Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for RELB
Z-value: 1.36
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Transcription factors associated with RELB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELB | hg38_v1_chr19_+_45001430_45001525 | 0.94 | 6.3e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_23949847 Show fit | 1.40 |
ENST00000588004.1
|
laminin subunit alpha 3 |
|
| chr12_-_8662619 Show fit | 1.37 |
ENST00000544889.1
ENST00000543369.5 |
microfibril associated protein 5 |
|
| chr12_-_8662703 Show fit | 1.33 |
ENST00000535336.5
|
microfibril associated protein 5 |
|
| chr6_-_136526177 Show fit | 1.02 |
ENST00000617204.4
|
microtubule associated protein 7 |
|
| chr11_+_18266254 Show fit | 1.00 |
ENST00000532858.5
ENST00000649195.1 ENST00000356524.9 ENST00000405158.2 |
serum amyloid A1 |
|
| chr6_-_136526472 Show fit | 0.94 |
ENST00000454590.5
ENST00000432797.6 |
microtubule associated protein 7 |
|
| chr12_-_57767057 Show fit | 0.87 |
ENST00000228606.9
|
cytochrome P450 family 27 subfamily B member 1 |
|
| chr6_-_136525961 Show fit | 0.85 |
ENST00000438100.6
|
microtubule associated protein 7 |
|
| chr12_-_8662808 Show fit | 0.71 |
ENST00000359478.7
ENST00000396549.6 |
microfibril associated protein 5 |
|
| chr1_-_186680411 Show fit | 0.67 |
ENST00000367468.10
|
prostaglandin-endoperoxide synthase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELB
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.0 | 2.6 | GO:0006970 | response to osmotic stress(GO:0006970) |
| 0.2 | 1.8 | GO:0061709 | reticulophagy(GO:0061709) |
| 0.0 | 1.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 1.0 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.0 | 1.0 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.3 | 0.9 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.2 | 0.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 0.9 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 0.8 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 2.8 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 1.5 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.2 | 1.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 1.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 1.1 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.7 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 0.1 | 0.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.6 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.2 | 0.5 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 1.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 0.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.8 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 0.8 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 0.8 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.7 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 1.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.4 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.2 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.0 | 1.4 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.8 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 0.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.6 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.4 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |