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avrg: Epithelial-Mesenchymal Transition, human (Scheel, 2011)

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Results for TFAP2E

Z-value: 0.29

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.9 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg38_v1_chr1_+_35573308_355733190.206.4e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_54173151 0.18 ENST00000619895.5
TMC4
transmembrane channel like 4
chr19_-_54173190 0.16 ENST00000617472.4
TMC4
transmembrane channel like 4
chr19_-_43465596 0.16 ENST00000244333.4
LYPD3
LY6/PLAUR domain containing 3
chr19_-_38773432 0.12 ENST00000599035.1
ENST00000378626.5
LGALS7
galectin 7
chr19_+_45001430 0.11 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB
RELB proto-oncogene, NF-kB subunit
chr3_+_50155305 0.11 ENST00000002829.8
ENST00000426511.5
SEMA3F
semaphorin 3F
chr17_-_41612757 0.11 ENST00000301653.9
ENST00000593067.1
KRT16
keratin 16
chr1_-_32336224 0.10 ENST00000329421.8
MARCKSL1
MARCKS like 1
chr20_+_6767678 0.10 ENST00000378827.5
BMP2
bone morphogenetic protein 2
chr22_+_39994926 0.10 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr11_+_118607579 0.09 ENST00000530708.4
PHLDB1
pleckstrin homology like domain family B member 1
chr18_-_76495191 0.07 ENST00000443185.7
ZNF516
zinc finger protein 516
chr1_-_85048437 0.07 ENST00000341115.8
ENST00000370587.5
ENST00000370589.7
MCOLN3
mucolipin TRP cation channel 3
chr6_+_13272709 0.07 ENST00000379335.8
PHACTR1
phosphatase and actin regulator 1
chr22_+_31248402 0.07 ENST00000333611.8
ENST00000340552.4
LIMK2
LIM domain kinase 2
chr22_+_31212207 0.06 ENST00000406516.5
ENST00000331728.9
LIMK2
LIM domain kinase 2
chr2_+_186694007 0.06 ENST00000304698.10
FAM171B
family with sequence similarity 171 member B
chr8_-_126557691 0.06 ENST00000652209.1
LRATD2
LRAT domain containing 2
chr15_-_65422894 0.06 ENST00000352385.3
IGDCC4
immunoglobulin superfamily DCC subclass member 4
chr9_+_135714425 0.05 ENST00000473941.5
ENST00000486577.6
KCNT1
potassium sodium-activated channel subfamily T member 1
chr2_+_6917404 0.05 ENST00000320892.11
RNF144A
ring finger protein 144A
chr3_+_52779916 0.05 ENST00000537050.5
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr3_-_55487295 0.05 ENST00000264634.9
WNT5A
Wnt family member 5A
chr19_+_35704540 0.04 ENST00000392197.7
ENST00000426659.6
ZBTB32
zinc finger and BTB domain containing 32
chr2_+_190649062 0.04 ENST00000409581.5
ENST00000337386.10
NAB1
NGFI-A binding protein 1
chr2_+_74834113 0.04 ENST00000290573.7
HK2
hexokinase 2
chr13_-_75482151 0.04 ENST00000377636.8
TBC1D4
TBC1 domain family member 4
chr2_+_38666059 0.04 ENST00000272252.10
ENST00000410063.5
GALM
galactose mutarotase
chr1_-_11805924 0.04 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase
chr13_-_75482114 0.04 ENST00000377625.6
ENST00000431480.6
TBC1D4
TBC1 domain family member 4
chr12_-_31324129 0.03 ENST00000454658.6
SINHCAF
SIN3-HDAC complex associated factor
chr19_+_43576800 0.03 ENST00000612042.4
PINLYP
phospholipase A2 inhibitor and LY6/PLAUR domain containing
chr1_-_40862354 0.03 ENST00000372638.4
CITED4
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4
chr7_+_151085858 0.03 ENST00000463381.5
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr1_-_11805949 0.03 ENST00000376590.9
MTHFR
methylenetetrahydrofolate reductase
chrX_-_124963768 0.03 ENST00000371130.7
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr7_+_148590760 0.03 ENST00000307003.3
C7orf33
chromosome 7 open reading frame 33
chr15_+_84817346 0.03 ENST00000258888.6
ALPK3
alpha kinase 3
chr13_+_19958708 0.03 ENST00000382874.6
ENST00000610343.5
ZMYM2
zinc finger MYM-type containing 2
chr4_+_6909775 0.03 ENST00000409757.9
TBC1D14
TBC1 domain family member 14
chrX_+_153724847 0.03 ENST00000218104.6
ABCD1
ATP binding cassette subfamily D member 1
chr4_+_6909444 0.03 ENST00000448507.5
TBC1D14
TBC1 domain family member 14
chr19_-_42255119 0.03 ENST00000222329.9
ENST00000594664.1
ERF
ENSG00000268643.2
ETS2 repressor factor
novel protein
chr11_-_66289007 0.03 ENST00000431556.6
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A, membrane trafficking protein
chr17_+_39667964 0.03 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr7_-_45088888 0.03 ENST00000490531.3
NACAD
NAC alpha domain containing
chr19_-_35490456 0.03 ENST00000338897.4
ENST00000484218.6
KRTDAP
keratinocyte differentiation associated protein
chr6_+_7107941 0.03 ENST00000379938.7
ENST00000467782.5
ENST00000334984.10
ENST00000349384.10
RREB1
ras responsive element binding protein 1
chr20_+_19212624 0.03 ENST00000328041.11
SLC24A3
solute carrier family 24 member 3
chr17_+_39668447 0.03 ENST00000269582.3
ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr1_-_113812254 0.03 ENST00000616024.4
ENST00000615321.1
RSBN1
round spermatid basic protein 1
chr2_+_186694076 0.03 ENST00000612606.1
FAM171B
family with sequence similarity 171 member B
chr1_-_43453902 0.03 ENST00000372430.9
ENST00000372432.5
ENST00000583037.5
HYI
hydroxypyruvate isomerase (putative)
chr3_+_4493340 0.03 ENST00000357086.10
ENST00000354582.12
ENST00000649015.2
ENST00000467056.6
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr1_-_43453716 0.02 ENST00000372433.5
HYI
hydroxypyruvate isomerase (putative)
chr17_-_44915486 0.02 ENST00000638281.1
ENST00000588316.1
ENST00000588735.3
ENST00000639277.1
ENST00000253408.11
ENST00000435360.8
ENST00000586793.6
ENST00000588037.1
ENST00000592320.6
GFAP
glial fibrillary acidic protein
chr3_+_49554436 0.02 ENST00000296452.5
BSN
bassoon presynaptic cytomatrix protein
chr2_-_177264686 0.02 ENST00000397062.8
ENST00000430047.1
NFE2L2
nuclear factor, erythroid 2 like 2
chr1_-_11805977 0.02 ENST00000376486.3
MTHFR
methylenetetrahydrofolate reductase
chr1_-_43453792 0.02 ENST00000372434.5
ENST00000486909.1
HYI
hydroxypyruvate isomerase (putative)
chr19_+_49157780 0.02 ENST00000599628.5
ENST00000252826.10
ENST00000427978.6
TRPM4
transient receptor potential cation channel subfamily M member 4
chr19_+_4969105 0.02 ENST00000611640.4
ENST00000159111.9
ENST00000588337.5
ENST00000381759.8
KDM4B
lysine demethylase 4B
chr14_+_103385450 0.02 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr10_-_110919146 0.02 ENST00000652396.1
ENST00000423273.5
ENST00000436562.1
ENST00000651952.1
ENST00000448814.7
ENST00000652400.1
ENST00000447005.5
ENST00000454061.5
BBIP1
BBSome interacting protein 1
chr14_-_25049889 0.02 ENST00000419632.6
ENST00000396700.5
STXBP6
syntaxin binding protein 6
chr10_-_124092445 0.02 ENST00000346248.7
CHST15
carbohydrate sulfotransferase 15
chr19_+_8390316 0.02 ENST00000328024.11
ENST00000601897.1
ENST00000594216.1
RAB11B
RAB11B, member RAS oncogene family
chr11_-_61295289 0.02 ENST00000335613.10
VWCE
von Willebrand factor C and EGF domains
chr1_+_213989691 0.02 ENST00000607425.1
PROX1
prospero homeobox 1
chr2_-_74529670 0.02 ENST00000377526.4
AUP1
AUP1 lipid droplet regulating VLDL assembly factor
chr3_+_4493442 0.02 ENST00000456211.8
ENST00000443694.5
ENST00000648266.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr1_-_113812448 0.02 ENST00000612242.4
ENST00000261441.9
RSBN1
round spermatid basic protein 1
chr8_+_124450806 0.02 ENST00000328599.4
TRMT12
tRNA methyltransferase 12 homolog
chr14_+_103385374 0.02 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr13_+_19958760 0.02 ENST00000382871.3
ZMYM2
zinc finger MYM-type containing 2
chr8_-_102655707 0.02 ENST00000285407.11
KLF10
Kruppel like factor 10
chr14_+_103385506 0.02 ENST00000303622.13
MARK3
microtubule affinity regulating kinase 3
chr17_+_42780592 0.02 ENST00000246914.10
WNK4
WNK lysine deficient protein kinase 4
chr16_-_381935 0.02 ENST00000431232.7
ENST00000250930.7
PGAP6
post-glycosylphosphatidylinositol attachment to proteins 6
chr2_-_240892007 0.02 ENST00000402775.6
ENST00000307486.12
MAB21L4
mab-21 like 4
chr14_+_24368020 0.02 ENST00000554050.5
ENST00000554903.1
ENST00000250373.9
ENST00000554779.1
ENST00000553708.5
NFATC4
nuclear factor of activated T cells 4
chr11_+_57805541 0.02 ENST00000683201.1
ENST00000683769.1
CTNND1
catenin delta 1
chr6_+_42564060 0.02 ENST00000372903.6
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr20_+_24469623 0.02 ENST00000376862.4
SYNDIG1
synapse differentiation inducing 1
chr11_-_35419213 0.02 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
SLC1A2
solute carrier family 1 member 2
chr14_-_25050111 0.02 ENST00000323944.9
STXBP6
syntaxin binding protein 6
chrX_+_132023294 0.02 ENST00000481105.5
ENST00000354719.10
ENST00000394334.7
ENST00000394335.6
STK26
serine/threonine kinase 26
chr11_-_27506751 0.02 ENST00000278193.7
ENST00000524596.1
LIN7C
lin-7 homolog C, crumbs cell polarity complex component
chr6_+_31586835 0.02 ENST00000211921.11
LST1
leukocyte specific transcript 1
chr6_-_87702221 0.02 ENST00000257787.6
AKIRIN2
akirin 2
chr2_+_218859794 0.01 ENST00000233948.4
WNT6
Wnt family member 6
chr9_-_122213903 0.01 ENST00000464484.3
LHX6
LIM homeobox 6
chr17_-_68601357 0.01 ENST00000592554.2
FAM20A
FAM20A golgi associated secretory pathway pseudokinase
chr11_-_66289125 0.01 ENST00000471387.6
ENST00000376901.9
ENST00000359461.10
YIF1A
Yip1 interacting factor homolog A, membrane trafficking protein
chr9_-_122213874 0.01 ENST00000482062.1
LHX6
LIM homeobox 6
chr11_-_35419098 0.01 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2
chr5_-_151924824 0.01 ENST00000455880.2
GLRA1
glycine receptor alpha 1
chr5_-_151924846 0.01 ENST00000274576.9
GLRA1
glycine receptor alpha 1
chr19_+_13118235 0.01 ENST00000292431.5
NACC1
nucleus accumbens associated 1
chr11_-_35420017 0.01 ENST00000643000.1
ENST00000646099.1
ENST00000647372.1
ENST00000642578.1
SLC1A2
solute carrier family 1 member 2
chr1_+_33256479 0.01 ENST00000539719.6
ENST00000483388.5
ZNF362
zinc finger protein 362
chr7_+_29194757 0.01 ENST00000222792.11
CHN2
chimerin 2
chr10_-_110918934 0.01 ENST00000605742.5
BBIP1
BBSome interacting protein 1
chr11_-_35419462 0.01 ENST00000643522.1
SLC1A2
solute carrier family 1 member 2
chr7_-_100468063 0.01 ENST00000423266.5
ENST00000456330.1
TSC22D4
TSC22 domain family member 4
chr3_+_156142962 0.01 ENST00000471742.5
KCNAB1
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
chr19_+_50432885 0.01 ENST00000357701.6
MYBPC2
myosin binding protein C2
chr10_-_131981948 0.01 ENST00000633835.1
BNIP3
BCL2 interacting protein 3
chr3_+_122795039 0.01 ENST00000261038.6
SLC49A4
solute carrier family 49 member 4
chr1_+_3069160 0.01 ENST00000511072.5
PRDM16
PR/SET domain 16
chr1_+_22563460 0.01 ENST00000166244.8
ENST00000374644.8
EPHA8
EPH receptor A8
chr4_-_152679984 0.01 ENST00000304385.8
ENST00000504064.1
TMEM154
transmembrane protein 154
chr1_+_3069195 0.01 ENST00000378391.6
ENST00000270722.10
ENST00000514189.5
PRDM16
PR/SET domain 16
chr6_+_31586859 0.01 ENST00000433492.5
LST1
leukocyte specific transcript 1
chr3_+_4493471 0.01 ENST00000544951.6
ENST00000650294.1
ITPR1
inositol 1,4,5-trisphosphate receptor type 1
chr3_+_53161120 0.01 ENST00000394729.6
ENST00000330452.8
ENST00000652449.1
PRKCD
protein kinase C delta
chrX_-_49079702 0.01 ENST00000636049.1
ENST00000474053.6
ENST00000635003.1
WDR45
WD repeat domain 45
chr16_-_75433391 0.01 ENST00000566254.1
ENST00000283882.4
CFDP1
craniofacial development protein 1
chr17_-_76726753 0.01 ENST00000617192.4
JMJD6
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
chr9_+_126326809 0.01 ENST00000361171.8
ENST00000489637.3
MVB12B
multivesicular body subunit 12B
chr2_-_37324826 0.01 ENST00000234179.8
PRKD3
protein kinase D3
chr7_-_32495238 0.01 ENST00000409952.3
ENST00000409909.7
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr13_-_30465923 0.01 ENST00000341423.10
ENST00000326004.4
HMGB1
high mobility group box 1
chr11_-_47848467 0.00 ENST00000378460.6
NUP160
nucleoporin 160
chr6_+_42563981 0.00 ENST00000372899.6
ENST00000372901.2
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr11_-_47848313 0.00 ENST00000530326.5
ENST00000528071.5
NUP160
nucleoporin 160
chr14_+_20745880 0.00 ENST00000326842.3
EDDM3A
epididymal protein 3A
chr22_-_38700655 0.00 ENST00000216039.9
JOSD1
Josephin domain containing 1
chr1_-_224434750 0.00 ENST00000414423.9
ENST00000678917.1
ENST00000678555.1
ENST00000678307.1
WDR26
WD repeat domain 26
chr7_+_73433761 0.00 ENST00000344575.5
FZD9
frizzled class receptor 9
chr5_-_180071708 0.00 ENST00000522208.6
ENST00000521389.6
RNF130
ring finger protein 130
chr9_+_133636355 0.00 ENST00000393056.8
DBH
dopamine beta-hydroxylase
chr12_-_14567714 0.00 ENST00000240617.10
PLBD1
phospholipase B domain containing 1
chr6_-_18264475 0.00 ENST00000515742.2
ENST00000651624.1
ENST00000507591.2
ENST00000652689.1
ENST00000244776.11
ENST00000503715.5
DEK
DEK proto-oncogene
chr11_+_3855629 0.00 ENST00000526596.2
ENST00000300737.8
ENST00000616714.4
STIM1
stromal interaction molecule 1
chr4_+_153466324 0.00 ENST00000409663.7
ENST00000409959.8
TMEM131L
transmembrane 131 like
chr7_-_140924900 0.00 ENST00000646891.1
ENST00000644969.2
BRAF
B-Raf proto-oncogene, serine/threonine kinase
chr10_-_124092390 0.00 ENST00000628426.1
CHST15
carbohydrate sulfotransferase 15
chr11_+_118607598 0.00 ENST00000600882.6
ENST00000356063.9
PHLDB1
pleckstrin homology like domain family B member 1
chr12_+_67269328 0.00 ENST00000545606.6
CAND1
cullin associated and neddylation dissociated 1
chr7_+_130070518 0.00 ENST00000335420.10
ENST00000463413.1
KLHDC10
kelch domain containing 10
chr9_+_35605234 0.00 ENST00000336395.6
TESK1
testis associated actin remodelling kinase 1
chr13_+_99981775 0.00 ENST00000376335.8
ZIC2
Zic family member 2
chrX_+_116436599 0.00 ENST00000598581.3
SLC6A14
solute carrier family 6 member 14
chr11_-_65857007 0.00 ENST00000527344.5
CFL1
cofilin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051040 regulation of calcium-independent cell-cell adhesion(GO:0051040) corticotropin hormone secreting cell differentiation(GO:0060128)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 0.1 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.0 GO:1904933 cardiac right atrium morphogenesis(GO:0003213) mediolateral intercalation(GO:0060031) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0071955 recycling endosome to Golgi transport(GO:0071955)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008903 hydroxypyruvate isomerase activity(GO:0008903)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)