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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PITX2

Z-value: 0.56

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.17 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg38_v1_chr4_-_110636963_110637042,
hg38_v1_chr4_-_110623051_110623085,
hg38_v1_chr4_-_110641920_110642123		0.561.5e-01Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_41518878 0.77 ENST00000254043.8
KRT15
keratin 15
chr2_+_120013111 0.41 ENST00000331393.8
ENST00000443124.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr9_+_12693327 0.31 ENST00000388918.10
TYRP1
tyrosinase related protein 1
chr17_-_4739866 0.21 ENST00000574412.6
ENST00000293778.12
CXCL16
C-X-C motif chemokine ligand 16
chr6_-_138572523 0.20 ENST00000427025.6
NHSL1
NHS like 1
chr6_+_130018565 0.14 ENST00000361794.7
ENST00000526087.5
ENST00000533560.5
L3MBTL3
L3MBTL histone methyl-lysine binding protein 3
chr11_-_36598221 0.13 ENST00000311485.8
ENST00000527033.5
ENST00000532616.1
ENST00000618712.4
RAG2
recombination activating 2
chr13_+_73058993 0.11 ENST00000377687.6
KLF5
Kruppel like factor 5
chr3_-_191282383 0.11 ENST00000427544.6
UTS2B
urotensin 2B
chr7_+_30284574 0.09 ENST00000323037.5
ZNRF2
zinc and ring finger 2
chr1_+_43300971 0.09 ENST00000372476.8
ENST00000538015.1
TIE1
tyrosine kinase with immunoglobulin like and EGF like domains 1
chr21_-_33542841 0.09 ENST00000381831.7
ENST00000381839.7
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr6_+_31137646 0.08 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr13_-_35855627 0.08 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr15_+_40929338 0.08 ENST00000249749.7
DLL4
delta like canonical Notch ligand 4
chr12_+_69739370 0.07 ENST00000550536.5
ENST00000362025.9
RAB3IP
RAB3A interacting protein
chr11_-_5227063 0.07 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr6_-_53148822 0.06 ENST00000259803.8
GCM1
glial cells missing transcription factor 1
chr10_-_60141004 0.05 ENST00000355288.6
ANK3
ankyrin 3
chr16_-_67980483 0.05 ENST00000268793.6
ENST00000672962.1
DPEP3
dipeptidase 3
chr15_+_41774539 0.05 ENST00000514566.5
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr12_-_54981838 0.04 ENST00000316577.12
TESPA1
thymocyte expressed, positive selection associated 1
chr5_+_38258373 0.04 ENST00000354891.7
EGFLAM
EGF like, fibronectin type III and laminin G domains
chr1_+_202010575 0.04 ENST00000367283.7
ENST00000367284.10
ELF3
E74 like ETS transcription factor 3
chr7_-_122699108 0.04 ENST00000340112.3
RNF133
ring finger protein 133
chr4_-_101346842 0.04 ENST00000507176.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr13_-_35855758 0.03 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr9_-_128724088 0.03 ENST00000406904.2
ENST00000452105.5
ENST00000372667.9
ENST00000372663.9
ZDHHC12
zinc finger DHHC-type palmitoyltransferase 12
chr6_+_35342614 0.03 ENST00000337400.6
ENST00000311565.4
PPARD
peroxisome proliferator activated receptor delta
chr17_+_4740042 0.03 ENST00000592813.5
ZMYND15
zinc finger MYND-type containing 15
chr4_-_101347492 0.03 ENST00000394854.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr17_+_4740005 0.03 ENST00000269289.10
ZMYND15
zinc finger MYND-type containing 15
chr4_-_101347327 0.03 ENST00000394853.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr13_-_94479671 0.03 ENST00000377028.10
ENST00000446125.1
DCT
dopachrome tautomerase
chrX_+_15749848 0.03 ENST00000479740.5
ENST00000454127.2
CA5B
carbonic anhydrase 5B
chr1_+_2476315 0.03 ENST00000419816.6
PLCH2
phospholipase C eta 2
chr1_+_91952162 0.03 ENST00000402388.1
ENST00000680541.1
BRDT
bromodomain testis associated
chr1_+_2476284 0.03 ENST00000378486.8
PLCH2
phospholipase C eta 2
chr4_-_101347471 0.03 ENST00000323055.10
ENST00000512215.5
PPP3CA
protein phosphatase 3 catalytic subunit alpha
chr22_-_29838227 0.02 ENST00000307790.8
ENST00000397771.6
ENST00000542393.5
ASCC2
activating signal cointegrator 1 complex subunit 2
chr11_-_133532493 0.02 ENST00000524381.6
OPCML
opioid binding protein/cell adhesion molecule like
chr12_-_118359639 0.02 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr12_+_6840800 0.02 ENST00000541978.5
ENST00000229264.8
ENST00000435982.6
GNB3
G protein subunit beta 3
chrM_+_9207 0.02 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr14_+_75522531 0.02 ENST00000555504.1
BATF
basic leucine zipper ATF-like transcription factor
chr2_+_167248638 0.02 ENST00000295237.10
XIRP2
xin actin binding repeat containing 2
chr18_-_49491586 0.02 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr9_-_14300231 0.01 ENST00000636735.1
NFIB
nuclear factor I B
chr12_-_52796110 0.01 ENST00000417996.2
KRT3
keratin 3
chr16_+_28711417 0.01 ENST00000395587.5
ENST00000569690.5
ENST00000331666.11
ENST00000564243.5
ENST00000566866.5
EIF3C
eukaryotic translation initiation factor 3 subunit C
chr2_-_65432591 0.01 ENST00000356388.9
SPRED2
sprouty related EVH1 domain containing 2
chrX_-_6228835 0.01 ENST00000381095.8
NLGN4X
neuroligin 4 X-linked
chr16_+_57976435 0.01 ENST00000290871.10
ENST00000441824.4
TEPP
testis, prostate and placenta expressed
chr15_-_89221558 0.01 ENST00000268125.10
RLBP1
retinaldehyde binding protein 1
chr8_-_132111159 0.01 ENST00000673615.1
ENST00000434736.6
HHLA1
HERV-H LTR-associating 1
chr7_+_155458129 0.01 ENST00000297375.4
EN2
engrailed homeobox 2
chr6_+_35342535 0.01 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
PPARD
peroxisome proliferator activated receptor delta
chr22_-_38700655 0.01 ENST00000216039.9
JOSD1
Josephin domain containing 1
chr10_-_73433550 0.00 ENST00000299432.7
MSS51
MSS51 mitochondrial translational activator
chr19_+_47821907 0.00 ENST00000539067.5
ENST00000221996.12
ENST00000613299.1
CRX
cone-rod homeobox
chr8_+_48008409 0.00 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048319 mesodermal cell migration(GO:0008078) axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.3 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.1 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.0 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 0.1 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)