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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PKNOX2

Z-value: 0.76

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
ENSG00000165495.16 PBX/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg38_v1_chr11_+_125164743_125164759-0.472.3e-01Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_32717994 1.11 ENST00000560677.5
ENST00000560830.1
ENST00000651154.1
gremlin 1, DAN family BMP antagonist
chr15_+_32718476 1.06 ENST00000652365.1
gremlin 1, DAN family BMP antagonist
chr8_+_96493803 0.66 ENST00000518385.5
ENST00000302190.9
syndecan 2
chr11_+_6390439 0.40 ENST00000530395.1
ENST00000342245.9
ENST00000527275.5
sphingomyelin phosphodiesterase 1
chr4_-_156970903 0.37 ENST00000422544.2
platelet derived growth factor C
chr5_-_128538230 0.33 ENST00000262464.9
fibrillin 2
chr16_+_2830155 0.31 ENST00000382280.7
zymogen granule protein 16B
chr9_-_76692181 0.30 ENST00000376717.6
ENST00000223609.10
prune homolog 2 with BCH domain
chr5_+_119071050 0.29 ENST00000539542.6
Dmx like 1
chr2_-_43676406 0.28 ENST00000475092.4
C1GALT1 specific chaperone 1 like
chr16_+_2830368 0.28 ENST00000572863.1
zymogen granule protein 16B
chr12_+_59596010 0.26 ENST00000547379.6
ENST00000552432.5
solute carrier family 16 member 7
chr5_+_119071358 0.26 ENST00000311085.8
Dmx like 1
chr6_-_87095059 0.22 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
glycoprotein hormones, alpha polypeptide
chr18_-_56638427 0.20 ENST00000586262.5
ENST00000217515.11
thioredoxin like 1
chr3_-_101677092 0.19 ENST00000461821.1
zinc finger and BTB domain containing 11
chr16_+_2830179 0.18 ENST00000570670.5
zymogen granule protein 16B
chr11_+_12110569 0.17 ENST00000683283.1
ENST00000256194.8
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr1_-_156859087 0.17 ENST00000368195.4
insulin receptor related receptor
chr22_-_50507678 0.16 ENST00000216080.5
ENST00000474879.7
lipase maturation factor 2
chr16_+_2537997 0.16 ENST00000441549.7
ENST00000268673.11
ENST00000342085.9
ENST00000389224.7
3-phosphoinositide dependent protein kinase 1
chr3_-_127822835 0.16 ENST00000453507.6
monoglyceride lipase
chr16_+_2830295 0.16 ENST00000571723.1
zymogen granule protein 16B
chr3_-_15797930 0.15 ENST00000683139.1
ankyrin repeat domain 28
chr5_-_128538218 0.15 ENST00000502468.5
fibrillin 2
chr10_+_92848461 0.15 ENST00000443748.6
ENST00000371543.5
ENST00000260762.10
exocyst complex component 6
chr22_-_31489528 0.14 ENST00000397525.5
eukaryotic translation initiation factor 4E nuclear import factor 1
chr2_-_196926717 0.14 ENST00000409475.5
ENST00000374738.3
post-GPI attachment to proteins inositol deacylase 1
chr3_-_127822455 0.14 ENST00000265052.10
monoglyceride lipase
chr9_-_120876356 0.14 ENST00000456291.1
PHD finger protein 19
chr7_-_148883474 0.13 ENST00000476773.5
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr6_-_116254063 0.12 ENST00000420283.3
TSPY like 4
chr19_-_5622768 0.12 ENST00000252542.9
scaffold attachment factor B2
chr11_-_19240936 0.12 ENST00000250024.9
E2F transcription factor 8
chr14_+_35534157 0.11 ENST00000307169.4
INSM transcriptional repressor 2
chr19_+_7669080 0.10 ENST00000629642.1
resistin
chr1_+_39081410 0.10 ENST00000602421.5
ENST00000361689.7
microtubule actin crosslinking factor 1
chr9_-_120877167 0.10 ENST00000373896.8
ENST00000312189.10
PHD finger protein 19
chr7_-_137343688 0.10 ENST00000348225.7
pleiotrophin
chr12_+_103587266 0.09 ENST00000388887.7
stabilin 2
chr1_+_52726441 0.09 ENST00000294353.7
ENST00000545132.5
zyg-11 family member B, cell cycle regulator
chr1_+_33864071 0.09 ENST00000681531.1
high mobility group box 4
chr6_-_11382247 0.09 ENST00000397378.7
ENST00000513989.5
ENST00000508546.5
ENST00000504387.5
neural precursor cell expressed, developmentally down-regulated 9
chr2_+_128091166 0.09 ENST00000259253.11
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_113116676 0.08 ENST00000671971.1
ENST00000672240.1
ENST00000673240.1
ENST00000673363.1
ankyrin 2
chr6_+_41053194 0.08 ENST00000244669.3
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr7_+_17299234 0.08 ENST00000637807.1
novel protein
chr8_+_56211686 0.08 ENST00000521831.5
ENST00000303759.3
ENST00000517636.5
ENST00000517933.5
ENST00000355315.8
ENST00000518801.5
ENST00000523975.5
ENST00000396723.9
ENST00000523061.5
ENST00000521524.5
coiled-coil-helix-coiled-coil-helix domain containing 7
chr18_+_9136757 0.08 ENST00000262126.9
ENST00000577992.1
ankyrin repeat domain 12
chr18_+_59139864 0.08 ENST00000509791.7
ENST00000587834.6
ENST00000588875.2
SEC11 homolog C, signal peptidase complex subunit
chr19_+_39268394 0.08 ENST00000331982.6
interferon lambda 2
chr11_-_111871271 0.08 ENST00000398006.6
ALG9 alpha-1,2-mannosyltransferase
chr11_-_19241598 0.08 ENST00000532666.1
ENST00000527884.5
ENST00000620009.4
E2F transcription factor 8
chr16_+_29973847 0.07 ENST00000308893.9
TAO kinase 2
chr16_+_50742059 0.07 ENST00000311559.13
ENST00000564326.5
ENST00000566206.5
ENST00000427738.8
CYLD lysine 63 deubiquitinase
chr9_-_96418334 0.07 ENST00000375256.5
zinc finger protein 367
chr18_+_3449413 0.07 ENST00000549253.5
TGFB induced factor homeobox 1
chr7_-_137343752 0.07 ENST00000393083.2
pleiotrophin
chr4_-_174829212 0.07 ENST00000340217.5
ENST00000274093.8
glycine receptor alpha 3
chr8_-_56211257 0.07 ENST00000316981.8
ENST00000423799.6
ENST00000429357.2
PLAG1 zinc finger
chr6_+_109978256 0.07 ENST00000414000.3
G protein-coupled receptor 6
chr9_-_120877026 0.07 ENST00000436309.5
PHD finger protein 19
chr22_+_50508216 0.07 ENST00000420993.7
ENST00000395698.7
ENST00000395701.7
ENST00000523045.5
ENST00000299821.15
non-SMC condensin II complex subunit H2
chr17_-_37609361 0.07 ENST00000614941.4
ENST00000619541.4
ENST00000622045.4
ENST00000616179.4
ENST00000621136.4
ENST00000612223.5
ENST00000620424.1
synergin gamma
chr15_-_61229297 0.07 ENST00000335670.11
RAR related orphan receptor A
chr10_-_100185993 0.07 ENST00000421367.7
ENST00000370408.2
ENST00000407654.7
ER lipid raft associated 1
chr17_+_4143168 0.06 ENST00000577075.6
ENST00000301391.8
ENST00000575251.5
cytochrome b5 domain containing 2
chr18_+_56651385 0.06 ENST00000615645.4
WD repeat domain 7
chr19_+_56538948 0.06 ENST00000301318.8
ENST00000591844.5
ZFP28 zinc finger protein
chr9_+_95875671 0.06 ENST00000683991.1
ENST00000683350.1
ENST00000653738.2
ENST00000288985.12
ENST00000665077.3
ERCC excision repair 6 like 2
chr6_+_109978297 0.06 ENST00000275169.5
G protein-coupled receptor 6
chr3_-_15798184 0.05 ENST00000624145.3
ankyrin repeat domain 28
chr18_+_24155938 0.05 ENST00000582229.1
calcium binding tyrosine phosphorylation regulated
chr2_-_196926670 0.05 ENST00000354764.9
post-GPI attachment to proteins inositol deacylase 1
chr11_+_74949241 0.05 ENST00000610881.4
ENST00000530257.5
ENST00000526361.1
ENST00000532972.5
ENST00000263672.11
signal peptidase complex subunit 2
chr19_-_39245006 0.05 ENST00000413851.3
ENST00000613087.4
interferon lambda 3
chr1_-_35193135 0.05 ENST00000357214.6
splicing factor proline and glutamine rich
chr18_+_56651335 0.05 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WD repeat domain 7
chr9_-_83817632 0.05 ENST00000376365.7
ENST00000376371.7
G kinase anchoring protein 1
chr1_+_161766282 0.05 ENST00000680688.1
activating transcription factor 6
chr12_-_132687307 0.05 ENST00000535270.5
ENST00000320574.10
DNA polymerase epsilon, catalytic subunit
chr5_-_59586393 0.04 ENST00000505453.1
ENST00000360047.9
phosphodiesterase 4D
chr3_-_3179674 0.04 ENST00000424814.5
ENST00000450014.1
ENST00000231948.9
ENST00000432408.6
ENST00000639284.1
cereblon
chr4_+_143184910 0.04 ENST00000510377.5
ENST00000307017.9
ubiquitin specific peptidase 38
chr1_-_247008042 0.04 ENST00000339986.8
ENST00000487338.6
zinc finger protein 695
chr22_+_23772839 0.04 ENST00000215743.8
matrix metallopeptidase 11
chr2_-_61538516 0.04 ENST00000676771.1
ENST00000677814.1
ENST00000443240.5
ENST00000677556.1
ENST00000676553.1
exportin 1
chr4_+_119135825 0.04 ENST00000307128.6
myozenin 2
chr1_+_230067198 0.03 ENST00000366672.5
polypeptide N-acetylgalactosaminyltransferase 2
chr11_-_74949142 0.03 ENST00000321448.12
ENST00000340360.10
X-ray radiation resistance associated 1
chr5_-_95284535 0.03 ENST00000515393.5
multiple C2 and transmembrane domain containing 1
chr16_+_71808439 0.03 ENST00000683775.1
ataxin 1 like
chr19_-_48044037 0.03 ENST00000293255.3
calcium binding protein 5
chr16_-_53503192 0.03 ENST00000568596.5
ENST00000394657.12
ENST00000570004.5
ENST00000564497.1
ENST00000300245.8
AKT interacting protein
chr17_-_74361860 0.03 ENST00000375366.4
BTB domain containing 17
chr11_-_74949079 0.03 ENST00000528219.5
ENST00000684022.1
ENST00000531852.5
X-ray radiation resistance associated 1
chr12_-_121296685 0.03 ENST00000412367.6
ENST00000404169.8
ENST00000402834.8
calcium/calmodulin dependent protein kinase kinase 2
chr11_-_74949114 0.03 ENST00000527087.5
X-ray radiation resistance associated 1
chr7_+_100589573 0.03 ENST00000468962.5
ENST00000427939.2
F-box protein 24
chr2_-_61538290 0.03 ENST00000678790.1
exportin 1
chr12_+_62260338 0.03 ENST00000353364.7
ENST00000549523.5
ubiquitin specific peptidase 15
chr17_-_73092657 0.03 ENST00000580557.5
ENST00000579732.5
ENST00000578620.1
ENST00000542342.6
ENST00000255559.7
ENST00000579018.5
solute carrier family 39 member 11
chr11_-_842508 0.03 ENST00000322028.5
RNA polymerase II, I and III subunit L
chr19_-_10010492 0.03 ENST00000264828.4
collagen type V alpha 3 chain
chr16_+_50742037 0.02 ENST00000569418.5
CYLD lysine 63 deubiquitinase
chr4_+_139301478 0.02 ENST00000296543.10
ENST00000398947.1
N-alpha-acetyltransferase 15, NatA auxiliary subunit
chr2_-_61538180 0.02 ENST00000677150.1
ENST00000678182.1
ENST00000677928.1
ENST00000406957.5
exportin 1
chr14_+_24070837 0.02 ENST00000537691.5
ENST00000397016.6
ENST00000560356.5
ENST00000558450.5
copine 6
chr2_-_61538313 0.02 ENST00000677803.1
ENST00000677239.1
ENST00000401558.7
exportin 1
chr3_+_172040554 0.02 ENST00000336824.8
ENST00000423424.5
fibronectin type III domain containing 3B
chr3_-_101677119 0.02 ENST00000312938.5
zinc finger and BTB domain containing 11
chr18_-_54959391 0.02 ENST00000591504.6
coiled-coil domain containing 68
chr16_+_50742110 0.02 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD lysine 63 deubiquitinase
chr2_-_178807415 0.02 ENST00000342992.10
ENST00000460472.6
ENST00000589042.5
ENST00000591111.5
ENST00000360870.10
titin
chr4_-_82561972 0.02 ENST00000454948.3
ENST00000449862.7
transmembrane protein 150C
chr3_+_52794768 0.02 ENST00000621946.4
ENST00000416872.6
ENST00000449956.2
inter-alpha-trypsin inhibitor heavy chain 3
chr12_+_113057687 0.02 ENST00000257600.3
deltex E3 ubiquitin ligase 1
chr2_+_232406836 0.02 ENST00000295453.8
alkaline phosphatase, germ cell
chr20_-_3084716 0.02 ENST00000380293.3
arginine vasopressin
chr7_+_6637311 0.02 ENST00000382252.6
zinc finger protein 316
chr2_-_218659592 0.02 ENST00000411696.7
zinc finger protein 142
chr18_+_3449620 0.01 ENST00000405385.7
TGFB induced factor homeobox 1
chr10_+_87863595 0.01 ENST00000371953.8
phosphatase and tensin homolog
chr3_+_185363129 0.01 ENST00000265026.8
mitogen-activated protein kinase kinase kinase 13
chr1_+_156106698 0.01 ENST00000675667.1
lamin A/C
chr12_+_49227874 0.01 ENST00000541364.5
tubulin alpha 1c
chr14_-_69152972 0.01 ENST00000389997.10
ENST00000557386.5
ENST00000554681.1
DDB1 and CUL4 associated factor 5
chr11_-_65134429 0.01 ENST00000526060.5
ENST00000307289.10
ENST00000528487.1
synoviolin 1
chr2_+_218659656 0.01 ENST00000443791.5
ENST00000359273.8
ENST00000392111.7
ENST00000392109.5
ENST00000392110.6
ENST00000423377.5
ENST00000412366.5
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
chr20_-_37527862 0.01 ENST00000373537.7
ENST00000445723.5
ENST00000414080.1
BLCAP apoptosis inducing factor
chr1_-_179143044 0.01 ENST00000504405.5
ENST00000512653.5
ENST00000344730.7
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr22_-_29838227 0.01 ENST00000307790.8
ENST00000397771.6
ENST00000542393.5
activating signal cointegrator 1 complex subunit 2
chr2_+_232456146 0.01 ENST00000295463.4
alkaline phosphatase, intestinal
chr12_-_121296669 0.01 ENST00000652382.1
calcium/calmodulin dependent protein kinase kinase 2
chr2_-_218659468 0.01 ENST00000450560.1
ENST00000449707.5
ENST00000440934.2
zinc finger protein 142
chr17_+_80545422 0.01 ENST00000544334.6
regulatory associated protein of MTOR complex 1
chr16_-_30445865 0.01 ENST00000478753.5
selenophosphate synthetase 2
chr2_+_218659749 0.01 ENST00000439945.5
ENST00000431802.5
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
chr17_+_80544817 0.01 ENST00000306801.8
ENST00000570891.5
regulatory associated protein of MTOR complex 1
chr19_+_10718114 0.00 ENST00000408974.8
dynamin 2
chr2_-_241900458 0.00 ENST00000404031.6
family with sequence similarity 240 member C
chr7_-_42237187 0.00 ENST00000395925.8
GLI family zinc finger 3
chr9_+_134880806 0.00 ENST00000291744.11
ENST00000350339.3
ficolin 2
chr6_+_31706866 0.00 ENST00000375832.5
ENST00000503322.1
lymphocyte antigen 6 family member G6F
LY6G6F-LY6G6D readthrough
chr14_-_21023954 0.00 ENST00000554094.5
NDRG family member 2
chr1_+_206440061 0.00 ENST00000604925.5
SLIT-ROBO Rho GTPase activating protein 2
chr11_-_65134507 0.00 ENST00000377190.8
ENST00000294256.12
synoviolin 1
chr1_+_100133135 0.00 ENST00000370143.5
ENST00000370141.7
tRNA methyltransferase 13 homolog

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:1900155 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.1 0.7 GO:0008218 bioluminescence(GO:0008218)
0.1 0.2 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 0.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.4 GO:0023021 termination of signal transduction(GO:0023021)
0.1 0.2 GO:1904397 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.1 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.2 GO:0071469 cellular response to alkaline pH(GO:0071469)
0.0 0.1 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.3 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.2 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.1 GO:2000196 positive regulation of female gonad development(GO:2000196)
0.0 0.4 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.0 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.0 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043291 RAVE complex(GO:0043291)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0042599 lamellar body(GO:0042599)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0097229 sperm end piece(GO:0097229)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0016015 morphogen activity(GO:0016015)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters