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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SMAD2

Z-value: 1.38

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
ENSG00000175387.16 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg38_v1_chr18_-_47930630_479306810.472.5e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_159171607 1.49 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
cell adhesion molecule 3
chr12_+_53050179 1.46 ENST00000546602.5
ENST00000552570.5
ENST00000549700.5
tensin 2
chrX_+_153494970 1.44 ENST00000331595.9
ENST00000431891.1
biglycan
chrX_-_107775740 1.29 ENST00000372383.9
TSC22 domain family member 3
chrX_-_107775951 1.07 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22 domain family member 3
chr22_-_24245059 0.98 ENST00000398292.3
ENST00000263112.11
ENST00000327365.10
ENST00000424217.1
gamma-glutamyltransferase 5
chr5_-_151141631 0.87 ENST00000523714.5
ENST00000521749.5
annexin A6
chr12_-_55712402 0.85 ENST00000452168.6
integrin subunit alpha 7
chr16_+_55479188 0.83 ENST00000219070.9
matrix metallopeptidase 2
chr12_+_53050014 0.73 ENST00000314250.11
tensin 2
chr6_-_152168291 0.68 ENST00000354674.5
spectrin repeat containing nuclear envelope protein 1
chr6_-_152168349 0.67 ENST00000539504.5
spectrin repeat containing nuclear envelope protein 1
chr19_+_49513154 0.61 ENST00000426395.7
ENST00000600273.5
ENST00000599988.5
Fc fragment of IgG receptor and transporter
chr17_-_78925376 0.57 ENST00000262768.11
TIMP metallopeptidase inhibitor 2
chr4_-_39638893 0.57 ENST00000511809.5
ENST00000505729.1
small integral membrane protein 14
chr4_-_39638846 0.50 ENST00000295958.10
small integral membrane protein 14
chr10_+_71212524 0.43 ENST00000335350.10
unc-5 netrin receptor B
chr8_-_94895195 0.42 ENST00000308108.9
ENST00000396133.7
cyclin E2
chr5_+_321695 0.42 ENST00000684583.1
ENST00000514523.1
aryl-hydrocarbon receptor repressor
chr5_-_151686908 0.40 ENST00000231061.9
secreted protein acidic and cysteine rich
chr6_+_56955097 0.38 ENST00000370746.8
ENST00000370748.7
BEN domain containing 6
chr6_+_101393699 0.36 ENST00000369134.9
ENST00000684068.1
ENST00000683903.1
ENST00000681975.1
glutamate ionotropic receptor kainate type subunit 2
chr18_-_3013114 0.34 ENST00000677752.1
lipin 2
chr4_+_673518 0.30 ENST00000506838.5
myosin light chain 5
chr6_-_56954747 0.30 ENST00000680361.1
dystonin
chr3_+_194685874 0.30 ENST00000329759.6
family with sequence similarity 43 member A
chr12_-_95996302 0.30 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
histidine ammonia-lyase
chr7_+_66629023 0.29 ENST00000639879.1
ENST00000640851.1
potassium channel tetramerization domain containing 7
chr10_-_14330879 0.29 ENST00000357447.7
FERM domain containing 4A
chr6_+_41042557 0.27 ENST00000373158.6
ENST00000470917.1
translocator protein 2
chrX_-_63754664 0.27 ENST00000677315.1
ENST00000636392.1
ENST00000637040.1
ENST00000637178.1
ENST00000637557.1
ENST00000636048.1
ENST00000638021.1
ENST00000672513.1
novel protein
Cdc42 guanine nucleotide exchange factor 9
chr5_-_88731827 0.27 ENST00000627170.2
myocyte enhancer factor 2C
chr5_+_141382702 0.26 ENST00000617050.1
ENST00000518325.2
protocadherin gamma subfamily A, 7
chr7_-_100896123 0.25 ENST00000428317.7
acetylcholinesterase (Cartwright blood group)
chr5_+_134526176 0.25 ENST00000681820.1
ENST00000512386.6
ENST00000612830.2
jade family PHD finger 2
chrX_-_151974668 0.25 ENST00000370328.4
gamma-aminobutyric acid type A receptor subunit epsilon
chr7_-_105876575 0.24 ENST00000318724.8
ENST00000419735.8
ataxin 7 like 1
chr16_+_2148603 0.24 ENST00000210187.11
RAB26, member RAS oncogene family
chr7_+_66629078 0.24 ENST00000449064.6
ENST00000638540.1
ENST00000640234.1
potassium channel tetramerization domain containing 7
chr9_+_122510802 0.23 ENST00000335302.5
olfactory receptor family 1 subfamily J member 2
chr3_+_111674654 0.23 ENST00000636933.1
ENST00000393934.7
ENST00000477665.2
phosphatidylinositol specific phospholipase C X domain containing 2
chr4_-_113761068 0.23 ENST00000342666.9
ENST00000514328.5
ENST00000515496.5
ENST00000508738.5
ENST00000379773.6
calcium/calmodulin dependent protein kinase II delta
chr4_+_37244735 0.22 ENST00000309447.6
NACHT and WD repeat domain containing 2
chr1_+_185734362 0.22 ENST00000271588.9
hemicentin 1
chr19_+_35775530 0.22 ENST00000314737.9
ENST00000007510.8
Rho GTPase activating protein 33
chr19_+_35775515 0.21 ENST00000378944.9
Rho GTPase activating protein 33
chr6_+_39792298 0.21 ENST00000633794.1
ENST00000274867.9
dishevelled associated activator of morphogenesis 2
chr4_-_113761441 0.21 ENST00000394524.7
calcium/calmodulin dependent protein kinase II delta
chr11_-_117295485 0.21 ENST00000680971.1
beta-secretase 1
chr5_+_134526100 0.20 ENST00000395003.5
jade family PHD finger 2
chr6_+_39792993 0.20 ENST00000538976.5
dishevelled associated activator of morphogenesis 2
chr6_+_39793008 0.20 ENST00000398904.6
dishevelled associated activator of morphogenesis 2
chr11_-_75669028 0.20 ENST00000304771.8
microtubule associated protein 6
chr1_-_1307861 0.19 ENST00000354700.10
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr7_-_100895878 0.19 ENST00000419336.6
ENST00000241069.11
ENST00000411582.4
ENST00000302913.8
acetylcholinesterase (Cartwright blood group)
chr16_+_28878382 0.19 ENST00000357084.7
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr17_-_15262537 0.19 ENST00000395936.7
ENST00000675819.1
ENST00000674707.1
ENST00000675854.1
ENST00000426385.4
ENST00000395938.7
ENST00000612492.5
ENST00000675808.1
peripheral myelin protein 22
chr4_-_113761724 0.19 ENST00000511664.6
calcium/calmodulin dependent protein kinase II delta
chr4_-_5888400 0.19 ENST00000397890.6
collapsin response mediator protein 1
chr14_-_104978360 0.18 ENST00000333244.6
AHNAK nucleoprotein 2
chr5_+_43603163 0.18 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
nicotinamide nucleotide transhydrogenase
chr1_-_153985366 0.18 ENST00000614713.4
RAB13, member RAS oncogene family
chr16_+_28878480 0.18 ENST00000395503.9
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr19_+_36140059 0.18 ENST00000246533.8
ENST00000587718.5
ENST00000592483.5
ENST00000590874.5
ENST00000588815.5
calpain small subunit 1
chr17_+_4950147 0.18 ENST00000522301.5
enolase 3
chr16_+_3305472 0.17 ENST00000574298.6
ENST00000669516.2
zinc finger protein 75a
chr22_-_31489528 0.17 ENST00000397525.5
eukaryotic translation initiation factor 4E nuclear import factor 1
chr18_+_3448456 0.16 ENST00000549780.5
TGFB induced factor homeobox 1
chr21_-_37267511 0.16 ENST00000398998.1
VPS26 endosomal protein sorting factor C
chr16_+_2033264 0.16 ENST00000565855.5
ENST00000566198.1
SLC9A3 regulator 2
chr3_-_165196369 0.16 ENST00000475390.2
SLIT and NTRK like family member 3
chr8_+_94895763 0.15 ENST00000523378.5
NADH:ubiquinone oxidoreductase complex assembly factor 6
chr12_+_49961864 0.15 ENST00000293599.7
aquaporin 5
chr19_+_38390055 0.15 ENST00000587947.5
ENST00000338502.8
sprouty related EVH1 domain containing 3
chr9_+_34990250 0.15 ENST00000454002.6
ENST00000545841.5
DnaJ heat shock protein family (Hsp40) member B5
chr7_-_105876477 0.15 ENST00000478915.1
ataxin 7 like 1
chr11_-_33892010 0.15 ENST00000257818.3
LIM domain only 2
chr4_-_102828022 0.15 ENST00000502690.5
ubiquitin conjugating enzyme E2 D3
chr22_+_22734577 0.15 ENST00000390310.3
immunoglobulin lambda variable 2-18
chr19_-_45785659 0.14 ENST00000537879.1
ENST00000596586.5
ENST00000595946.1
DM1 locus, WD repeat containing
novel protein
chr1_+_36306359 0.14 ENST00000453908.8
SH3 domain containing 21
chr17_+_68205453 0.14 ENST00000674770.2
archaelysin family metallopeptidase 2
chr1_-_149936816 0.14 ENST00000439741.4
myotubularin related protein 11
chr9_-_128067310 0.14 ENST00000373078.5
nuclear apoptosis inducing factor 1
chr19_+_735026 0.14 ENST00000592155.5
ENST00000590161.2
paralemmin
chr11_-_65382632 0.14 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
solute carrier family 25 member 45
chr22_-_38455199 0.13 ENST00000303592.3
potassium inwardly rectifying channel subfamily J member 4
chrX_+_153764178 0.13 ENST00000538966.5
plexin B3
chr4_-_102827723 0.13 ENST00000349311.12
ubiquitin conjugating enzyme E2 D3
chr1_-_149936324 0.13 ENST00000369140.7
myotubularin related protein 11
chr2_-_240682879 0.13 ENST00000407834.4
ENST00000621682.4
aquaporin 12B
chr9_+_5890872 0.13 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
melan-A
chr1_-_201946469 0.13 ENST00000367288.5
leiomodin 1
chr1_-_201946571 0.13 ENST00000616739.1
leiomodin 1
chr11_-_75668566 0.13 ENST00000526740.3
microtubule associated protein 6
chr17_-_3668557 0.12 ENST00000225525.4
Tax1 binding protein 3
chr19_+_11355386 0.12 ENST00000251473.9
ENST00000591329.5
ENST00000586380.5
phospholipid phosphatase related 2
chr4_-_102827948 0.12 ENST00000394804.6
ENST00000394801.8
ubiquitin conjugating enzyme E2 D3
chrX_+_48801949 0.12 ENST00000376610.6
ENST00000462730.5
ENST00000376619.6
ENST00000465269.5
ENST00000334136.11
ENST00000476625.5
ENST00000646703.1
histone deacetylase 6
chr9_+_79573162 0.12 ENST00000425506.5
TLE family member 4, transcriptional corepressor
chr7_-_14841267 0.12 ENST00000406247.7
ENST00000399322.7
diacylglycerol kinase beta
chrX_+_48802156 0.12 ENST00000643374.1
ENST00000644068.1
ENST00000441703.6
ENST00000643934.1
ENST00000489352.5
histone deacetylase 6
chr3_-_88058928 0.12 ENST00000482016.6
CGG triplet repeat binding protein 1
chr1_+_36307090 0.12 ENST00000505871.7
SH3 domain containing 21
chrX_+_101488044 0.12 ENST00000423738.4
armadillo repeat containing X-linked 4
chr5_+_134525649 0.11 ENST00000282605.8
ENST00000681547.2
ENST00000361895.6
ENST00000402835.5
jade family PHD finger 2
chr15_+_96332432 0.11 ENST00000559679.1
ENST00000394171.6
nuclear receptor subfamily 2 group F member 2
chr22_+_22822658 0.11 ENST00000620395.2
immunoglobulin lambda variable 2-8
chr9_+_79572715 0.11 ENST00000265284.10
TLE family member 4, transcriptional corepressor
chr12_-_119804298 0.11 ENST00000678652.1
ENST00000678494.1
citron rho-interacting serine/threonine kinase
chr16_+_57668299 0.11 ENST00000333493.9
ENST00000450388.7
adhesion G protein-coupled receptor G3
chr1_-_206946448 0.11 ENST00000356495.5
polymeric immunoglobulin receptor
chr3_-_88059042 0.11 ENST00000309534.10
CGG triplet repeat binding protein 1
chrX_+_153764233 0.10 ENST00000361971.10
plexin B3
chr22_-_36028773 0.10 ENST00000438146.7
RNA binding fox-1 homolog 2
chr4_-_102828048 0.10 ENST00000508249.1
ubiquitin conjugating enzyme E2 D3
chr6_-_159045010 0.10 ENST00000338313.5
T cell activation RhoGTPase activating protein
chr16_+_53130921 0.10 ENST00000564845.5
chromodomain helicase DNA binding protein 9
chr17_-_3668640 0.10 ENST00000611779.4
Tax1 binding protein 3
chr15_+_45587366 0.10 ENST00000220531.9
biogenesis of lysosomal organelles complex 1 subunit 6
chr4_-_102828159 0.10 ENST00000394803.9
ubiquitin conjugating enzyme E2 D3
chr3_+_40505992 0.10 ENST00000420891.5
ENST00000314529.10
ENST00000418905.1
zinc finger protein 620
chr19_+_11355491 0.10 ENST00000591608.1
phospholipid phosphatase related 2
chr9_+_137251261 0.10 ENST00000620243.4
ENST00000388931.7
ENST00000412566.5
ENST00000611378.4
sperm-tail PG-rich repeat containing 3
chr15_+_45587580 0.09 ENST00000566801.5
ENST00000565323.6
ENST00000568816.5
biogenesis of lysosomal organelles complex 1 subunit 6
chr11_-_65381951 0.09 ENST00000526432.5
ENST00000527174.5
solute carrier family 25 member 45
chr3_-_71130892 0.09 ENST00000491238.7
ENST00000674446.1
forkhead box P1
chr2_-_219308963 0.09 ENST00000423636.6
ENST00000442029.5
ENST00000412847.5
protein tyrosine phosphatase receptor type N
chr3_+_50279080 0.09 ENST00000316436.4
leucine rich single-pass membrane protein 2
chr12_+_110468803 0.08 ENST00000377673.10
family with sequence similarity 216 member A
chr7_-_10940123 0.08 ENST00000339600.6
NDUFA4 mitochondrial complex associated
chr3_-_71130963 0.08 ENST00000649695.2
forkhead box P1
chr3_-_71130557 0.08 ENST00000497355.7
forkhead box P1
chr3_-_9792404 0.08 ENST00000301964.7
transcriptional adaptor 3
chr4_-_112516176 0.08 ENST00000313341.4
neurogenin 2
chr5_+_64768921 0.08 ENST00000381070.8
ENST00000508024.1
CWC27 spliceosome associated cyclophilin
chr7_+_129126518 0.07 ENST00000467614.2
novel protein similar to mitogen-activated protein kinase kinase 2 MAP2K2
chrX_-_48470243 0.07 ENST00000429543.2
ENST00000620913.5
solute carrier family 38 member 5
chr18_+_13218195 0.07 ENST00000679167.1
low density lipoprotein receptor class A domain containing 4
chr19_+_48469354 0.07 ENST00000452733.7
ENST00000641098.1
cytohesin 2
chr1_-_58784035 0.07 ENST00000371222.4
Jun proto-oncogene, AP-1 transcription factor subunit
chr7_-_75994574 0.07 ENST00000439537.5
ENST00000493111.7
ENST00000417509.5
ENST00000485200.1
transmembrane protein 120A
chr13_-_26760741 0.07 ENST00000405846.5
G protein-coupled receptor 12
chr17_-_42185452 0.07 ENST00000293330.1
hypocretin neuropeptide precursor
chrX_-_48470163 0.07 ENST00000595796.5
solute carrier family 38 member 5
chr16_-_375205 0.07 ENST00000448854.1
post-glycosylphosphatidylinositol attachment to proteins 6
chr17_+_7407838 0.07 ENST00000302926.7
neuroligin 2
chr19_-_35135011 0.07 ENST00000310123.8
leucine rich repeat LGI family member 4
chr5_-_43412323 0.07 ENST00000361115.4
C-C motif chemokine ligand 28
chr2_-_219243577 0.06 ENST00000409640.5
galactosidase beta 1 like
chr15_+_75206398 0.06 ENST00000565074.1
chromosome 15 open reading frame 39
chr5_-_74640575 0.06 ENST00000651128.1
ectodermal-neural cortex 1
chr22_+_50089879 0.06 ENST00000545383.5
ENST00000262794.10
Mov10 like RISC complex RNA helicase 1
chr7_+_99408609 0.06 ENST00000403633.6
BUD31 homolog
chr22_+_22327298 0.06 ENST00000390291.2
immunoglobulin lambda variable 1-50 (non-functional)
chr3_-_51903341 0.06 ENST00000310914.10
IQ motif containing F1
chr1_+_160115715 0.06 ENST00000361216.8
ATPase Na+/K+ transporting subunit alpha 2
chr9_+_130835246 0.06 ENST00000318560.6
ABL proto-oncogene 1, non-receptor tyrosine kinase
chr14_-_106038355 0.06 ENST00000390597.3
immunoglobulin heavy variable 2-5
chrX_+_102651366 0.05 ENST00000415986.5
ENST00000444152.5
ENST00000361600.9
G protein-coupled receptor associated sorting protein 1
chr20_-_17682234 0.05 ENST00000377813.6
ENST00000377807.6
ENST00000360807.8
ENST00000398782.2
ribosome binding protein 1
chr1_-_154961720 0.05 ENST00000368457.3
pygopus family PHD finger 2
chr3_+_9792495 0.05 ENST00000498623.6
actin related protein 2/3 complex subunit 4
chr12_-_10098940 0.05 ENST00000420265.2
C-type lectin domain family 1 member A
chr19_+_47130782 0.05 ENST00000597808.5
ENST00000413379.7
ENST00000600706.5
ENST00000270225.12
ENST00000598840.5
ENST00000600753.1
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr3_-_168095885 0.05 ENST00000470487.6
golgi integral membrane protein 4
chr5_+_71455636 0.05 ENST00000358731.9
ENST00000380675.3
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr12_-_8612850 0.05 ENST00000229335.11
ENST00000537228.5
activation induced cytidine deaminase
chr17_-_7207245 0.05 ENST00000649971.1
discs large MAGUK scaffold protein 4
chr5_+_180494344 0.05 ENST00000261951.9
CCR4-NOT transcription complex subunit 6
chr12_+_109900518 0.04 ENST00000312777.9
ENST00000536408.2
trichoplein keratin filament binding
chr14_+_35826298 0.04 ENST00000216807.12
BRMS1 like transcriptional repressor
chr1_+_160127672 0.04 ENST00000447527.1
ATPase Na+/K+ transporting subunit alpha 2
chr19_-_51458448 0.04 ENST00000430817.5
ENST00000321424.7
ENST00000340550.5
sialic acid binding Ig like lectin 8
chr7_-_102517755 0.04 ENST00000306682.6
ENST00000465829.6
ENST00000541662.5
RAS p21 protein activator 4B
chr21_+_44600597 0.04 ENST00000609664.2
keratin associated protein 10-7
chr3_-_62373538 0.04 ENST00000283268.8
FEZ family zinc finger 2
chr21_-_33479914 0.04 ENST00000542230.7
transmembrane protein 50B
chr17_-_10114546 0.04 ENST00000323816.8
growth arrest specific 7
chr11_-_66317037 0.04 ENST00000311330.4
CD248 molecule
chr2_-_219309350 0.04 ENST00000295718.7
protein tyrosine phosphatase receptor type N
chr9_-_28670285 0.04 ENST00000379992.6
ENST00000308675.5
ENST00000613945.3
leucine rich repeat and Ig domain containing 2
chr9_-_133356448 0.04 ENST00000615505.4
ENST00000371974.8
SURF1 cytochrome c oxidase assembly factor
chr4_-_102827494 0.04 ENST00000453744.7
ENST00000321805.11
ubiquitin conjugating enzyme E2 D3
chr10_+_101061973 0.03 ENST00000370200.6
Kazal type serine peptidase inhibitor domain 1
chr12_+_67648737 0.03 ENST00000344096.4
ENST00000393555.3
dual specificity tyrosine phosphorylation regulated kinase 2
chr19_-_42132391 0.03 ENST00000528894.8
ENST00000560804.6
ENST00000560558.5
ENST00000560398.5
ENST00000526816.6
ENST00000625670.2
POU class 2 homeobox 2
chr9_+_101028721 0.03 ENST00000374874.8
phospholipid phosphatase related 1
chr22_+_41560973 0.03 ENST00000306149.12
cold shock domain containing C2
chrX_-_135098695 0.03 ENST00000433425.4
small integral membrane protein 10 like 2B
chrX_+_21940693 0.03 ENST00000404933.7
ENST00000379404.5
spermine synthase
chr1_+_15456727 0.03 ENST00000359621.5
chymotrypsin like elastase 2A
chr19_+_48624952 0.03 ENST00000599748.5
ENST00000599029.2
sphingosine kinase 2
chr1_+_27725945 0.03 ENST00000373954.11
ENST00000419687.6
family with sequence similarity 76 member A
chr7_-_150955796 0.03 ENST00000330883.9
potassium voltage-gated channel subfamily H member 2
chr3_+_52495330 0.03 ENST00000321725.10
stabilin 1
chr20_+_58651785 0.03 ENST00000358029.8
syntaxin 16
chr7_-_99408548 0.03 ENST00000626285.1
ENST00000350498.8
PDGFA associated protein 1
chr4_-_54064586 0.03 ENST00000263921.8
cysteine rich hydrophobic domain 2
chr6_+_34514853 0.03 ENST00000538621.2
protein kinase C and casein kinase substrate in neurons 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.4 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 1.3 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 0.4 GO:0031443 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) relaxation of skeletal muscle(GO:0090076)
0.1 0.8 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.6 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.2 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.1 0.2 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 2.2 GO:0014850 response to muscle activity(GO:0014850)
0.1 0.3 GO:0043606 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 1.0 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.2 GO:1904692 positive regulation of type B pancreatic cell proliferation(GO:1904692)
0.0 0.4 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
0.0 0.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.6 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.1 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:0006740 NADPH regeneration(GO:0006740)
0.0 0.1 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.0 0.3 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0 0.9 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.0 0.1 GO:0051365 leading edge cell differentiation(GO:0035026) cellular response to potassium ion starvation(GO:0051365)
0.0 0.4 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.1 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.0 GO:0070898 RNA polymerase III transcriptional preinitiation complex assembly(GO:0070898)
0.0 0.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:1904862 inhibitory synapse assembly(GO:1904862)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.9 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.2 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 0.4 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 1.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.2 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.3 GO:0071682 endocytic vesicle lumen(GO:0071682)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 0.6 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.2 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.2 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 1.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 0.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0001156 TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.0 0.1 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins