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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for NR4A1

Z-value: 0.37

Motif logo

Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
ENSG00000123358.20 nuclear receptor subfamily 4 group A member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR4A1hg38_v1_chr12_+_52051402_52051459-0.108.2e-01Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_119673368 0.50 ENST00000427067.6
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_184337591 0.22 ENST00000383847.7
family with sequence similarity 131 member A
chr20_+_13008919 0.21 ENST00000399002.7
ENST00000434210.5
serine palmitoyltransferase long chain base subunit 3
chr1_-_161132577 0.18 ENST00000464113.1
death effector domain containing
chr4_-_158159657 0.17 ENST00000590648.5
golgi associated kinase 1B
chr7_-_38631356 0.17 ENST00000356264.7
ENST00000325590.9
amphiphysin
chr12_+_18242955 0.16 ENST00000676171.1
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr20_-_44187153 0.15 ENST00000372980.4
junctophilin 2
chr3_+_29280945 0.14 ENST00000434693.6
RNA binding motif single stranded interacting protein 3
chr6_-_152168291 0.14 ENST00000354674.5
spectrin repeat containing nuclear envelope protein 1
chr6_-_152168349 0.14 ENST00000539504.5
spectrin repeat containing nuclear envelope protein 1
chr6_+_69232406 0.13 ENST00000238918.12
adhesion G protein-coupled receptor B3
chr10_-_59906509 0.13 ENST00000263102.7
coiled-coil domain containing 6
chr15_+_75043263 0.12 ENST00000563393.1
phosphopantothenoylcysteine decarboxylase
chr17_-_7404039 0.12 ENST00000576017.1
ENST00000302422.4
transmembrane protein 256
chr4_+_70242583 0.12 ENST00000304954.3
casein kappa
chr2_+_161160299 0.12 ENST00000440506.5
ENST00000429217.5
ENST00000406287.5
ENST00000402568.5
TRAF family member associated NFKB activator
chr11_-_111923722 0.12 ENST00000527950.5
crystallin alpha B
chr19_+_6372757 0.12 ENST00000245812.8
alkB homolog 7
chr2_-_177392673 0.12 ENST00000447413.1
ENST00000397057.6
ENST00000456746.5
ENST00000464747.5
novel transcript
nuclear factor, erythroid 2 like 2
chr1_-_161132659 0.12 ENST00000368006.8
ENST00000490843.6
ENST00000545495.5
death effector domain containing
chr12_+_32502114 0.11 ENST00000682739.1
ENST00000427716.7
ENST00000583694.2
FYVE, RhoGEF and PH domain containing 4
chr12_+_21526287 0.11 ENST00000256969.7
spexin hormone
chr7_-_105876575 0.11 ENST00000318724.8
ENST00000419735.8
ataxin 7 like 1
chr6_-_152637351 0.10 ENST00000367255.10
spectrin repeat containing nuclear envelope protein 1
chr20_+_38962299 0.10 ENST00000373325.6
ENST00000373323.8
ENST00000252011.8
ENST00000615559.1
DEAH-box helicase 35
novel transcript, sense intronic to DHX35
chr4_-_88823165 0.10 ENST00000508369.5
family with sequence similarity 13 member A
chr20_+_17699942 0.09 ENST00000427254.1
ENST00000377805.7
BANF family member 2
chr19_+_17305801 0.09 ENST00000602206.1
ENST00000252602.2
mitochondrial ribosomal protein L34
chr12_+_95858928 0.09 ENST00000266735.9
ENST00000553192.5
ENST00000552085.1
small nuclear ribonucleoprotein polypeptide F
chr20_-_44187093 0.09 ENST00000342272.3
junctophilin 2
chr1_+_61404076 0.09 ENST00000357977.5
nuclear factor I A
chr4_-_88823214 0.09 ENST00000513837.5
ENST00000503556.5
family with sequence similarity 13 member A
chr6_+_44158807 0.08 ENST00000532171.5
ENST00000398776.2
calpain 11
chr2_+_161160420 0.08 ENST00000392749.7
ENST00000405852.5
TRAF family member associated NFKB activator
chr4_+_99574812 0.08 ENST00000422897.6
ENST00000265517.10
microsomal triglyceride transfer protein
chr20_+_11917859 0.08 ENST00000618296.4
ENST00000378226.7
BTB domain containing 3
chr10_+_35195843 0.08 ENST00000488741.5
ENST00000474931.5
ENST00000468236.5
ENST00000344351.5
ENST00000490511.1
cAMP responsive element modulator
chr2_+_233307806 0.08 ENST00000447536.5
ENST00000409110.6
S-antigen visual arrestin
chr13_-_30306997 0.08 ENST00000380617.7
ENST00000441394.1
katanin catalytic subunit A1 like 1
chr1_+_192809031 0.08 ENST00000235382.7
regulator of G protein signaling 2
chr11_+_116829898 0.07 ENST00000227667.8
ENST00000375345.3
apolipoprotein C3
chr2_+_177392734 0.07 ENST00000680770.1
ENST00000637633.2
ENST00000679459.1
ENST00000409888.1
ENST00000264167.11
ENST00000642466.2
alkylglycerone phosphate synthase
chr8_+_98426943 0.07 ENST00000287042.5
potassium voltage-gated channel modifier subfamily S member 2
chr17_-_7219813 0.07 ENST00000399510.8
ENST00000648172.8
discs large MAGUK scaffold protein 4
chr14_-_77028663 0.07 ENST00000238647.5
interferon regulatory factor 2 binding protein like
chr1_+_160205374 0.07 ENST00000368077.5
ENST00000360472.9
proliferation and apoptosis adaptor protein 15
chr1_+_160205411 0.06 ENST00000368076.1
proliferation and apoptosis adaptor protein 15
chr3_-_115147237 0.06 ENST00000357258.8
zinc finger and BTB domain containing 20
chr19_+_54415427 0.06 ENST00000301194.8
ENST00000376530.8
ENST00000445095.5
ENST00000376531.3
tweety family member 1
chr3_-_48898813 0.06 ENST00000319017.5
ENST00000430379.5
solute carrier family 25 member 20
chr3_-_115147277 0.06 ENST00000675478.1
zinc finger and BTB domain containing 20
chr8_-_91040814 0.06 ENST00000520014.1
ENST00000285419.8
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
chr20_-_45857196 0.05 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
acyl-CoA thioesterase 8
chr12_+_109139397 0.05 ENST00000377854.9
ENST00000377848.7
acetyl-CoA carboxylase beta
chr1_+_165631199 0.05 ENST00000367888.8
ENST00000367889.8
ENST00000367885.5
ENST00000367884.6
microsomal glutathione S-transferase 3
chr11_-_113706292 0.05 ENST00000544634.5
ENST00000539732.5
ENST00000538770.1
ENST00000536856.5
ENST00000299882.11
ENST00000544476.1
transmembrane serine protease 5
chr6_-_43627302 0.05 ENST00000307114.11
GTP binding protein 2
chr17_-_2266131 0.05 ENST00000570606.5
ENST00000354901.8
SMG6 nonsense mediated mRNA decay factor
chr12_-_76878985 0.05 ENST00000547435.1
ENST00000552330.5
ENST00000311083.10
ENST00000546966.5
cysteine and glycine rich protein 2
chr2_+_176157293 0.05 ENST00000683222.1
homeobox D3
chr4_-_88823306 0.05 ENST00000395002.6
family with sequence similarity 13 member A
chr7_-_6009072 0.05 ENST00000642456.1
ENST00000642292.1
ENST00000441476.6
PMS1 homolog 2, mismatch repair system component
chr17_+_7219857 0.05 ENST00000583312.5
ENST00000350303.9
ENST00000584103.5
ENST00000356839.10
ENST00000579886.2
acyl-CoA dehydrogenase very long chain
chr11_-_113706330 0.05 ENST00000540540.5
ENST00000538955.5
ENST00000545579.6
transmembrane serine protease 5
chr12_+_6535278 0.05 ENST00000396858.5
glyceraldehyde-3-phosphate dehydrogenase
chr4_-_56387422 0.05 ENST00000513376.5
ENST00000205214.11
ENST00000502617.1
ENST00000451613.5
ENST00000602986.5
aminoadipate-semialdehyde dehydrogenase
chr7_-_105876477 0.05 ENST00000478915.1
ataxin 7 like 1
chr16_-_31150058 0.05 ENST00000569305.1
ENST00000268281.9
ENST00000418068.6
serine protease 36
chr19_-_40750302 0.05 ENST00000598485.6
ENST00000378313.7
ENST00000470681.5
chromosome 19 open reading frame 54
chr10_-_73874461 0.05 ENST00000305762.11
calcium/calmodulin dependent protein kinase II gamma
chr12_+_57941499 0.05 ENST00000300145.4
ATP23 metallopeptidase and ATP synthase assembly factor homolog
chr3_-_185821092 0.04 ENST00000421047.3
insulin like growth factor 2 mRNA binding protein 2
chr2_-_25252072 0.04 ENST00000683760.1
DNA methyltransferase 3 alpha
chr12_+_53985138 0.04 ENST00000303460.5
homeobox C10
chr7_-_73522278 0.04 ENST00000404251.1
ENST00000339594.9
bromodomain adjacent to zinc finger domain 1B
chr20_+_17699960 0.04 ENST00000246090.6
BANF family member 2
chr17_+_4951080 0.04 ENST00000521811.5
ENST00000323997.10
ENST00000522249.5
ENST00000519584.5
ENST00000519602.6
enolase 3
chrX_-_129523436 0.04 ENST00000371123.5
ENST00000371121.5
ENST00000371122.8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr1_+_40247926 0.04 ENST00000372766.4
transmembrane and coiled-coil domains 2
chr5_-_127073467 0.04 ENST00000607731.5
ENST00000509733.7
ENST00000296662.10
ENST00000535381.6
chromosome 5 open reading frame 63
chr20_+_58891981 0.03 ENST00000488652.6
ENST00000476935.6
ENST00000492907.6
ENST00000603546.2
GNAS complex locus
chr3_-_113746059 0.03 ENST00000477813.5
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr2_-_24972032 0.03 ENST00000534855.5
DnaJ heat shock protein family (Hsp40) member C27
chr6_+_31927683 0.03 ENST00000456570.5
novel complement component 2 (C2) and complement factor B (CFB) protein
chr3_+_138621225 0.03 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr6_+_63636481 0.03 ENST00000509330.5
PHD finger protein 3
chr16_+_53207981 0.03 ENST00000565803.2
chromodomain helicase DNA binding protein 9
chr14_-_103921494 0.03 ENST00000557040.5
ENST00000414262.6
ENST00000555030.5
ENST00000554713.2
ENST00000286953.8
ENST00000553430.5
ATP synthase membrane subunit j
chr3_-_157503574 0.03 ENST00000494677.5
ENST00000468233.5
ventricular zone expressed PH domain containing 1
chr12_+_21372899 0.03 ENST00000240652.8
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr1_+_15736251 0.03 ENST00000294454.6
solute carrier family 25 member 34
chr14_+_35122537 0.03 ENST00000604948.5
ENST00000321130.14
ENST00000534898.9
ENST00000605201.1
ENST00000250377.11
protein only RNase P catalytic subunit
chrX_+_2828808 0.03 ENST00000381163.7
glycogenin 2
chr13_-_32538683 0.03 ENST00000674456.1
ENST00000504114.5
NEDD4 binding protein 2 like 2
chr7_-_6009019 0.03 ENST00000382321.5
ENST00000265849.12
PMS1 homolog 2, mismatch repair system component
chr18_+_46174055 0.03 ENST00000615553.1
chromosome 18 open reading frame 25
chr4_-_40630588 0.03 ENST00000514014.1
RNA binding motif protein 47
chr17_+_4951758 0.02 ENST00000518175.1
enolase 3
chr3_-_157503375 0.02 ENST00000362010.7
ventricular zone expressed PH domain containing 1
chr3_+_138621207 0.02 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr7_-_81770039 0.02 ENST00000222390.11
ENST00000453411.6
ENST00000457544.7
ENST00000444829.7
hepatocyte growth factor
chr18_-_63319729 0.02 ENST00000333681.5
BCL2 apoptosis regulator
chr3_-_157503339 0.02 ENST00000392833.6
ventricular zone expressed PH domain containing 1
chr12_-_16605939 0.02 ENST00000541295.5
ENST00000535535.5
LIM domain only 3
chr3_-_44477639 0.02 ENST00000396077.8
zinc finger protein 445
chr14_+_21918161 0.02 ENST00000390439.2
T cell receptor alpha variable 13-2
chr2_-_24971900 0.02 ENST00000264711.7
DnaJ heat shock protein family (Hsp40) member C27
chr22_+_24495242 0.02 ENST00000382760.2
ENST00000326010.10
beta-ureidopropionase 1
chr10_+_99782628 0.02 ENST00000648689.1
ENST00000647814.1
ATP binding cassette subfamily C member 2
chrX_+_2828921 0.02 ENST00000398806.8
glycogenin 2
chr12_+_93569814 0.02 ENST00000340600.6
suppressor of cytokine signaling 2
chr18_-_27143024 0.02 ENST00000581714.5
carbohydrate sulfotransferase 9
chr15_+_36594868 0.01 ENST00000566807.5
ENST00000643612.1
ENST00000567389.5
ENST00000562877.5
CDAN1 interacting nuclease 1
chr1_+_69567906 0.01 ENST00000651989.2
leucine rich repeat containing 7
chr19_+_14028148 0.01 ENST00000431365.3
ENST00000585987.1
relaxin 3
chrX_-_132961390 0.01 ENST00000370836.6
ENST00000521489.5
heparan sulfate 6-O-sulfotransferase 2
chr1_+_50103903 0.01 ENST00000371827.5
ELAV like RNA binding protein 4
chr3_-_139044892 0.01 ENST00000413199.1
proline rich 23C
chr17_+_42998779 0.01 ENST00000586277.5
ribosomal protein L27
chr17_+_42998379 0.01 ENST00000253788.12
ENST00000589913.6
ribosomal protein L27
chr6_+_30626842 0.01 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
alpha tubulin acetyltransferase 1
chr12_-_16606102 0.01 ENST00000537304.6
LIM domain only 3
chr6_+_31927703 0.01 ENST00000418949.6
ENST00000299367.10
ENST00000383177.7
ENST00000477310.1
complement C2
novel complement component 2 (C2) and complement factor B (CFB) protein
chr17_+_42998264 0.01 ENST00000589037.5
ribosomal protein L27
chr14_-_35121950 0.01 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr17_-_31297231 0.01 ENST00000247271.5
oligodendrocyte myelin glycoprotein
chr3_+_101724602 0.01 ENST00000341893.8
centrosomal protein 97
chr7_+_121328991 0.01 ENST00000222462.3
Wnt family member 16
chr2_-_206159410 0.01 ENST00000457011.5
ENST00000440274.5
ENST00000432169.5
ENST00000233190.11
NADH:ubiquinone oxidoreductase core subunit S1
chr3_+_113747022 0.01 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATPase H+ transporting V1 subunit A
chr10_-_72954790 0.01 ENST00000373032.4
phospholipase A2 group XIIB
chr19_-_11529116 0.01 ENST00000592312.5
ENST00000590480.1
ENST00000585318.5
ENST00000270517.12
ENST00000252440.11
ENST00000417981.6
ECSIT signaling integrator
chr2_+_206159884 0.01 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2
chr1_+_13749408 0.01 ENST00000343137.8
ENST00000503842.5
ENST00000407521.7
ENST00000505823.5
PR/SET domain 2
chr12_-_16606795 0.00 ENST00000447609.5
LIM domain only 3
chr4_-_73223082 0.00 ENST00000509867.6
ankyrin repeat domain 17
chr7_-_102616692 0.00 ENST00000521076.5
ENST00000462172.5
ENST00000522801.5
ENST00000262940.12
ENST00000449970.6
RAS p21 protein activator 4
chr6_-_33803980 0.00 ENST00000507738.1
ENST00000266003.9
ENST00000430124.7
motilin
chr1_+_212565334 0.00 ENST00000366981.8
ENST00000366987.6
activating transcription factor 3
chr20_+_3071618 0.00 ENST00000217386.2
oxytocin/neurophysin I prepropeptide
chr7_-_107803215 0.00 ENST00000340010.10
ENST00000453332.1
solute carrier family 26 member 3
chr1_+_228208024 0.00 ENST00000570156.7
ENST00000680850.1
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr3_-_30894661 0.00 ENST00000282538.10
ENST00000454381.3
glutamate decarboxylase like 1
chr11_+_66857056 0.00 ENST00000309602.5
ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr16_+_55655960 0.00 ENST00000568943.6
solute carrier family 6 member 2
chr16_-_30029429 0.00 ENST00000564806.1
TLC domain containing 3B

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0 0.1 GO:0046223 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0060621 regulation of high-density lipoprotein particle clearance(GO:0010982) negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.1 GO:1904304 regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.1 GO:0052816 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.0 0.0 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)