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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for SRF

Z-value: 1.98

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.8 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg38_v1_chr6_+_43171260_43171281-0.265.4e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_36541484 4.06 ENST00000346786.2
MYL9
myosin light chain 9
chr10_-_62816341 2.78 ENST00000242480.4
ENST00000637191.1
EGR2
early growth response 2
chr10_-_62816309 2.72 ENST00000411732.3
EGR2
early growth response 2
chr8_+_96584920 2.69 ENST00000521590.5
SDC2
syndecan 2
chr5_+_93583212 2.41 ENST00000327111.8
NR2F1
nuclear receptor subfamily 2 group F member 1
chr20_+_36541511 2.10 ENST00000279022.7
MYL9
myosin light chain 9
chr10_+_31321152 1.60 ENST00000446923.7
ZEB1
zinc finger E-box binding homeobox 1
chr14_+_103928432 1.40 ENST00000409874.9
TDRD9
tudor domain containing 9
chr9_-_76906090 1.40 ENST00000376718.8
PRUNE2
prune homolog 2 with BCH domain
chr19_+_2476118 1.34 ENST00000215631.9
ENST00000587345.1
GADD45B
growth arrest and DNA damage inducible beta
chr9_+_36136416 1.30 ENST00000396613.7
GLIPR2
GLI pathogenesis related 2
chr9_-_76906041 1.26 ENST00000443509.6
ENST00000428286.5
ENST00000376713.3
PRUNE2
prune homolog 2 with BCH domain
chr9_+_36136703 1.25 ENST00000377960.9
ENST00000377959.5
GLIPR2
GLI pathogenesis related 2
chr9_+_36136752 1.23 ENST00000619700.1
GLIPR2
GLI pathogenesis related 2
chr14_-_89417148 1.23 ENST00000557258.6
FOXN3
forkhead box N3
chr9_+_89605004 1.22 ENST00000252506.11
ENST00000375769.1
GADD45G
growth arrest and DNA damage inducible gamma
chr5_+_138465472 1.18 ENST00000239938.5
EGR1
early growth response 1
chr11_+_117199363 0.92 ENST00000392951.9
ENST00000525531.5
ENST00000278968.10
TAGLN
transgelin
chr1_-_85578345 0.78 ENST00000426972.8
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_-_124744513 0.73 ENST00000504926.5
ZNF608
zinc finger protein 608
chr5_+_138439020 0.72 ENST00000378339.7
ENST00000254901.9
ENST00000506158.5
REEP2
receptor accessory protein 2
chr2_-_105438503 0.67 ENST00000393352.7
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr3_+_48989876 0.66 ENST00000343546.8
P4HTM
prolyl 4-hydroxylase, transmembrane
chr7_-_27143672 0.66 ENST00000222726.4
HOXA5
homeobox A5
chr6_-_3751703 0.64 ENST00000380283.5
PXDC1
PX domain containing 1
chr10_-_88952763 0.61 ENST00000224784.10
ACTA2
actin alpha 2, smooth muscle
chr2_-_105398978 0.60 ENST00000408995.5
ENST00000530340.6
ENST00000393353.7
ENST00000322142.13
ENST00000344213.9
ENST00000358129.8
FHL2
four and a half LIM domains 2
chr20_-_35147285 0.58 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr3_-_99876104 0.57 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1 like
chr15_+_83107572 0.56 ENST00000379390.10
ENST00000322019.14
ENST00000565774.5
ENST00000565982.1
TM6SF1
transmembrane 6 superfamily member 1
chr5_-_177496802 0.53 ENST00000506161.5
PDLIM7
PDZ and LIM domain 7
chr3_-_46863435 0.51 ENST00000395869.5
ENST00000653454.1
ENST00000292327.6
MYL3
myosin light chain 3
chr6_+_151239951 0.50 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chr5_-_177496845 0.50 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7
chr2_-_127675459 0.50 ENST00000355119.9
LIMS2
LIM zinc finger domain containing 2
chr2_-_127675065 0.45 ENST00000545738.6
ENST00000409808.6
LIMS2
LIM zinc finger domain containing 2
chr1_-_89065200 0.45 ENST00000370473.5
GBP1
guanylate binding protein 1
chr1_-_41662298 0.44 ENST00000643665.1
HIVEP3
HIVEP zinc finger 3
chr12_+_18242955 0.43 ENST00000676171.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
chr3_+_188212931 0.43 ENST00000618621.4
ENST00000640853.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_57514876 0.41 ENST00000528450.5
SLC43A1
solute carrier family 43 member 1
chr22_-_35961623 0.41 ENST00000408983.2
RBFOX2
RNA binding fox-1 homolog 2
chr3_-_99876193 0.41 ENST00000383694.3
FILIP1L
filamin A interacting protein 1 like
chr11_-_65859282 0.39 ENST00000526975.1
ENST00000531413.5
ENST00000525451.6
CFL1
cofilin 1
chr2_+_73892967 0.35 ENST00000409731.7
ENST00000409918.5
ENST00000442912.5
ENST00000345517.8
ENST00000409624.1
ACTG2
actin gamma 2, smooth muscle
chr17_-_74361860 0.35 ENST00000375366.4
BTBD17
BTB domain containing 17
chr15_-_55289756 0.35 ENST00000336787.6
RAB27A
RAB27A, member RAS oncogene family
chr3_-_121660892 0.34 ENST00000428394.6
ENST00000314583.8
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr6_+_151240368 0.33 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr12_+_59596010 0.33 ENST00000547379.6
ENST00000552432.5
SLC16A7
solute carrier family 16 member 7
chr1_-_207911027 0.31 ENST00000310833.12
CD34
CD34 molecule
chr19_+_13024573 0.30 ENST00000358552.7
ENST00000360105.8
ENST00000588228.5
ENST00000676441.1
ENST00000591028.1
NFIX
nuclear factor I X
chr1_+_223701582 0.30 ENST00000433674.6
CAPN2
calpain 2
chr12_+_75480745 0.29 ENST00000266659.8
GLIPR1
GLI pathogenesis related 1
chr19_+_16067526 0.29 ENST00000646974.2
TPM4
tropomyosin 4
chr1_+_27773189 0.28 ENST00000373943.9
ENST00000440806.2
STX12
syntaxin 12
chr10_-_17617235 0.28 ENST00000466335.1
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr1_+_226063466 0.27 ENST00000666609.1
ENST00000661429.1
H3-3A
H3.3 histone A
chr17_+_3475959 0.27 ENST00000263080.3
ASPA
aspartoacylase
chr12_-_6663136 0.26 ENST00000396807.8
ENST00000619641.4
ENST00000446105.6
ING4
inhibitor of growth family member 4
chr19_-_35757009 0.26 ENST00000587965.1
ENST00000004982.6
HSPB6
heat shock protein family B (small) member 6
chr1_-_207911384 0.26 ENST00000356522.4
CD34
CD34 molecule
chr2_-_171231314 0.25 ENST00000521943.5
TLK1
tousled like kinase 1
chr7_+_143381286 0.25 ENST00000449630.5
ENST00000322764.10
ENST00000457235.5
ZYX
zyxin
chr15_-_34795541 0.25 ENST00000290378.6
ACTC1
actin alpha cardiac muscle 1
chr12_-_6663083 0.24 ENST00000467678.5
ENST00000493873.1
ENST00000412586.6
ENST00000423703.6
ENST00000444704.5
ENST00000341550.9
ING4
inhibitor of growth family member 4
chr19_-_4518465 0.24 ENST00000633942.1
PLIN4
perilipin 4
chr12_+_75480800 0.23 ENST00000456650.7
GLIPR1
GLI pathogenesis related 1
chr1_+_223701607 0.23 ENST00000434648.5
CAPN2
calpain 2
chr3_-_9792404 0.23 ENST00000301964.7
TADA3
transcriptional adaptor 3
chr5_-_58999885 0.22 ENST00000317118.12
PDE4D
phosphodiesterase 4D
chr11_+_60040402 0.21 ENST00000278855.7
ENST00000532905.1
OOSP2
oocyte secreted protein 2
chr17_+_44557476 0.20 ENST00000315323.5
FZD2
frizzled class receptor 2
chr1_-_89126066 0.19 ENST00000370466.4
GBP2
guanylate binding protein 2
chr16_+_30065753 0.19 ENST00000642816.3
ENST00000643777.4
ENST00000569798.5
ALDOA
aldolase, fructose-bisphosphate A
chr16_+_30372291 0.19 ENST00000568749.5
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr7_+_143381561 0.19 ENST00000354434.8
ZYX
zyxin
chr16_+_30065777 0.19 ENST00000395240.7
ENST00000566846.5
ALDOA
aldolase, fructose-bisphosphate A
chr1_+_219173861 0.19 ENST00000366927.3
ENST00000366928.10
LYPLAL1
lysophospholipase like 1
chr10_-_16817362 0.18 ENST00000377921.7
ENST00000345264.10
RSU1
Ras suppressor protein 1
chr11_-_2141238 0.18 ENST00000434045.6
IGF2
insulin like growth factor 2
chr10_-_16817443 0.17 ENST00000602389.1
RSU1
Ras suppressor protein 1
chr3_+_9793074 0.17 ENST00000397261.8
ENST00000485273.1
ENST00000433034.1
ENST00000397256.5
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex subunit 4
ARPC4-TTLL3 readthrough
chr17_-_81514629 0.17 ENST00000681052.1
ENST00000575659.6
ACTG1
actin gamma 1
chr11_-_2140967 0.17 ENST00000381389.5
IGF2
insulin like growth factor 2
chr15_+_96330691 0.17 ENST00000394166.8
NR2F2
nuclear receptor subfamily 2 group F member 2
chr3_+_9792495 0.15 ENST00000498623.6
ARPC4
actin related protein 2/3 complex subunit 4
chr18_-_3219849 0.15 ENST00000261606.11
MYOM1
myomesin 1
chr3_-_157503574 0.15 ENST00000494677.5
ENST00000468233.5
VEPH1
ventricular zone expressed PH domain containing 1
chr1_+_6045914 0.14 ENST00000378083.7
KCNAB2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr20_-_21514046 0.14 ENST00000377142.5
NKX2-2
NK2 homeobox 2
chr19_+_35856885 0.14 ENST00000347900.10
ENST00000360202.10
KIRREL2
kirre like nephrin family adhesion molecule 2
chr4_-_108166715 0.14 ENST00000510624.5
LEF1
lymphoid enhancer binding factor 1
chr2_+_218419114 0.14 ENST00000454069.5
ENST00000392114.6
ENST00000248444.10
VIL1
villin 1
chr6_-_159045010 0.14 ENST00000338313.5
TAGAP
T cell activation RhoGTPase activating protein
chr10_+_86668501 0.13 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LDB3
LIM domain binding 3
chr4_+_87006988 0.12 ENST00000307808.10
AFF1
AF4/FMR2 family member 1
chr1_-_152360004 0.12 ENST00000388718.5
FLG2
filaggrin family member 2
chr3_-_9792691 0.12 ENST00000343450.2
TADA3
transcriptional adaptor 3
chr10_-_29634964 0.11 ENST00000375398.6
ENST00000355867.8
SVIL
supervillin
chr19_+_57389839 0.11 ENST00000366197.9
ENST00000336128.12
ENST00000596282.5
ENST00000597400.5
ENST00000598895.5
ENST00000596617.5
ZNF548
ENSG00000269533.5
zinc finger protein 548
novel transcript
chr17_-_4967790 0.10 ENST00000575142.5
ENST00000206020.8
SPAG7
sperm associated antigen 7
chr2_-_73293538 0.08 ENST00000436467.4
ENST00000545030.1
EGR4
early growth response 4
chr7_+_107891135 0.08 ENST00000639772.1
ENST00000440410.5
ENST00000437604.6
ENST00000205402.10
DLD
dihydrolipoamide dehydrogenase
chr2_-_30807411 0.08 ENST00000295055.12
CAPN13
calpain 13
chr14_-_93976550 0.08 ENST00000555019.6
ASB2
ankyrin repeat and SOCS box containing 2
chr14_+_104801082 0.08 ENST00000342537.8
ZBTB42
zinc finger and BTB domain containing 42
chr1_-_91021996 0.07 ENST00000337393.10
ZNF644
zinc finger protein 644
chr10_-_17617326 0.07 ENST00000326961.6
ENST00000361271.8
HACD1
3-hydroxyacyl-CoA dehydratase 1
chr18_-_56651122 0.07 ENST00000590954.5
TXNL1
thioredoxin like 1
chr12_-_11310420 0.07 ENST00000621732.4
ENST00000445719.2
ENST00000279575.7
PRB4
proline rich protein BstNI subfamily 4
chr2_+_206159884 0.07 ENST00000392222.7
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr17_-_81512671 0.07 ENST00000679480.1
ENST00000644774.2
ENST00000571721.6
ENST00000575842.5
ENST00000575087.5
ENST00000573283.7
ENST00000571691.6
ENST00000570382.2
ACTG1
actin gamma 1
chr3_+_63967738 0.07 ENST00000484332.1
ATXN7
ataxin 7
chr11_-_72112750 0.06 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr17_+_35147807 0.06 ENST00000394570.7
ENST00000268876.9
UNC45B
unc-45 myosin chaperone B
chr19_+_45467988 0.05 ENST00000615753.4
ENST00000585836.5
ENST00000417353.6
ENST00000591858.5
ENST00000443841.6
ENST00000590335.1
ENST00000353609.8
FOSB
FosB proto-oncogene, AP-1 transcription factor subunit
chr3_-_185923893 0.05 ENST00000259043.11
TRA2B
transformer 2 beta homolog
chr11_-_72112669 0.05 ENST00000545944.5
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr6_+_157981826 0.05 ENST00000355585.9
ENST00000640338.1
ENST00000367113.5
SYNJ2
synaptojanin 2
chr8_+_74320832 0.05 ENST00000676377.1
GDAP1
ganglioside induced differentiation associated protein 1
chr17_-_4987354 0.04 ENST00000361571.9
CAMTA2
calmodulin binding transcription activator 2
chr4_+_94489030 0.04 ENST00000510099.5
PDLIM5
PDZ and LIM domain 5
chr2_-_208254232 0.04 ENST00000415913.5
ENST00000415282.5
ENST00000446179.5
IDH1
isocitrate dehydrogenase (NADP(+)) 1
chrX_-_153674325 0.04 ENST00000370142.5
ENST00000447676.6
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr1_+_47416280 0.04 ENST00000335071.4
FOXE3
forkhead box E3
chr7_-_80919017 0.04 ENST00000265361.8
SEMA3C
semaphorin 3C
chr16_+_71845958 0.03 ENST00000427980.7
ENST00000568581.5
ATXN1L
IST1
ataxin 1 like
IST1 factor associated with ESCRT-III
chrX_-_104254921 0.03 ENST00000372588.4
ESX1
ESX homeobox 1
chr7_+_114414997 0.03 ENST00000462331.5
ENST00000393491.7
ENST00000403559.8
ENST00000408937.7
ENST00000393498.6
ENST00000393495.7
ENST00000378237.7
FOXP2
forkhead box P2
chr7_-_5530581 0.03 ENST00000676397.1
ENST00000645576.1
ENST00000674681.1
ENST00000646664.1
ENST00000493945.6
ENST00000676319.1
ENST00000473257.3
ENST00000647275.1
ENST00000432588.6
ACTB
actin beta
chr2_+_138501753 0.03 ENST00000280098.9
SPOPL
speckle type BTB/POZ protein like
chr10_+_6144883 0.03 ENST00000379789.8
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_+_206159580 0.02 ENST00000236957.9
ENST00000392221.5
ENST00000445505.5
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr10_+_19489054 0.02 ENST00000377265.3
MALRD1
MAM and LDL receptor class A domain containing 1
chr18_+_56651335 0.02 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr17_-_4987624 0.02 ENST00000572543.5
ENST00000381311.9
ENST00000348066.8
CAMTA2
calmodulin binding transcription activator 2
chr2_+_190927649 0.01 ENST00000409428.5
ENST00000409215.5
GLS
glutaminase
chr19_+_57670242 0.01 ENST00000612521.1
ZSCAN4
zinc finger and SCAN domain containing 4
chr18_+_56651385 0.01 ENST00000615645.4
WDR7
WD repeat domain 7
chr7_+_114414809 0.01 ENST00000350908.9
FOXP2
forkhead box P2
chr7_-_108003122 0.01 ENST00000393559.2
ENST00000222399.11
ENST00000676777.1
ENST00000439976.6
ENST00000393560.5
ENST00000677793.1
ENST00000679244.1
LAMB1
laminin subunit beta 1
chr6_-_16761447 0.01 ENST00000244769.8
ENST00000436367.6
ATXN1
ataxin 1
chr11_-_47352693 0.01 ENST00000256993.8
ENST00000399249.6
ENST00000545968.6
MYBPC3
myosin binding protein C3
chr11_-_72112068 0.00 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
ANAPC15
anaphase promoting complex subunit 15
chr17_+_7583828 0.00 ENST00000396501.8
ENST00000250124.11
ENST00000584378.5
ENST00000423172.6
ENST00000579445.5
ENST00000585217.5
ENST00000581380.1
MPDU1
mannose-P-dolichol utilization defect 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0021593 rhombomere morphogenesis(GO:0021593) rhombomere 3 morphogenesis(GO:0021658)
0.4 2.7 GO:0008218 bioluminescence(GO:0008218)
0.4 1.2 GO:0098758 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182)
0.3 1.3 GO:0055014 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.2 1.2 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.7 GO:0060435 bronchiole development(GO:0060435)
0.2 0.6 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 0.6 GO:1901258 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.2 1.6 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 2.6 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.1 0.9 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.3 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 1.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 6.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:2000771 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.1 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.2 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 3.8 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.8 GO:1900038 negative regulation of cellular response to hypoxia(GO:1900038)
0.0 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.3 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.5 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.2 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.2 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.5 GO:0016540 protein autoprocessing(GO:0016540)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.0 GO:0006097 glyoxylate cycle(GO:0006097)
0.0 0.0 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.0 GO:0021757 caudate nucleus development(GO:0021757) putamen development(GO:0021758)
0.0 0.7 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 2.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0071547 piP-body(GO:0071547)
0.1 6.1 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 1.7 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 0.1 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 2.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 5.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.3 GO:0080023 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023)
0.1 0.3 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.8 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.6 GO:0043199 sulfate binding(GO:0043199)
0.0 0.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.2 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 1.6 GO:0070888 E-box binding(GO:0070888)
0.0 2.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.0 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450) (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 8.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 2.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 5.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing