Project
avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)
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Results for TAF1
Z-value: 3.75
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Transcription factors associated with TAF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TAF1 | hg38_v1_chrX_+_71366222_71366264 | 0.95 | 2.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TAF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.5 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 1.7 | 5.0 | GO:0006683 | galactosylceramide catabolic process(GO:0006683) |
| 0.5 | 4.8 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.1 | 4.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.0 | 4.1 | GO:2000314 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 4.0 | GO:0032784 | regulation of DNA-templated transcription, elongation(GO:0032784) |
| 0.0 | 3.8 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 3.7 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 3.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 3.4 | GO:0007030 | Golgi organization(GO:0007030) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 4.6 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 4.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 4.0 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 3.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 3.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 3.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 2.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 2.6 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 2.5 | GO:1904115 | axon cytoplasm(GO:1904115) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.5 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 5.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.7 | 5.0 | GO:0004336 | galactosylceramidase activity(GO:0004336) |
| 0.2 | 4.8 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 4.0 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.2 | 3.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 3.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 3.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 3.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 3.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 3.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 2.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 2.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 5.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 5.1 | REACTOME SPHINGOLIPID METABOLISM | Genes involved in Sphingolipid metabolism |
| 0.1 | 4.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 4.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.9 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 2.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 2.2 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.1 | 2.1 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |