Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for MAFF_MAFG
Z-value: 0.80
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Transcription factors associated with MAFF_MAFG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFF | hg38_v1_chr22_+_38213530_38213541, hg38_v1_chr22_+_38201932_38202014 | 0.86 | 6.0e-03 | Click! |
| MAFG | hg38_v1_chr17_-_81923532_81923547 | 0.83 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_190122317 Show fit | 0.66 |
ENST00000427335.6
|
prolyl 3-hydroxylase 2 |
|
| chr12_-_84911178 Show fit | 0.65 |
ENST00000681688.1
|
solute carrier family 6 member 15 |
|
| chr19_+_35118456 Show fit | 0.65 |
ENST00000604621.5
|
FXYD domain containing ion transport regulator 3 |
|
| chr16_+_4788411 Show fit | 0.64 |
ENST00000589327.5
|
small integral membrane protein 22 |
|
| chr16_+_4788394 Show fit | 0.63 |
ENST00000615471.4
ENST00000589721.5 ENST00000615889.4 |
small integral membrane protein 22 |
|
| chr1_-_62319264 Show fit | 0.60 |
ENST00000354381.3
|
KN motif and ankyrin repeat domains 4 |
|
| chr1_-_62319425 Show fit | 0.56 |
ENST00000371153.9
|
KN motif and ankyrin repeat domains 4 |
|
| chr1_+_89364051 Show fit | 0.55 |
ENST00000370456.5
|
guanylate binding protein family member 6 |
|
| chr4_-_170003738 Show fit | 0.55 |
ENST00000502832.1
ENST00000393704.3 |
microfibril associated protein 3 like |
|
| chr1_+_153031195 Show fit | 0.54 |
ENST00000307098.5
|
small proline rich protein 1B |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFF_MAFG
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
| 0.0 | 0.8 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 0.7 | GO:0051122 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 0.7 | GO:0035524 | proline transmembrane transport(GO:0035524) |
| 0.0 | 0.7 | GO:0019511 | peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 0.5 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.0 | 0.5 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.0 | 0.5 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 0.4 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0043203 | axon hillock(GO:0043203) |
| 0.0 | 0.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 0.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.8 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.2 | 0.7 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) |
| 0.1 | 0.7 | GO:0005298 | proline:sodium symporter activity(GO:0005298) |
| 0.1 | 0.6 | GO:0051120 | hepoxilin A3 synthase activity(GO:0051120) |
| 0.0 | 0.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.5 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 0.5 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 0.4 | GO:1903136 | cuprous ion binding(GO:1903136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |