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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for KLF16_SP2
Z-value: 0.94
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Transcription factors associated with KLF16_SP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP2 | hg38_v1_chr17_+_47896150_47896262 | -0.22 | 6.0e-01 | Click! |
| KLF16 | hg38_v1_chr19_-_1863497_1863587 | 0.05 | 9.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF16_SP2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | GO:0000052 | citrulline metabolic process(GO:0000052) |
| 0.3 | 3.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 3.7 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.1 | 3.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 2.9 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.0 | 2.8 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.2 | 2.6 | GO:0032025 | response to cobalt ion(GO:0032025) |
| 0.1 | 2.5 | GO:0060180 | female mating behavior(GO:0060180) |
| 0.0 | 2.5 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.0 | 2.4 | GO:0043966 | histone H3 acetylation(GO:0043966) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 4.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.4 | 3.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 3.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 2.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.4 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.0 | 2.4 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 2.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 2.3 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 5.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 3.8 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.2 | 3.0 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
| 0.1 | 3.0 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 2.7 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 2.3 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 2.0 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.0 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 2.0 | GO:0061650 | ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 2.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.3 | PID EPO PATHWAY | EPO signaling pathway |
| 0.1 | 2.1 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 2.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.6 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 3.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 3.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 2.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 2.7 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.1 | 2.4 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |