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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for LHX2

Z-value: 0.72

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
ENSG00000106689.11 LIM homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg38_v1_chr9_+_124015397_124015421,
hg38_v1_chr9_+_124011738_124011777
0.176.8e-01Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_31447732 1.41 ENST00000257189.5
desmoglein 3
chr10_+_116427839 0.53 ENST00000369230.4
pancreatic lipase related protein 3
chr20_-_47786553 0.46 ENST00000467815.5
ENST00000359930.8
ENST00000484875.5
sulfatase 2
chr6_+_125203639 0.45 ENST00000392482.6
TPD52 like 1
chr1_+_160400543 0.41 ENST00000368061.3
VANGL planar cell polarity protein 2
chr7_-_22194709 0.39 ENST00000458533.5
Rap guanine nucleotide exchange factor 5
chr1_-_207032749 0.38 ENST00000359470.6
ENST00000461135.2
chromosome 1 open reading frame 116
chr2_+_68734773 0.31 ENST00000409202.8
Rho GTPase activating protein 25
chr6_+_30880780 0.31 ENST00000460944.6
ENST00000324771.12
discoidin domain receptor tyrosine kinase 1
chr18_+_36544544 0.30 ENST00000591635.5
formin homology 2 domain containing 3
chr10_-_114526897 0.25 ENST00000428430.1
ENST00000392952.7
actin binding LIM protein 1
chr4_-_89835617 0.25 ENST00000611107.1
ENST00000345009.8
ENST00000505199.5
ENST00000502987.5
synuclein alpha
chr1_-_183590876 0.24 ENST00000367536.5
neutrophil cytosolic factor 2
chr11_+_18132565 0.23 ENST00000621697.2
MAS related GPR family member X3
chr5_-_35938572 0.22 ENST00000651391.1
ENST00000397366.5
ENST00000513623.5
ENST00000514524.2
ENST00000397367.6
calcyphosine like
chr4_+_68447453 0.21 ENST00000305363.9
transmembrane serine protease 11E
chr5_+_36606355 0.21 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr2_+_68734861 0.21 ENST00000467265.5
Rho GTPase activating protein 25
chr3_-_191282383 0.20 ENST00000427544.6
urotensin 2B
chr2_+_102355750 0.18 ENST00000233957.7
interleukin 18 receptor 1
chr12_-_11022620 0.18 ENST00000390673.2
taste 2 receptor member 19
chr4_-_159035226 0.18 ENST00000434826.3
chromosome 4 open reading frame 45
chr1_-_68050615 0.16 ENST00000646789.1
DIRAS family GTPase 3
chr15_-_51243011 0.16 ENST00000405913.7
ENST00000559878.5
cytochrome P450 family 19 subfamily A member 1
chr6_+_130018565 0.14 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr11_-_55936400 0.14 ENST00000301532.3
olfactory receptor family 5 subfamily I member 1
chr5_-_78985951 0.14 ENST00000396151.7
arylsulfatase B
chr13_+_24270681 0.14 ENST00000343003.10
ENST00000399949.6
spermatogenesis associated 13
chr10_+_93566659 0.13 ENST00000371481.9
ENST00000371483.8
ENST00000604414.1
free fatty acid receptor 4
chr14_-_33951052 0.12 ENST00000250457.9
ENST00000547327.2
egl-9 family hypoxia inducible factor 3
chr18_+_58341038 0.12 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr7_+_144000320 0.12 ENST00000641698.1
olfactory receptor family 6 subfamily B member 1
chrX_-_11265975 0.12 ENST00000303025.10
ENST00000657361.1
Rho GTPase activating protein 6
chr1_+_99646025 0.11 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
palmdelphin
chr20_+_5750437 0.11 ENST00000445603.1
ENST00000442185.1
shieldin complex subunit 1
chr14_+_22226711 0.11 ENST00000390463.3
T cell receptor alpha variable 36/delta variable 7
chr1_+_160739286 0.10 ENST00000359331.8
ENST00000495334.1
SLAM family member 7
chr9_+_121651594 0.10 ENST00000408936.7
DAB2 interacting protein
chr11_+_27055215 0.10 ENST00000525090.1
gamma-butyrobetaine hydroxylase 1
chr13_+_73058993 0.10 ENST00000377687.6
Kruppel like factor 5
chr1_+_152811971 0.10 ENST00000360090.4
late cornified envelope 1B
chr17_-_41140487 0.10 ENST00000345847.4
keratin associated protein 4-6
chr7_+_37920602 0.09 ENST00000199448.9
ENST00000423717.1
ependymin related 1
chr2_+_102337148 0.09 ENST00000311734.6
ENST00000409584.5
interleukin 1 receptor like 1
chr11_+_63838902 0.09 ENST00000377810.8
microtubule affinity regulating kinase 2
chr6_+_29111560 0.09 ENST00000377169.2
olfactory receptor family 2 subfamily J member 3
chr8_-_81483226 0.09 ENST00000256104.5
fatty acid binding protein 4
chr5_-_157109025 0.09 ENST00000307851.9
hepatitis A virus cellular receptor 2
chr12_-_123272234 0.09 ENST00000544658.5
cyclin dependent kinase 2 associated protein 1
chr6_-_27873525 0.08 ENST00000618305.2
H4 clustered histone 13
chr6_+_26199509 0.08 ENST00000356530.5
H2B clustered histone 7
chr5_+_141177790 0.08 ENST00000239444.4
ENST00000623995.1
protocadherin beta 8
novel transcript
chr17_-_7857139 0.08 ENST00000576384.1
N-alpha-acetyltransferase 38, NatC auxiliary subunit
chr3_+_4680617 0.08 ENST00000648212.1
inositol 1,4,5-trisphosphate receptor type 1
chr1_+_92168915 0.08 ENST00000637221.2
BTB domain containing 8
chr3_-_161105224 0.07 ENST00000651254.1
ENST00000651178.1
ENST00000476999.6
ENST00000652596.1
ENST00000651305.1
ENST00000652111.1
ENST00000651292.1
ENST00000651282.1
ENST00000651380.1
ENST00000494173.7
ENST00000484127.5
ENST00000650733.1
ENST00000494818.6
ENST00000492353.5
ENST00000652143.1
ENST00000473142.5
ENST00000651147.1
ENST00000468268.5
ENST00000460353.2
ENST00000651953.1
ENST00000651972.1
ENST00000652730.1
ENST00000651460.1
ENST00000652059.1
ENST00000651509.1
ENST00000651801.1
ENST00000651686.1
ENST00000320474.10
ENST00000392781.7
ENST00000392779.6
ENST00000651791.1
ENST00000651117.1
ENST00000652032.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_+_160739265 0.07 ENST00000368042.7
SLAM family member 7
chr17_-_41168219 0.07 ENST00000391356.4
keratin associated protein 4-3
chr17_-_40703744 0.07 ENST00000264651.3
keratin 24
chr3_-_161105399 0.07 ENST00000652593.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_+_160739239 0.07 ENST00000368043.8
SLAM family member 7
chr3_-_161105070 0.06 ENST00000651430.1
ENST00000650695.1
ENST00000651689.1
ENST00000651916.1
ENST00000488170.5
ENST00000652377.1
ENST00000652669.1
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr1_+_86547070 0.06 ENST00000370563.3
chloride channel accessory 4
chr3_+_37975773 0.06 ENST00000436654.1
CTD small phosphatase like
chr5_-_59216826 0.06 ENST00000638939.1
phosphodiesterase 4D
chr3_+_35680994 0.06 ENST00000441454.5
cAMP regulated phosphoprotein 21
chr16_-_23641270 0.06 ENST00000568219.5
ENST00000261584.9
partner and localizer of BRCA2
chr1_+_244352627 0.06 ENST00000366537.5
ENST00000308105.5
chromosome 1 open reading frame 100
chr6_-_26199272 0.06 ENST00000650491.1
ENST00000635200.1
ENST00000341023.2
novel protein
H2A clustered histone 7
chr2_+_102418642 0.06 ENST00000264260.6
interleukin 18 receptor accessory protein
chr8_-_108248700 0.05 ENST00000220849.10
ENST00000678937.1
ENST00000678901.1
ENST00000678243.1
ENST00000677674.1
ENST00000521297.2
ENST00000677272.1
ENST00000522352.6
ENST00000678042.1
ENST00000519627.2
ENST00000521440.6
ENST00000678773.1
ENST00000676698.1
ENST00000518345.2
ENST00000677447.1
ENST00000676548.1
ENST00000519030.6
ENST00000518442.5
eukaryotic translation initiation factor 3 subunit E
chr6_+_122717544 0.05 ENST00000354275.2
ENST00000368446.1
cAMP-dependent protein kinase inhibitor beta
chr7_-_38265678 0.05 ENST00000443402.6
T cell receptor gamma constant 1
chr14_+_69398683 0.05 ENST00000556605.5
ENST00000031146.8
ENST00000336643.10
solute carrier family 39 member 9
chr16_-_48610150 0.05 ENST00000262384.4
NEDD4 binding protein 1
chr15_+_21579912 0.05 ENST00000628444.1
long intergenic non-protein coding RNA 2203
chr12_-_100262356 0.05 ENST00000548313.5
DEP domain containing 4
chr4_+_69931066 0.05 ENST00000246891.9
casein alpha s1
chr13_-_19181773 0.05 ENST00000618094.1
ENST00000400113.8
tubulin alpha 3c
chr14_-_69398276 0.05 ENST00000557016.6
ENST00000555373.1
ERH mRNA splicing and mitosis factor
chr10_-_97687191 0.04 ENST00000370626.4
arginine vasopressin induced 1
chr17_-_38853629 0.04 ENST00000378096.3
ENST00000479035.7
ENST00000394332.5
ENST00000394333.5
ENST00000577407.5
ribosomal protein L23
chr11_+_55635113 0.04 ENST00000641760.1
olfactory receptor family 4 subfamily P member 4
chr1_-_147670235 0.04 ENST00000392988.6
acid phosphatase 6, lysophosphatidic
chr3_-_20012250 0.04 ENST00000389050.5
protein phosphatase 2C like domain containing 1
chr8_+_75539893 0.04 ENST00000674002.1
hepatocyte nuclear factor 4 gamma
chr8_+_75539862 0.04 ENST00000396423.4
hepatocyte nuclear factor 4 gamma
chr10_-_60141004 0.04 ENST00000355288.6
ankyrin 3
chr14_+_56117702 0.04 ENST00000559044.5
pellino E3 ubiquitin protein ligase family member 2
chr17_+_59331633 0.03 ENST00000312655.9
yippee like 2
chr12_-_21775581 0.03 ENST00000537950.1
ENST00000665145.1
potassium inwardly rectifying channel subfamily J member 8
chr2_+_119679154 0.03 ENST00000401466.5
ENST00000424086.5
transmembrane protein 177
chr15_+_22015233 0.03 ENST00000639059.1
ENST00000640156.1
novel protein
novel transcript
chr16_+_31259922 0.03 ENST00000648685.1
ENST00000544665.9
integrin subunit alpha M
chr6_+_32844789 0.03 ENST00000414474.5
proteasome 20S subunit beta 9
chr1_-_89126066 0.03 ENST00000370466.4
guanylate binding protein 2
chr2_+_119679184 0.03 ENST00000445518.1
ENST00000272521.7
ENST00000409951.1
transmembrane protein 177
chr2_+_233307806 0.03 ENST00000447536.5
ENST00000409110.6
S-antigen visual arrestin
chr18_+_63702958 0.03 ENST00000544088.6
serpin family B member 11
chr9_+_122519141 0.03 ENST00000340750.1
olfactory receptor family 1 subfamily J member 4
chr6_+_26087281 0.03 ENST00000353147.9
ENST00000397022.7
ENST00000352392.8
ENST00000349999.8
ENST00000317896.11
ENST00000470149.5
ENST00000336625.12
ENST00000461397.5
ENST00000488199.5
homeostatic iron regulator
chr2_+_233718734 0.03 ENST00000373409.8
UDP glucuronosyltransferase family 1 member A4
chr11_+_124184244 0.03 ENST00000641546.1
olfactory receptor family 10 subfamily D member 3
chr14_+_55611977 0.03 ENST00000395309.7
ENST00000413890.6
kinectin 1
chr16_-_56451316 0.03 ENST00000300291.10
nudix hydrolase 21
chr17_-_59151794 0.03 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr2_+_172821575 0.03 ENST00000397087.7
Rap guanine nucleotide exchange factor 4
chr17_-_40984297 0.02 ENST00000377755.9
keratin 40
chr5_-_175961324 0.02 ENST00000432305.6
ENST00000505969.1
THO complex 3
chr11_+_124183219 0.02 ENST00000641351.2
olfactory receptor family 10 subfamily D member 3
chr1_-_7940825 0.02 ENST00000377507.8
TNF receptor superfamily member 9
chr7_-_5959083 0.02 ENST00000539903.5
radial spoke head 10 homolog B
chr10_-_104232301 0.02 ENST00000369720.6
ENST00000369719.2
ENST00000278064.7
ENST00000357060.8
cilia and flagella associated protein 43
chr11_+_94973640 0.02 ENST00000335080.6
ENST00000536741.1
lysine demethylase 4D
chr20_+_35954564 0.02 ENST00000622112.4
ENST00000614708.1
cyclic nucleotide binding domain containing 2
chr1_-_150765785 0.02 ENST00000680311.1
ENST00000681728.1
ENST00000680288.1
cathepsin S
chr15_+_58138368 0.02 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr2_-_127526444 0.02 ENST00000295321.9
interacts with SUPT6H, CTD assembly factor 1
chr13_-_99307387 0.02 ENST00000376414.5
G protein-coupled receptor 183
chr6_+_29306626 0.02 ENST00000377160.4
olfactory receptor family 14 subfamily J member 1
chrX_-_139642518 0.02 ENST00000370573.8
ENST00000338585.6
MCF.2 cell line derived transforming sequence
chr7_-_140398456 0.02 ENST00000340308.7
ENST00000447932.6
ENST00000326232.14
ENST00000469193.5
solute carrier family 37 member 3
chr11_-_40294089 0.02 ENST00000278198.2
leucine rich repeat containing 4C
chr14_+_22086401 0.02 ENST00000390451.2
T cell receptor alpha variable 23/delta variable 6
chr21_-_14210884 0.01 ENST00000679868.1
ENST00000400211.3
ENST00000680801.1
ENST00000536861.6
ENST00000614229.5
lipase I
chr1_-_115089414 0.01 ENST00000433172.3
ENST00000369515.6
ENST00000369516.7
tetraspanin 2
chr5_-_75712419 0.01 ENST00000510798.5
ENST00000446329.6
POC5 centriolar protein
chr2_-_178651500 0.01 ENST00000446966.1
ENST00000426232.5
titin
chr11_+_64234569 0.01 ENST00000309422.7
ENST00000426086.3
vascular endothelial growth factor B
chr7_-_54759182 0.01 ENST00000450622.1
ENST00000352861.9
ENST00000395535.7
SEC61 translocon subunit gamma
chr15_-_72271244 0.01 ENST00000287196.13
poly(ADP-ribose) polymerase family member 6
chr12_-_118359639 0.01 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chr7_-_83649097 0.01 ENST00000643230.2
semaphorin 3E
chr1_-_186461089 0.01 ENST00000391997.3
phosducin
chr15_-_59689283 0.01 ENST00000607373.6
ENST00000612191.4
ENST00000267859.8
BCL2 interacting protein 2
chr1_+_192716132 0.01 ENST00000647225.1
ENST00000443181.2
ribosomal protein S27a pseudogene 5
chr20_+_5750381 0.01 ENST00000378979.8
ENST00000303142.11
shieldin complex subunit 1
chr3_-_131502946 0.01 ENST00000512877.1
ENST00000264995.8
ENST00000511168.5
ENST00000425847.6
mitochondrial ribosomal protein L3
chr11_+_36594369 0.01 ENST00000678060.1
ENST00000446510.6
ENST00000676979.1
ENST00000677808.1
ENST00000617650.5
ENST00000334307.10
ENST00000531554.6
ENST00000679022.1
ENST00000347206.8
ENST00000534635.5
ENST00000676921.1
ENST00000678950.1
ENST00000530697.6
ENST00000527108.6
ENST00000532470.3
intraflagellar transport associated protein
chr10_+_70404129 0.01 ENST00000373218.5
eukaryotic translation initiation factor 4E binding protein 2
chr7_-_81770039 0.01 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr5_-_134367144 0.01 ENST00000265334.9
cyclin dependent kinase like 3
chr7_+_20647343 0.01 ENST00000443026.6
ENST00000406935.5
ATP binding cassette subfamily B member 5
chr2_-_208124514 0.01 ENST00000264376.5
crystallin gamma D
chr4_+_89901979 0.00 ENST00000508372.1
multimerin 1
chr1_-_27604176 0.00 ENST00000642416.1
AT-hook DNA binding motif containing 1
chr1_-_27604135 0.00 ENST00000673934.1
ENST00000642245.1
AT-hook DNA binding motif containing 1
chr3_+_98147479 0.00 ENST00000641380.1
olfactory receptor family 5 subfamily H member 14
chr4_+_37960397 0.00 ENST00000504686.2
pituitary tumor-transforming 2
chr2_-_177618705 0.00 ENST00000355689.6
tetratricopeptide repeat domain 30A
chr20_+_33283205 0.00 ENST00000253354.2
BPI fold containing family B member 1
chr19_+_55857437 0.00 ENST00000587891.5
NLR family pyrin domain containing 4

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.4 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0061580 colon epithelial cell migration(GO:0061580)
0.0 0.2 GO:2000470 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0071656 negative regulation of interleukin-3 production(GO:0032712) negative regulation of granulocyte colony-stimulating factor production(GO:0071656) negative regulation of macrophage colony-stimulating factor production(GO:1901257)
0.0 0.2 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655)
0.0 0.2 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.0 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.0 1.5 GO:0070268 cornification(GO:0070268)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.0 1.4 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0032010 phagolysosome(GO:0032010)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.2 GO:0042008 interleukin-18 receptor activity(GO:0042008)
0.1 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.2 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.3 GO:0008527 taste receptor activity(GO:0008527)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins