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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TBX5

Z-value: 0.79

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Transcription factors associated with TBX5

Gene Symbol Gene ID Gene Info
TBX5
ENSG00000089225.20 T-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX5hg38_v1_chr12_-_114403898_1144039210.551.6e-01Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_52493250 0.75 ENST00000330722.7
KRT6A
keratin 6A
chr1_-_12616762 0.64 ENST00000464917.5
DHRS3
dehydrogenase/reductase 3
chr14_-_105168753 0.60 ENST00000331782.8
ENST00000347004.2
JAG2
jagged canonical Notch ligand 2
chr2_+_68734773 0.60 ENST00000409202.8
ARHGAP25
Rho GTPase activating protein 25
chr1_+_101237009 0.57 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chr16_-_31135699 0.50 ENST00000317508.11
ENST00000568261.5
ENST00000567797.1
PRSS8
serine protease 8
chr8_+_32548303 0.47 ENST00000650967.1
NRG1
neuregulin 1
chr1_+_2050387 0.44 ENST00000378567.8
PRKCZ
protein kinase C zeta
chr1_-_205321737 0.43 ENST00000367157.6
NUAK2
NUAK family kinase 2
chr12_+_107318395 0.43 ENST00000420571.6
ENST00000280758.10
BTBD11
BTB domain containing 11
chr8_+_32548210 0.43 ENST00000523079.5
ENST00000650919.1
NRG1
neuregulin 1
chr3_-_134029914 0.41 ENST00000493729.5
ENST00000310926.11
SLCO2A1
solute carrier organic anion transporter family member 2A1
chr2_-_215138603 0.40 ENST00000272895.12
ABCA12
ATP binding cassette subfamily A member 12
chr15_+_40239857 0.38 ENST00000260404.8
PAK6
p21 (RAC1) activated kinase 6
chr14_+_75280078 0.37 ENST00000555347.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr1_+_59814939 0.37 ENST00000371208.5
HOOK1
hook microtubule tethering protein 1
chr12_-_27971970 0.36 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone
chr5_+_66828762 0.34 ENST00000490016.6
ENST00000403666.5
ENST00000450827.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_+_21057822 0.33 ENST00000308227.2
RNASE8
ribonuclease A family member 8
chr8_-_74321532 0.33 ENST00000342232.5
JPH1
junctophilin 1
chr6_-_13487593 0.32 ENST00000379287.4
ENST00000603223.1
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr18_-_55302613 0.31 ENST00000561831.7
TCF4
transcription factor 4
chr8_+_32548267 0.30 ENST00000356819.7
NRG1
neuregulin 1
chr1_+_151511376 0.30 ENST00000427934.2
ENST00000271636.12
CGN
cingulin
chr2_+_68734861 0.30 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chr8_-_22131043 0.27 ENST00000312841.9
HR
HR lysine demethylase and nuclear receptor corepressor
chr8_+_119208322 0.27 ENST00000614891.5
MAL2
mal, T cell differentiation protein 2
chr11_+_1838970 0.26 ENST00000381911.6
TNNI2
troponin I2, fast skeletal type
chr8_-_22131003 0.26 ENST00000381418.9
HR
HR lysine demethylase and nuclear receptor corepressor
chr3_+_167735704 0.26 ENST00000446050.7
ENST00000295777.9
ENST00000472747.2
SERPINI1
serpin family I member 1
chr12_-_52434363 0.26 ENST00000252245.6
KRT75
keratin 75
chr14_+_61529005 0.25 ENST00000556347.1
ENSG00000258989.1
novel protein
chr2_-_162318129 0.25 ENST00000679938.1
IFIH1
interferon induced with helicase C domain 1
chr1_+_13584262 0.25 ENST00000376061.8
ENST00000513143.5
PDPN
podoplanin
chr11_-_16356538 0.24 ENST00000683767.1
SOX6
SRY-box transcription factor 6
chr1_+_13583762 0.24 ENST00000376057.8
ENST00000621990.5
ENST00000510906.5
PDPN
podoplanin
chr13_+_77535669 0.24 ENST00000535157.5
SCEL
sciellin
chr14_+_21042352 0.23 ENST00000298690.5
RNASE7
ribonuclease A family member 7
chr17_+_49495286 0.23 ENST00000172229.8
NGFR
nerve growth factor receptor
chr1_+_156284299 0.23 ENST00000456810.1
ENST00000405535.3
TMEM79
transmembrane protein 79
chr13_+_77535681 0.23 ENST00000349847.4
SCEL
sciellin
chr13_+_77535742 0.22 ENST00000377246.7
SCEL
sciellin
chr8_+_122781621 0.22 ENST00000314393.6
ZHX2
zinc fingers and homeoboxes 2
chr14_+_75278820 0.22 ENST00000554617.1
ENST00000554212.5
ENST00000535987.5
ENST00000303562.9
ENST00000555242.1
FOS
Fos proto-oncogene, AP-1 transcription factor subunit
chr8_+_31639291 0.21 ENST00000651149.1
ENST00000650866.1
NRG1
neuregulin 1
chr15_+_88639009 0.21 ENST00000306072.10
ISG20
interferon stimulated exonuclease gene 20
chr8_+_31639222 0.21 ENST00000519301.6
ENST00000652698.1
NRG1
neuregulin 1
chr6_-_2841853 0.20 ENST00000380739.6
SERPINB1
serpin family B member 1
chr9_-_133149334 0.19 ENST00000393160.7
RALGDS
ral guanine nucleotide dissociation stimulator
chr11_+_35176575 0.19 ENST00000526000.6
CD44
CD44 molecule (Indian blood group)
chr15_+_89776326 0.18 ENST00000341735.5
MESP2
mesoderm posterior bHLH transcription factor 2
chr17_+_32487686 0.18 ENST00000584792.5
CDK5R1
cyclin dependent kinase 5 regulatory subunit 1
chr1_-_153549238 0.18 ENST00000368713.8
S100A3
S100 calcium binding protein A3
chrX_+_136536099 0.18 ENST00000440515.5
ENST00000456412.1
VGLL1
vestigial like family member 1
chr3_+_142596385 0.18 ENST00000457734.7
ENST00000483373.5
ENST00000475296.5
ENST00000495744.5
ENST00000476044.5
ENST00000461644.5
ENST00000464320.5
PLS1
plastin 1
chr4_+_119212636 0.18 ENST00000274030.10
USP53
ubiquitin specific peptidase 53
chr3_-_183162726 0.17 ENST00000265598.8
LAMP3
lysosomal associated membrane protein 3
chr8_+_127737610 0.17 ENST00000652288.1
MYC
MYC proto-oncogene, bHLH transcription factor
chr15_+_88638947 0.17 ENST00000559876.2
ISG20
interferon stimulated exonuclease gene 20
chr12_+_19205294 0.17 ENST00000424268.5
PLEKHA5
pleckstrin homology domain containing A5
chr21_+_42513834 0.17 ENST00000352133.3
SLC37A1
solute carrier family 37 member 1
chrX_-_129654946 0.17 ENST00000429967.3
APLN
apelin
chr1_-_156816841 0.16 ENST00000368199.8
ENST00000392306.2
SH2D2A
SH2 domain containing 2A
chr18_+_32018817 0.16 ENST00000217740.4
ENST00000583184.1
RNF125
ENSG00000263917.1
ring finger protein 125
novel transcript
chr11_-_58578096 0.16 ENST00000528954.5
ENST00000528489.1
LPXN
leupaxin
chr8_-_143572748 0.16 ENST00000529971.1
ENST00000398882.8
MROH6
maestro heat like repeat family member 6
chr5_-_177409535 0.16 ENST00000253496.4
F12
coagulation factor XII
chr10_-_124093582 0.16 ENST00000462406.1
ENST00000435907.6
CHST15
carbohydrate sulfotransferase 15
chr11_+_67056805 0.16 ENST00000308831.7
RHOD
ras homolog family member D
chr3_-_129121761 0.16 ENST00000476465.5
ENST00000393304.5
ENST00000315150.10
ENST00000615093.1
ENST00000393308.5
ENST00000393307.5
ENST00000393305.5
RAB43
RAB43, member RAS oncogene family
chr1_-_206921867 0.16 ENST00000628511.2
ENST00000367091.8
FCMR
Fc fragment of IgM receptor
chr2_+_152335163 0.15 ENST00000288670.14
FMNL2
formin like 2
chr1_-_156816738 0.15 ENST00000368198.7
SH2D2A
SH2 domain containing 2A
chr21_+_42219123 0.15 ENST00000398449.8
ABCG1
ATP binding cassette subfamily G member 1
chr8_+_103819244 0.15 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chr17_+_57105899 0.15 ENST00000576295.5
AKAP1
A-kinase anchoring protein 1
chr1_+_153774210 0.15 ENST00000271857.6
SLC27A3
solute carrier family 27 member 3
chr20_-_22584547 0.15 ENST00000419308.7
FOXA2
forkhead box A2
chr2_+_170816868 0.14 ENST00000358196.8
GAD1
glutamate decarboxylase 1
chr1_-_54406385 0.14 ENST00000610401.5
SSBP3
single stranded DNA binding protein 3
chr1_-_204359885 0.14 ENST00000414478.1
ENST00000272203.8
PLEKHA6
pleckstrin homology domain containing A6
chr17_+_39737923 0.14 ENST00000577695.5
ENST00000309156.9
GRB7
growth factor receptor bound protein 7
chr17_-_28902930 0.14 ENST00000426464.2
DHRS13
dehydrogenase/reductase 13
chr21_+_42219111 0.14 ENST00000450121.5
ENST00000361802.6
ABCG1
ATP binding cassette subfamily G member 1
chr12_-_120904337 0.14 ENST00000353487.7
SPPL3
signal peptide peptidase like 3
chr16_-_69351778 0.14 ENST00000288025.4
TMED6
transmembrane p24 trafficking protein 6
chr2_-_74529670 0.14 ENST00000377526.4
AUP1
AUP1 lipid droplet regulating VLDL assembly factor
chr5_-_135578983 0.13 ENST00000512158.6
CXCL14
C-X-C motif chemokine ligand 14
chrX_+_21374476 0.13 ENST00000644585.1
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr2_-_74441882 0.13 ENST00000272430.10
RTKN
rhotekin
chr17_+_36103819 0.13 ENST00000615863.2
ENST00000621626.1
CCL4
C-C motif chemokine ligand 4
chr11_-_34513750 0.13 ENST00000532417.1
ELF5
E74 like ETS transcription factor 5
chrX_+_16786421 0.13 ENST00000398155.4
ENST00000380122.10
TXLNG
taxilin gamma
chr7_-_27095972 0.13 ENST00000355633.5
ENST00000643460.2
HOXA1
homeobox A1
chr13_+_24270681 0.13 ENST00000343003.10
ENST00000399949.6
SPATA13
spermatogenesis associated 13
chr11_+_67056875 0.12 ENST00000532559.1
RHOD
ras homolog family member D
chr9_-_93955347 0.12 ENST00000253968.11
BARX1
BARX homeobox 1
chr3_+_50267606 0.12 ENST00000618865.4
SEMA3B
semaphorin 3B
chr8_-_24956604 0.12 ENST00000610854.2
NEFL
neurofilament light
chr1_+_206507520 0.12 ENST00000579436.7
RASSF5
Ras association domain family member 5
chr16_+_2988256 0.12 ENST00000573315.2
LINC00514
long intergenic non-protein coding RNA 514
chr3_+_49689531 0.12 ENST00000432042.5
ENST00000454491.5
ENST00000327697.11
RNF123
ring finger protein 123
chr2_-_72147819 0.12 ENST00000001146.7
ENST00000546307.5
ENST00000474509.1
CYP26B1
cytochrome P450 family 26 subfamily B member 1
chr17_-_76537699 0.12 ENST00000293230.10
CYGB
cytoglobin
chr17_-_28903017 0.12 ENST00000394901.7
ENST00000378895.9
DHRS13
dehydrogenase/reductase 13
chr1_-_202808406 0.11 ENST00000650569.1
ENST00000367265.9
ENST00000649770.1
KDM5B
lysine demethylase 5B
chr7_-_138981307 0.11 ENST00000440172.5
ENST00000422774.2
KIAA1549
KIAA1549
chr11_+_19117123 0.11 ENST00000399351.7
ENST00000446113.7
ZDHHC13
zinc finger DHHC-type palmitoyltransferase 13
chr7_-_100656384 0.11 ENST00000461605.1
ENST00000160382.10
ACTL6B
actin like 6B
chr3_-_52409783 0.11 ENST00000470173.1
ENST00000296288.9
ENST00000460680.6
BAP1
BRCA1 associated protein 1
chr5_+_139795795 0.11 ENST00000274710.4
PSD2
pleckstrin and Sec7 domain containing 2
chr5_-_54985579 0.11 ENST00000381405.5
ENST00000381403.4
ESM1
endothelial cell specific molecule 1
chr6_+_30326835 0.10 ENST00000440271.5
ENST00000376656.8
ENST00000396551.7
ENST00000428728.5
ENST00000396548.5
ENST00000428404.5
TRIM39
tripartite motif containing 39
chr18_-_31162849 0.10 ENST00000257197.7
ENST00000257198.6
DSC1
desmocollin 1
chr17_-_4560564 0.10 ENST00000574584.1
ENST00000381550.8
ENST00000301395.7
GGT6
gamma-glutamyltransferase 6
chr11_+_35176611 0.10 ENST00000279452.10
CD44
CD44 molecule (Indian blood group)
chr11_-_34513785 0.10 ENST00000257832.7
ENST00000429939.6
ELF5
E74 like ETS transcription factor 5
chr11_-_72674394 0.10 ENST00000418754.6
ENST00000334456.10
ENST00000542969.2
PDE2A
phosphodiesterase 2A
chr4_-_40629842 0.10 ENST00000295971.12
RBM47
RNA binding motif protein 47
chr2_+_11556337 0.09 ENST00000234142.9
GREB1
growth regulating estrogen receptor binding 1
chr4_-_109729956 0.09 ENST00000502283.1
PLA2G12A
phospholipase A2 group XIIA
chr11_-_59615673 0.09 ENST00000263847.6
OSBP
oxysterol binding protein
chr11_-_123654581 0.09 ENST00000392770.6
ENST00000530277.5
ENST00000299333.8
SCN3B
sodium voltage-gated channel beta subunit 3
chr1_-_10982037 0.09 ENST00000377004.8
C1orf127
chromosome 1 open reading frame 127
chr3_+_4680617 0.09 ENST00000648212.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr11_-_67647577 0.09 ENST00000529256.1
ACY3
aminoacylase 3
chr10_-_124092445 0.09 ENST00000346248.7
CHST15
carbohydrate sulfotransferase 15
chr17_+_37489882 0.09 ENST00000617516.5
DUSP14
dual specificity phosphatase 14
chr17_+_76376581 0.09 ENST00000591651.5
ENST00000545180.5
SPHK1
sphingosine kinase 1
chr7_-_80919017 0.09 ENST00000265361.8
SEMA3C
semaphorin 3C
chr11_-_128867364 0.09 ENST00000440599.6
ENST00000324036.7
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chrX_+_21374357 0.09 ENST00000643841.1
ENST00000379510.5
ENST00000425654.7
ENST00000644798.1
ENST00000543067.6
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr13_-_103066411 0.09 ENST00000245312.5
SLC10A2
solute carrier family 10 member 2
chr6_+_25726767 0.09 ENST00000274764.5
H2BC1
H2B clustered histone 1
chr11_-_128867268 0.09 ENST00000392665.6
ENST00000392666.6
KCNJ1
potassium inwardly rectifying channel subfamily J member 1
chr1_+_165543992 0.09 ENST00000294818.2
LRRC52
leucine rich repeat containing 52
chr11_-_132943671 0.09 ENST00000331898.11
OPCML
opioid binding protein/cell adhesion molecule like
chr20_+_34363241 0.09 ENST00000486883.5
ENST00000374864.10
ENST00000535650.7
ENST00000670516.1
ENST00000665484.1
ENST00000654846.1
ENST00000665428.1
ENST00000660337.1
ENST00000262650.10
ENST00000665346.1
ITCH
itchy E3 ubiquitin protein ligase
chr21_-_45542465 0.08 ENST00000380010.8
SLC19A1
solute carrier family 19 member 1
chr1_+_26863140 0.08 ENST00000339276.6
SFN
stratifin
chr12_-_18738006 0.08 ENST00000266505.12
ENST00000543242.5
ENST00000539072.5
ENST00000541966.5
ENST00000648272.1
PLCZ1
phospholipase C zeta 1
chr1_+_15756659 0.08 ENST00000375771.5
FBLIM1
filamin binding LIM protein 1
chrX_-_110318062 0.08 ENST00000372059.6
ENST00000262844.10
AMMECR1
AMMECR nuclear protein 1
chr12_+_80707625 0.08 ENST00000228641.4
MYF6
myogenic factor 6
chr16_-_11256192 0.08 ENST00000644787.1
ENST00000332029.4
SOCS1
suppressor of cytokine signaling 1
chr1_+_7784411 0.08 ENST00000613533.4
ENST00000614998.4
PER3
period circadian regulator 3
chr8_-_20303955 0.08 ENST00000381569.5
LZTS1
leucine zipper tumor suppressor 1
chr1_+_93079264 0.08 ENST00000370298.9
ENST00000370303.4
MTF2
metal response element binding transcription factor 2
chr1_-_44017296 0.08 ENST00000357730.6
ENST00000360584.6
ENST00000528803.1
SLC6A9
solute carrier family 6 member 9
chr4_-_151015713 0.08 ENST00000357115.9
LRBA
LPS responsive beige-like anchor protein
chr2_+_29113989 0.08 ENST00000404424.5
CLIP4
CAP-Gly domain containing linker protein family member 4
chr18_-_3874247 0.08 ENST00000581699.5
DLGAP1
DLG associated protein 1
chr3_+_184315347 0.07 ENST00000424196.5
EIF4G1
eukaryotic translation initiation factor 4 gamma 1
chr19_-_41428730 0.07 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr1_+_93079234 0.07 ENST00000540243.5
ENST00000545708.5
MTF2
metal response element binding transcription factor 2
chr1_+_158355894 0.07 ENST00000368162.2
CD1E
CD1e molecule
chr7_+_142511614 0.07 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr2_+_170715317 0.07 ENST00000375281.4
SP5
Sp5 transcription factor
chr11_-_95231046 0.07 ENST00000416495.6
ENST00000536441.7
SESN3
sestrin 3
chr11_+_34622053 0.07 ENST00000530286.5
ENST00000533754.5
EHF
ETS homologous factor
chr1_-_11805924 0.07 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase
chr4_+_80197493 0.07 ENST00000415738.3
PRDM8
PR/SET domain 8
chrX_-_49200174 0.07 ENST00000472598.5
ENST00000263233.9
ENST00000479808.5
SYP
synaptophysin
chr19_+_10286971 0.07 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10286944 0.07 ENST00000380770.5
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_41443130 0.07 ENST00000378187.3
ERICH4
glutamate rich 4
chr6_+_30327259 0.07 ENST00000376659.9
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr12_+_30926716 0.07 ENST00000546076.6
ENST00000535215.5
ENST00000261177.10
TSPAN11
tetraspanin 11
chr10_+_133527355 0.07 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
CYP2E1
cytochrome P450 family 2 subfamily E member 1
chr19_+_17751467 0.07 ENST00000596536.5
ENST00000593870.5
ENST00000598086.5
ENST00000598932.5
ENST00000595023.5
ENST00000594068.5
ENST00000596507.5
ENST00000595033.5
ENST00000597718.5
FCHO1
FCH and mu domain containing endocytic adaptor 1
chr2_+_233760265 0.07 ENST00000305208.10
ENST00000360418.4
UGT1A1
UDP glucuronosyltransferase family 1 member A1
chr20_-_40689228 0.07 ENST00000373313.3
MAFB
MAF bZIP transcription factor B
chrX_-_55030970 0.07 ENST00000493869.2
ENST00000396198.7
ENST00000650242.1
ENST00000335854.8
ENST00000477869.6
ENST00000455688.2
ENST00000644983.1
ALAS2
5'-aminolevulinate synthase 2
chr11_+_46332905 0.07 ENST00000343674.10
DGKZ
diacylglycerol kinase zeta
chr12_+_6946468 0.07 ENST00000543115.5
ENST00000399448.5
PTPN6
protein tyrosine phosphatase non-receptor type 6
chr1_+_99646025 0.07 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr3_+_184315131 0.06 ENST00000427845.5
ENST00000342981.8
EIF4G1
eukaryotic translation initiation factor 4 gamma 1
chrX_+_21374434 0.06 ENST00000279451.9
ENST00000645245.1
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr22_+_31082860 0.06 ENST00000619644.4
SMTN
smoothelin
chrX_-_131289412 0.06 ENST00000652189.1
ENST00000651556.1
IGSF1
immunoglobulin superfamily member 1
chr1_+_171781635 0.06 ENST00000361735.4
ENST00000362019.7
ENST00000367737.9
EEF1AKNMT
eEF1A lysine and N-terminal methyltransferase
chr7_-_82443766 0.06 ENST00000356860.8
CACNA2D1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr17_+_17042433 0.06 ENST00000651222.2
MPRIP
myosin phosphatase Rho interacting protein
chr16_+_2019777 0.06 ENST00000566435.4
NPW
neuropeptide W
chr7_-_82443715 0.06 ENST00000356253.9
ENST00000423588.1
CACNA2D1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr10_-_101229449 0.06 ENST00000370193.4
LBX1
ladybird homeobox 1
chr13_-_35855627 0.06 ENST00000379893.5
DCLK1
doublecortin like kinase 1
chr10_+_113125536 0.06 ENST00000349937.7
TCF7L2
transcription factor 7 like 2
chr16_+_727117 0.06 ENST00000562141.5
HAGHL
hydroxyacylglutathione hydrolase like
chr14_+_91114364 0.06 ENST00000518868.5
DGLUCY
D-glutamate cyclase
chr5_+_132673983 0.06 ENST00000622422.1
ENST00000231449.7
ENST00000350025.2
IL4
interleukin 4
chr17_-_7394514 0.06 ENST00000571802.1
ENST00000619711.5
ENST00000576201.5
ENST00000573213.1
ENST00000324822.15
PLSCR3
phospholipid scramblase 3
chr10_+_102503985 0.06 ENST00000369899.6
ENST00000423559.2
SUFU
SUFU negative regulator of hedgehog signaling
chr1_-_37947010 0.06 ENST00000458109.6
ENST00000373024.8
ENST00000373023.6
INPP5B
inositol polyphosphate-5-phosphatase B
chr1_-_11805949 0.06 ENST00000376590.9
MTHFR
methylenetetrahydrofolate reductase
chrX_-_53422644 0.06 ENST00000322213.9
ENST00000375340.10
ENST00000674590.1
SMC1A
structural maintenance of chromosomes 1A
chr19_-_42217667 0.06 ENST00000336034.8
ENST00000596251.6
ENST00000598200.1
ENST00000598727.5
DEDD2
death effector domain containing 2
chr19_-_42427379 0.06 ENST00000244289.9
LIPE
lipase E, hormone sensitive type
chr2_+_176107272 0.06 ENST00000249504.7
HOXD11
homeobox D11
chr4_-_101347327 0.06 ENST00000394853.8
PPP3CA
protein phosphatase 3 catalytic subunit alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 0.7 GO:0001897 cytolysis by symbiont of host cells(GO:0001897)
0.2 0.5 GO:1990764 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1 1.6 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.4 GO:0035627 ceramide transport(GO:0035627)
0.1 0.3 GO:0009720 detection of hormone stimulus(GO:0009720)
0.1 0.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.6 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.2 GO:0021718 pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.2 GO:0042335 cuticle development(GO:0042335)
0.1 0.2 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.1 0.2 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1 0.6 GO:0009912 auditory receptor cell fate commitment(GO:0009912) gamma-delta T cell differentiation(GO:0042492) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.2 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.2 GO:0090095 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.2 GO:0051919 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:1903937 response to acrylamide(GO:1903937)
0.0 0.2 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.2 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.2 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.2 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.0 0.2 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.0 0.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.4 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission(GO:0099557)
0.0 0.1 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.4 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.1 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.1 GO:0021571 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0030221 basophil differentiation(GO:0030221)
0.0 0.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.0 0.0 GO:0007518 myoblast fate determination(GO:0007518)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0 0.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0031296 T-helper 1 cell lineage commitment(GO:0002296) B cell costimulation(GO:0031296)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.0 GO:0030719 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.0 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.1 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.0 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.0 GO:0060309 elastin catabolic process(GO:0060309)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035976 AP1 complex(GO:0035976)
0.1 0.4 GO:0070695 FHF complex(GO:0070695)
0.1 0.2 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.4 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.4 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.4 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.6 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.0 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 0.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 1.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.3 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.3 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.6 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.2 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.1 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.0 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.0 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.0 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 1.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation