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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for PRDM14

Z-value: 0.95

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.4 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg38_v1_chr8_-_70071226_700712580.108.2e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_19748285 0.96 ENST00000570414.1
ENST00000225740.11
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748341 0.96 ENST00000395555.7
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_19748355 0.90 ENST00000494157.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr11_+_15114912 0.82 ENST00000379556.8
INSC
INSC spindle orientation adaptor protein
chr5_-_168883333 0.63 ENST00000404867.7
SLIT3
slit guidance ligand 3
chr5_+_32711313 0.49 ENST00000265074.13
NPR3
natriuretic peptide receptor 3
chr1_-_31373067 0.48 ENST00000373713.7
FABP3
fatty acid binding protein 3
chr5_+_32710630 0.48 ENST00000326958.5
NPR3
natriuretic peptide receptor 3
chr2_-_144520315 0.44 ENST00000465070.5
ENST00000465308.5
ENST00000636471.1
ENST00000629520.2
ENST00000675069.1
ENST00000636026.2
ENST00000444559.5
ZEB2
zinc finger E-box binding homeobox 2
chr3_-_114759115 0.36 ENST00000471418.5
ZBTB20
zinc finger and BTB domain containing 20
chr4_+_80266639 0.30 ENST00000456523.3
ENST00000312465.12
FGF5
fibroblast growth factor 5
chr11_+_65111845 0.29 ENST00000526809.5
ENST00000524986.5
ENST00000534371.5
ENST00000279263.14
ENST00000525385.5
ENST00000345348.9
ENST00000531321.5
ENST00000529414.5
ENST00000526085.5
ENST00000530750.5
TM7SF2
transmembrane 7 superfamily member 2
chr1_+_65264694 0.25 ENST00000263441.11
ENST00000395325.7
DNAJC6
DnaJ heat shock protein family (Hsp40) member C6
chr1_+_108560031 0.24 ENST00000405454.1
ENST00000370035.8
FAM102B
family with sequence similarity 102 member B
chr11_-_106022209 0.24 ENST00000301919.9
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT DNA binding domain containing 4 with coiled-coils
chr5_-_160685379 0.23 ENST00000642502.1
ATP10B
ATPase phospholipid transporting 10B (putative)
chr2_-_191847068 0.23 ENST00000304141.5
CAVIN2
caveolae associated protein 2
chrX_+_51893533 0.21 ENST00000375722.5
ENST00000326587.12
ENST00000375695.2
MAGED1
MAGE family member D1
chr17_+_38717424 0.21 ENST00000615858.1
MLLT6
MLLT6, PHD finger containing
chr12_+_71938837 0.19 ENST00000333850.4
TPH2
tryptophan hydroxylase 2
chr1_-_33182030 0.18 ENST00000291416.10
TRIM62
tripartite motif containing 62
chr1_+_23959109 0.17 ENST00000471915.5
PNRC2
proline rich nuclear receptor coactivator 2
chrX_-_120077690 0.17 ENST00000371402.5
RHOXF2B
Rhox homeobox family member 2B
chr17_+_77453993 0.16 ENST00000592951.5
SEPTIN9
septin 9
chr19_-_48810900 0.16 ENST00000597011.5
ENST00000601681.5
BCAT2
branched chain amino acid transaminase 2
chr19_-_48811012 0.15 ENST00000545387.6
ENST00000402551.5
ENST00000598162.5
ENST00000316273.11
ENST00000599246.5
BCAT2
branched chain amino acid transaminase 2
chr8_+_109334317 0.15 ENST00000521662.5
ENST00000520147.5
ENST00000521688.6
ENY2
ENY2 transcription and export complex 2 subunit
chrX_+_120158600 0.14 ENST00000371388.5
RHOXF2
Rhox homeobox family member 2
chr11_-_62707413 0.14 ENST00000360796.10
ENST00000449636.6
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr20_-_3173516 0.14 ENST00000360342.7
ENST00000645462.1
ENST00000337576.7
LZTS3
leucine zipper tumor suppressor family member 3
chr11_-_62707581 0.13 ENST00000684475.1
ENST00000683296.1
ENST00000684067.1
ENST00000682223.1
BSCL2
BSCL2 lipid droplet biogenesis associated, seipin
chr1_-_182672882 0.13 ENST00000367557.8
ENST00000258302.8
RGS8
regulator of G protein signaling 8
chr4_+_4859658 0.13 ENST00000382723.5
MSX1
msh homeobox 1
chr5_-_136193143 0.12 ENST00000607574.2
SMIM32
small integral membrane protein 32
chr19_+_3572777 0.10 ENST00000416526.5
HMG20B
high mobility group 20B
chr1_-_41918666 0.10 ENST00000372584.5
HIVEP3
HIVEP zinc finger 3
chr11_-_65857543 0.09 ENST00000534784.1
CFL1
cofilin 1
chr1_-_41918858 0.09 ENST00000372583.6
HIVEP3
HIVEP zinc finger 3
chr1_-_153113507 0.08 ENST00000468739.2
SPRR2F
small proline rich protein 2F
chr17_-_48614628 0.08 ENST00000576562.1
HOXB8
homeobox B8
chr12_-_48957365 0.07 ENST00000398092.4
ENST00000539611.1
ENSG00000272822.2
ARF3
novel protein
ADP ribosylation factor 3
chr2_-_227379297 0.07 ENST00000304568.4
TM4SF20
transmembrane 4 L six family member 20
chr1_+_21570303 0.07 ENST00000374830.2
ALPL
alkaline phosphatase, biomineralization associated
chr6_+_31946086 0.07 ENST00000425368.7
CFB
complement factor B
chr1_+_50106265 0.06 ENST00000357083.8
ELAVL4
ELAV like RNA binding protein 4
chr1_+_26787926 0.06 ENST00000674202.1
ENST00000674222.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr1_+_26788166 0.05 ENST00000374145.6
ENST00000431541.6
ENST00000674273.1
PIGV
phosphatidylinositol glycan anchor biosynthesis class V
chr16_+_53703963 0.05 ENST00000636218.1
ENST00000637001.1
ENST00000471389.6
ENST00000637969.1
ENST00000640179.1
FTO
FTO alpha-ketoglutarate dependent dioxygenase
chr14_+_78170336 0.05 ENST00000634499.2
ENST00000335750.7
NRXN3
neurexin 3
chr12_+_54008961 0.05 ENST00000040584.6
HOXC8
homeobox C8
chr3_+_36993798 0.04 ENST00000455445.6
ENST00000539477.6
ENST00000435176.5
ENST00000429117.5
ENST00000441265.6
MLH1
mutL homolog 1
chr1_+_50105666 0.04 ENST00000651347.1
ELAVL4
ELAV like RNA binding protein 4
chr12_+_121210160 0.04 ENST00000542067.5
P2RX4
purinergic receptor P2X 4
chr7_-_141014939 0.04 ENST00000324787.10
ENST00000467334.1
MRPS33
mitochondrial ribosomal protein S33
chr12_-_76348404 0.04 ENST00000650064.2
BBS10
Bardet-Biedl syndrome 10
chr19_-_6279921 0.03 ENST00000252674.9
MLLT1
MLLT1 super elongation complex subunit
chr11_-_65856944 0.03 ENST00000524553.5
CFL1
cofilin 1
chr17_+_43847142 0.03 ENST00000377203.8
ENST00000539718.5
ENST00000588884.1
ENST00000293396.12
ENST00000586233.5
CD300LG
CD300 molecule like family member g
chr3_+_156120572 0.03 ENST00000389636.9
ENST00000490337.6
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr3_+_36993764 0.02 ENST00000674019.1
ENST00000458205.6
MLH1
mutL homolog 1
chr11_-_65857007 0.01 ENST00000527344.5
CFL1
cofilin 1
chr7_+_150514851 0.01 ENST00000313543.5
GIMAP7
GTPase, IMAP family member 7
chr12_+_121210065 0.01 ENST00000359949.11
ENST00000337233.9
ENST00000538701.5
P2RX4
purinergic receptor P2X 4
chr1_-_167914089 0.01 ENST00000476818.2
ENST00000367848.1
ENST00000367851.9
ENST00000545172.5
ADCY10
adenylate cyclase 10
chr12_-_48957445 0.01 ENST00000541959.5
ENST00000447318.6
ENST00000256682.9
ARF3
ADP ribosylation factor 3
chr16_-_53703883 0.01 ENST00000262135.9
ENST00000564374.5
ENST00000566096.5
RPGRIP1L
RPGRIP1 like
chr9_+_97633811 0.01 ENST00000375147.8
NCBP1
nuclear cap binding protein subunit 1
chr7_+_39950013 0.01 ENST00000340829.10
CDK13
cyclin dependent kinase 13
chr1_+_245154963 0.01 ENST00000407071.7
KIF26B
kinesin family member 26B
chr2_+_112275588 0.01 ENST00000409871.6
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr11_+_62707668 0.00 ENST00000294117.6
GNG3
G protein subunit gamma 3
chr3_-_71132099 0.00 ENST00000650188.1
ENST00000648121.1
ENST00000648794.1
ENST00000649592.1
FOXP1
forkhead box P1
chr19_+_38619082 0.00 ENST00000614624.4
ENST00000593149.5
ENST00000538434.5
ENST00000588934.5
ENST00000248342.9
ENST00000545173.6
ENST00000591409.5
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3 subunit K
chr16_-_53703810 0.00 ENST00000569716.1
ENST00000562588.5
ENST00000621565.5
ENST00000562230.5
ENST00000563746.5
ENST00000568653.7
ENST00000647211.2
RPGRIP1L
RPGRIP1 like
chr20_-_50153637 0.00 ENST00000341698.2
ENST00000371652.9
ENST00000371650.9
PEDS1-UBE2V1
PEDS1
PEDS1-UBE2V1 readthrough
plasmanylethanolamine desaturase 1
chr6_-_46080332 0.00 ENST00000185206.12
CLIC5
chloride intracellular channel 5

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) apoptotic process involved in luteolysis(GO:0061364)
0.1 0.5 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.1 0.3 GO:0006550 isoleucine catabolic process(GO:0006550)
0.1 1.0 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0090427 embryonic nail plate morphogenesis(GO:0035880) activation of meiosis(GO:0090427)
0.0 2.8 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.0 GO:0035552 oxidative single-stranded DNA demethylation(GO:0035552)
0.0 0.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.3 GO:0023019 signal transduction involved in regulation of gene expression(GO:0023019)
0.0 0.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.8 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 1.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.2 0.5 GO:0070538 oleic acid binding(GO:0070538)
0.1 0.3 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.0 GO:0035514 DNA demethylase activity(GO:0035514)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism