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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SMAD3

Z-value: 0.26

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
ENSG00000166949.17 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg38_v1_chr15_+_67065586_67065614,
hg38_v1_chr15_+_67067780_67067811
0.667.6e-02Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_89838289 0.16 ENST00000336904.7
synuclein alpha
chr20_+_59676661 0.13 ENST00000355648.8
phosphatase and actin regulator 3
chr19_-_55180010 0.12 ENST00000589172.5
synaptotagmin 5
chr12_+_3491189 0.12 ENST00000382622.4
protein arginine methyltransferase 8
chr6_+_26124161 0.11 ENST00000377791.4
ENST00000602637.1
H2A clustered histone 6
chr6_-_27132750 0.10 ENST00000607124.1
ENST00000339812.3
H2B clustered histone 11
chr4_-_185775271 0.10 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
sorbin and SH3 domain containing 2
chr6_-_27831557 0.10 ENST00000611927.2
H4 clustered histone 12
chr6_-_27146841 0.09 ENST00000356950.2
H2B clustered histone 12
chr3_+_12796662 0.09 ENST00000456430.6
ENST00000626378.1
cullin associated and neddylation dissociated 2 (putative)
chr1_+_153416517 0.08 ENST00000368729.9
S100 calcium binding protein A7A
chr6_-_27807916 0.08 ENST00000377401.3
H2B clustered histone 13
chr15_-_82647336 0.08 ENST00000617522.4
ENST00000684509.1
cytoplasmic polyadenylation element binding protein 1
chr6_+_30882914 0.07 ENST00000509639.5
ENST00000412274.6
ENST00000507901.5
ENST00000507046.5
ENST00000437124.6
ENST00000454612.6
ENST00000396342.6
discoidin domain receptor tyrosine kinase 1
chr15_-_82709886 0.07 ENST00000666055.1
ENST00000261722.8
ENST00000535513.2
adaptor related protein complex 3 subunit beta 2
chr9_-_133131109 0.07 ENST00000372062.8
ral guanine nucleotide dissociation stimulator
chr10_+_92691897 0.07 ENST00000492654.3
hematopoietically expressed homeobox
chr6_-_27814757 0.07 ENST00000333151.5
H2A clustered histone 14
chr15_+_81299416 0.06 ENST00000558332.3
interleukin 16
chr6_+_27824084 0.06 ENST00000355057.3
H4 clustered histone 11
chr15_-_82709859 0.06 ENST00000542200.2
ENST00000535359.6
ENST00000668990.2
ENST00000652847.1
adaptor related protein complex 3 subunit beta 2
chr17_+_50095331 0.06 ENST00000503176.6
pyruvate dehydrogenase kinase 2
chr15_-_82647503 0.06 ENST00000567678.1
ENST00000620182.4
cytoplasmic polyadenylation element binding protein 1
chr6_+_27815010 0.06 ENST00000621112.2
H2B clustered histone 14
chr7_+_134565098 0.06 ENST00000652743.1
aldo-keto reductase family 1 member B15
chr10_-_88952763 0.06 ENST00000224784.10
actin alpha 2, smooth muscle
chr6_-_11807045 0.05 ENST00000379415.6
androgen dependent TFPI regulating protein
chr3_+_125969172 0.05 ENST00000514116.6
ENST00000513830.5
rhophilin associated tail protein 1B
chr6_-_26216673 0.05 ENST00000541790.3
H2B clustered histone 8
chr6_+_25726767 0.05 ENST00000274764.5
H2B clustered histone 1
chr15_-_82647960 0.05 ENST00000615198.4
cytoplasmic polyadenylation element binding protein 1
chr6_+_122717544 0.05 ENST00000354275.2
ENST00000368446.1
cAMP-dependent protein kinase inhibitor beta
chr16_-_58295019 0.05 ENST00000567164.6
ENST00000219301.8
ENST00000569727.1
serine protease 54
chr19_-_11577632 0.05 ENST00000590420.1
ENST00000648477.1
acid phosphatase 5, tartrate resistant
chr16_-_58294976 0.05 ENST00000543437.5
ENST00000569079.1
serine protease 54
chr6_+_27808163 0.05 ENST00000358739.4
H2A clustered histone 13
chr6_-_65707214 0.05 ENST00000370621.7
ENST00000393380.6
ENST00000503581.6
eyes shut homolog
chr11_-_133532493 0.05 ENST00000524381.6
opioid binding protein/cell adhesion molecule like
chr11_+_61102465 0.05 ENST00000347785.8
ENST00000544014.1
CD5 molecule
chr18_+_32018817 0.04 ENST00000217740.4
ENST00000583184.1
ring finger protein 125
novel transcript
chr6_+_27133032 0.04 ENST00000359193.3
H2A clustered histone 11
chr20_+_45408276 0.04 ENST00000372710.5
ENST00000443296.1
dysbindin domain containing 2
chr1_+_149832647 0.04 ENST00000578186.2
H4 clustered histone 14
chr19_+_51225059 0.04 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr11_+_73272201 0.04 ENST00000393590.3
pyrimidinergic receptor P2Y6
chr14_+_91114364 0.04 ENST00000518868.5
D-glutamate cyclase
chr14_+_91114667 0.04 ENST00000523894.5
ENST00000522322.5
ENST00000523771.5
D-glutamate cyclase
chr6_+_27147094 0.04 ENST00000377459.3
H2A clustered histone 12
chr14_+_91114431 0.04 ENST00000428926.6
ENST00000517362.5
D-glutamate cyclase
chr2_+_219245455 0.04 ENST00000409638.7
ENST00000396738.7
ENST00000409516.7
serine/threonine kinase 16
chr2_-_24793382 0.04 ENST00000328379.6
peptidyl-tRNA hydrolase domain containing 1
chr1_+_59297057 0.04 ENST00000303721.12
FGGY carbohydrate kinase domain containing
chr1_+_59296971 0.04 ENST00000371218.8
FGGY carbohydrate kinase domain containing
chr17_-_40937445 0.03 ENST00000436344.7
ENST00000485751.1
keratin 23
chr7_+_139829242 0.03 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
thromboxane A synthase 1
chr4_+_186069144 0.03 ENST00000513189.1
ENST00000296795.8
toll like receptor 3
chr6_-_132798587 0.03 ENST00000275227.9
solute carrier family 18 member B1
chr10_-_100286660 0.03 ENST00000370372.7
biogenesis of lysosomal organelles complex 1 subunit 2
chr10_+_28677487 0.03 ENST00000375533.6
BMP and activin membrane bound inhibitor
chr7_-_14903319 0.03 ENST00000403951.6
diacylglycerol kinase beta
chr3_-_14178569 0.03 ENST00000285021.12
XPC complex subunit, DNA damage recognition and repair factor
chr2_+_96325294 0.03 ENST00000439118.3
ENST00000420176.5
ENST00000536814.1
ITPRIP like 1
chr19_-_42220109 0.03 ENST00000595337.5
death effector domain containing 2
chr19_-_45645560 0.03 ENST00000587152.6
EMAP like 2
chr7_-_22822829 0.03 ENST00000358435.9
ENST00000621567.1
translocase of outer mitochondrial membrane 7
chr6_+_47698538 0.03 ENST00000327753.7
adhesion G protein-coupled receptor F4
chr11_-_64744993 0.03 ENST00000377485.5
RAS guanyl releasing protein 2
chr6_+_47698574 0.03 ENST00000283303.3
adhesion G protein-coupled receptor F4
chr1_-_110607307 0.03 ENST00000639048.2
ENST00000675391.1
ENST00000639233.2
potassium voltage-gated channel subfamily A member 2
chr6_+_27838600 0.03 ENST00000606613.1
H2B clustered histone 15
chr6_-_26123910 0.03 ENST00000314332.5
ENST00000396984.1
H2B clustered histone 4
chr1_-_110607425 0.03 ENST00000633222.1
potassium voltage-gated channel subfamily A member 2
chr5_+_55851349 0.03 ENST00000652347.2
interleukin 31 receptor A
chr1_-_88891496 0.03 ENST00000448623.5
ENST00000370500.10
ENST00000418217.1
general transcription factor IIB
chr11_-_65382632 0.02 ENST00000294187.10
ENST00000398802.6
ENST00000530936.1
solute carrier family 25 member 45
chr7_-_22822779 0.02 ENST00000372879.8
translocase of outer mitochondrial membrane 7
chr14_+_91114026 0.02 ENST00000521081.5
ENST00000520328.5
ENST00000524232.5
ENST00000522170.5
ENST00000256324.15
ENST00000519950.5
ENST00000523879.5
ENST00000521077.6
ENST00000518665.6
D-glutamate cyclase
chr18_+_46946821 0.02 ENST00000245121.9
ENST00000356157.12
katanin catalytic subunit A1 like 2
chrX_-_27463341 0.02 ENST00000412172.4
protein phosphatase 4 regulatory subunit 3C
chr7_+_150405146 0.02 ENST00000498682.3
ENST00000641717.1
novel zinc finger protein
chr19_+_41088450 0.02 ENST00000330436.4
cytochrome P450 family 2 subfamily A member 13
chr5_+_55851378 0.02 ENST00000396836.6
ENST00000359040.10
interleukin 31 receptor A
chr6_-_27873525 0.02 ENST00000618305.2
H4 clustered histone 13
chr3_-_154430184 0.02 ENST00000389740.3
G protein-coupled receptor 149
chr21_+_44133610 0.02 ENST00000644251.1
ENST00000427803.6
ENST00000348499.9
ENST00000291577.11
ENST00000389690.7
glutamine amidotransferase like class 1 domain containing 3A
chr18_+_13611764 0.02 ENST00000585931.5
low density lipoprotein receptor class A domain containing 4
chr11_+_117199363 0.02 ENST00000392951.9
ENST00000525531.5
ENST00000278968.10
transgelin
chr17_+_38297023 0.02 ENST00000619548.1
ENST00000613675.5
mitochondrial ribosomal protein L45
chr7_-_19773569 0.02 ENST00000422233.5
ENST00000433641.5
ENST00000405844.6
transmembrane protein 196
chr7_+_142656688 0.02 ENST00000390397.2
T cell receptor beta variable 24-1
chr1_-_44017296 0.02 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
solute carrier family 6 member 9
chrX_-_154295085 0.02 ENST00000617225.4
ENST00000619903.4
testis expressed 28
chr15_+_63504583 0.02 ENST00000380324.8
ENST00000561442.5
ENST00000560070.5
ubiquitin specific peptidase 3
chr15_+_63504511 0.02 ENST00000540797.5
ubiquitin specific peptidase 3
chr15_+_67067780 0.02 ENST00000679624.1
SMAD family member 3
chr6_-_26027274 0.02 ENST00000377745.4
H4 clustered histone 2
chr6_+_139028680 0.02 ENST00000367660.4
ABRA C-terminal like
chr3_+_51707059 0.02 ENST00000395052.8
glutamate metabotropic receptor 2
chr6_+_292050 0.02 ENST00000344450.9
dual specificity phosphatase 22
chr18_+_13218195 0.02 ENST00000679167.1
low density lipoprotein receptor class A domain containing 4
chr15_-_82709823 0.02 ENST00000666973.1
ENST00000664460.1
ENST00000669930.1
adaptor related protein complex 3 subunit beta 2
chr14_-_24081928 0.02 ENST00000396995.1
neural retina leucine zipper
chr1_-_152036984 0.02 ENST00000271638.3
S100 calcium binding protein A11
chr8_-_100105955 0.02 ENST00000523437.5
regulator of G protein signaling 22
chr14_+_91114388 0.02 ENST00000519019.5
ENST00000523816.5
ENST00000517518.5
D-glutamate cyclase
chr1_-_9129085 0.01 ENST00000377411.5
G protein-coupled receptor 157
chr15_-_82709775 0.01 ENST00000535348.5
adaptor related protein complex 3 subunit beta 2
chr20_-_64079479 0.01 ENST00000395042.2
regulator of G protein signaling 19
chr6_+_26272923 0.01 ENST00000377733.4
H2B clustered histone 10
chr18_+_13612614 0.01 ENST00000586765.1
ENST00000677910.1
low density lipoprotein receptor class A domain containing 4
chr1_+_66332004 0.01 ENST00000371045.9
ENST00000531025.5
ENST00000526197.5
phosphodiesterase 4B
chr8_-_100106034 0.01 ENST00000360863.11
ENST00000617334.1
regulator of G protein signaling 22
chr6_+_26216928 0.01 ENST00000303910.4
H2A clustered histone 8
chr6_+_116616467 0.01 ENST00000229554.10
ENST00000368581.8
ENST00000368580.4
radial spoke head component 4A
chr14_+_92923143 0.01 ENST00000216492.10
ENST00000334654.4
chromogranin A
chr1_-_10982037 0.01 ENST00000377004.8
chromosome 1 open reading frame 127
chrX_-_69165430 0.01 ENST00000374584.3
ENST00000590146.1
ENST00000374571.5
praja ring finger ubiquitin ligase 1
chr16_+_2471284 0.01 ENST00000293973.2
netrin 3
chr15_-_70763430 0.01 ENST00000539319.5
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_-_20802402 0.01 ENST00000412779.2
ribonuclease A family member 1, pancreatic
chr9_+_133534697 0.01 ENST00000651351.2
ADAMTS like 2
chrX_-_69165509 0.01 ENST00000361478.1
praja ring finger ubiquitin ligase 1
chr16_+_30762289 0.01 ENST00000566811.5
ENST00000565995.5
ENST00000563683.5
ENST00000357890.9
ENST00000324685.11
ENST00000565931.1
ring finger protein 40
chr8_-_100105619 0.01 ENST00000523287.5
ENST00000519092.5
regulator of G protein signaling 22
chr1_-_225941383 0.01 ENST00000420304.6
left-right determination factor 2
chr1_-_225923891 0.01 ENST00000472798.2
ENST00000489681.5
ENST00000612651.4
pyrroline-5-carboxylate reductase 2
chr14_-_64942783 0.01 ENST00000612794.1
glutathione peroxidase 2
chr7_+_100720463 0.01 ENST00000252723.3
erythropoietin
chr9_+_133534807 0.01 ENST00000393060.1
ADAMTS like 2
chr12_+_119178920 0.01 ENST00000281938.7
heat shock protein family B (small) member 8
chr7_+_142384328 0.01 ENST00000390361.3
T cell receptor beta variable 7-3
chr3_+_14178808 0.01 ENST00000306024.4
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
chr6_+_27893411 0.01 ENST00000616182.2
H2B clustered histone 17
chr5_+_132873660 0.01 ENST00000296877.3
liver enriched antimicrobial peptide 2
chr6_-_27838362 0.01 ENST00000618958.2
H2A clustered histone 15
chr12_+_119178953 0.01 ENST00000674542.1
heat shock protein family B (small) member 8
chr1_-_9069608 0.01 ENST00000377424.9
solute carrier family 2 member 5
chr12_+_48818763 0.01 ENST00000548279.5
ENST00000547230.5
calcium voltage-gated channel auxiliary subunit beta 3
chr21_+_31659666 0.01 ENST00000389995.4
ENST00000270142.11
superoxide dismutase 1
chr14_-_24081986 0.01 ENST00000560550.1
neural retina leucine zipper
chr3_+_125969152 0.01 ENST00000251776.8
ENST00000504401.1
rhophilin associated tail protein 1B
chr4_+_2812259 0.01 ENST00000502260.5
ENST00000435136.8
SH3 domain binding protein 2
chr13_+_45464901 0.01 ENST00000349995.10
component of oligomeric golgi complex 3
chr6_-_53148822 0.01 ENST00000259803.8
glial cells missing transcription factor 1
chr1_-_225941212 0.01 ENST00000366820.10
left-right determination factor 2
chr7_+_50308672 0.01 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKAROS family zinc finger 1
chr15_+_51341648 0.01 ENST00000335449.11
ENST00000560215.5
gliomedin
chr20_-_6123019 0.01 ENST00000217289.9
ENST00000536936.1
fermitin family member 1
chr14_-_64942720 0.01 ENST00000557049.1
ENST00000389614.6
glutathione peroxidase 2
chr15_-_82806054 0.01 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
fibronectin type III and SPRY domain containing 2
chr19_+_16077006 0.01 ENST00000586833.7
ENST00000642221.1
tropomyosin 4
chr12_+_14774362 0.01 ENST00000544848.2
H2A.J histone
chr14_-_58152179 0.01 ENST00000267485.7
armadillo like helical domain containing 4
chr3_-_112846856 0.01 ENST00000488794.5
CD200 receptor 1 like
chr5_+_141245384 0.01 ENST00000623671.1
ENST00000231173.6
protocadherin beta 15
chr16_-_20669855 0.01 ENST00000524149.5
acyl-CoA synthetase medium chain family member 1
chr17_+_4710622 0.01 ENST00000574954.5
ENST00000269260.7
ENST00000346341.6
ENST00000572457.5
ENST00000381488.10
ENST00000412477.7
ENST00000571428.5
ENST00000575877.5
arrestin beta 2
chr4_-_147684114 0.00 ENST00000322396.7
protein arginine methyltransferase 9
chr1_-_9069572 0.00 ENST00000377414.7
solute carrier family 2 member 5
chr15_+_82262781 0.00 ENST00000566205.1
ENST00000339465.5
ENST00000569120.1
ENST00000682753.1
ENST00000566861.5
ENST00000565432.1
stabilizer of axonemal microtubules 2
chr16_+_30472733 0.00 ENST00000356798.11
ENST00000433423.2
integrin subunit alpha L
chr16_-_30762052 0.00 ENST00000543610.6
ENST00000545825.1
ENST00000541260.5
coiled-coil domain containing 189
chr1_+_202416826 0.00 ENST00000466968.1
protein phosphatase 1 regulatory subunit 12B
chr8_-_118951876 0.00 ENST00000297350.9
TNF receptor superfamily member 11b
chr9_-_34691204 0.00 ENST00000378800.3
ENST00000311925.7
C-C motif chemokine ligand 19
chr10_+_127998126 0.00 ENST00000455661.5
protein tyrosine phosphatase receptor type E
chr11_-_72434330 0.00 ENST00000542555.2
ENST00000535990.5
ENST00000294053.9
ENST00000538039.6
ENST00000340729.9
caseinolytic mitochondrial matrix peptidase chaperone subunit B
chr3_-_120647018 0.00 ENST00000475447.2
homogentisate 1,2-dioxygenase
chr5_-_69332723 0.00 ENST00000511257.1
ENST00000396496.7
ENST00000383374.6
coiled-coil domain containing 125
chr10_+_69278492 0.00 ENST00000643399.2
hexokinase 1
chr11_+_66638678 0.00 ENST00000578778.5
ENST00000483858.5
ENST00000398692.8
ENST00000310092.12
ENST00000510173.6
ENST00000506523.6
ENST00000530235.1
ENST00000532968.1
RNA binding motif protein 4
chr5_-_133026533 0.00 ENST00000509437.6
ENST00000355372.6
ENST00000513541.5
ENST00000509008.1
ENST00000513848.5
ENST00000504170.2
ENST00000324170.7
zinc finger CCHC-type containing 10
chr1_-_60073750 0.00 ENST00000371201.3
chromosome 1 open reading frame 87
chr16_-_84186998 0.00 ENST00000567759.5
TATA-box binding protein associated factor, RNA polymerase I subunit C
chrX_-_49073989 0.00 ENST00000376386.3
ENST00000553851.3
PRA1 domain family member 2
chr1_-_60073733 0.00 ENST00000450089.6
chromosome 1 open reading frame 87
chr1_-_36440873 0.00 ENST00000433045.6
organic solute carrier partner 1
chr6_-_26285526 0.00 ENST00000377727.2
H4 clustered histone 8
chr1_-_160647287 0.00 ENST00000235739.6
signaling lymphocytic activation molecule family member 1
chr12_+_67269328 0.00 ENST00000545606.6
cullin associated and neddylation dissociated 1
chr19_+_42220283 0.00 ENST00000301215.8
ENST00000597945.1
zinc finger protein 526

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0051945 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.1 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.1 GO:0072144 glomerular mesangial cell development(GO:0072144) mesenchyme migration(GO:0090131)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.2 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.1 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.0 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)