | GO:0010579 | regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) |
| 0.0 | 0.3 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.0 | 0.2 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 0.6 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 0.1 | GO:0032661 | regulation of interleukin-18 production(GO:0032661) |
| 0.0 | 0.4 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 0.6 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.2 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.0 | 0.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.0 | 0.3 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.0 | 0.1 | GO:0098957 | anterograde axonal transport of mitochondrion(GO:0098957) |
| 0.0 | 3.2 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.2 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.0 | 0.2 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.0 | 0.5 | GO:1903764 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 0.2 | GO:0002880 | chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880) |
| 0.0 | 0.1 | GO:0052027 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.3 | GO:0010637 | negative regulation of mitochondrial fusion(GO:0010637) |
| 0.0 | 0.1 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
| 0.0 | 2.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.2 | GO:0061760 | antifungal innate immune response(GO:0061760) |
| 0.0 | 0.3 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.2 | GO:0016199 | axon midline choice point recognition(GO:0016199) |
| 0.0 | 0.2 | GO:0006788 | heme oxidation(GO:0006788) |
| 0.0 | 0.2 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
| 0.0 | 0.4 | GO:2001286 | regulation of caveolin-mediated endocytosis(GO:2001286) |
| 0.0 | 0.1 | GO:2000979 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.0 | 0.4 | GO:1902570 | protein localization to nucleolus(GO:1902570) |
| 0.0 | 0.1 | GO:1903974 | positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.0 | 0.1 | GO:0060024 | rhythmic synaptic transmission(GO:0060024) |
| 0.0 | 0.2 | GO:0035469 | determination of pancreatic left/right asymmetry(GO:0035469) |
| 0.0 | 0.3 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.0 | 0.1 | GO:1990258 | box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258) |
| 0.0 | 0.2 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.0 | 0.1 | GO:1903576 | response to L-arginine(GO:1903576) |
| 0.0 | 0.1 | GO:0036229 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 0.0 | 0.2 | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) |
| 0.0 | 0.1 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.0 | 0.2 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.0 | 0.4 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 1.5 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.0 | 0.2 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) cellular response to leucine starvation(GO:1990253) |
| 0.0 | 0.3 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 0.2 | GO:1903243 | negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243) |
| 0.0 | 0.7 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.0 | 1.0 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.0 | 0.1 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.0 | 0.2 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.0 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) |
| 0.0 | 0.1 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.0 | 0.1 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 0.0 | 0.2 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.0 | 3.1 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.1 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.0 | 0.1 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.0 | 0.2 | GO:0061589 | calcium activated phosphatidylserine scrambling(GO:0061589) |
| 0.0 | 0.2 | GO:0097623 | potassium ion export across plasma membrane(GO:0097623) |
| 0.0 | 0.4 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.2 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.0 | 0.7 | GO:0045063 | T-helper 1 cell differentiation(GO:0045063) |
| 0.0 | 0.1 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.0 | 0.2 | GO:1905146 | lysosomal protein catabolic process(GO:1905146) |
| 0.0 | 0.1 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.0 | 0.2 | GO:0050747 | sphingomyelin biosynthetic process(GO:0006686) S-adenosylhomocysteine metabolic process(GO:0046498) positive regulation of lipoprotein metabolic process(GO:0050747) |
| 0.0 | 0.2 | GO:0035459 | cargo loading into vesicle(GO:0035459) |
| 0.0 | 0.1 | GO:0030186 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
| 0.0 | 0.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.0 | 0.1 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.0 | 0.1 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.0 | 3.1 | GO:0046330 | positive regulation of JNK cascade(GO:0046330) |
| 0.0 | 0.3 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.3 | GO:0030046 | parallel actin filament bundle assembly(GO:0030046) |
| 0.0 | 0.1 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.0 | 0.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.8 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.6 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 0.0 | 0.0 | GO:0060032 | notochord regression(GO:0060032) |
| 0.0 | 0.2 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 0.0 | 0.1 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563) |
| 0.0 | 0.1 | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.0 | 0.2 | GO:0000183 | chromatin silencing at rDNA(GO:0000183) |
| 0.0 | 0.2 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.0 | 0.1 | GO:0000965 | mitochondrial RNA 3'-end processing(GO:0000965) |
| 0.0 | 0.3 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.3 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 0.2 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.0 | 0.1 | GO:1904219 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.0 | 0.1 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296) |
| 0.0 | 0.2 | GO:0045408 | regulation of interleukin-6 biosynthetic process(GO:0045408) |
| 0.0 | 0.1 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.0 | 0.1 | GO:0008615 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 0.0 | 0.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.0 | 0.7 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 0.1 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 0.1 | GO:0038155 | interleukin-23-mediated signaling pathway(GO:0038155) |
| 0.0 | 0.1 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.0 | 0.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.1 | GO:2000609 | regulation of thyroid hormone generation(GO:2000609) |
| 0.0 | 0.0 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.0 | 0.1 | GO:0071440 | regulation of histone H3-K14 acetylation(GO:0071440) positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 0.1 | GO:1901594 | detection of temperature stimulus involved in thermoception(GO:0050960) positive regulation of gastric acid secretion(GO:0060454) response to capsazepine(GO:1901594) |
| 0.0 | 0.0 | GO:2000118 | regulation of sodium-dependent phosphate transport(GO:2000118) |
| 0.0 | 0.2 | GO:0032310 | prostaglandin secretion(GO:0032310) |
| 0.0 | 0.2 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.0 | 0.2 | GO:0006032 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.2 | GO:0060033 | anatomical structure regression(GO:0060033) |
| 0.0 | 0.1 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.0 | 0.1 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 0.2 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 0.4 | GO:0071243 | cellular response to arsenic-containing substance(GO:0071243) |
| 0.0 | 0.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 0.3 | GO:0051255 | spindle midzone assembly(GO:0051255) |
| 0.0 | 0.1 | GO:1903142 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.0 | 0.1 | GO:0060748 | tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) |
| 0.0 | 0.1 | GO:0032439 | endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549) |
| 0.0 | 0.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.0 | 0.1 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.0 | 1.2 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.0 | 0.1 | GO:0061084 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) |
| 0.0 | 0.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.1 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 0.0 | 0.3 | GO:0071404 | cellular response to low-density lipoprotein particle stimulus(GO:0071404) |
| 0.0 | 0.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 0.3 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.2 | GO:1900864 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.0 | 0.2 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 0.1 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.0 | 0.1 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 0.2 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.2 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.0 | 0.3 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.4 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.1 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 0.0 | 0.0 | GO:0033625 | positive regulation of integrin activation(GO:0033625) |
| 0.0 | 0.4 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.0 | 0.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.0 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.0 | 0.1 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 0.1 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.1 | GO:0035768 | cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) positive regulation of cholesterol biosynthetic process(GO:0045542) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544) |
| 0.0 | 0.1 | GO:0036005 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 0.0 | 0.1 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.0 | 0.1 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.0 | 0.0 | GO:0046013 | T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 0.0 | GO:0046707 | IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709) |
| 0.0 | 0.0 | GO:0003420 | regulation of growth plate cartilage chondrocyte proliferation(GO:0003420) |
| 0.0 | 0.1 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 0.1 | GO:0033211 | adiponectin-activated signaling pathway(GO:0033211) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.6 | 4.1 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 1.9 | GO:0043256 | laminin complex(GO:0043256) |
| 0.3 | 1.0 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 1.7 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.2 | 5.3 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.2 | 2.1 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 1.6 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.1 | 2.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 2.0 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 0.6 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 0.3 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.1 | 0.9 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 6.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.3 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.1 | 1.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 0.6 | GO:1903439 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 0.1 | 0.4 | GO:0031417 | NatC complex(GO:0031417) |
| 0.1 | 0.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 0.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 0.4 | GO:1990393 | 3M complex(GO:1990393) |
| 0.1 | 1.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.2 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.1 | 0.4 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.0 | 1.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 0.2 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.2 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.0 | 3.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 1.3 | GO:1902710 | GABA receptor complex(GO:1902710) |
| 0.0 | 0.1 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.0 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.2 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 0.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.1 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 0.0 | 0.3 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.2 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.1 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.0 | 0.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.5 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 0.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.0 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.1 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.0 | 0.4 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.1 | GO:0072536 | interleukin-23 receptor complex(GO:0072536) |
| 0.0 | 1.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.2 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.1 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 2.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.2 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 0.4 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.3 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.1 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.0 | 1.7 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.2 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 3.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 0.3 | 1.7 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.2 | 1.0 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.2 | 1.2 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.2 | 1.9 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.2 | 1.5 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.2 | 0.9 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.1 | 0.9 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.1 | 0.6 | GO:0004948 | calcitonin receptor activity(GO:0004948) calcitonin receptor binding(GO:0031716) |
| 0.1 | 1.0 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 5.3 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 1.1 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.1 | 0.3 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
| 0.1 | 0.4 | GO:0033897 | ribonuclease T2 activity(GO:0033897) |
| 0.1 | 2.1 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0047757 | chondroitin-glucuronate 5-epimerase activity(GO:0047757) |
| 0.1 | 0.6 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 0.4 | GO:0050253 | retinyl-palmitate esterase activity(GO:0050253) |
| 0.1 | 0.8 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.1 | 0.3 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.1 | 1.2 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.1 | 0.6 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 0.2 | GO:0070025 | oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) |
| 0.1 | 1.2 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.1 | 0.2 | GO:0097604 | temperature-gated cation channel activity(GO:0097604) |
| 0.1 | 0.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 0.2 | GO:0080101 | phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101) |
| 0.1 | 0.2 | GO:0005497 | androgen binding(GO:0005497) |
| 0.1 | 1.9 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 1.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.3 | GO:0005119 | smoothened binding(GO:0005119) hedgehog family protein binding(GO:0097108) |
| 0.1 | 0.2 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 1.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 0.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 1.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.1 | GO:0004122 | cystathionine beta-synthase activity(GO:0004122) |
| 0.1 | 0.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.3 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 0.9 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.1 | 1.8 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0003990 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 0.0 | 1.0 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.1 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.0 | 0.6 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 0.2 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 0.0 | 0.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.0 | 0.2 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.0 | 0.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.2 | GO:0008311 | double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311) |
| 0.0 | 0.8 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.2 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.0 | 0.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.1 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.0 | 0.2 | GO:0001602 | pancreatic polypeptide receptor activity(GO:0001602) |
| 0.0 | 0.4 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.0 | 0.1 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
| 0.0 | 0.8 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 0.2 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.0 | 0.1 | GO:0097259 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.0 | 0.2 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 2.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.5 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.0 | 0.1 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.0 | 0.2 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 1.6 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.2 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 0.2 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 0.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.2 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.0 | 0.1 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.0 | 0.5 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.1 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.0 | 0.2 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.0 | 0.1 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.0 | 0.1 | GO:1990259 | protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259) |
| 0.0 | 0.1 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 2.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.0 | 0.2 | GO:0045174 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 0.0 | 0.5 | GO:0031404 | chloride ion binding(GO:0031404) |
| 0.0 | 0.1 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.0 | 0.2 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.0 | 0.1 | GO:0047685 | amine sulfotransferase activity(GO:0047685) |
| 0.0 | 0.1 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.0 | 0.1 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 0.0 | 0.3 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 2.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.3 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 1.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.1 | GO:0034736 | sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736) |
| 0.0 | 0.1 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.1 | GO:0097677 | STAT family protein binding(GO:0097677) |
| 0.0 | 7.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0051800 | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800) |
| 0.0 | 0.2 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 0.1 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.0 | 0.1 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 3.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.0 | 0.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.1 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 0.0 | 0.4 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.1 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.0 | 0.4 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 1.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.2 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.1 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.1 | GO:0042019 | interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020) |
| 0.0 | 0.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.0 | 0.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.2 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.2 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 0.1 | GO:0097603 | temperature-gated ion channel activity(GO:0097603) |
| 0.0 | 0.2 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.0 | 0.0 | GO:0009032 | thymidine phosphorylase activity(GO:0009032) pyrimidine-nucleoside phosphorylase activity(GO:0016154) |
| 0.0 | 0.1 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.0 | 0.2 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.0 | 0.2 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
| 0.0 | 0.5 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.0 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
| 0.0 | 0.5 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.1 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 0.0 | 0.2 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.0 | 0.1 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.3 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.5 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 0.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.1 | GO:0032558 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.0 | 0.2 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 1.4 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.2 | GO:1990239 | steroid hormone binding(GO:1990239) |
| 0.0 | 0.3 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 0.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 0.1 | GO:0050211 | procollagen galactosyltransferase activity(GO:0050211) |
| 0.0 | 0.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 0.1 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 0.2 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.0 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.0 | 0.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 0.2 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.1 | GO:0016520 | growth hormone-releasing hormone receptor activity(GO:0016520) |
| 0.0 | 0.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.1 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.0 | 0.3 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.1 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 0.1 | GO:0016618 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 0.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.0 | 0.0 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976) |
| 0.0 | 1.1 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 0.0 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.4 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 0.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 2.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 3.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.8 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 1.0 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 2.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.4 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.4 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.8 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.4 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 0.7 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 1.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.4 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.1 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 2.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 0.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 6.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.9 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 6.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.8 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.1 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 0.6 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 1.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 2.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.4 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 0.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.3 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.2 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.5 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.0 | 0.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.1 | REACTOME GAP JUNCTION TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.0 | 0.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.9 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.2 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.0 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.0 | 0.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |