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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for PRRX1_ALX4_PHOX2A
Z-value: 1.22
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Transcription factors associated with PRRX1_ALX4_PHOX2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX1 | hg38_v1_chr1_+_170663917_170663943 | 0.94 | 5.9e-04 | Click! |
| PHOX2A | hg38_v1_chr11_-_72241192_72241275, hg38_v1_chr11_-_72244166_72244184 | -0.62 | 1.0e-01 | Click! |
| ALX4 | hg38_v1_chr11_-_44310126_44310152 | -0.56 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_68106109 Show fit | 2.31 |
ENST00000540630.5
ENST00000354393.6 |
myopalladin |
|
| chr1_-_91906280 Show fit | 2.25 |
ENST00000370399.6
|
transforming growth factor beta receptor 3 |
|
| chr5_-_111758061 Show fit | 1.46 |
ENST00000509979.5
ENST00000513100.5 ENST00000508161.5 ENST00000455559.6 |
neuronal regeneration related protein |
|
| chr12_-_91153149 Show fit | 1.38 |
ENST00000550758.1
|
decorin |
|
| chr1_+_183805105 Show fit | 1.30 |
ENST00000360851.4
|
ral guanine nucleotide dissociation stimulator like 1 |
|
| chr12_-_91179472 Show fit | 1.27 |
ENST00000550099.5
ENST00000546391.5 |
decorin |
|
| chr5_-_111976925 Show fit | 1.14 |
ENST00000395634.7
|
neuronal regeneration related protein |
|
| chr3_-_195583931 Show fit | 1.01 |
ENST00000343267.8
ENST00000421243.5 ENST00000453131.1 |
apolipoprotein D |
|
| chr10_-_20897288 Show fit | 0.86 |
ENST00000377122.9
|
nebulette |
|
| chr2_+_151357583 Show fit | 0.84 |
ENST00000243347.5
|
TNF alpha induced protein 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRRX1_ALX4_PHOX2A
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.6 | 2.3 | GO:0034699 | transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699) |
| 0.1 | 2.3 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 1.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.3 | 1.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 0.9 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.3 | 0.8 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.1 | 0.8 | GO:2000230 | negative regulation of pancreatic stellate cell proliferation(GO:2000230) |
| 0.0 | 0.7 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.6 | GO:0045109 | intermediate filament organization(GO:0045109) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 3.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.4 | 2.3 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.0 | 1.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 1.0 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 2.3 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 2.3 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.3 | 1.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 1.0 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.9 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 0.8 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.8 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.8 | GO:0015485 | cholesterol binding(GO:0015485) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.5 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.3 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |