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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SIX6

Z-value: 1.12

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
ENSG00000184302.7 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg38_v1_chr14_+_60509138_60509163-0.147.4e-01Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_27970273 0.98 ENST00000542963.1
ENST00000535992.5
parathyroid hormone like hormone
chr1_+_13585453 0.84 ENST00000487038.5
ENST00000475043.5
podoplanin
chr12_-_27970047 0.76 ENST00000395868.7
parathyroid hormone like hormone
chr3_+_187024614 0.72 ENST00000416235.6
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr8_+_100158029 0.63 ENST00000251809.4
sperm associated antigen 1
chr18_+_11752041 0.52 ENST00000423027.8
G protein subunit alpha L
chr13_+_73054969 0.51 ENST00000539231.5
Kruppel like factor 5
chr5_+_55851378 0.41 ENST00000396836.6
ENST00000359040.10
interleukin 31 receptor A
chrX_-_33211540 0.38 ENST00000357033.9
dystrophin
chr14_+_21042352 0.35 ENST00000298690.5
ribonuclease A family member 7
chr1_+_156150008 0.31 ENST00000355014.6
semaphorin 4A
chr1_+_156149657 0.31 ENST00000414683.5
semaphorin 4A
chr14_-_69574845 0.30 ENST00000599174.3
coiled-coil domain containing 177
chr8_+_32721823 0.29 ENST00000539990.3
ENST00000519240.5
neuregulin 1
chr1_+_160739286 0.28 ENST00000359331.8
ENST00000495334.1
SLAM family member 7
chr4_-_154590735 0.27 ENST00000403106.8
ENST00000622532.1
ENST00000651975.1
fibrinogen alpha chain
chr1_+_212565334 0.25 ENST00000366981.8
ENST00000366987.6
activating transcription factor 3
chr1_+_160739265 0.24 ENST00000368042.7
SLAM family member 7
chr12_-_14696571 0.24 ENST00000261170.5
guanylate cyclase 2C
chr8_+_2045058 0.23 ENST00000523438.1
myomesin 2
chr1_+_31413187 0.22 ENST00000373709.8
serine incorporator 2
chr8_+_2045037 0.22 ENST00000262113.9
myomesin 2
chr12_-_86838867 0.21 ENST00000621808.4
MGAT4 family member C
chr2_+_176269473 0.20 ENST00000452865.1
metaxin 2
chr19_+_3136026 0.20 ENST00000262958.4
G protein subunit alpha 15
chr1_+_160739239 0.19 ENST00000368043.8
SLAM family member 7
chrX_+_8465426 0.19 ENST00000381029.4
variable charge X-linked 3B
chr2_+_176269406 0.19 ENST00000249442.11
ENST00000443241.5
metaxin 2
chr5_+_140821598 0.19 ENST00000614258.1
ENST00000529859.2
ENST00000529619.5
protocadherin alpha 5
chr19_-_15898057 0.18 ENST00000011989.11
ENST00000221700.11
cytochrome P450 family 4 subfamily F member 2
chr1_-_161045961 0.18 ENST00000368021.7
upstream transcription factor 1
chr14_+_20469399 0.17 ENST00000361505.10
ENST00000553591.1
purine nucleoside phosphorylase
chr13_+_33818122 0.17 ENST00000380071.8
replication factor C subunit 3
chr20_+_56412249 0.17 ENST00000679887.1
ENST00000434344.2
Cas scaffold protein family member 4
chr20_+_56412393 0.16 ENST00000679529.1
Cas scaffold protein family member 4
chr22_-_19150292 0.15 ENST00000086933.3
goosecoid homeobox 2
chr20_+_56412112 0.14 ENST00000360314.7
Cas scaffold protein family member 4
chr13_+_75549477 0.14 ENST00000618773.4
ubiquitin C-terminal hydrolase L3
chr6_-_26285526 0.13 ENST00000377727.2
H4 clustered histone 8
chr6_+_29170907 0.13 ENST00000641417.1
olfactory receptor family 2 subfamily J member 2
chr2_-_133568393 0.13 ENST00000317721.10
ENST00000405974.7
ENST00000409261.6
ENST00000409213.5
NCK associated protein 5
chr13_+_42138042 0.12 ENST00000628433.2
ENST00000536612.3
diacylglycerol kinase eta
chr1_+_234373439 0.12 ENST00000366615.10
ENST00000619305.1
cytochrome c oxidase assembly factor 6
chr4_+_73436198 0.12 ENST00000395792.7
alpha fetoprotein
chr12_-_121580954 0.12 ENST00000536437.5
ENST00000611216.4
ENST00000538046.6
ENST00000377071.9
lysine demethylase 2B
chrX_+_7843088 0.12 ENST00000341408.5
variable charge X-linked
chr4_+_73436244 0.12 ENST00000226359.2
alpha fetoprotein
chr4_+_77605807 0.12 ENST00000682537.1
C-X-C motif chemokine ligand 13
chr18_+_44680093 0.12 ENST00000426838.8
ENST00000677068.1
SET binding protein 1
chr11_-_5227063 0.11 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
hemoglobin subunit beta
chr5_+_40909490 0.11 ENST00000313164.10
complement C7
chr4_+_112818032 0.11 ENST00000672356.1
ENST00000672955.1
ankyrin 2
chr6_+_29396555 0.11 ENST00000623183.1
olfactory receptor family 12 subfamily D member 2
chr1_+_86468902 0.11 ENST00000394711.2
chloride channel accessory 1
chr12_-_121580441 0.11 ENST00000377069.8
lysine demethylase 2B
chr19_-_35563653 0.11 ENST00000262623.4
ATPase H+/K+ transporting subunit alpha
chrX_-_119565362 0.11 ENST00000320339.8
ENST00000536133.2
ENST00000644802.2
STING1 ER exit protein 1
chr15_-_79971164 0.10 ENST00000335661.6
ENST00000267953.4
ENST00000677151.1
BCL2 related protein A1
chr4_+_112818088 0.10 ENST00000673044.1
ENST00000672696.1
ENST00000672315.1
ENST00000672088.1
ENST00000671793.1
ENST00000672402.1
ENST00000671825.1
ENST00000672312.1
ENST00000672830.1
ENST00000672731.1
ENST00000671854.1
ENST00000672350.1
ENST00000672684.1
ENST00000672934.1
ENST00000673546.1
ENST00000673573.1
ENST00000503423.6
ENST00000673255.1
ENST00000671893.1
ENST00000672246.1
ENST00000672930.1
ENST00000673334.1
ENST00000673453.1
ENST00000673555.1
ENST00000672880.1
ENST00000672990.1
ENST00000673430.1
ENST00000673298.1
ENST00000672068.1
ENST00000672362.1
ENST00000672793.1
ENST00000672209.1
ENST00000671756.1
ENST00000671809.1
ENST00000671906.1
ENST00000672090.1
ENST00000672177.1
ENST00000672759.1
ENST00000672965.1
ENST00000673109.1
ENST00000503271.5
ENST00000506722.5
ENST00000673536.1
ENST00000672986.1
ankyrin 2
chr11_+_74988896 0.10 ENST00000526068.1
ENST00000294064.9
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
neuraminidase 3
chr4_-_122456725 0.10 ENST00000226730.5
interleukin 2
chr13_+_102656933 0.10 ENST00000650757.1
tripeptidyl peptidase 2
chr15_+_58138368 0.09 ENST00000219919.9
ENST00000536493.1
aquaporin 9
chr11_-_84273188 0.08 ENST00000330014.11
ENST00000418306.6
ENST00000531015.5
discs large MAGUK scaffold protein 2
chr5_-_83720813 0.08 ENST00000515590.1
ENST00000274341.9
hyaluronan and proteoglycan link protein 1
chr1_+_234373667 0.08 ENST00000366613.1
ENST00000366612.1
cytochrome c oxidase assembly factor 6
chr19_-_15125659 0.08 ENST00000533747.1
ENST00000598709.1
ENST00000534378.5
ilvB acetolactate synthase like
chr21_+_44697172 0.08 ENST00000400365.3
keratin associated protein 10-12
chr19_-_14848922 0.08 ENST00000641129.1
olfactory receptor family 7 subfamily A member 10
chr6_+_52186373 0.07 ENST00000648244.1
interleukin 17A
chr6_-_107824294 0.07 ENST00000369020.8
ENST00000369022.6
Scm polycomb group protein like 4
chr6_-_26197272 0.07 ENST00000356476.3
H3 clustered histone 4
chr12_-_21334858 0.06 ENST00000445053.1
ENST00000458504.5
ENST00000422327.5
ENST00000683939.1
solute carrier organic anion transporter family member 1A2
chr5_-_43043170 0.06 ENST00000314890.3
annexin A2 receptor
chr4_-_64409444 0.06 ENST00000381210.8
ENST00000507440.5
trans-2,3-enoyl-CoA reductase like
chr15_-_100341899 0.06 ENST00000568565.2
ENST00000268070.9
ADAM metallopeptidase with thrombospondin type 1 motif 17
chr7_+_117611617 0.05 ENST00000468795.1
CF transmembrane conductance regulator
chr11_-_105035113 0.05 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr12_-_10826358 0.05 ENST00000240619.2
taste 2 receptor member 10
chr1_+_62597510 0.05 ENST00000371129.4
angiopoietin like 3
chr4_+_106315689 0.05 ENST00000358008.7
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
chr9_-_21141832 0.04 ENST00000380229.4
interferon omega 1
chr13_-_19505940 0.04 ENST00000400103.6
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr12_+_71686473 0.04 ENST00000549735.5
transmembrane protein 19
chrY_+_14056226 0.03 ENST00000250823.5
variable charge Y-linked 1B
chr2_-_151973780 0.03 ENST00000637514.1
ENST00000636350.1
ENST00000434468.2
ENST00000637762.1
ENST00000637779.1
ENST00000637547.1
ENST00000636901.1
ENST00000397327.7
ENST00000636721.1
ENST00000636380.1
ENST00000637284.1
ENST00000636617.1
ENST00000636947.1
ENST00000638091.1
ENST00000636108.1
ENST00000638040.1
ENST00000636773.1
ENST00000637418.1
ENST00000637216.1
calcium voltage-gated channel auxiliary subunit beta 4
chr18_-_36798482 0.03 ENST00000590258.2
tubulin polyglutamylase complex subunit 2
chrY_-_13986473 0.03 ENST00000250825.5
variable charge Y-linked
chr9_-_97944832 0.03 ENST00000259456.7
hemogen
chrX_+_65488735 0.03 ENST00000338957.4
zinc finger CCCH-type containing 12B
chr9_-_21351378 0.03 ENST00000380210.1
interferon alpha 6
chr1_-_35769928 0.03 ENST00000373220.7
ENST00000520551.1
claspin
chrX_+_129540236 0.03 ENST00000371113.9
ENST00000357121.5
OCRL inositol polyphosphate-5-phosphatase
chr7_-_93226449 0.02 ENST00000394468.7
ENST00000453812.2
HEPACAM family member 2
chr6_+_127577168 0.02 ENST00000329722.8
chromosome 6 open reading frame 58
chr16_-_20352707 0.02 ENST00000396134.6
ENST00000573567.5
ENST00000570757.5
ENST00000396138.9
ENST00000571174.5
ENST00000576688.2
uromodulin
chr20_-_5010284 0.02 ENST00000379333.5
solute carrier family 23 member 2
chr1_-_13347134 0.02 ENST00000334600.7
PRAME family member 14
chr12_-_121039156 0.02 ENST00000339275.10
2'-5'-oligoadenylate synthetase like
chr13_+_33818063 0.02 ENST00000434425.5
replication factor C subunit 3
chr12_-_121039236 0.01 ENST00000257570.9
2'-5'-oligoadenylate synthetase like
chr6_+_26204552 0.01 ENST00000615164.2
H4 clustered histone 5
chr12_+_53954870 0.01 ENST00000243103.4
homeobox C12
chr5_-_157109025 0.01 ENST00000307851.9
hepatitis A virus cellular receptor 2
chr5_+_75512058 0.01 ENST00000514296.5
DNA polymerase kappa
chr4_+_106315534 0.01 ENST00000510207.5
aminoacyl tRNA synthetase complex interacting multifunctional protein 1
chr1_-_161223559 0.01 ENST00000469730.2
ENST00000463273.5
ENST00000464492.5
ENST00000367990.7
ENST00000470459.6
ENST00000463812.1
ENST00000468465.5
apolipoprotein A2
chr3_-_151461011 0.01 ENST00000282466.4
immunoglobulin superfamily member 10
chr12_-_121038967 0.01 ENST00000680620.1
ENST00000679655.1
ENST00000543677.2
2'-5'-oligoadenylate synthetase like
chr1_-_35769958 0.01 ENST00000251195.9
ENST00000318121.8
claspin
chr12_-_121039204 0.01 ENST00000620239.5
2'-5'-oligoadenylate synthetase like
chr6_-_26017779 0.01 ENST00000244573.5
H1.1 linker histone, cluster member
chr1_-_38876351 0.01 ENST00000360786.3
gap junction protein alpha 9
chr9_+_107306459 0.00 ENST00000457811.1
RAD23 homolog B, nucleotide excision repair protein
chr3_-_3109980 0.00 ENST00000256452.7
ENST00000311981.12
ENST00000430514.6
ENST00000456302.5
interleukin 5 receptor subunit alpha
chr6_+_29587455 0.00 ENST00000383640.4
olfactory receptor family 2 subfamily H member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 0.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 0.2 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 0.2 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592)
0.1 0.5 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.0 0.3 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 1.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0 0.7 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.2 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.3 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:1904823 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.2 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.4 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.1 GO:0035377 transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.2 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 0.8 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 1.7 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383) toxic substance binding(GO:0015643)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.4 GO:0050998 vinculin binding(GO:0017166) nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching