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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HAND1

Z-value: 0.22

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
HAND1
ENSG00000113196.3 heart and neural crest derivatives expressed 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg38_v1_chr5_-_154478218_1544782340.403.3e-01Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_148697784 0.22 ENST00000497524.5
ENST00000418473.7
ENST00000349243.8
ENST00000404754.2
AGTR1
angiotensin II receptor type 1
chr19_+_12751789 0.22 ENST00000553030.6
BEST2
bestrophin 2
chr6_+_101181254 0.21 ENST00000682090.1
ENST00000421544.6
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr19_+_12751672 0.20 ENST00000549706.5
BEST2
bestrophin 2
chr2_+_209579399 0.20 ENST00000360351.8
MAP2
microtubule associated protein 2
chr2_+_209579598 0.20 ENST00000445941.5
ENST00000673860.1
MAP2
microtubule associated protein 2
chr6_+_123803853 0.17 ENST00000368417.6
NKAIN2
sodium/potassium transporting ATPase interacting 2
chr2_+_209579429 0.13 ENST00000361559.8
MAP2
microtubule associated protein 2
chr3_+_141384790 0.13 ENST00000507722.5
ZBTB38
zinc finger and BTB domain containing 38
chr20_-_1184981 0.12 ENST00000429036.2
TMEM74B
transmembrane protein 74B
chr19_+_35868585 0.11 ENST00000652533.1
APLP1
amyloid beta precursor like protein 1
chr19_+_35868518 0.11 ENST00000221891.9
APLP1
amyloid beta precursor like protein 1
chrX_+_150363306 0.10 ENST00000370401.7
ENST00000432680.7
MAMLD1
mastermind like domain containing 1
chrX_+_150363258 0.10 ENST00000683696.1
MAMLD1
mastermind like domain containing 1
chr5_-_147906530 0.10 ENST00000318315.5
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chr8_+_78516329 0.09 ENST00000396418.7
ENST00000352966.9
PKIA
cAMP-dependent protein kinase inhibitor alpha
chr1_+_65309517 0.09 ENST00000371069.5
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr8_-_92017637 0.08 ENST00000422361.6
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr3_+_51861604 0.08 ENST00000333127.4
IQCF2
IQ motif containing F2
chr4_+_41613476 0.08 ENST00000508466.1
LIMCH1
LIM and calponin homology domains 1
chr7_-_81770122 0.08 ENST00000423064.7
HGF
hepatocyte growth factor
chr6_-_39314445 0.08 ENST00000453413.2
KCNK17
potassium two pore domain channel subfamily K member 17
chr6_-_39314412 0.08 ENST00000373231.9
KCNK17
potassium two pore domain channel subfamily K member 17
chr4_-_25030922 0.08 ENST00000382114.9
LGI2
leucine rich repeat LGI family member 2
chr1_-_110064916 0.08 ENST00000649954.1
ALX3
ALX homeobox 3
chr8_+_30744150 0.07 ENST00000265616.10
ENST00000341403.9
ENST00000615729.4
UBXN8
UBX domain protein 8
chr4_+_41612702 0.07 ENST00000509277.5
LIMCH1
LIM and calponin homology domains 1
chr11_+_101914997 0.07 ENST00000263468.13
CEP126
centrosomal protein 126
chrX_-_34657274 0.07 ENST00000275954.4
TMEM47
transmembrane protein 47
chr20_+_31368594 0.07 ENST00000253381.3
DEFB118
defensin beta 118
chr2_+_201132958 0.06 ENST00000479953.6
ENST00000340870.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr20_+_142573 0.06 ENST00000382398.4
DEFB126
defensin beta 126
chr6_+_133889105 0.06 ENST00000367882.5
TCF21
transcription factor 21
chr3_-_9769910 0.06 ENST00000256460.8
CAMK1
calcium/calmodulin dependent protein kinase I
chr10_+_97584314 0.06 ENST00000370647.8
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr2_+_201132928 0.05 ENST00000462763.5
CFLAR
CASP8 and FADD like apoptosis regulator
chr6_-_87095059 0.05 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr11_+_67403887 0.05 ENST00000526387.5
TBC1D10C
TBC1 domain family member 10C
chr2_+_227813834 0.05 ENST00000358813.5
ENST00000409189.7
CCL20
C-C motif chemokine ligand 20
chr17_-_66220630 0.05 ENST00000585162.1
APOH
apolipoprotein H
chr11_+_67404077 0.05 ENST00000542590.2
ENST00000312390.9
TBC1D10C
TBC1 domain family member 10C
chr1_+_1281224 0.05 ENST00000400928.7
SCNN1D
sodium channel epithelial 1 subunit delta
chr20_-_57710539 0.05 ENST00000395816.7
ENST00000347215.8
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_-_12834548 0.05 ENST00000590404.6
ENST00000592204.5
ENST00000674343.2
RTBDN
retbindin
chr19_-_10102659 0.05 ENST00000592641.5
ENST00000253109.5
ANGPTL6
angiopoietin like 6
chr2_-_196926717 0.05 ENST00000409475.5
ENST00000374738.3
PGAP1
post-GPI attachment to proteins inositol deacylase 1
chr14_+_93207229 0.04 ENST00000554232.5
ENST00000556871.5
ENST00000013070.11
ENST00000555113.5
UBR7
ubiquitin protein ligase E3 component n-recognin 7
chr14_-_74426102 0.04 ENST00000554953.1
ENST00000331628.8
SYNDIG1L
synapse differentiation inducing 1 like
chr12_+_25958891 0.04 ENST00000381352.7
ENST00000535907.5
ENST00000405154.6
ENST00000615708.4
RASSF8
Ras association domain family member 8
chr5_-_41870416 0.04 ENST00000196371.10
OXCT1
3-oxoacid CoA-transferase 1
chr7_-_117323041 0.04 ENST00000491214.1
ENST00000265441.8
WNT2
Wnt family member 2
chr16_-_89490479 0.04 ENST00000642600.1
ENST00000301030.10
ANKRD11
ankyrin repeat domain 11
chr3_+_112333147 0.04 ENST00000473539.5
ENST00000315711.12
ENST00000383681.7
CD200
CD200 molecule
chr19_-_12835400 0.04 ENST00000591512.2
ENST00000587549.1
ENST00000322912.9
RTBDN
retbindin
chr19_-_12835421 0.04 ENST00000589272.5
RTBDN
retbindin
chr12_-_7109176 0.04 ENST00000545280.5
ENST00000543933.5
ENST00000545337.1
ENST00000266542.9
ENST00000544702.5
C1RL
complement C1r subcomponent like
chr2_+_201132769 0.04 ENST00000494258.5
CFLAR
CASP8 and FADD like apoptosis regulator
chr19_+_7920313 0.04 ENST00000221573.11
ENST00000595637.1
SNAPC2
small nuclear RNA activating complex polypeptide 2
chr3_-_15341368 0.04 ENST00000408919.7
SH3BP5
SH3 domain binding protein 5
chr2_+_230996115 0.04 ENST00000424440.5
ENST00000452881.5
ENST00000433428.6
ENST00000455816.1
ENST00000440792.5
ENST00000423134.1
SPATA3
spermatogenesis associated 3
chr17_-_8210203 0.03 ENST00000578549.5
ENST00000582368.5
AURKB
aurora kinase B
chr11_-_26722051 0.03 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr18_+_7567266 0.03 ENST00000580170.6
PTPRM
protein tyrosine phosphatase receptor type M
chr15_-_78811415 0.03 ENST00000388820.5
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif 7
chr15_-_60397964 0.03 ENST00000558998.5
ENST00000560165.5
ENST00000557986.5
ENST00000559467.5
ENST00000677968.1
ENST00000678450.1
ENST00000332680.8
ENST00000396024.7
ENST00000557906.6
ENST00000558558.6
ENST00000559113.6
ENST00000559780.6
ENST00000559956.6
ENST00000560468.6
ENST00000678870.1
ENST00000678061.1
ENST00000451270.7
ENST00000421017.6
ENST00000560466.5
ENST00000558132.5
ENST00000559370.5
ENST00000559725.5
ENST00000558985.6
ENST00000679109.1
ANXA2
annexin A2
chr5_+_168486462 0.03 ENST00000231572.8
ENST00000626454.1
RARS1
arginyl-tRNA synthetase 1
chr9_-_35828579 0.03 ENST00000377984.2
ENST00000423537.7
ENST00000472182.1
FAM221B
family with sequence similarity 221 member B
chr2_+_201132872 0.03 ENST00000470178.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr14_-_93207007 0.03 ENST00000556566.1
ENST00000306954.5
GON7
GON7 subunit of KEOPS complex
chr6_+_123804141 0.03 ENST00000368416.5
NKAIN2
sodium/potassium transporting ATPase interacting 2
chr11_-_6771976 0.03 ENST00000641124.1
ENST00000641169.1
OR2AG2
olfactory receptor family 2 subfamily AG member 2
chrX_+_71144818 0.03 ENST00000536169.5
ENST00000358741.4
ENST00000395855.6
ENST00000374051.7
NLGN3
neuroligin 3
chr12_-_53336342 0.03 ENST00000537210.2
ENST00000536324.4
SP7
Sp7 transcription factor
chr9_+_70043840 0.03 ENST00000377182.5
MAMDC2
MAM domain containing 2
chr3_+_15601736 0.03 ENST00000303498.10
ENST00000417015.3
ENST00000672065.1
ENST00000672112.1
ENST00000643237.3
ENST00000672141.1
ENST00000646371.1
ENST00000672427.1
ENST00000672336.1
ENST00000673467.1
ENST00000672760.1
ENST00000437172.6
BTD
biotinidase
chr19_+_4304588 0.03 ENST00000221856.11
FSD1
fibronectin type III and SPRY domain containing 1
chr12_+_109900258 0.02 ENST00000405876.9
TCHP
trichoplein keratin filament binding
chr22_-_23751080 0.02 ENST00000341976.5
ZNF70
zinc finger protein 70
chr10_+_116590956 0.02 ENST00000358834.9
ENST00000528052.5
PNLIPRP1
pancreatic lipase related protein 1
chr19_+_55488404 0.02 ENST00000594321.5
ENST00000389623.11
SSC5D
scavenger receptor cysteine rich family member with 5 domains
chr12_-_53335737 0.02 ENST00000303846.3
SP7
Sp7 transcription factor
chr12_+_120694167 0.02 ENST00000535656.1
MLEC
malectin
chr16_+_6019663 0.02 ENST00000422070.8
RBFOX1
RNA binding fox-1 homolog 1
chr22_+_24607638 0.02 ENST00000432867.5
GGT1
gamma-glutamyltransferase 1
chr14_+_21030509 0.02 ENST00000481535.5
TPPP2
tubulin polymerization promoting protein family member 2
chr17_-_63704388 0.02 ENST00000582026.2
STRADA
STE20 related adaptor alpha
chr19_-_37210484 0.02 ENST00000527838.5
ENST00000591492.5
ENST00000532828.7
ZNF585B
zinc finger protein 585B
chr19_-_40425982 0.02 ENST00000357949.5
SERTAD1
SERTA domain containing 1
chr2_-_196926670 0.02 ENST00000354764.9
PGAP1
post-GPI attachment to proteins inositol deacylase 1
chr10_+_116591010 0.02 ENST00000530319.5
ENST00000527980.5
ENST00000471549.5
ENST00000534537.5
PNLIPRP1
pancreatic lipase related protein 1
chr17_+_47831608 0.02 ENST00000269025.9
LRRC46
leucine rich repeat containing 46
chr1_-_155934398 0.02 ENST00000368320.7
ENST00000368321.8
KHDC4
KH domain containing 4, pre-mRNA splicing factor
chr6_-_111873421 0.02 ENST00000368678.8
ENST00000523238.5
ENST00000354650.7
FYN
FYN proto-oncogene, Src family tyrosine kinase
chr11_+_2302119 0.02 ENST00000381121.7
TSPAN32
tetraspanin 32
chr7_-_141014939 0.02 ENST00000324787.10
ENST00000467334.1
MRPS33
mitochondrial ribosomal protein S33
chr5_-_181205284 0.02 ENST00000334421.5
TRIM7
tripartite motif containing 7
chr14_+_73616844 0.02 ENST00000381139.1
ACOT6
acyl-CoA thioesterase 6
chr4_-_25160375 0.02 ENST00000382103.7
SEPSECS
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr5_+_144205250 0.01 ENST00000507359.3
KCTD16
potassium channel tetramerization domain containing 16
chr12_+_53454718 0.01 ENST00000552819.5
ENST00000455667.7
PCBP2
poly(rC) binding protein 2
chr10_+_50990864 0.01 ENST00000401604.8
PRKG1
protein kinase cGMP-dependent 1
chr4_-_25160546 0.01 ENST00000681948.1
SEPSECS
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr10_+_101354083 0.01 ENST00000408038.6
ENST00000370187.8
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr1_+_61203496 0.01 ENST00000663597.1
NFIA
nuclear factor I A
chr17_-_47831509 0.01 ENST00000414011.1
ENST00000351111.7
MRPL10
mitochondrial ribosomal protein L10
chr12_-_56360084 0.01 ENST00000314128.9
ENST00000557235.5
ENST00000651915.1
STAT2
signal transducer and activator of transcription 2
chr1_+_202122881 0.01 ENST00000683302.1
ENST00000683557.1
GPR37L1
G protein-coupled receptor 37 like 1
chr2_-_42361198 0.01 ENST00000234301.3
COX7A2L
cytochrome c oxidase subunit 7A2 like
chr21_+_33230073 0.01 ENST00000342101.7
ENST00000413881.5
ENST00000443073.5
IFNAR2
interferon alpha and beta receptor subunit 2
chr6_-_117602447 0.01 ENST00000368498.7
ENST00000052569.10
ENST00000535237.2
GOPC
golgi associated PDZ and coiled-coil motif containing
chr17_+_6444441 0.01 ENST00000250056.12
ENST00000571373.5
ENST00000570337.6
ENST00000572595.6
ENST00000572447.6
ENST00000576056.5
PIMREG
PICALM interacting mitotic regulator
chr10_+_5048748 0.01 ENST00000602997.5
ENST00000439082.7
AKR1C3
aldo-keto reductase family 1 member C3
chr6_-_36986122 0.01 ENST00000460219.2
ENST00000373627.10
ENST00000373616.9
MTCH1
mitochondrial carrier 1
chr1_+_202122910 0.01 ENST00000682545.1
ENST00000367282.6
ENST00000682887.1
GPR37L1
G protein-coupled receptor 37 like 1
chr4_-_40630588 0.01 ENST00000514014.1
RBM47
RNA binding motif protein 47
chr1_+_6206077 0.01 ENST00000377939.5
RNF207
ring finger protein 207
chr9_+_77177511 0.01 ENST00000360280.8
ENST00000645632.1
ENST00000643348.1
VPS13A
vacuolar protein sorting 13 homolog A
chr6_+_6588082 0.01 ENST00000379953.6
LY86
lymphocyte antigen 86
chr8_+_93794816 0.01 ENST00000519845.5
ENST00000684343.1
TMEM67
transmembrane protein 67
chr19_+_17075767 0.01 ENST00000682292.1
ENST00000595618.5
ENST00000594824.5
MYO9B
myosin IXB
chr6_+_6588708 0.01 ENST00000230568.5
LY86
lymphocyte antigen 86
chr17_-_42028662 0.01 ENST00000461831.1
ZNF385C
zinc finger protein 385C
chr7_-_142258027 0.01 ENST00000552471.1
ENST00000547058.6
PRSS58
serine protease 58
chr20_-_3786677 0.01 ENST00000379751.5
CENPB
centromere protein B
chr13_-_41019289 0.01 ENST00000239882.7
ELF1
E74 like ETS transcription factor 1
chr1_-_51878711 0.01 ENST00000352171.12
NRDC
nardilysin convertase
chr18_-_46757012 0.01 ENST00000315087.12
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr10_-_116273606 0.01 ENST00000682743.1
GFRA1
GDNF family receptor alpha 1
chr18_-_46756791 0.01 ENST00000538168.5
ENST00000536490.1
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr12_+_53454819 0.01 ENST00000562264.5
PCBP2
poly(rC) binding protein 2
chr11_-_2301859 0.01 ENST00000456145.2
ENST00000381153.8
C11orf21
chromosome 11 open reading frame 21
chr7_+_100219236 0.01 ENST00000317271.2
PVRIG
PVR related immunoglobulin domain containing
chr12_+_67648737 0.01 ENST00000344096.4
ENST00000393555.3
DYRK2
dual specificity tyrosine phosphorylation regulated kinase 2
chr10_+_101354028 0.01 ENST00000393441.8
BTRC
beta-transducin repeat containing E3 ubiquitin protein ligase
chr6_-_52803807 0.00 ENST00000334575.6
GSTA1
glutathione S-transferase alpha 1
chr3_+_46877705 0.00 ENST00000449590.6
PTH1R
parathyroid hormone 1 receptor
chr1_-_51878799 0.00 ENST00000354831.11
ENST00000544028.5
NRDC
nardilysin convertase
chr21_+_33229883 0.00 ENST00000382264.7
ENST00000342136.9
ENST00000404220.7
IFNAR2
interferon alpha and beta receptor subunit 2
chr16_+_56935371 0.00 ENST00000568358.1
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr12_-_68253502 0.00 ENST00000328087.6
ENST00000538666.6
IL22
interleukin 22
chr12_+_53454764 0.00 ENST00000439930.7
ENST00000548933.5
PCBP2
poly(rC) binding protein 2
chr1_+_45012896 0.00 ENST00000428106.1
UROD
uroporphyrinogen decarboxylase
chr1_-_10947870 0.00 ENST00000468348.1
C1orf127
chromosome 1 open reading frame 127
chr12_+_49295138 0.00 ENST00000257860.9
PRPH
peripherin
chr2_-_128027273 0.00 ENST00000259235.7
ENST00000357702.9
ENST00000424298.5
SAP130
Sin3A associated protein 130
chr14_+_104138578 0.00 ENST00000423312.7
KIF26A
kinesin family member 26A
chr14_+_23953729 0.00 ENST00000558263.5
ENST00000543741.6
ENST00000313250.10
ENST00000397075.7
ENST00000397074.7
ENST00000559632.5
ENST00000558581.5
DHRS4
dehydrogenase/reductase 4
chr1_-_53940100 0.00 ENST00000371376.1
HSPB11
heat shock protein family B (small) member 11
chr4_+_25160631 0.00 ENST00000510415.1
ENST00000507794.2
ENST00000512921.4
SEPSECS-AS1
PI4K2B
SEPSECS antisense RNA 1 (head to head)
phosphatidylinositol 4-kinase type 2 beta
chr1_+_45012691 0.00 ENST00000469548.5
UROD
uroporphyrinogen decarboxylase

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0072276 branchiomeric skeletal muscle development(GO:0014707) bronchiole development(GO:0060435) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.1 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.2 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.1 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.2 GO:0031696 alpha-2C adrenergic receptor binding(GO:0031696)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:1902444 riboflavin binding(GO:1902444)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)