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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PPARD

Z-value: 0.43

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
ENSG00000112033.14 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg38_v1_chr6_+_35342614_353426330.849.4e-03Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_43593054 0.52 ENST00000453782.5
ENST00000300283.10
ENST00000437924.5
creatine kinase, mitochondrial 1B
chr15_+_43692886 0.48 ENST00000434505.5
ENST00000411750.5
creatine kinase, mitochondrial 1A
chr19_-_10577231 0.30 ENST00000589348.1
ENST00000592285.1
ENST00000587069.5
adaptor related protein complex 1 subunit mu 2
chr17_+_50532713 0.26 ENST00000503690.5
ENST00000514874.5
ENST00000268933.8
epsin 3
chr2_+_205682491 0.22 ENST00000360409.7
ENST00000450507.5
ENST00000357785.10
ENST00000417189.5
neuropilin 2
chr5_-_16508858 0.15 ENST00000684456.1
reticulophagy regulator 1
chr5_-_16508951 0.15 ENST00000682628.1
reticulophagy regulator 1
chr12_-_52926459 0.15 ENST00000552150.5
keratin 8
chr5_-_16508812 0.14 ENST00000683414.1
reticulophagy regulator 1
chr1_+_61952283 0.14 ENST00000307297.8
PATJ crumbs cell polarity complex component
chr1_+_61952036 0.14 ENST00000646453.1
ENST00000635137.1
PATJ crumbs cell polarity complex component
chr4_+_139665768 0.13 ENST00000616265.4
ENST00000265498.6
ENST00000506797.5
microsomal glutathione S-transferase 2
chr5_-_16508990 0.13 ENST00000399793.6
reticulophagy regulator 1
chr5_-_16508788 0.13 ENST00000682142.1
reticulophagy regulator 1
chr1_-_156705764 0.13 ENST00000621784.4
ENST00000368220.1
cellular retinoic acid binding protein 2
chr2_+_95274439 0.12 ENST00000317620.14
ENST00000403131.6
ENST00000317668.8
prominin 2
chr3_+_50273119 0.12 ENST00000456560.6
ENST00000418576.3
semaphorin 3B
chr1_+_6451304 0.11 ENST00000636644.1
espin
chr17_-_41572052 0.09 ENST00000588431.1
ENST00000246662.9
keratin 9
chr12_-_95073490 0.07 ENST00000330677.7
nuclear receptor subfamily 2 group C member 1
chr15_+_75201873 0.07 ENST00000394987.5
chromosome 15 open reading frame 39
chr17_+_39737923 0.07 ENST00000577695.5
ENST00000309156.9
growth factor receptor bound protein 7
chr9_-_33402551 0.06 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
aquaporin 7
chr7_+_143477873 0.06 ENST00000408916.1
taste 2 receptor member 41
chr19_-_1822038 0.06 ENST00000643515.1
RNA exonuclease 1 homolog
chr1_+_202348727 0.06 ENST00000356764.6
protein phosphatase 1 regulatory subunit 12B
chr6_+_33204645 0.06 ENST00000374662.4
hydroxysteroid 17-beta dehydrogenase 8
chr9_-_33402449 0.05 ENST00000377425.8
aquaporin 7
chr7_+_112450451 0.05 ENST00000429071.5
ENST00000403825.8
ENST00000675268.1
interferon related developmental regulator 1
novel protein
chr22_-_42130800 0.05 ENST00000645361.2
ENST00000359033.4
cytochrome P450 family 2 subfamily D member 6
chr11_-_61891381 0.05 ENST00000525588.5
fatty acid desaturase 3
chr1_-_119768892 0.05 ENST00000369406.8
ENST00000544913.2
3-hydroxy-3-methylglutaryl-CoA synthase 2
chr19_+_11435619 0.05 ENST00000589126.5
ENST00000588269.1
ENST00000587509.5
ENST00000591462.6
ENST00000592741.5
ENST00000677123.1
ENST00000593101.5
ENST00000587327.5
protein kinase C substrate 80K-H
chr2_-_99255107 0.04 ENST00000333017.6
ENST00000626374.2
ENST00000409679.5
ENST00000423306.1
lysozyme g2
chr11_-_117098415 0.04 ENST00000445177.6
ENST00000375300.6
ENST00000446921.6
SIK family kinase 3
chr1_-_161069857 0.04 ENST00000368013.8
Rho GTPase activating protein 30
chr14_+_74084947 0.04 ENST00000674221.1
ENST00000554938.2
lin-52 DREAM MuvB core complex component
chr16_+_81238682 0.04 ENST00000258168.7
ENST00000564552.1
beta-carotene oxygenase 1
chr2_+_158795309 0.04 ENST00000309950.8
ENST00000621326.4
ENST00000409042.5
death associated protein like 1
chr11_-_61891534 0.04 ENST00000278829.7
fatty acid desaturase 3
chr1_-_161069962 0.04 ENST00000368015.1
Rho GTPase activating protein 30
chr2_-_64019367 0.04 ENST00000272322.9
VPS54 subunit of GARP complex
chr19_+_1205761 0.04 ENST00000326873.12
ENST00000586243.5
serine/threonine kinase 11
chr16_-_4351283 0.03 ENST00000318059.8
presequence translocase associated motor 16
chr22_-_29388530 0.03 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
adaptor related protein complex 1 subunit beta 1
chr2_+_218568809 0.03 ENST00000273064.11
CCR4-NOT transcription complex subunit 9
chr2_+_218568865 0.03 ENST00000295701.9
CCR4-NOT transcription complex subunit 9
chr6_+_43298326 0.03 ENST00000372574.7
solute carrier family 22 member 7
chr11_-_45917823 0.03 ENST00000533151.5
ENST00000241041.7
peroxisomal biogenesis factor 16
chr16_-_4351257 0.03 ENST00000577031.5
presequence translocase associated motor 16
chr10_-_48251757 0.03 ENST00000305531.3
FERM and PDZ domain containing 2
chr10_+_70672457 0.03 ENST00000373207.2
ADAM metallopeptidase with thrombospondin type 1 motif 14
chr16_-_75251482 0.03 ENST00000393420.10
ENST00000162330.10
BCAR1 scaffold protein, Cas family member
chr19_+_39125769 0.03 ENST00000602004.1
ENST00000599470.5
ENST00000321944.8
ENST00000593480.5
ENST00000358301.7
ENST00000593690.5
ENST00000599386.5
p21 (RAC1) activated kinase 4
chr4_-_7068033 0.03 ENST00000264954.5
GrpE like 1, mitochondrial
chr6_+_30327259 0.03 ENST00000376659.9
ENST00000428555.1
tripartite motif containing 39
chr15_-_82262660 0.03 ENST00000557844.1
ENST00000359445.7
ENST00000268206.12
elongation factor like GTPase 1
chr14_-_24576240 0.03 ENST00000216336.3
cathepsin G
chr6_+_32038382 0.02 ENST00000478281.5
ENST00000471671.4
ENST00000435122.3
ENST00000644719.2
cytochrome P450 family 21 subfamily A member 2
chr1_-_11047225 0.02 ENST00000400898.3
ENST00000400897.8
mannan binding lectin serine peptidase 2
chr20_+_45857607 0.02 ENST00000255152.3
zinc finger SWIM-type containing 3
chr6_-_142147122 0.02 ENST00000258042.2
neuromedin B receptor
chr2_-_158456702 0.02 ENST00000409889.1
ENST00000283233.10
coiled-coil domain containing 148
chr17_-_35943707 0.02 ENST00000615905.5
lysozyme like 6
chr19_+_11436044 0.02 ENST00000589838.5
protein kinase C substrate 80K-H
chr17_-_35943662 0.02 ENST00000618542.4
lysozyme like 6
chr19_-_48835823 0.02 ENST00000595764.1
hydroxysteroid 17-beta dehydrogenase 14
chr12_-_108826161 0.02 ENST00000546697.1
slingshot protein phosphatase 1
chr1_+_54641806 0.02 ENST00000409996.5
maestro heat like repeat family member 7
chr15_+_82262781 0.02 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000682753.1
ENST00000566861.5
ENST00000565432.1
stabilizer of axonemal microtubules 2
chr1_-_197067234 0.02 ENST00000367412.2
coagulation factor XIII B chain
chr22_+_22822658 0.02 ENST00000620395.2
immunoglobulin lambda variable 2-8
chr19_+_4153616 0.02 ENST00000078445.7
ENST00000595923.5
ENST00000602257.5
ENST00000602147.1
cAMP responsive element binding protein 3 like 3
chr10_-_95069489 0.02 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
cytochrome P450 family 2 subfamily C member 8
chr6_+_30626842 0.02 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
alpha tubulin acetyltransferase 1
chr1_-_161223559 0.02 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
apolipoprotein A2
chr6_+_143677935 0.02 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
phosphatase and actin regulator 2
chr1_+_54641754 0.01 ENST00000339553.9
ENST00000421030.7
maestro heat like repeat family member 7
chr2_+_206159580 0.01 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
eukaryotic translation elongation factor 1 beta 2
chr9_+_124011738 0.01 ENST00000373615.9
LIM homeobox 2
chr19_+_50770464 0.01 ENST00000270590.4
G protein-coupled receptor 32
chr11_-_45917867 0.01 ENST00000378750.10
peroxisomal biogenesis factor 16
chr20_-_63499074 0.01 ENST00000217182.6
ENST00000642899.1
eukaryotic translation elongation factor 1 alpha 2
chr1_-_161069666 0.01 ENST00000368016.7
Rho GTPase activating protein 30
chr2_-_197499826 0.01 ENST00000439605.2
ENST00000388968.8
ENST00000418022.2
heat shock protein family D (Hsp60) member 1
chr16_-_74774812 0.01 ENST00000219368.8
fatty acid 2-hydroxylase
chr1_-_145707387 0.01 ENST00000451928.6
PDZ domain containing 1
chr12_+_130953898 0.01 ENST00000261654.10
adhesion G protein-coupled receptor D1
chr1_-_145707345 0.01 ENST00000417171.6
PDZ domain containing 1
chr10_-_72954790 0.01 ENST00000373032.4
phospholipase A2 group XIIB
chr2_-_197499857 0.01 ENST00000428204.6
ENST00000678170.1
ENST00000676933.1
ENST00000678621.1
heat shock protein family D (Hsp60) member 1
chr11_+_64306227 0.01 ENST00000405666.5
ENST00000468670.2
estrogen related receptor alpha
chr2_+_206159884 0.01 ENST00000392222.7
eukaryotic translation elongation factor 1 beta 2
chr7_-_87713287 0.01 ENST00000416177.1
ENST00000265724.8
ENST00000543898.5
ATP binding cassette subfamily B member 1
chr6_+_31670167 0.01 ENST00000375864.4
lymphocyte antigen 6 family member G5B
chr11_+_17260353 0.01 ENST00000530527.5
nucleobindin 2
chr6_-_33580229 0.01 ENST00000374467.4
ENST00000442998.6
ENST00000360661.9
BCL2 antagonist/killer 1
chr2_+_218568558 0.01 ENST00000627282.2
ENST00000542068.5
CCR4-NOT transcription complex subunit 9
chr1_+_6451578 0.00 ENST00000434576.2
ENST00000477679.2
espin
chr3_-_71132099 0.00 ENST00000650188.1
ENST00000648121.1
ENST00000648794.1
ENST00000649592.1
forkhead box P1
chr17_+_76000906 0.00 ENST00000448471.2
cyclin dependent kinase 3
chr19_+_10086305 0.00 ENST00000253110.16
ENST00000591813.5
shiftless antiviral inhibitor of ribosomal frameshifting
chr3_+_46497970 0.00 ENST00000296142.4
receptor transporter protein 3
chr3_+_186666003 0.00 ENST00000232003.5
histidine rich glycoprotein
chr20_-_775979 0.00 ENST00000676154.1
ENST00000674666.1
ENST00000217254.11
solute carrier family 52 member 3
chr12_+_120725796 0.00 ENST00000242592.9
ENST00000411593.2
acyl-CoA dehydrogenase short chain
chr6_+_142147162 0.00 ENST00000452973.6
ENST00000620996.4
ENST00000367621.1
ENST00000367630.9
vesicle trafficking 1
chr5_-_177554545 0.00 ENST00000514747.6
family with sequence similarity 193 member B
chrX_+_38352573 0.00 ENST00000039007.5
ornithine transcarbamylase
chr9_+_34458752 0.00 ENST00000614641.4
ENST00000242317.9
ENST00000437363.5
dynein axonemal intermediate chain 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0061709 reticulophagy(GO:0061709)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.5 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.2 GO:0097490 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0 0.1 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.1 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0009822 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076)
0.0 0.1 GO:0051599 response to hydrostatic pressure(GO:0051599)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044393 microspike(GO:0044393)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.0 GO:0036398 TCR signalosome(GO:0036398)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions