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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NKX1-2_RAX

Z-value: 0.51

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
ENSG00000229544.9 NK1 homeobox 2
ENSG00000134438.10 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-2hg38_v1_chr10_-_124450027_1244500430.821.2e-02Click!
RAXhg38_v1_chr18_-_59273379_59273429,
hg38_v1_chr18_-_59273447_59273459
0.216.2e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_151316795 0.80 ENST00000260843.5
G protein-coupled receptor 87
chr5_+_67004618 0.42 ENST00000261569.11
ENST00000436277.5
microtubule associated serine/threonine kinase family member 4
chr6_+_125153649 0.39 ENST00000304877.17
ENST00000368402.9
ENST00000368388.6
ENST00000534000.6
TPD52 like 1
chr4_+_76435216 0.38 ENST00000296043.7
shroom family member 3
chr10_-_104085847 0.34 ENST00000648076.2
collagen type XVII alpha 1 chain
chr1_+_160400543 0.31 ENST00000368061.3
VANGL planar cell polarity protein 2
chr4_-_25863537 0.27 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L family member 3
chr5_-_83673544 0.26 ENST00000503117.1
ENST00000510978.5
hyaluronan and proteoglycan link protein 1
chr17_-_7263959 0.21 ENST00000571932.2
claudin 7
chr6_+_132538290 0.19 ENST00000434551.2
trace amine associated receptor 9
chr4_+_94974984 0.18 ENST00000672698.1
bone morphogenetic protein receptor type 1B
chr6_+_130018565 0.17 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL histone methyl-lysine binding protein 3
chr11_-_59615673 0.16 ENST00000263847.6
oxysterol binding protein
chr1_+_27934980 0.16 ENST00000373894.8
sphingomyelin phosphodiesterase acid like 3B
chr17_+_59155726 0.14 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
proline rich 11
chr14_+_22202561 0.14 ENST00000390460.1
T cell receptor alpha variable 26-2
chr19_-_3557563 0.12 ENST00000389395.7
ENST00000355415.7
major facilitator superfamily domain containing 12
chrX_+_136536099 0.12 ENST00000440515.5
ENST00000456412.1
vestigial like family member 1
chr2_+_90038848 0.12 ENST00000390270.2
immunoglobulin kappa variable 3D-20
chr16_-_81220370 0.12 ENST00000337114.8
polycystin 1 like 2 (gene/pseudogene)
chr10_+_24466487 0.11 ENST00000396446.5
ENST00000396445.5
ENST00000376451.4
KIAA1217
chr3_+_186842687 0.11 ENST00000444204.2
ENST00000320741.7
adiponectin, C1Q and collagen domain containing
chr1_-_92486916 0.10 ENST00000294702.6
growth factor independent 1 transcriptional repressor
chr9_-_5304713 0.10 ENST00000381627.4
relaxin 2
chrX_+_115593570 0.09 ENST00000539310.5
plastin 3
chr8_+_104223320 0.09 ENST00000339750.3
regulating synaptic membrane exocytosis 2
chr9_+_121567057 0.08 ENST00000394340.7
ENST00000436835.5
ENST00000259371.6
DAB2 interacting protein
chr4_-_73620629 0.08 ENST00000342081.7
Ras association domain family member 6
chr13_-_35476682 0.08 ENST00000379919.6
mab-21 like 1
chr10_+_97446137 0.08 ENST00000370854.7
ENST00000393760.6
ENST00000414567.5
zinc finger DHHC-type palmitoyltransferase 16
chr5_+_64505981 0.07 ENST00000334025.3
regulator of G protein signaling 7 binding protein
chr14_+_103385450 0.07 ENST00000416682.6
microtubule affinity regulating kinase 3
chr17_-_41060109 0.07 ENST00000391418.3
keratin associated protein 2-3
chrX_+_89921903 0.07 ENST00000283891.6
ENST00000561129.2
TGFB induced factor homeobox 2 like X-linked
chr10_+_97446194 0.07 ENST00000370846.8
ENST00000352634.8
ENST00000353979.7
ENST00000370842.6
ENST00000345745.9
zinc finger DHHC-type palmitoyltransferase 16
chr1_+_153774210 0.06 ENST00000271857.6
solute carrier family 27 member 3
chr17_-_59155164 0.06 ENST00000583380.5
ENST00000580541.1
ENST00000578105.1
ENST00000330137.12
ENST00000437036.6
spindle and kinetochore associated complex subunit 2
chr3_-_191282383 0.06 ENST00000427544.6
urotensin 2B
chr6_-_93419545 0.06 ENST00000369297.1
ENST00000369303.9
ENST00000680224.1
ENST00000681532.1
ENST00000679565.1
EPH receptor A7
chr18_+_58341038 0.06 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr8_+_104223344 0.06 ENST00000523362.5
regulating synaptic membrane exocytosis 2
chr8_-_30812867 0.06 ENST00000518243.5
protein phosphatase 2 catalytic subunit beta
chr19_-_14674829 0.06 ENST00000443157.6
ENST00000253673.6
adhesion G protein-coupled receptor E3
chr3_+_45945019 0.05 ENST00000458629.1
ENST00000457814.1
C-X-C motif chemokine receptor 6
chr12_+_32679200 0.05 ENST00000452533.6
ENST00000414834.6
dynamin 1 like
chr8_-_100559702 0.05 ENST00000520311.5
ENST00000520552.5
ENST00000521345.1
ENST00000523000.5
ENST00000335659.7
ENST00000358990.3
ENST00000519597.5
ankyrin repeat domain 46
chr1_+_45688165 0.05 ENST00000372025.5
transmembrane protein 69
chr14_+_103385374 0.05 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
microtubule affinity regulating kinase 3
chr1_-_201171545 0.05 ENST00000367333.6
transmembrane protein 9
chr19_-_14674886 0.05 ENST00000344373.8
ENST00000595472.1
adhesion G protein-coupled receptor E3
chr20_-_52105644 0.05 ENST00000371523.8
ZFP64 zinc finger protein
chr13_-_110242694 0.05 ENST00000648989.1
ENST00000647797.1
ENST00000648966.1
ENST00000649484.1
ENST00000648695.1
ENST00000650115.1
ENST00000650566.1
collagen type IV alpha 1 chain
chr11_+_112176364 0.05 ENST00000526088.5
ENST00000532593.5
ENST00000531169.5
beta-carotene oxygenase 2
chr13_+_108629605 0.05 ENST00000457511.7
myosin XVI
chr12_-_9869345 0.05 ENST00000228438.3
C-type lectin domain family 2 member B
chr19_-_9107475 0.05 ENST00000641081.1
olfactory receptor family 7 subfamily G member 2
chr12_+_32679269 0.04 ENST00000358214.9
ENST00000553257.6
ENST00000549701.6
ENST00000266481.10
ENST00000551476.5
ENST00000550154.5
ENST00000547312.5
ENST00000381000.8
ENST00000548750.5
dynamin 1 like
chrX_-_21658324 0.04 ENST00000379499.3
kelch like family member 34
chr16_-_28597042 0.04 ENST00000533150.5
ENST00000335715.9
sulfotransferase family 1A member 2
chrX_+_108045050 0.04 ENST00000458383.1
ENST00000217957.10
V-set and immunoglobulin domain containing 1
chr5_-_35938572 0.04 ENST00000651391.1
ENST00000397366.5
ENST00000513623.5
ENST00000514524.2
ENST00000397367.6
calcyphosine like
chr2_-_238288600 0.04 ENST00000254657.8
period circadian regulator 2
chr6_-_111606260 0.04 ENST00000340026.10
TRAF3 interacting protein 2
chr7_-_93117956 0.04 ENST00000446617.1
ENST00000379958.3
ENST00000620985.4
sterile alpha motif domain containing 9
chr9_-_5339874 0.04 ENST00000223862.2
relaxin 1
chr1_-_211134061 0.04 ENST00000639602.1
ENST00000638498.1
ENST00000367007.5
novel protein
potassium voltage-gated channel subfamily H member 1
chr11_-_111871271 0.04 ENST00000398006.6
ALG9 alpha-1,2-mannosyltransferase
chr3_+_129528632 0.03 ENST00000296271.4
rhodopsin
chr2_-_207167220 0.03 ENST00000421199.5
ENST00000457962.5
Kruppel like factor 7
chr6_+_26402237 0.03 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
butyrophilin subfamily 3 member A1
chr12_-_23584600 0.03 ENST00000396007.6
SRY-box transcription factor 5
chr6_-_118935114 0.03 ENST00000316068.7
minichromosome maintenance 9 homologous recombination repair factor
chr6_+_26365215 0.03 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
butyrophilin subfamily 3 member A2
chr6_+_26365176 0.03 ENST00000377708.7
butyrophilin subfamily 3 member A2
chr3_-_11643871 0.03 ENST00000430365.7
vestigial like family member 4
chr11_-_111871530 0.03 ENST00000614444.4
ENST00000616540.5
ALG9 alpha-1,2-mannosyltransferase
chr17_-_40665121 0.03 ENST00000394052.5
keratin 222
chr7_+_21543020 0.03 ENST00000409508.8
ENST00000620169.4
ENST00000328843.10
dynein axonemal heavy chain 11
chr3_+_195720867 0.03 ENST00000436408.6
mucin 20, cell surface associated
chr1_-_152414256 0.03 ENST00000271835.3
cornulin
chr6_-_31862809 0.02 ENST00000375631.5
neuraminidase 1
chr13_+_48037692 0.02 ENST00000258662.3
nudix hydrolase 15
chr12_-_21910853 0.02 ENST00000544039.5
ATP binding cassette subfamily C member 9
chr2_+_89884740 0.02 ENST00000509129.1
immunoglobulin kappa variable 1D-37 (non-functional)
chr12_-_12684490 0.02 ENST00000540510.1
G protein-coupled receptor 19
chr3_-_64019334 0.02 ENST00000480205.5
proteasome 26S subunit, non-ATPase 6
chr7_-_87713287 0.02 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr19_-_6424802 0.02 ENST00000600480.2
KH-type splicing regulatory protein
chr2_+_74455077 0.02 ENST00000431187.5
ENST00000233331.12
ENST00000409917.5
ENST00000409493.3
INO80 complex subunit B
chr2_-_89297785 0.02 ENST00000465170.1
immunoglobulin kappa variable 1-37 (non-functional)
chr2_+_165239432 0.02 ENST00000636071.2
ENST00000636985.2
sodium voltage-gated channel alpha subunit 2
chr10_+_35605337 0.02 ENST00000321660.2
gap junction protein delta 4
chr12_+_6904962 0.02 ENST00000415834.5
ENST00000436789.5
leucine rich repeat containing 23
chr3_-_105869035 0.02 ENST00000447441.6
ENST00000403724.5
ENST00000405772.5
Cbl proto-oncogene B
chr8_+_106726012 0.02 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr12_+_26195313 0.02 ENST00000422622.3
sarcospan
chrX_+_44844015 0.02 ENST00000339042.6
dual specificity phosphatase 21
chr9_+_34646589 0.02 ENST00000450095.6
galactose-1-phosphate uridylyltransferase
chr2_+_165239388 0.02 ENST00000424833.5
ENST00000375437.7
ENST00000631182.3
sodium voltage-gated channel alpha subunit 2
chr5_+_132873660 0.02 ENST00000296877.3
liver enriched antimicrobial peptide 2
chr19_-_6424772 0.02 ENST00000619396.4
ENST00000398148.7
KH-type splicing regulatory protein
chr1_+_54715837 0.02 ENST00000371281.4
tetratricopeptide repeat domain 4
chr9_+_34646654 0.02 ENST00000378842.8
galactose-1-phosphate uridylyltransferase
chr19_+_54137740 0.02 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CCR4-NOT transcription complex subunit 3
chr19_+_10111689 0.02 ENST00000321826.5
purinergic receptor P2Y11
chr7_+_50308672 0.02 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKAROS family zinc finger 1
chr12_-_118359639 0.02 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAO kinase 3
chrM_+_9207 0.02 ENST00000362079.2
mitochondrially encoded cytochrome c oxidase III
chr11_+_118527463 0.02 ENST00000302783.10
tetratricopeptide repeat domain 36
chr5_-_103562775 0.02 ENST00000230792.7
ENST00000507423.1
nudix hydrolase 12
chr16_+_3283443 0.01 ENST00000572748.1
ENST00000219069.6
ENST00000573578.1
ENST00000574253.1
zinc finger protein 263
chr9_+_133061981 0.01 ENST00000372080.8
carboxyl ester lipase
chr19_-_3985451 0.01 ENST00000309311.7
eukaryotic translation elongation factor 2
chr17_-_5035418 0.01 ENST00000254853.10
ENST00000424747.1
solute carrier family 52 member 1
chr4_-_119322128 0.01 ENST00000274024.4
fatty acid binding protein 2
chr16_-_48247533 0.01 ENST00000356608.7
ENST00000569991.1
ATP binding cassette subfamily C member 11
chr6_-_111605859 0.01 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3 interacting protein 2
chr14_+_99481395 0.01 ENST00000389879.9
ENST00000557441.5
ENST00000555049.5
ENST00000555842.1
cyclin K
chrX_+_114584037 0.01 ENST00000371951.5
ENST00000371950.3
ENST00000276198.6
5-hydroxytryptamine receptor 2C
chr3_+_23810436 0.01 ENST00000467766.5
ENST00000424381.5
ubiquitin conjugating enzyme E2 E1
chrX_+_30243715 0.01 ENST00000378981.8
ENST00000397550.6
MAGE family member B1
chr1_-_211134135 0.01 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
novel protein
potassium voltage-gated channel subfamily H member 1
chrX_-_18672101 0.01 ENST00000379984.4
retinoschisin 1
chr7_-_88795732 0.01 ENST00000297203.3
testis expressed 47
chr3_+_51817596 0.01 ENST00000456080.5
novel protein
chr18_+_24460655 0.01 ENST00000426880.2
histamine receptor H4
chr12_+_16347637 0.01 ENST00000543076.5
ENST00000396210.8
microsomal glutathione S-transferase 1
chr7_-_88226965 0.01 ENST00000490437.5
ENST00000431660.5
sorcin
chr18_+_24460630 0.01 ENST00000256906.5
histamine receptor H4
chr4_-_145180496 0.01 ENST00000447906.8
OTU deubiquitinase 4
chr9_+_122371036 0.01 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
prostaglandin-endoperoxide synthase 1
chr17_-_59155235 0.01 ENST00000581068.5
spindle and kinetochore associated complex subunit 2
chr6_+_154039102 0.01 ENST00000360422.8
ENST00000330432.12
opioid receptor mu 1
chr14_+_32329256 0.01 ENST00000280979.9
A-kinase anchoring protein 6
chr2_-_169031317 0.01 ENST00000650372.1
ATP binding cassette subfamily B member 11
chr4_+_94207596 0.01 ENST00000359052.8
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr2_+_26786020 0.01 ENST00000335756.9
ENST00000233505.12
centromere protein A
chr12_-_55296569 0.01 ENST00000358433.3
olfactory receptor family 6 subfamily C member 6
chr1_+_186296267 0.01 ENST00000533951.5
ENST00000367482.8
ENST00000635041.1
ENST00000367483.8
ENST00000367485.4
ENST00000445192.7
proteoglycan 4
chr1_+_192636121 0.01 ENST00000543215.5
ENST00000391995.7
regulator of G protein signaling 13
chr20_-_31390580 0.01 ENST00000339144.3
ENST00000376321.4
defensin beta 119
chr7_-_88226987 0.01 ENST00000394641.7
sorcin
chr6_+_26440472 0.01 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
butyrophilin subfamily 3 member A3
chr10_+_123154414 0.01 ENST00000368858.9
BUB3 mitotic checkpoint protein
chr7_-_107803215 0.01 ENST00000340010.10
ENST00000453332.1
solute carrier family 26 member 3
chr14_-_80959484 0.01 ENST00000555529.5
ENST00000556042.5
ENST00000556981.5
centrosomal protein 128
chr6_+_30720335 0.00 ENST00000327892.13
tubulin beta class I
chr3_-_180679468 0.00 ENST00000651046.1
ENST00000476379.6
coiled-coil domain containing 39
chr6_+_106360668 0.00 ENST00000633556.3
crystallin beta-gamma domain containing 1
chr12_-_25195074 0.00 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
cilia and flagella associated protein 94
chr15_+_94355956 0.00 ENST00000557742.1
multiple C2 and transmembrane domain containing 2
chr22_+_22720615 0.00 ENST00000390309.2
immunoglobulin lambda variable 3-19
chr15_+_22015233 0.00 ENST00000639059.1
ENST00000640156.1
novel protein
novel transcript
chr17_-_10469558 0.00 ENST00000255381.2
myosin heavy chain 4
chr7_+_71132123 0.00 ENST00000333538.10
polypeptide N-acetylgalactosaminyltransferase 17
chrX_+_19343893 0.00 ENST00000540249.5
ENST00000545074.5
ENST00000379806.9
ENST00000423505.5
ENST00000422285.7
ENST00000417819.5
ENST00000355808.9
ENST00000379805.3
pyruvate dehydrogenase E1 subunit alpha 1
chr16_-_55833186 0.00 ENST00000361503.8
ENST00000422046.6
carboxylesterase 1
chr20_-_31390483 0.00 ENST00000376315.2
defensin beta 119
chr11_+_28108248 0.00 ENST00000406787.7
ENST00000403099.5
ENST00000407364.8
methyltransferase like 15
chr3_+_158801926 0.00 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
major facilitator superfamily domain containing 1
chr9_+_122370523 0.00 ENST00000643810.1
ENST00000540753.6
prostaglandin-endoperoxide synthase 1
chr8_+_91249307 0.00 ENST00000309536.6
ENST00000276609.8
solute carrier family 26 member 7
chr3_-_139006268 0.00 ENST00000383163.4
proline rich 23A
chr21_-_36542600 0.00 ENST00000399136.5
claudin 14

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0072244 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
0.0 0.4 GO:0045176 apical protein localization(GO:0045176)
0.0 0.2 GO:1902731 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.0 0.0 GO:0046247 tetraterpenoid metabolic process(GO:0016108) carotenoid metabolic process(GO:0016116) carotene catabolic process(GO:0016121) xanthophyll metabolic process(GO:0016122) terpene catabolic process(GO:0046247)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.0 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.0 GO:0060342 photoreceptor inner segment membrane(GO:0060342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)