ISMARA results: MLX_USF2_USF1

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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for MLX_USF2_USF1_PAX2

Z-value: 2.60

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Transcription factors associated with MLX_USF2_USF1_PAX2

Gene Symbol	Gene ID	Gene Info
MLX Ensembl NCBI GeneCards UniProt	ENSG00000108788.12	MAX dimerization protein MLX
USF2 Ensembl NCBI GeneCards UniProt	ENSG00000105698.16	upstream transcription factor 2, c-fos interacting
USF1 Ensembl NCBI GeneCards UniProt	ENSG00000158773.14	upstream transcription factor 1
PAX2 Ensembl NCBI GeneCards UniProt	ENSG00000075891.23	paired box 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
USF1	hg38_v1_chr1_-_161044941_161044998, hg38_v1_chr1_-_161045961_161045988	-0.55	1.6e-01	Click!
USF2	hg38_v1_chr19_+_35269065_35269140	0.45	2.6e-01	Click!
PAX2	hg38_v1_chr10_+_100745711_100745790, hg38_v1_chr10_+_100745570_100745588, hg38_v1_chr10_+_100735390_100735402	-0.31	4.6e-01	Click!
MLX	hg38_v1_chr17_+_42567084_42567125	-0.21	6.2e-01	Click!

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_48954850 Show fit	3.97	ENST00000345358.12 ENST00000539787.2 ENST00000415969.6 ENST00000354470.7 ENST00000506183.5 ENST00000391871.4 ENST00000293288.12	BAX Ensembl NCBI GeneCards UniProt Show fit	BCL2 associated X, apoptosis regulator
chr1_+_183636065 Show fit	3.06	ENST00000304685.8	RGL1 Ensembl NCBI GeneCards UniProt Show fit	ral guanine nucleotide dissociation stimulator like 1
chr9_-_76692181 Show fit	2.58	ENST00000376717.6 ENST00000223609.10	PRUNE2 Ensembl NCBI GeneCards UniProt Show fit	prune homolog 2 with BCH domain
chr19_+_14433284 Show fit	2.39	ENST00000242783.11	PKN1 Ensembl NCBI GeneCards UniProt Show fit	protein kinase N1
chr15_+_41621492 Show fit	2.31	ENST00000570161.6	MGA Ensembl NCBI GeneCards UniProt Show fit	MAX dimerization protein MGA
chr22_+_35381086 Show fit	2.31	ENST00000216117.9 ENST00000677931.1 ENST00000679074.1	HMOX1 Ensembl NCBI GeneCards UniProt Show fit	heme oxygenase 1
chr15_+_43792305 Show fit	2.09	ENST00000249786.9 ENST00000409960.6 ENST00000409646.5 ENST00000339624.9 ENST00000409291.5 ENST00000402131.5 ENST00000403425.5 ENST00000430901.1	SERF2 Ensembl NCBI GeneCards UniProt Show fit	small EDRK-rich factor 2
chr15_+_41621134 Show fit	2.06	ENST00000566718.6	MGA Ensembl NCBI GeneCards UniProt Show fit	MAX dimerization protein MGA
chr5_-_172771187 Show fit	2.05	ENST00000239223.4	DUSP1 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 1
chrX_+_30653478 Show fit	2.05	ENST00000378945.7 ENST00000378941.4	GK Ensembl NCBI GeneCards UniProt Show fit	glycerol kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	5.4	GO:0006824	cobalt ion transport(GO:0006824)
0.4	5.3	GO:0060155	platelet dense granule organization(GO:0060155)
1.3	4.0	GO:0002339	B cell selection(GO:0002339) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.7	3.7	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	3.6	GO:0006457	protein folding(GO:0006457)
0.3	3.4	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2	2.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.4	2.5	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.4	2.5	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.6	2.4	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)

Showing 1 to 10 of 327 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.9	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1	6.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	5.4	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	4.3	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.3	4.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	3.3	GO:0043202	lysosomal lumen(GO:0043202)
0.0	3.1	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2	2.7	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.4	2.4	GO:1990131	Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	2.2	GO:0005746	mitochondrial respiratory chain(GO:0005746)

Showing 1 to 10 of 149 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.8	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.1	5.8	GO:0005507	copper ion binding(GO:0005507)
0.1	5.7	GO:0050699	WW domain binding(GO:0050699)
0.4	5.4	GO:0031419	cobalamin binding(GO:0031419)
0.0	4.1	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.3	4.0	GO:0051434	BH3 domain binding(GO:0051434)
0.7	3.7	GO:0004370	glycerol kinase activity(GO:0004370)
0.6	3.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	2.5	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.6	2.4	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)

Showing 1 to 10 of 204 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	4.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	4.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	3.7	PID MYC PATHWAY	C-MYC pathway
0.0	3.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	2.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	2.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.0	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	2.0	PID E2F PATHWAY	E2F transcription factor network
0.0	1.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.7	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	6.6	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	4.1	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	3.2	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.1	2.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	2.7	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	2.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.3	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	2.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	2.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Showing 1 to 10 of 53 entries

Results for MLX_USF2_USF1_PAX2

Z-value: 2.60

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Activity-expression correlation:

Activity profile of MLX_USF2_USF1_PAX2 motif

Sorted Z-values of MLX_USF2_USF1_PAX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: