ISMARA results: KLF3

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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for KLF3

Z-value: 1.71

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Transcription factors associated with KLF3

Gene Symbol	Gene ID	Gene Info
KLF3 Ensembl NCBI GeneCards UniProt	ENSG00000109787.13	Kruppel like factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
KLF3	hg38_v1_chr4_+_38664189_38664206	0.65	8.3e-02	Click!

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_35501878 Show fit	2.73	ENST00000593342.5 ENST00000601650.1 ENST00000408915.6	DMKN Ensembl NCBI GeneCards UniProt Show fit	dermokine
chr15_+_43593054 Show fit	2.11	ENST00000453782.5 ENST00000300283.10 ENST00000437924.5	CKMT1B Ensembl NCBI GeneCards UniProt Show fit	creatine kinase, mitochondrial 1B
chr19_-_51020019 Show fit	1.97	ENST00000309958.7	KLK10 Ensembl NCBI GeneCards UniProt Show fit	kallikrein related peptidase 10
chr1_+_2073462 Show fit	1.76	ENST00000400921.6	PRKCZ Ensembl NCBI GeneCards UniProt Show fit	protein kinase C zeta
chr18_+_63887698 Show fit	1.37	ENST00000457692.5 ENST00000299502.9 ENST00000413956.5	SERPINB2 Ensembl NCBI GeneCards UniProt Show fit	serpin family B member 2
chr20_+_46008900 Show fit	1.32	ENST00000372330.3	MMP9 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 9
chr6_-_106974721 Show fit	1.32	ENST00000606017.2 ENST00000620405.1	CD24 Ensembl NCBI GeneCards UniProt Show fit	CD24 molecule
chr1_+_2073986 Show fit	1.15	ENST00000461106.6	PRKCZ Ensembl NCBI GeneCards UniProt Show fit	protein kinase C zeta
chr6_-_136526472 Show fit	1.12	ENST00000454590.5 ENST00000432797.6	MAP7 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 7
chr6_-_136525961 Show fit	1.00	ENST00000438100.6	MAP7 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein 7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.9	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.7	2.7	GO:1903575	cornified envelope assembly(GO:1903575)
0.0	2.2	GO:0006970	response to osmotic stress(GO:0006970)
0.5	1.9	GO:1900138	negative regulation of phospholipase A2 activity(GO:1900138)
0.0	1.8	GO:0008088	axo-dendritic transport(GO:0008088)
0.2	1.7	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.2	1.5	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	1.5	GO:0042730	fibrinolysis(GO:0042730)
0.3	1.3	GO:0032595	B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.2	1.1	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)

Showing 1 to 10 of 128 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.0	GO:0043203	axon hillock(GO:0043203)
0.1	2.0	GO:0035253	ciliary rootlet(GO:0035253)
0.0	1.3	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	1.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.2	1.0	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.0	1.0	GO:0005861	troponin complex(GO:0005861)
0.0	0.9	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.9	GO:0044295	axonal growth cone(GO:0044295)
0.2	0.8	GO:0072534	perineuronal net(GO:0072534)
0.0	0.8	GO:0005922	connexon complex(GO:0005922)

Showing 1 to 10 of 47 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	2.9	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	2.0	GO:0019894	kinesin binding(GO:0019894)
0.1	1.8	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	1.8	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	1.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.5	GO:0038191	neuropilin binding(GO:0038191)
0.0	1.3	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.2	1.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1	1.0	GO:0038132	neuregulin binding(GO:0038132)

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	1.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.7	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.5	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.6	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	2.2	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	1.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	1.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.8	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.7	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 24 entries

Results for KLF3

Z-value: 1.71

Motif logo

Transcription factors associated with KLF3

Activity-expression correlation:

Activity profile of KLF3 motif

Sorted Z-values of KLF3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of KLF3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: