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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for HOXD1

Z-value: 1.33

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.15 homeobox D1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg38_v1_chr2_+_176188658_1761886740.686.5e-02Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_7263959 0.96 ENST00000571932.2
CLDN7
claudin 7
chr3_-_151316795 0.94 ENST00000260843.5
GPR87
G protein-coupled receptor 87
chr11_-_102780620 0.72 ENST00000279441.9
ENST00000539681.1
MMP10
matrix metallopeptidase 10
chr5_+_67004618 0.70 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_99766620 0.67 ENST00000646001.2
FRRS1
ferric chelate reductase 1
chr1_+_160400543 0.57 ENST00000368061.3
VANGL2
VANGL planar cell polarity protein 2
chr6_+_130421086 0.56 ENST00000545622.5
TMEM200A
transmembrane protein 200A
chr3_+_111999189 0.54 ENST00000455401.6
TAGLN3
transgelin 3
chr3_+_111999326 0.52 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111998915 0.51 ENST00000478951.6
TAGLN3
transgelin 3
chr3_+_111998739 0.50 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr4_+_143433491 0.44 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr5_+_36606355 0.43 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr20_-_51802433 0.41 ENST00000395997.3
SALL4
spalt like transcription factor 4
chr4_-_25863537 0.38 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L3
SEL1L family member 3
chr6_+_121437378 0.38 ENST00000650427.1
ENST00000647564.1
GJA1
gap junction protein alpha 1
chr9_-_5304713 0.35 ENST00000381627.4
RLN2
relaxin 2
chr5_-_140346596 0.33 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chrX_-_31178220 0.33 ENST00000681026.1
DMD
dystrophin
chr11_+_65787056 0.32 ENST00000335987.8
OVOL1
ovo like transcriptional repressor 1
chr12_+_29223730 0.32 ENST00000547116.5
FAR2
fatty acyl-CoA reductase 2
chr12_+_29223659 0.32 ENST00000182377.8
FAR2
fatty acyl-CoA reductase 2
chr20_-_51802509 0.30 ENST00000371539.7
ENST00000217086.9
SALL4
spalt like transcription factor 4
chr9_-_5339874 0.29 ENST00000223862.2
RLN1
relaxin 1
chr11_-_124320197 0.26 ENST00000624618.2
OR8D2
olfactory receptor family 8 subfamily D member 2
chr6_+_130018565 0.25 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr3_-_191282383 0.23 ENST00000427544.6
UTS2B
urotensin 2B
chrX_+_108045050 0.21 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr19_-_3557563 0.19 ENST00000389395.7
ENST00000355415.7
MFSD12
major facilitator superfamily domain containing 12
chrX_+_108044967 0.18 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr9_+_121567057 0.17 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2IP
DAB2 interacting protein
chr6_-_111606260 0.14 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr13_-_35476682 0.14 ENST00000379919.6
MAB21L1
mab-21 like 1
chr1_-_92486916 0.13 ENST00000294702.6
GFI1
growth factor independent 1 transcriptional repressor
chr8_-_48921419 0.12 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chrX_+_115593570 0.12 ENST00000539310.5
PLS3
plastin 3
chr9_+_72577939 0.11 ENST00000645773.1
TMC1
transmembrane channel like 1
chr14_+_56117702 0.10 ENST00000559044.5
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr12_-_9869345 0.10 ENST00000228438.3
CLEC2B
C-type lectin domain family 2 member B
chr1_-_201171545 0.10 ENST00000367333.6
TMEM9
transmembrane protein 9
chr20_+_9514562 0.09 ENST00000246070.3
LAMP5
lysosomal associated membrane protein family member 5
chr17_-_10469558 0.09 ENST00000255381.2
MYH4
myosin heavy chain 4
chr12_+_28257195 0.09 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr10_+_97446137 0.09 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
ZDHHC16
zinc finger DHHC-type palmitoyltransferase 16
chr17_-_40799939 0.09 ENST00000306658.8
KRT28
keratin 28
chr4_-_149815826 0.09 ENST00000636793.2
ENST00000636414.1
IQCM
IQ motif containing M
chr19_+_54137740 0.08 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CNOT3
CCR4-NOT transcription complex subunit 3
chr12_-_23584600 0.08 ENST00000396007.6
SOX5
SRY-box transcription factor 5
chr10_+_97446194 0.08 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
ZDHHC16
zinc finger DHHC-type palmitoyltransferase 16
chr3_+_129528632 0.08 ENST00000296271.4
RHO
rhodopsin
chr12_-_21910853 0.08 ENST00000544039.5
ABCC9
ATP binding cassette subfamily C member 9
chr11_+_118527463 0.07 ENST00000302783.10
TTC36
tetratricopeptide repeat domain 36
chr4_+_85827745 0.07 ENST00000509300.5
ARHGAP24
Rho GTPase activating protein 24
chr17_+_59155726 0.07 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chr5_+_64505981 0.07 ENST00000334025.3
RGS7BP
regulator of G protein signaling 7 binding protein
chr11_-_72112068 0.07 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
ANAPC15
anaphase promoting complex subunit 15
chr1_+_207325629 0.06 ENST00000618707.2
CD55
CD55 molecule (Cromer blood group)
chr5_+_132873660 0.06 ENST00000296877.3
LEAP2
liver enriched antimicrobial peptide 2
chr1_+_117001744 0.06 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr12_-_118359639 0.06 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr19_+_10252206 0.06 ENST00000253099.11
ENST00000393733.6
ENST00000588502.5
MRPL4
mitochondrial ribosomal protein L4
chr4_+_85827891 0.05 ENST00000514229.5
ARHGAP24
Rho GTPase activating protein 24
chr2_+_134838610 0.05 ENST00000356140.10
ENST00000392928.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr6_-_111605859 0.05 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr6_-_110179995 0.05 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASF1
WASP family member 1
chr15_+_58410543 0.05 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr6_+_110180418 0.04 ENST00000368930.5
ENST00000307731.2
CDC40
cell division cycle 40
chr5_-_97142579 0.04 ENST00000274382.9
LIX1
limb and CNS expressed 1
chr11_-_72112669 0.03 ENST00000545944.5
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr11_-_72112750 0.03 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr15_+_22015233 0.03 ENST00000639059.1
ENST00000640156.1
ENSG00000285472.1
ENSG00000284500.3
novel protein
novel transcript
chr17_+_18183803 0.03 ENST00000399138.5
ALKBH5
alkB homolog 5, RNA demethylase
chr14_+_32329341 0.03 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
AKAP6
A-kinase anchoring protein 6
chr10_-_97445850 0.03 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
EXOSC1
exosome component 1
chr19_-_14848922 0.03 ENST00000641129.1
OR7A10
olfactory receptor family 7 subfamily A member 10
chr7_-_73842508 0.02 ENST00000297873.9
METTL27
methyltransferase like 27
chr15_+_21579912 0.02 ENST00000628444.1
LINC02203
long intergenic non-protein coding RNA 2203
chr10_+_27532521 0.02 ENST00000683924.1
RAB18
RAB18, member RAS oncogene family
chr15_-_55270280 0.02 ENST00000564609.5
RAB27A
RAB27A, member RAS oncogene family
chr4_-_68245683 0.01 ENST00000332644.6
TMPRSS11B
transmembrane serine protease 11B
chr6_+_110180116 0.01 ENST00000368932.5
CDC40
cell division cycle 40
chr8_+_91249307 0.01 ENST00000309536.6
ENST00000276609.8
SLC26A7
solute carrier family 26 member 7
chr17_+_58169401 0.01 ENST00000641866.1
OR4D2
olfactory receptor family 4 subfamily D member 2
chr7_-_81770122 0.01 ENST00000423064.7
HGF
hepatocyte growth factor
chr7_-_81770039 0.00 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
HGF
hepatocyte growth factor
chr11_+_72189659 0.00 ENST00000393681.6
FOLR1
folate receptor alpha
chr2_+_186506713 0.00 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.3 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 0.6 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.4 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.0 0.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.4 GO:0009449 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 1.0 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.2 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.2 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.3 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:1902688 regulation of NAD metabolic process(GO:1902688)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.1 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.0 0.2 GO:1990032 parallel fiber(GO:1990032)
0.0 1.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0060342 photoreceptor inner segment membrane(GO:0060342)
0.0 0.3 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916) connexon complex(GO:0005922)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.0 0.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0050998 vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.4 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling