Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for KLF6
Z-value: 0.98
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Transcription factors associated with KLF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF6 | hg38_v1_chr10_-_3785197_3785216 | 0.07 | 8.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_159171607 Show fit | 1.32 |
ENST00000368124.8
ENST00000368125.9 ENST00000416746.1 |
cell adhesion molecule 3 |
|
| chr14_-_29927596 Show fit | 1.21 |
ENST00000415220.6
|
protein kinase D1 |
|
| chr14_-_29927473 Show fit | 0.94 |
ENST00000616995.4
|
protein kinase D1 |
|
| chr14_-_29927801 Show fit | 0.91 |
ENST00000331968.11
|
protein kinase D1 |
|
| chr5_+_93584916 Show fit | 0.85 |
ENST00000647447.1
ENST00000615873.1 |
nuclear receptor subfamily 2 group F member 1 |
|
| chr14_-_59630806 Show fit | 0.81 |
ENST00000342503.8
|
reticulon 1 |
|
| chr14_-_59630582 Show fit | 0.80 |
ENST00000395090.5
|
reticulon 1 |
|
| chr5_+_68215738 Show fit | 0.77 |
ENST00000521381.6
ENST00000521657.5 |
phosphoinositide-3-kinase regulatory subunit 1 |
|
| chr1_+_113979460 Show fit | 0.76 |
ENST00000320334.5
|
olfactomedin like 3 |
|
| chr1_+_113979391 Show fit | 0.76 |
ENST00000393300.6
ENST00000369551.5 |
olfactomedin like 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.8 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.2 | 1.4 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.2 | 1.2 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 0.1 | 1.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.3 | 1.0 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.0 | 0.9 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.0 | 0.9 | GO:0050884 | neuromuscular process controlling posture(GO:0050884) |
| 0.0 | 0.9 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.8 | GO:0060988 | lipid tube assembly(GO:0060988) |
| 0.1 | 0.8 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.4 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.4 | 1.2 | GO:0060987 | lipid tube(GO:0060987) |
| 0.0 | 1.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.1 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.1 | 1.0 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.9 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 0.8 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 1.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.3 | 1.0 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 1.0 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 1.0 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.1 | 0.9 | GO:0035014 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) |
| 0.1 | 0.8 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.8 | GO:0051430 | corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.1 | 0.7 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.1 | 0.6 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 2.3 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 1.5 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.2 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.2 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 1.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.9 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.0 | 0.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 0.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.5 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |