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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NKX2-4

Z-value: 1.08

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Transcription factors associated with NKX2-4

Gene Symbol Gene ID Gene Info
ENSG00000125816.5 NK2 homeobox 4

Activity profile of NKX2-4 motif

Sorted Z-values of NKX2-4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_96584920 1.27 ENST00000521590.5
syndecan 2
chr4_-_99352754 1.02 ENST00000639454.1
alcohol dehydrogenase 1B (class I), beta polypeptide
chr9_+_87498491 0.93 ENST00000622514.4
death associated protein kinase 1
chr2_-_174597795 0.81 ENST00000679041.1
WAS/WASL interacting protein family member 1
chr2_-_187554351 0.61 ENST00000437725.5
ENST00000409676.5
ENST00000233156.9
ENST00000339091.8
ENST00000420747.1
tissue factor pathway inhibitor
chr17_-_55722857 0.57 ENST00000424486.3
transmembrane protein 100
chr9_+_87497852 0.57 ENST00000408954.8
death associated protein kinase 1
chr4_-_99321362 0.56 ENST00000625860.2
ENST00000305046.13
ENST00000506651.5
alcohol dehydrogenase 1B (class I), beta polypeptide
chr10_+_68109433 0.56 ENST00000613327.4
ENST00000358913.10
ENST00000373675.3
myopalladin
chr1_-_85404494 0.55 ENST00000633113.1
dimethylarginine dimethylaminohydrolase 1
chr18_-_27990256 0.51 ENST00000675173.1
cadherin 2
chr7_+_130293134 0.50 ENST00000445470.6
ENST00000492072.5
ENST00000222482.10
ENST00000473956.5
ENST00000493259.5
ENST00000486598.1
carboxypeptidase A4
chr2_-_144430934 0.49 ENST00000638087.1
ENST00000638007.1
zinc finger E-box binding homeobox 2
chr21_+_36135071 0.47 ENST00000290354.6
carbonyl reductase 3
chr4_-_174522791 0.46 ENST00000541923.5
ENST00000542498.5
15-hydroxyprostaglandin dehydrogenase
chr6_-_152637351 0.45 ENST00000367255.10
spectrin repeat containing nuclear envelope protein 1
chr17_-_69141878 0.44 ENST00000590645.1
ENST00000284425.7
ATP binding cassette subfamily A member 6
chr4_-_57110373 0.43 ENST00000295666.6
ENST00000514062.2
insulin like growth factor binding protein 7
chr9_-_92482350 0.41 ENST00000375543.2
asporin
chr1_+_63773966 0.40 ENST00000371079.6
ENST00000371080.5
receptor tyrosine kinase like orphan receptor 1
chr5_-_95822711 0.39 ENST00000512469.2
ENST00000379979.8
ENST00000505427.1
ENST00000508780.5
ENST00000237858.11
glutaredoxin
chr3_-_112610262 0.39 ENST00000479368.1
coiled-coil domain containing 80
chr5_-_147906530 0.39 ENST00000318315.5
ENST00000515291.1
chromosome 5 open reading frame 46
chr5_+_68288346 0.38 ENST00000320694.12
phosphoinositide-3-kinase regulatory subunit 1
chr9_-_92482499 0.37 ENST00000375544.7
asporin
chr21_+_46111434 0.35 ENST00000397763.5
ENST00000409416.6
collagen type VI alpha 2 chain
chr11_-_106022209 0.33 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr7_+_134843884 0.33 ENST00000445569.6
caldesmon 1
chr5_+_173918186 0.30 ENST00000657000.1
cytoplasmic polyadenylation element binding protein 4
chr7_-_38631356 0.28 ENST00000356264.7
ENST00000325590.9
amphiphysin
chr1_+_109494052 0.28 ENST00000393709.3
ENST00000496961.5
ENST00000533024.5
ENST00000420578.7
ENST00000310611.8
ENST00000527072.5
ENST00000528785.1
ENST00000369868.7
ENST00000430195.2
cytochrome b561 family member D1
chr1_-_75932392 0.28 ENST00000284142.7
ankyrin repeat and SOCS box containing 17
chr5_+_138084015 0.28 ENST00000504809.5
ENST00000506684.6
ENST00000398754.1
Wnt family member 8A
chr2_-_174597728 0.28 ENST00000409891.5
ENST00000410117.5
WAS/WASL interacting protein family member 1
chr2_-_174598206 0.27 ENST00000392546.6
ENST00000436221.1
WAS/WASL interacting protein family member 1
chr17_-_65826445 0.27 ENST00000317442.12
centrosomal protein 112
chr3_-_18438767 0.27 ENST00000454909.6
SATB homeobox 1
chr11_-_102955705 0.27 ENST00000615555.4
ENST00000340273.4
ENST00000260302.8
matrix metallopeptidase 13
chr2_+_148021083 0.26 ENST00000642680.2
methyl-CpG binding domain protein 5
chr1_-_241357225 0.26 ENST00000366565.5
regulator of G protein signaling 7
chr2_+_178451598 0.26 ENST00000644554.1
ENST00000647226.1
pejvakin
chr5_+_173918216 0.25 ENST00000519467.1
cytoplasmic polyadenylation element binding protein 4
chr5_+_140125935 0.25 ENST00000333305.5
IgA inducing protein
chr1_-_241357171 0.25 ENST00000440928.6
regulator of G protein signaling 7
chr2_+_148021001 0.25 ENST00000407073.5
methyl-CpG binding domain protein 5
chr2_+_10420021 0.25 ENST00000422133.1
hippocalcin like 1
chr1_-_241357085 0.25 ENST00000366564.5
regulator of G protein signaling 7
chr14_+_51489112 0.25 ENST00000356218.8
FERM domain containing 6
chr7_-_73325571 0.25 ENST00000453152.1
tripartite motif containing 50
chr7_+_151341764 0.24 ENST00000413040.7
ENST00000470229.6
ENST00000568733.6
negative regulator of ubiquitin like proteins 1
chr2_-_37672178 0.24 ENST00000457889.1
CDC42 effector protein 3
chr18_+_68798065 0.24 ENST00000360242.9
coiled-coil domain containing 102B
chr9_+_137225166 0.24 ENST00000650725.2
cysteine rich tail 1
chr1_+_225825346 0.24 ENST00000366837.5
epoxide hydrolase 1
chr7_+_134866831 0.23 ENST00000435928.1
caldesmon 1
chr10_-_28282086 0.23 ENST00000375719.7
ENST00000375732.5
membrane palmitoylated protein 7
chr7_-_13988863 0.22 ENST00000405358.8
ETS variant transcription factor 1
chr5_-_88823763 0.22 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
myocyte enhancer factor 2C
chr7_+_20647388 0.22 ENST00000258738.10
ATP binding cassette subfamily B member 5
chr19_+_40611863 0.22 ENST00000601032.5
latent transforming growth factor beta binding protein 4
chr1_+_152878312 0.22 ENST00000368765.4
sperm mitochondria associated cysteine rich protein
chr9_-_92404559 0.22 ENST00000262551.8
ENST00000375561.10
osteoglycin
chr5_+_141338753 0.21 ENST00000528330.2
ENST00000394576.3
protocadherin gamma subfamily A, 2
chr9_+_121286586 0.21 ENST00000545652.6
gelsolin
chr8_+_27311471 0.20 ENST00000397501.5
protein tyrosine kinase 2 beta
chr1_-_204213943 0.20 ENST00000308302.4
golgi transport 1A
chrX_-_15854791 0.20 ENST00000545766.7
ENST00000380291.5
ENST00000672987.1
ENST00000329235.6
adaptor related protein complex 1 subunit sigma 2
chr18_-_58629084 0.20 ENST00000361673.4
alpha kinase 2
chr2_+_108449178 0.19 ENST00000309863.11
ENST00000409821.5
GRIP and coiled-coil domain containing 2
chr16_-_31150058 0.19 ENST00000569305.1
ENST00000268281.9
ENST00000418068.6
serine protease 36
chr1_+_65309517 0.18 ENST00000371069.5
DnaJ heat shock protein family (Hsp40) member C6
chr20_-_41300066 0.18 ENST00000436099.6
ENST00000309060.7
ENST00000373261.5
ENST00000436440.6
ENST00000560364.5
ENST00000560361.5
zinc fingers and homeoboxes 3
chr15_-_63156774 0.18 ENST00000462430.5
ribosomal protein S27 like
chr19_-_49813151 0.18 ENST00000528094.5
ENST00000526575.1
fuzzy planar cell polarity protein
chr2_-_187554473 0.18 ENST00000453013.5
ENST00000417013.5
tissue factor pathway inhibitor
chr17_-_5234801 0.18 ENST00000571800.5
ENST00000574081.6
ENST00000399600.8
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr11_+_35943981 0.18 ENST00000528989.5
ENST00000524419.5
ENST00000315571.6
low density lipoprotein receptor class A domain containing 3
chr9_-_131531178 0.18 ENST00000372210.7
ENST00000372211.7
uridine-cytidine kinase 1
chr7_-_29195186 0.18 ENST00000449801.5
ENST00000409850.5
carboxypeptidase vitellogenic like
chr5_-_160852200 0.18 ENST00000327245.10
ATPase phospholipid transporting 10B (putative)
chr19_-_49813223 0.17 ENST00000533418.5
fuzzy planar cell polarity protein
chr19_-_49813259 0.17 ENST00000313777.9
fuzzy planar cell polarity protein
chr14_-_87992838 0.17 ENST00000544807.6
galactosylceramidase
chr22_-_49918404 0.17 ENST00000330817.11
ALG12 alpha-1,6-mannosyltransferase
chr5_+_160009113 0.17 ENST00000522793.5
ENST00000682719.1
ENST00000684137.1
ENST00000683219.1
ENST00000684018.1
ENST00000231238.10
ENST00000682131.1
tetratricopeptide repeat domain 1
chr2_-_37672448 0.17 ENST00000611976.1
CDC42 effector protein 3
chr10_+_35195124 0.16 ENST00000487763.5
ENST00000473940.5
ENST00000488328.5
ENST00000356917.9
cAMP responsive element modulator
chr2_-_105396943 0.16 ENST00000409807.5
four and a half LIM domains 2
chr5_-_88877967 0.16 ENST00000508610.5
ENST00000636294.1
myocyte enhancer factor 2C
chr12_+_7061206 0.16 ENST00000423384.5
ENST00000413211.5
complement C1s
chr3_-_179266971 0.16 ENST00000349697.2
ENST00000497599.5
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr9_-_131531224 0.15 ENST00000372208.7
ENST00000372215.5
uridine-cytidine kinase 1
chr2_+_161136901 0.15 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chr14_+_88005128 0.15 ENST00000267549.5
G protein-coupled receptor 65
chr9_+_37667997 0.15 ENST00000539465.5
FERM and PDZ domain containing 1
chr6_-_41736239 0.14 ENST00000358871.6
transcription factor EB
chr5_+_102808057 0.14 ENST00000684043.1
ENST00000682407.1
peptidylglycine alpha-amidating monooxygenase
chr19_+_57746799 0.14 ENST00000317178.10
ENST00000431353.1
zinc finger protein 776
chr9_-_21482313 0.14 ENST00000448696.4
interferon epsilon
chr6_+_101398788 0.14 ENST00000369138.5
ENST00000413795.5
ENST00000358361.7
glutamate ionotropic receptor kainate type subunit 2
chr12_+_57782742 0.14 ENST00000540550.6
ENST00000323833.12
ENST00000652027.2
ENST00000550559.5
ENST00000548851.5
ENST00000543727.5
ENST00000434359.5
ENST00000457189.1
Ts translation elongation factor, mitochondrial
chr11_+_57338344 0.14 ENST00000263314.3
ENST00000616487.4
purinergic receptor P2X 3
chr1_+_161663147 0.14 ENST00000236937.13
ENST00000367961.8
ENST00000358671.9
Fc fragment of IgG receptor IIb
chr11_-_104164361 0.14 ENST00000302251.9
platelet derived growth factor D
chr19_-_6670151 0.13 ENST00000675206.1
TNF superfamily member 14
chr2_-_85602681 0.13 ENST00000334462.10
ENST00000306353.7
transmembrane protein 150A
chr16_-_1771495 0.13 ENST00000564628.1
ENST00000219302.8
ENST00000563498.1
NME/NM23 nucleoside diphosphate kinase 3
chr1_-_89126066 0.13 ENST00000370466.4
guanylate binding protein 2
chr11_-_83035545 0.13 ENST00000528379.1
ENST00000534103.5
RAB30, member RAS oncogene family
chr1_+_109090726 0.13 ENST00000338272.9
ENST00000651489.1
transmembrane protein 167B
chr4_+_122339221 0.12 ENST00000442707.1
KIAA1109
chr16_+_28931942 0.12 ENST00000324662.8
ENST00000538922.8
CD19 molecule
chr20_-_41300116 0.12 ENST00000432768.6
zinc fingers and homeoboxes 3
chr19_-_6670117 0.12 ENST00000245912.7
TNF superfamily member 14
chrX_-_108091520 0.12 ENST00000340200.5
ENST00000217958.8
ENST00000372296.5
ENST00000372295.5
ENST00000361815.9
proteasome 26S subunit, non-ATPase 10
chr4_+_85827891 0.12 ENST00000514229.5
Rho GTPase activating protein 24
chr15_-_26939518 0.11 ENST00000541819.6
gamma-aminobutyric acid type A receptor subunit beta3
chr2_-_219160781 0.11 ENST00000356853.10
non-homologous end joining factor 1
chr15_+_44427793 0.11 ENST00000558966.5
ENST00000559793.5
ENST00000558968.1
CTD small phosphatase like 2
chr10_+_22316445 0.11 ENST00000448361.5
COMM domain containing 3
chr6_+_45422485 0.11 ENST00000359524.7
RUNX family transcription factor 2
chr15_-_92655712 0.11 ENST00000327355.6
family with sequence similarity 174 member B
chr1_+_161581339 0.11 ENST00000543859.5
ENST00000611236.1
Fc fragment of IgG receptor IIc (gene/pseudogene)
chr6_+_125919296 0.11 ENST00000444128.2
nuclear receptor coactivator 7
chr1_-_144456805 0.11 ENST00000581897.6
ENST00000577412.5
NBPF member 15
chr1_-_56966133 0.10 ENST00000535057.5
ENST00000543257.5
complement C8 beta chain
chrX_-_52520803 0.10 ENST00000518075.1
X antigen family member 1B
chr17_-_44218406 0.10 ENST00000526094.5
ENST00000529383.5
ENST00000530828.1
upstream binding transcription factor
chr15_-_82806054 0.10 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr2_-_85602351 0.10 ENST00000409668.1
transmembrane protein 150A
chr10_+_22316375 0.10 ENST00000376836.8
ENST00000456711.5
ENST00000444869.5
ENST00000475460.6
ENST00000602390.5
ENST00000489125.2
COMM domain containing 3
COMMD3-BMI1 readthrough
chr14_+_64914361 0.10 ENST00000607599.6
ENST00000548752.7
ENST00000551947.6
ENST00000549115.7
ENST00000552002.7
ENST00000551093.6
ENST00000549987.1
churchill domain containing 1
CHURC1-FNTB readthrough
chr12_-_7109176 0.10 ENST00000545280.5
ENST00000543933.5
ENST00000545337.1
ENST00000266542.9
ENST00000544702.5
complement C1r subcomponent like
chr15_-_19988117 0.10 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr2_-_27489716 0.10 ENST00000260570.8
ENST00000675690.1
intraflagellar transport 172
chr12_+_12725897 0.10 ENST00000326765.10
apolipoprotein L domain containing 1
chr17_+_8002610 0.10 ENST00000254854.5
guanylate cyclase 2D, retinal
chr12_+_55974059 0.10 ENST00000360299.10
ENST00000548068.5
ENST00000549915.5
ENST00000551459.5
ENST00000448789.2
RAB5B, member RAS oncogene family
chr19_+_41114430 0.10 ENST00000331105.7
cytochrome P450 family 2 subfamily F member 1
chr10_-_32378720 0.10 ENST00000375110.6
enhancer of polycomb homolog 1
chr14_-_24232332 0.10 ENST00000534348.5
ENST00000524927.1
ENST00000250495.10
NEDD8-MDP1 readthrough
NEDD8 ubiquitin like modifier
chr19_-_37172432 0.09 ENST00000392157.2
zinc finger protein 585A
chr6_+_125919210 0.09 ENST00000438495.6
nuclear receptor coactivator 7
chr17_-_21253398 0.09 ENST00000611551.1
N-acetyltransferase domain containing 1
chr12_-_13095628 0.09 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr8_+_42541569 0.09 ENST00000417410.7
ENST00000518574.1
ENST00000414154.6
small integral membrane protein 19
chr12_-_12350222 0.09 ENST00000543314.1
ENST00000396349.3
ENST00000535902.6
MANSC domain containing 1
chr18_+_9136757 0.09 ENST00000262126.9
ENST00000577992.1
ankyrin repeat domain 12
chr7_+_66087761 0.09 ENST00000450043.2
novel protein
chr14_-_33951052 0.09 ENST00000250457.9
ENST00000547327.2
egl-9 family hypoxia inducible factor 3
chr11_+_104036624 0.09 ENST00000302259.5
DNA damage inducible 1 homolog 1
chr17_+_44846318 0.09 ENST00000591513.5
HIG1 hypoxia inducible domain family member 1B
chr15_+_67138001 0.09 ENST00000439724.7
SMAD family member 3
chr6_-_149648693 0.09 ENST00000367411.7
katanin catalytic subunit A1
chr7_-_8262533 0.09 ENST00000447326.5
ENST00000406470.6
ENST00000407906.5
islet cell autoantigen 1
chr12_-_75209814 0.09 ENST00000549446.6
potassium voltage-gated channel subfamily C member 2
chr1_-_225567270 0.09 ENST00000497899.6
ENAH actin regulator
chr12_+_122980060 0.09 ENST00000543566.6
ENST00000453766.7
ENST00000392435.7
ENST00000413381.6
ENST00000426960.6
ADP ribosylation factor like GTPase 6 interacting protein 4
chr6_-_130956371 0.08 ENST00000639623.1
ENST00000525193.5
ENST00000527659.5
erythrocyte membrane protein band 4.1 like 2
chr5_-_108367860 0.08 ENST00000496714.2
F-box and leucine rich repeat protein 17
chr16_+_77788554 0.08 ENST00000302536.3
vesicle amine transport 1 like
chr15_+_74173693 0.08 ENST00000249842.8
immunoglobulin superfamily containing leucine rich repeat
chr17_-_31314066 0.08 ENST00000577894.1
ecotropic viral integration site 2B
chr10_+_100535927 0.08 ENST00000299163.7
hypoxia inducible factor 1 subunit alpha inhibitor
chr17_+_39688079 0.08 ENST00000578199.5
erb-b2 receptor tyrosine kinase 2
chr6_-_149648735 0.08 ENST00000335643.12
ENST00000444282.5
katanin catalytic subunit A1
chr19_-_39934626 0.08 ENST00000616721.6
Fc fragment of IgG binding protein
chr17_-_39688016 0.08 ENST00000579146.5
ENST00000300658.9
ENST00000378011.8
ENST00000429199.6
post-GPI attachment to proteins phospholipase 3
chrX_+_30243715 0.08 ENST00000378981.8
ENST00000397550.6
MAGE family member B1
chr3_+_141738263 0.08 ENST00000480908.1
ENST00000393000.3
ENST00000273480.4
ring finger protein 7
chr2_+_161160420 0.08 ENST00000392749.7
ENST00000405852.5
TRAF family member associated NFKB activator
chr15_+_74174403 0.08 ENST00000560862.1
ENST00000395118.1
immunoglobulin superfamily containing leucine rich repeat
chr7_-_96709780 0.07 ENST00000623693.3
ENST00000623498.3
ENST00000488005.5
ENST00000413065.5
SEM1 26S proteasome complex subunit
chr12_-_53207241 0.07 ENST00000267082.10
ENST00000549086.2
integrin subunit beta 7
chr8_+_42541775 0.07 ENST00000416469.6
small integral membrane protein 19
chr22_+_25069819 0.07 ENST00000401395.1
KIAA1671
chr7_+_142424942 0.07 ENST00000426318.2
T cell receptor beta variable 10-2
chr12_-_75209701 0.07 ENST00000350228.6
ENST00000298972.5
potassium voltage-gated channel subfamily C member 2
chr5_-_148654522 0.07 ENST00000377888.8
5-hydroxytryptamine receptor 4
chr6_-_136289778 0.07 ENST00000530767.5
ENST00000527759.5
BCL2 associated transcription factor 1
chr1_+_61404076 0.07 ENST00000357977.5
nuclear factor I A
chr2_-_162838728 0.07 ENST00000328032.8
ENST00000332142.10
potassium voltage-gated channel subfamily H member 7
chr1_+_222713310 0.07 ENST00000537020.5
ENST00000539697.5
BRO1 domain and CAAX motif containing
chr12_+_12717359 0.07 ENST00000614874.2
ENST00000228872.9
cyclin dependent kinase inhibitor 1B
chr22_-_36817510 0.07 ENST00000443735.1
parvalbumin
chr1_+_202462730 0.06 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chr10_-_63465968 0.06 ENST00000399262.7
jumonji domain containing 1C
chr14_+_44962177 0.06 ENST00000361462.7
ENST00000361577.7
TOG array regulator of axonemal microtubules 1
chr20_-_21514046 0.06 ENST00000377142.5
NK2 homeobox 2
chr21_-_33491386 0.06 ENST00000617313.4
ENST00000314399.3
DnaJ heat shock protein family (Hsp40) member C28
chr1_-_197775435 0.06 ENST00000620048.6
DENN domain containing 1B
chr5_-_131994579 0.06 ENST00000379240.5
acyl-CoA synthetase long chain family member 6
chr5_+_43602648 0.06 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
nicotinamide nucleotide transhydrogenase
chr11_-_10693955 0.06 ENST00000547195.5
inositol 1,4,5-triphosphate receptor associated 1
chr4_+_3766348 0.06 ENST00000509482.1
ENST00000330055.7
adrenoceptor alpha 2C
chr11_+_60455839 0.06 ENST00000532491.5
ENST00000532073.5
ENST00000345732.9
ENST00000534668.6
ENST00000528313.1
ENST00000533306.6
ENST00000674194.1
membrane spanning 4-domains A1
chr12_-_53207271 0.06 ENST00000552972.5
ENST00000422257.7
integrin subunit beta 7
chr1_-_56819365 0.06 ENST00000343433.7
FYN binding protein 2
chr1_-_101846957 0.06 ENST00000338858.9
olfactomedin 3
chr1_-_94925759 0.06 ENST00000415017.1
ENST00000545882.5
calponin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0008218 bioluminescence(GO:0008218)
0.1 0.5 GO:0090301 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1 0.8 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.5 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1 0.3 GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation(GO:0044335)
0.1 1.5 GO:0006069 ethanol oxidation(GO:0006069)
0.1 0.8 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.1 0.5 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.1 0.2 GO:0048058 compound eye corneal lens development(GO:0048058)
0.1 0.1 GO:2000439 positive regulation of monocyte extravasation(GO:2000439)
0.1 0.2 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 0.5 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.2 GO:0006683 galactosylceramide catabolic process(GO:0006683)
0.1 0.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 0.4 GO:0051414 response to cortisol(GO:0051414)
0.1 1.5 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.4 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.1 GO:0090264 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) follicular B cell differentiation(GO:0002316) immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
0.0 0.5 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 0.2 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.6 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.2 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.5 GO:2001300 lipoxin metabolic process(GO:2001300)
0.0 0.2 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:0018032 protein amidation(GO:0018032)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.6 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.6 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.6 GO:0043116 negative regulation of vascular permeability(GO:0043116) negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.1 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0032811 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.0 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.1 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0003417 growth plate cartilage development(GO:0003417)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.1 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.5 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.2 0.5 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.5 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.1 1.4 GO:0005522 profilin binding(GO:0005522)
0.1 0.6 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.2 GO:0004336 galactosylceramidase activity(GO:0004336)
0.0 0.4 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.8 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.1 GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity(GO:0003860)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.0 GO:0047315 kynurenine-glyoxylate transaminase activity(GO:0047315)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.9 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction