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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for KLF1
Z-value: 3.88
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg38_v1_chr19_-_12887188_12887207 | 0.54 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_43593054 Show fit | 6.14 |
ENST00000453782.5
ENST00000300283.10 ENST00000437924.5 |
creatine kinase, mitochondrial 1B |
|
| chr15_+_43692886 Show fit | 5.36 |
ENST00000434505.5
ENST00000411750.5 |
creatine kinase, mitochondrial 1A |
|
| chr1_-_153616289 Show fit | 5.08 |
ENST00000368701.5
ENST00000344616.4 |
S100 calcium binding protein A14 |
|
| chr19_-_35513641 Show fit | 3.94 |
ENST00000339686.8
ENST00000447113.6 |
dermokine |
|
| chr18_+_31447732 Show fit | 3.92 |
ENST00000257189.5
|
desmoglein 3 |
|
| chr19_-_51020154 Show fit | 3.65 |
ENST00000391805.5
ENST00000599077.1 |
kallikrein related peptidase 10 |
|
| chr19_-_51020019 Show fit | 3.49 |
ENST00000309958.7
|
kallikrein related peptidase 10 |
|
| chr11_+_130159773 Show fit | 3.39 |
ENST00000278742.6
|
ST14 transmembrane serine protease matriptase |
|
| chr19_-_51019699 Show fit | 3.37 |
ENST00000358789.8
|
kallikrein related peptidase 10 |
|
| chr10_-_47484081 Show fit | 3.22 |
ENST00000583448.2
ENST00000583874.5 ENST00000585281.6 |
annexin A8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.0 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 7.7 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.2 | 6.5 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.2 | 6.2 | GO:0061146 | Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021) |
| 0.1 | 6.1 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.4 | 5.8 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.2 | 5.1 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.1 | 4.9 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.5 | 4.3 | GO:0002934 | desmosome organization(GO:0002934) |
| 1.0 | 3.9 | GO:1903575 | cornified envelope assembly(GO:1903575) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 6.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 5.7 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.2 | 5.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.2 | 5.4 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 3.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 3.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.4 | 3.0 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 3.0 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 2.6 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 11.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 7.2 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.9 | 6.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 5.0 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 5.0 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.4 | 4.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.5 | 4.4 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.2 | 3.9 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.3 | 3.6 | GO:0019534 | toxin transporter activity(GO:0019534) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 12.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 11.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 6.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 2.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 2.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 1.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.4 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 9.1 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.3 | 7.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 5.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 5.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 3.1 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 2.9 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 2.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |