Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for IRX5
Z-value: 0.88
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Transcription factors associated with IRX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX5 | hg38_v1_chr16_+_54930827_54930898 | 0.57 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_107498041 Show fit | 1.04 |
ENST00000297450.7
|
angiopoietin 1 |
|
| chr5_+_93583212 Show fit | 0.99 |
ENST00000327111.8
|
nuclear receptor subfamily 2 group F member 1 |
|
| chr11_-_35526024 Show fit | 0.87 |
ENST00000615849.4
|
peptidase domain containing associated with muscle regeneration 1 |
|
| chr1_-_145910031 Show fit | 0.85 |
ENST00000369304.8
|
integrin subunit alpha 10 |
|
| chr1_-_145910066 Show fit | 0.74 |
ENST00000539363.2
|
integrin subunit alpha 10 |
|
| chr8_-_107497909 Show fit | 0.71 |
ENST00000517746.6
|
angiopoietin 1 |
|
| chr3_+_12351493 Show fit | 0.65 |
ENST00000683699.1
|
peroxisome proliferator activated receptor gamma |
|
| chr3_+_12351470 Show fit | 0.57 |
ENST00000287820.10
|
peroxisome proliferator activated receptor gamma |
|
| chr12_+_21526287 Show fit | 0.48 |
ENST00000256969.7
|
spexin hormone |
|
| chr12_+_55720405 Show fit | 0.46 |
ENST00000548082.1
|
retinol dehydrogenase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 0.2 | 1.2 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.0 | 0.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.1 | 0.8 | GO:0010966 | regulation of phosphate transport(GO:0010966) |
| 0.1 | 0.7 | GO:1904306 | regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306) |
| 0.1 | 0.5 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.0 | 0.4 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.0 | 0.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.0 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.3 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.3 | 1.6 | GO:0034680 | integrin alpha10-beta1 complex(GO:0034680) |
| 0.0 | 0.7 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.2 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.0 | 0.1 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 0.0 | 0.1 | GO:0033150 | cytoskeletal calyx(GO:0033150) |
| 0.0 | 0.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.1 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.2 | 1.6 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.1 | 1.2 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 1.0 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.9 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.3 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.1 | GO:0070538 | oleic acid binding(GO:0070538) |
| 0.0 | 0.1 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.6 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 1.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.9 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 1.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.5 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.2 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |