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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for RUNX1_RUNX2

Z-value: 0.31

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Transcription factors associated with RUNX1_RUNX2

Gene Symbol Gene ID Gene Info
RUNX1
ENSG00000159216.19 RUNX family transcription factor 1
RUNX2
ENSG00000124813.23 RUNX family transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RUNX1hg38_v1_chr21_-_34888683_348887140.285.0e-01Click!
RUNX2hg38_v1_chr6_+_45422485_45422561-0.226.0e-01Click!

Activity profile of RUNX1_RUNX2 motif

Sorted Z-values of RUNX1_RUNX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_48978313 0.31 ENST00000293549.4
WNT1
Wnt family member 1
chr19_-_6720641 0.28 ENST00000245907.11
C3
complement C3
chr1_+_86424154 0.27 ENST00000370565.5
CLCA2
chloride channel accessory 2
chr2_+_168802563 0.26 ENST00000445023.6
NOSTRIN
nitric oxide synthase trafficking
chr2_+_168802610 0.26 ENST00000397206.6
ENST00000317647.12
ENST00000397209.6
NOSTRIN
nitric oxide synthase trafficking
chr3_-_190122317 0.24 ENST00000427335.6
P3H2
prolyl 3-hydroxylase 2
chr12_+_57583101 0.20 ENST00000674858.1
ENST00000675433.1
ENST00000674980.1
KIF5A
kinesin family member 5A
chr2_+_37344594 0.20 ENST00000404976.5
ENST00000338415.8
QPCT
glutaminyl-peptide cyclotransferase
chr5_+_132073782 0.20 ENST00000296871.4
CSF2
colony stimulating factor 2
chr17_-_36196748 0.19 ENST00000619989.1
CCL3L1
C-C motif chemokine ligand 3 like 1
chr8_-_19682576 0.19 ENST00000332246.10
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr18_+_13611910 0.18 ENST00000590308.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr9_-_127778659 0.17 ENST00000314830.13
SH2D3C
SH2 domain containing 3C
chr4_+_70226116 0.17 ENST00000317987.6
FDCSP
follicular dendritic cell secreted protein
chr6_+_26500296 0.17 ENST00000684113.1
BTN1A1
butyrophilin subfamily 1 member A1
chr12_-_55707865 0.17 ENST00000347027.10
ENST00000257879.11
ENST00000553804.6
ITGA7
integrin subunit alpha 7
chr5_+_76403266 0.16 ENST00000274364.11
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_-_36090133 0.16 ENST00000613922.2
CCL3
C-C motif chemokine ligand 3
chr20_+_46008900 0.16 ENST00000372330.3
MMP9
matrix metallopeptidase 9
chr11_-_1750558 0.15 ENST00000340134.5
IFITM10
interferon induced transmembrane protein 10
chr11_+_121576760 0.15 ENST00000532694.5
ENST00000534286.5
SORL1
sortilin related receptor 1
chr18_-_55422306 0.15 ENST00000566777.5
ENST00000626584.2
TCF4
transcription factor 4
chr14_+_22497657 0.15 ENST00000390496.1
TRAJ41
T cell receptor alpha joining 41
chr19_-_54242751 0.14 ENST00000245621.6
ENST00000396365.6
LILRA6
leukocyte immunoglobulin like receptor A6
chr15_+_73683938 0.14 ENST00000567189.5
CD276
CD276 molecule
chr1_+_152514474 0.14 ENST00000368790.4
CRCT1
cysteine rich C-terminal 1
chr2_-_218985176 0.14 ENST00000295727.2
FEV
FEV transcription factor, ETS family member
chr4_-_83114715 0.14 ENST00000426923.2
ENST00000311507.9
ENST00000509973.5
PLAC8
placenta associated 8
chr7_+_144000320 0.14 ENST00000641698.1
OR6B1
olfactory receptor family 6 subfamily B member 1
chr16_+_30375820 0.13 ENST00000566955.1
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr18_+_23949847 0.13 ENST00000588004.1
LAMA3
laminin subunit alpha 3
chr2_+_127418420 0.13 ENST00000234071.8
ENST00000429925.5
ENST00000442644.5
PROC
protein C, inactivator of coagulation factors Va and VIIIa
chr16_-_66918839 0.13 ENST00000565235.2
ENST00000568632.5
ENST00000565796.5
CDH16
cadherin 16
chr6_-_33080710 0.13 ENST00000419277.5
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr16_-_66918876 0.13 ENST00000570262.5
ENST00000299752.9
ENST00000394055.7
CDH16
cadherin 16
chr1_+_200894892 0.13 ENST00000413687.3
INAVA
innate immunity activator
chr1_+_236394268 0.13 ENST00000334232.9
EDARADD
EDAR associated death domain
chr17_-_58417547 0.13 ENST00000577716.5
RNF43
ring finger protein 43
chr17_-_58417521 0.13 ENST00000584437.5
ENST00000407977.7
RNF43
ring finger protein 43
chr1_-_23369813 0.12 ENST00000314011.9
ZNF436
zinc finger protein 436
chr10_-_62816341 0.12 ENST00000242480.4
ENST00000637191.1
EGR2
early growth response 2
chr16_+_85611401 0.12 ENST00000405402.6
GSE1
Gse1 coiled-coil protein
chr6_+_72216745 0.12 ENST00000517827.5
RIMS1
regulating synaptic membrane exocytosis 1
chr6_-_29045175 0.12 ENST00000377175.2
OR2W1
olfactory receptor family 2 subfamily W member 1
chr17_-_41586887 0.12 ENST00000167586.7
KRT14
keratin 14
chr3_+_45026296 0.12 ENST00000296130.5
CLEC3B
C-type lectin domain family 3 member B
chr7_-_29195186 0.12 ENST00000449801.5
ENST00000409850.5
CPVL
carboxypeptidase vitellogenic like
chr6_-_29375291 0.12 ENST00000396806.3
OR12D3
olfactory receptor family 12 subfamily D member 3
chr10_-_13234329 0.12 ENST00000463405.2
UCMA
upper zone of growth plate and cartilage matrix associated
chr18_-_55422492 0.12 ENST00000561992.5
ENST00000630712.2
TCF4
transcription factor 4
chr10_-_13234368 0.12 ENST00000378681.8
UCMA
upper zone of growth plate and cartilage matrix associated
chr10_+_80413817 0.12 ENST00000372187.9
PRXL2A
peroxiredoxin like 2A
chr6_-_106975309 0.11 ENST00000615659.1
CD24
CD24 molecule
chr20_-_1588632 0.11 ENST00000262929.9
ENST00000567028.5
SIRPB1
ENSG00000260861.6
signal regulatory protein beta 1
novel protein, SIRPB1-SIRPD readthrough
chr17_-_7261092 0.11 ENST00000574070.5
CLDN7
claudin 7
chr18_+_31447732 0.11 ENST00000257189.5
DSG3
desmoglein 3
chr11_+_1838970 0.11 ENST00000381911.6
TNNI2
troponin I2, fast skeletal type
chr15_-_43776956 0.11 ENST00000319359.8
ELL3
elongation factor for RNA polymerase II 3
chr11_+_60971668 0.11 ENST00000313421.11
CD6
CD6 molecule
chr1_-_184037695 0.11 ENST00000361927.9
ENST00000649786.1
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr14_-_24634266 0.11 ENST00000382540.5
GZMB
granzyme B
chr17_-_31314066 0.11 ENST00000577894.1
EVI2B
ecotropic viral integration site 2B
chr1_+_209686173 0.11 ENST00000615289.4
ENST00000367028.6
ENST00000261465.5
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
chr19_-_51372640 0.11 ENST00000600427.5
ENST00000221978.10
NKG7
natural killer cell granule protein 7
chr14_-_24634160 0.10 ENST00000616551.1
ENST00000382542.5
ENST00000216341.9
ENST00000526004.1
ENST00000415355.7
GZMB
granzyme B
chr6_+_31575557 0.10 ENST00000449264.3
TNF
tumor necrosis factor
chr15_-_93089192 0.10 ENST00000329082.11
RGMA
repulsive guidance molecule BMP co-receptor a
chr18_+_68798065 0.10 ENST00000360242.9
CCDC102B
coiled-coil domain containing 102B
chr19_-_43465596 0.10 ENST00000244333.4
LYPD3
LY6/PLAUR domain containing 3
chr10_-_104085847 0.10 ENST00000648076.2
COL17A1
collagen type XVII alpha 1 chain
chr19_+_17470474 0.10 ENST00000598424.5
ENST00000252595.12
SLC27A1
solute carrier family 27 member 1
chr11_+_113908983 0.10 ENST00000537778.5
HTR3B
5-hydroxytryptamine receptor 3B
chr11_-_102530738 0.10 ENST00000260227.5
MMP7
matrix metallopeptidase 7
chr22_+_46620380 0.10 ENST00000406902.6
GRAMD4
GRAM domain containing 4
chr6_+_72216442 0.10 ENST00000425662.6
ENST00000453976.6
RIMS1
regulating synaptic membrane exocytosis 1
chr2_+_232662733 0.10 ENST00000410095.5
ENST00000611312.1
EFHD1
EF-hand domain family member D1
chr11_-_118264445 0.10 ENST00000438295.2
MPZL2
myelin protein zero like 2
chr3_-_151316795 0.10 ENST00000260843.5
GPR87
G protein-coupled receptor 87
chr1_-_56966006 0.10 ENST00000371237.9
C8B
complement C8 beta chain
chr10_+_128047559 0.10 ENST00000306042.9
PTPRE
protein tyrosine phosphatase receptor type E
chr15_+_83447411 0.10 ENST00000324537.5
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr11_+_1868673 0.10 ENST00000405957.6
LSP1
lymphocyte specific protein 1
chr7_+_75398915 0.10 ENST00000437796.1
TRIM73
tripartite motif containing 73
chr19_+_41262656 0.10 ENST00000599719.5
ENST00000601309.5
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chr5_-_150086511 0.10 ENST00000675795.1
CSF1R
colony stimulating factor 1 receptor
chr2_+_112977998 0.10 ENST00000259205.5
ENST00000376489.6
IL36G
interleukin 36 gamma
chrX_-_48971829 0.10 ENST00000218176.4
KCND1
potassium voltage-gated channel subfamily D member 1
chr3_-_49903863 0.09 ENST00000296474.8
ENST00000621387.4
MST1R
macrophage stimulating 1 receptor
chr2_-_216694794 0.09 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr10_+_110226805 0.09 ENST00000651495.1
ENST00000652506.1
ENST00000651811.1
ENST00000651167.1
ENST00000651516.1
ENST00000651467.1
ENST00000651004.1
ENST00000650843.1
ENST00000650644.1
ENST00000650696.1
ENST00000652604.1
ENST00000652463.1
ENST00000650810.1
ENST00000650952.1
ENST00000652028.1
ENST00000651866.1
ENST00000651848.1
ENST00000442296.5
ENST00000369612.1
MXI1
MAX interactor 1, dimerization protein
chr22_+_24607638 0.09 ENST00000432867.5
GGT1
gamma-glutamyltransferase 1
chr2_-_162318129 0.09 ENST00000679938.1
IFIH1
interferon induced with helicase C domain 1
chr11_-_111923722 0.09 ENST00000527950.5
CRYAB
crystallin alpha B
chr17_-_7294592 0.09 ENST00000007699.10
YBX2
Y-box binding protein 2
chr1_-_56966133 0.09 ENST00000535057.5
ENST00000543257.5
C8B
complement C8 beta chain
chr19_-_49155130 0.09 ENST00000595625.1
HRC
histidine rich calcium binding protein
chr4_+_75556048 0.09 ENST00000616557.1
ENST00000435974.2
ENST00000311623.9
ODAPH
odontogenesis associated phosphoprotein
chr20_-_1619996 0.09 ENST00000381603.7
ENST00000381605.9
ENST00000279477.11
ENST00000568365.1
ENST00000564763.1
SIRPB1
ENSG00000260861.6
signal regulatory protein beta 1
novel protein, SIRPB1-SIRPD readthrough
chr12_-_85836372 0.09 ENST00000361228.5
RASSF9
Ras association domain family member 9
chr11_+_2902258 0.09 ENST00000649076.2
ENST00000449793.6
SLC22A18
solute carrier family 22 member 18
chr2_-_221572272 0.09 ENST00000409854.5
ENST00000443796.5
ENST00000281821.7
EPHA4
EPH receptor A4
chr15_+_73684204 0.09 ENST00000537340.6
ENST00000318424.9
CD276
CD276 molecule
chr5_+_145936554 0.09 ENST00000359120.9
SH3RF2
SH3 domain containing ring finger 2
chr11_+_1853049 0.09 ENST00000311604.8
LSP1
lymphocyte specific protein 1
chr19_-_43780957 0.09 ENST00000648319.1
KCNN4
potassium calcium-activated channel subfamily N member 4
chr17_-_31314040 0.09 ENST00000330927.5
EVI2B
ecotropic viral integration site 2B
chr4_-_158159657 0.09 ENST00000590648.5
GASK1B
golgi associated kinase 1B
chr4_+_87975829 0.09 ENST00000614857.5
SPP1
secreted phosphoprotein 1
chr5_+_170861990 0.09 ENST00000523189.6
RANBP17
RAN binding protein 17
chr17_-_42050587 0.09 ENST00000587304.3
C17orf113
chromosome 17 open reading frame 113
chr12_+_25052512 0.09 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr1_-_3611470 0.08 ENST00000356575.9
MEGF6
multiple EGF like domains 6
chr7_-_141946926 0.08 ENST00000438351.1
ENST00000439991.1
ENST00000551012.6
ENST00000546910.6
CLEC5A
C-type lectin domain containing 5A
chr17_+_19378476 0.08 ENST00000395604.8
ENST00000482850.1
MAPK7
mitogen-activated protein kinase 7
chr7_+_100969565 0.08 ENST00000536621.6
ENST00000379442.7
MUC12
mucin 12, cell surface associated
chr16_+_56932134 0.08 ENST00000439977.7
ENST00000300302.9
ENST00000344114.8
ENST00000379792.6
HERPUD1
homocysteine inducible ER protein with ubiquitin like domain 1
chr3_-_151203201 0.08 ENST00000480322.1
ENST00000309180.6
GPR171
G protein-coupled receptor 171
chr11_+_76783349 0.08 ENST00000333090.5
TSKU
tsukushi, small leucine rich proteoglycan
chr2_+_74458400 0.08 ENST00000393972.7
ENST00000233615.7
ENST00000409737.5
ENST00000428943.1
WBP1
WW domain binding protein 1
chr2_-_89143133 0.08 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr12_+_29223730 0.08 ENST00000547116.5
FAR2
fatty acyl-CoA reductase 2
chr6_-_106974721 0.08 ENST00000606017.2
ENST00000620405.1
CD24
CD24 molecule
chr4_+_87975667 0.08 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
SPP1
secreted phosphoprotein 1
chr1_+_196774813 0.08 ENST00000471440.6
ENST00000391985.7
ENST00000617219.1
ENST00000367425.9
CFHR3
complement factor H related 3
chr12_+_29223659 0.08 ENST00000182377.8
FAR2
fatty acyl-CoA reductase 2
chr4_-_185775271 0.08 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr6_+_26440472 0.08 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr3_+_98763331 0.08 ENST00000485391.5
ENST00000492254.5
ST3GAL6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr13_-_28100556 0.08 ENST00000241453.12
FLT3
fms related receptor tyrosine kinase 3
chr1_-_237890922 0.08 ENST00000611898.4
ENST00000366570.5
ZP4
zona pellucida glycoprotein 4
chr1_+_111229813 0.08 ENST00000524472.5
CHI3L2
chitinase 3 like 2
chr2_+_219460719 0.08 ENST00000396688.5
SPEG
striated muscle enriched protein kinase
chr16_-_87936529 0.08 ENST00000649794.3
ENST00000649158.1
ENST00000648177.1
CA5A
carbonic anhydrase 5A
chr10_+_97584314 0.08 ENST00000370647.8
HOGA1
4-hydroxy-2-oxoglutarate aldolase 1
chr10_+_89392546 0.08 ENST00000546318.2
ENST00000371804.4
IFIT1
interferon induced protein with tetratricopeptide repeats 1
chr11_-_120138104 0.08 ENST00000341846.10
TRIM29
tripartite motif containing 29
chr11_-_16356538 0.08 ENST00000683767.1
SOX6
SRY-box transcription factor 6
chr19_-_8502621 0.08 ENST00000600262.1
ENST00000423345.5
PRAM1
PML-RARA regulated adaptor molecule 1
chr6_-_137219028 0.07 ENST00000647124.1
ENST00000642390.1
ENST00000645753.1
ENST00000646036.1
ENST00000646898.1
ENST00000644894.1
IFNGR1
interferon gamma receptor 1
chr15_-_78937198 0.07 ENST00000677207.1
CTSH
cathepsin H
chr2_+_101998955 0.07 ENST00000393414.6
IL1R2
interleukin 1 receptor type 2
chr21_+_41361999 0.07 ENST00000436410.5
ENST00000435611.6
ENST00000330714.8
MX2
MX dynamin like GTPase 2
chrX_-_66639022 0.07 ENST00000374719.8
EDA2R
ectodysplasin A2 receptor
chr7_+_29194757 0.07 ENST00000222792.11
CHN2
chimerin 2
chr17_+_7455571 0.07 ENST00000575379.1
CHRNB1
cholinergic receptor nicotinic beta 1 subunit
chr4_-_142474395 0.07 ENST00000507861.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr12_+_25052634 0.07 ENST00000548766.5
IRAG2
inositol 1,4,5-triphosphate receptor associated 2
chr1_-_223363337 0.07 ENST00000608996.5
SUSD4
sushi domain containing 4
chr9_-_92404559 0.07 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr1_-_24964984 0.07 ENST00000338888.3
ENST00000399916.5
RUNX3
RUNX family transcription factor 3
chr11_+_124611420 0.07 ENST00000284288.3
PANX3
pannexin 3
chr5_-_150113344 0.07 ENST00000286301.7
ENST00000511344.1
CSF1R
colony stimulating factor 1 receptor
chrX_+_48683763 0.07 ENST00000376701.5
WAS
WASP actin nucleation promoting factor
chr4_+_88378842 0.07 ENST00000264346.12
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr12_-_70637405 0.07 ENST00000548122.2
ENST00000551525.5
ENST00000550358.5
ENST00000334414.11
PTPRB
protein tyrosine phosphatase receptor type B
chr21_-_46605073 0.07 ENST00000291700.9
ENST00000367071.4
S100B
S100 calcium binding protein B
chr7_+_117020191 0.07 ENST00000434836.5
ENST00000393443.5
ENST00000465133.5
ENST00000477742.5
ENST00000393444.7
ENST00000393447.8
ST7
suppression of tumorigenicity 7
chr15_+_43594027 0.07 ENST00000453733.5
ENST00000441322.6
ENST00000627381.1
CKMT1B
creatine kinase, mitochondrial 1B
chr3_-_99850976 0.07 ENST00000487087.5
FILIP1L
filamin A interacting protein 1 like
chr20_+_63861498 0.07 ENST00000369916.5
ABHD16B
abhydrolase domain containing 16B
chr11_+_108223027 0.07 ENST00000675843.1
ENST00000683468.1
ENST00000532931.5
ENST00000530958.5
ATM
ATM serine/threonine kinase
chr14_-_24508251 0.07 ENST00000250378.7
ENST00000206446.4
CMA1
chymase 1
chr11_+_64340191 0.07 ENST00000356786.10
CCDC88B
coiled-coil domain containing 88B
chr11_+_7605719 0.07 ENST00000530181.5
PPFIBP2
PPFIA binding protein 2
chr4_+_88378733 0.07 ENST00000273960.7
ENST00000380265.9
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr11_+_36375978 0.07 ENST00000378867.7
PRR5L
proline rich 5 like
chr15_+_83447328 0.07 ENST00000427482.7
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3
chr8_+_133113483 0.07 ENST00000521107.1
TG
thyroglobulin
chr17_-_41521719 0.07 ENST00000393976.6
KRT15
keratin 15
chr18_+_36544544 0.06 ENST00000591635.5
FHOD3
formin homology 2 domain containing 3
chr4_+_105895458 0.06 ENST00000379987.7
NPNT
nephronectin
chr20_+_44714853 0.06 ENST00000372865.4
CCN5
cellular communication network factor 5
chr9_+_34653864 0.06 ENST00000556792.5
ENST00000318041.13
IL11RA
interleukin 11 receptor subunit alpha
chr16_-_10694922 0.06 ENST00000283025.7
TEKT5
tektin 5
chr1_+_6448448 0.06 ENST00000475228.6
ESPN
espin
chr16_-_58294976 0.06 ENST00000543437.5
ENST00000569079.1
PRSS54
serine protease 54
chrX_-_78659328 0.06 ENST00000321110.2
RTL3
retrotransposon Gag like 3
chr6_+_89081787 0.06 ENST00000354922.3
PNRC1
proline rich nuclear receptor coactivator 1
chr16_-_58295019 0.06 ENST00000567164.6
ENST00000219301.8
ENST00000569727.1
PRSS54
serine protease 54
chr4_+_165873711 0.06 ENST00000513213.5
TLL1
tolloid like 1
chr1_+_111229692 0.06 ENST00000466741.5
ENST00000477185.6
CHI3L2
chitinase 3 like 2
chr16_+_82035245 0.06 ENST00000199936.9
HSD17B2
hydroxysteroid 17-beta dehydrogenase 2
chrX_-_151974668 0.06 ENST00000370328.4
GABRE
gamma-aminobutyric acid type A receptor subunit epsilon
chr20_+_44714835 0.06 ENST00000372868.6
CCN5
cellular communication network factor 5
chr6_+_88047822 0.06 ENST00000237201.2
SPACA1
sperm acrosome associated 1
chr10_+_102461380 0.06 ENST00000238936.8
ENST00000369931.3
MFSD13A
major facilitator superfamily domain containing 13A
chr5_-_43412323 0.06 ENST00000361115.4
CCL28
C-C motif chemokine ligand 28
chr17_-_74546082 0.06 ENST00000330793.2
CD300C
CD300c molecule
chrX_-_47574738 0.06 ENST00000640721.1
SYN1
synapsin I
chr5_+_35856883 0.06 ENST00000506850.5
ENST00000303115.8
ENST00000511982.1
IL7R
interleukin 7 receptor
chr14_+_104745960 0.06 ENST00000556623.1
ENST00000555674.1
ADSS1
adenylosuccinate synthase 1
chr2_-_230960954 0.06 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chr1_+_153774210 0.06 ENST00000271857.6
SLC27A3
solute carrier family 27 member 3
chr4_+_105895435 0.06 ENST00000453617.6
ENST00000427316.6
ENST00000514622.5
ENST00000305572.12
NPNT
nephronectin
chr18_+_63907948 0.06 ENST00000238508.8
SERPINB10
serpin family B member 10
chr17_+_19377721 0.06 ENST00000308406.9
ENST00000299612.11
MAPK7
mitogen-activated protein kinase 7
chr6_-_48111132 0.06 ENST00000398738.3
ENST00000679966.1
ENST00000339488.9
PTCHD4
patched domain containing 4
chr19_+_39997031 0.06 ENST00000599504.5
ENST00000596894.5
ENST00000601138.5
ENST00000347077.9
ENST00000600094.5
ZNF546
zinc finger protein 546
chr14_-_94388589 0.06 ENST00000402629.1
ENST00000556091.1
ENST00000393087.9
ENST00000554720.1
SERPINA1
serpin family A member 1
chr19_-_49155384 0.06 ENST00000252825.9
HRC
histidine rich calcium binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX1_RUNX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061184 positive regulation of dermatome development(GO:0061184)
0.1 0.3 GO:0001796 type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892)
0.1 0.2 GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.3 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.2 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.1 GO:1902948 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.1 GO:1901899 positive regulation of relaxation of cardiac muscle(GO:1901899)
0.0 0.2 GO:0032599 B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.0 0.1 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.0 0.2 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.1 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.0 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.1 GO:0030806 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821)
0.0 0.1 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.0 0.1 GO:0009386 translational attenuation(GO:0009386)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:1904808 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.2 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.1 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.2 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.2 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.1 GO:2000721 pilomotor reflex(GO:0097195) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.1 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.0 0.1 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.0 0.2 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.1 GO:1904882 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.1 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.0 0.1 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.2 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.1 GO:1903904 negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
0.0 0.1 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.1 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.1 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761) negative regulation of vascular smooth muscle cell differentiation(GO:1905064)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.0 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.0 GO:0044691 tooth eruption(GO:0044691)
0.0 0.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.0 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.0 0.0 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.0 GO:0051695 actin filament uncapping(GO:0051695)
0.0 0.1 GO:0051459 regulation of corticotropin secretion(GO:0051459)
0.0 0.1 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.0 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.0 0.0 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.0 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.0 GO:0042412 taurine biosynthetic process(GO:0042412)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.0 GO:0070889 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) platelet alpha granule organization(GO:0070889) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.0 GO:2001170 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) negative regulation of ATP biosynthetic process(GO:2001170)
0.0 0.0 GO:0044278 cell wall disruption in other organism(GO:0044278)
0.0 0.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.0 GO:0043000 negative regulation of anion channel activity(GO:0010360) Golgi to plasma membrane CFTR protein transport(GO:0043000)
0.0 0.0 GO:1903216 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.2 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0097325 melanocyte proliferation(GO:0097325)
0.0 0.2 GO:0048681 negative regulation of axon regeneration(GO:0048681)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071754 IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
0.0 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.0 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.2 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.0 GO:0044753 amphisome(GO:0044753)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.1 0.2 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.1 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.0 0.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.4 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.1 GO:0030395 lactose binding(GO:0030395)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.0 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.0 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.0 0.0 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.0 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.2 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)